Collard Green Promotes Bile Acid Binding Activity

By Kyle J. Norton

Bile acids synthesized by oxidation from cholesterol in the liver, that flow to the gallbladder to aid digestion.

Bile acid-binding is a process to interferes with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.

In other words, the binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.

By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.

Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 gram/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% compared to high doses of 24 gram/day of only 25%.

In other words, bile acid-binding medicine such as Cholestyramine used alone is less effective, compared to statins in lowering LDL cholesterol.

The most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.

Bile acid sequestrants such as lovastatin combined with niacin may be used to lower aggressively lower LDL cholesterol levels.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

On finding a potential plant that process bile acid-binding activity researchers compared the effects of
various vegetables, using a mixture of bile acids secreted in human bile under physiological conditions.

The study compared the mixture of 8 replicate incubations which were conducted for each treatment simulating gastric and intestinal digestion, including a substrate only, a bile acid mixture only, and 6 with the substrate and bile acid mixture with Cholestyramine (a cholesterol-lowering, bile acid-binding drug) as the positive control treatment and cellulose as the negative control on bile acid-binding activity

Based on the tested results, the significantly different (P < or = .05) health-promoting potential are collard greens = kale = mustard greens > broccoli > Brussels sprouts = spinach = green bell pepper > cabbage as indicated by their bile acid binding on dry matter basis.

In other words, collard green scored the highest bile acid-binding activity, similar to those of kale and mustard greens.

More important, steam cooking significantly was found to enhance the bile acid-binding property of the collard green, compared to those of uncooked.

Collectively, researchers said, "These green/leafy vegetables, when consumed regularly after steam cooking, would lower the risk of cardiovascular disease and cancer, advance human nutrition research, and improve public health".

Taken altogether, collard green, particularly the stream veggie may be considered a functional food to enhance the bile acid-binding activity, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage by Kahlon TS1, Chiu MC, Chapman MH. (PubMed)

Omega -3 Fatty Acids Inhibit the Onset of Nonalcoholic Fatty Liver Disease

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reducing partly or completely the function of the liver, including liver failure.

Non-alcoholic fatty liver disease is a condition of fatty liver diseases as a result of the accumulated of fat in the liver, not caused by abusive alcohol consumption.

Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in the US, approximately 30% of the adult population are obese.

The disease is also manifested by steatosis, steatohepatitis, cirrhosis.

Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).

In conventional medicine, treatments of NAFLD mainly focus on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.

As of today, there is no effective pharmacologic therapy approved specifically and directly for the treatment of nonalcoholic fatty liver disease (NAFLD).

The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications(8), genetic preposition(8), insulin resistance(8), high cholesterol(8) and triglycerides(8) in the blood, polycystic ovary syndrome(8), metabolic syndrome(8), obesity(8), and type 2 diabetes(8) are associated with the onset of the disease.

Recent studies also found that people with obstructive sleep apnea(11), underactive thyroid (hypothyroidism(10), and underactive pituitary gland (hypopituitarism) (9) also at an increased risk of the NALFD.

Some researchers suggested that an unhealthy diet such as a high-fat diet may also have a strong implication on NAFLD(12)(13).

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic liver diseases, researchers examined the efficacy of C20-22 ω3 polyunsaturated fatty acids (PUFA) on NAFLD in adults and children.

According to the results of the experiment, humans with NAFLD and NASH; and preclinical mouse models of NASH, showed a high abundance of hepatic saturated (SFA) and monounsaturated (MUFA) fat, but a low abundance of hepatic C20-22 ω3 PUFA.

In other words, the imbalance of such change has been found to induce hepatic lipotoxicity, inflammation, oxidative stress, and fibrosis.

Furthermore, recent meta-analyses and clinical trials in the evaluation of the capacity of C20-22 ω3 PUFA suggested that dietary supplementation improves health outcomes in adults and children with preexisting NAFLD.

Additionally, diets supplemented with docosahexaenoic acid (DHA, 22 : 6,ω3) alone or with eicosapentaenoic acid (EPA, 20 : 5,ω3) are tolerated and effective at lowering liver fat in NAFLD patients.

Based on the evidence, researchers said, "dietary supplementation with C20-22 ω3 PUFA should be considered as a viable and effective option to lower liver fat in obese adults and children with NAFLD".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of non-alcoholic fatty liver,  pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 fatty acids and nonalcoholic fatty liver disease in adults and children: where do we stand? by Spooner MH1, Jump DB. (PubMed)
(2) Non-alcoholic Fatty Liver Disease (NAFLD)Treatment in Phytochemicals Perspective by Kyle J. Norton

Tocopherols, the Potential Supplementations for the Prevention of Osteoradionecrosis

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.


Osteoradionecrosis is a condition associated with bone death due to radiation or radiation treatment.

The death of bone cells is a result of radiation induce-damage of the blood vessel that supplies the nutrients to the bone.

Osteoradionecrosis is a rare side effect occurred sometime after radiation therapy has ended. The complication usually occurs in the lower jaw or mandible.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of side effects induced by radiotherapy, researchers evaluated the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline-tocopherol or pentoxifylline-tocopherol-clodronate in combination therapy for osteoradionecrosis.

According to the research of the related study of subjects, the combination of pentoxifylline plus tocopherol with or without clodronate was effective for the treatment of mandibular osteoradionecrosis.

Most of the identified studies were found to be from retrospective case series.

The numbers of studies were generally scarce.

Furthermore, the combination of drug therapy was well tolerated and showed a promising result for the treatment of mandibular osteoradionecrosis.

Moreover, in an18 consecutive patients previously irradiated for head and neck cancer-induced mandible, ORN with the length of the exposed bone (L) was 13.4 +/- 8 mm, and the mean of 12.6 +/- 4.9, either given a daily oral combination of 800 mg of PTX and 1000 IU of vitamin E for 6 to 24 months between June 1995 and January 2002 with eight patients who were the worst cases were given 1600 mg/day clodronate 5 days a week, all patients improved at 6 months, with 84% mean L and 67% mean SOMA score reductions.

Additionally, 18 patients achieved complete recovery, 14 in 5 +/- 2.6 months, compared to only two patients who exhibited a 75% response at 6 months.

Collectively, researchers said, "PTX-vitamin E boosted by clodronate is an effective treatment of mandibular ORN that induces mucosal and bone healing in a median period of 6 months".

Taken altogether, tocopherols used in a combination with other medicines including pentoxifylline may be considered a supplement for reducing the side effects of radiotherapy, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review by Martos-Fernández M1, Saez-Barba M2, López-López J3, Estrugo-Devesa A3, Balibrea-Del-Castillo JM4, Bescós-Atín C. (PubMed)
(2) Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial by Delanian S1, Depondt J, Lefaix JL. (PubMed)

Beta-Sitosterol Inhibits the Risk of Chronic Inflammation in Vivo

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.

However, people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.

Epidemiologically, diseases associated with chronic inflammation are asthma, chronic peptic ulcer, tuberculosis, rheumatoid arthritis, periodontitis, inflammatory bowel inflammatory disease (ulcerative colitis and Crohn's disease), sinusitis and hepatitis.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers examined the topical anti-inflammatory effect of the chloroform extract from Achillea ageratum (Asteraceae) and of stigmasterol and beta-sitosterol on mouse ears edema.

According to the chemical analysis, on 12-0-tetradecanoylphorbol acetate (TPA)-induced mouse ear edema,* All the doses assayed (1, 3 and 5 mg/ear) significantly reduced the edema (50%, 66%, and 82%, respectively),

* The isolated sterols stigmasterol and beta-sitosterol (with doses of 0.5 mg/ear) had similar effects as those of extract with doses of 1 and 3 mg (59% and 65% respectively).

Furthermore, In the chronic model, the anti-inflammatory effect generally more moderate mice, 

* The highest dose of the extract decreased the edema reduction to 26% with the highest dose of the extract applied, compared to the compounds the effect that decreased to 36% with stigmasterol, and 40.6% with beta-sitosterol.

* Moreover, Myeloperoxidase activity (MPO) associated with oxidative stress was reduced by the extract and the compounds in the acute model,

Based on the evidence, researchers said, "These results indicate that the chloroform extract of Achillea ageratum and some of its components stigmasterol and beta-sitosterol are more effective as topical anti-inflammatory agents in acute than in the chronic process and their action is markedly influenced by the inhibition of neutrophil migration into inflamed tissue".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of acute and chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models by Gómez MA1, Sáenz MT, García MD, Fernández MA. (PubMed)

Ashwagandha Protects the Neurons Against Excitotoxicity

By Kyle J. Norton

A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.

The function of neurons can be classified into 3 types

* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses.

 In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.

*The motor neurons transmit impulses from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.

* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.

The most common diseases associated with neuron dysfunction are amyotrophic lateral sclerosis (ALS). Lou Gehrig's disease or classical motor neuron disease that disrupts signals to all voluntary muscles on both sides of the body.

Excitotoxicity is the pathological process associated with neurons damage and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and AMPA receptor.

Where NMDAR (The N-methyl-D-aspartate receptor) is a glutamate receptor and ion channel protein found in nerve cells and glutamate is the anion of glutamic acid which plays a critical role as a neurotransmitter.

Excitotoxicity has been found to induce, neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease.

Most cases of excitotoxicity have been found to be caused by spinal cord injury, stroke, traumatic brain injury,...

On finding a potent compound that processes the neuroprotective effect, researchers examined the effects of Withania somnifera anti excitotoxicity that lead to neurons' damage or killed.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

According to tested differentiation, Withanone isolated from Withania somnifera showed a significant activity to protect the neurons against NMDA-induced excitotoxicity in retinoic acid, differentiated Neuro2a cells.

Furthermore, the pretreatment of Withanone at 5, 10 and 20 μM doses were found to inhibit the NMDA induce- significant neuron cell death through several parameters associated with the accumulation of intracellular Ca2+,  generation of reactive oxygen species (ROS), loss of mitochondrial membrane potential.

Additionally, Withanone also improved the ratio of Bax/Bcl-2 ratio, the release of cell cytochrome c and lipid peroxidation involved in neuron DNA damage and the death of neurons.

Based on the findings, researchers said," All these parameters were attenuated with various doses of Withanone pre-treatment. These results suggest that Withanone may serve as a potential neuroprotective agent".

Taken altogether, Ashwagandha processed a high amount of antioxidant Withanone may be considered a functional herb for the prevention and treatment of neurological diseases including Parkinson's disease, Alzheimer's disease, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells by Dar NJ1,2,3, Bhat JA2, Satti NK4, Sharma PR2, Hamid A5,6, Ahmad M. (PubMed)

Omega 3 Fatty Acids Inhibit Inflammatory Allergic Diseases

By Kyle J. Norton

Chronic allergic airways disease (AAD) is a group of the disease characterized by airway inflammation and airway hyperresponsiveness (AHR).

Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by persistent production of proinflammatory cytokines by the immune system in the airway.

On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.

Most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airways conditions.

Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improved quality of life through avoidance of irritants.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

During the asthma attacks, patients may experience symptoms of difficult breathing, and severe wheezing in the breath and coughs that won't stop.

According to the statistic provided by the Centers for Disease Control and Prevention (CDC), 1 in 13 people in the US has asthma.

In other words, more than 26 million Americans have asthma, with half of the patients are children.

If you experience symptoms of a cough which often worse at night or early in the morning, wheezing in your breath, accompanied by chest tightness and shortness of breath, you may be at the early stage of asthma. Please check with your doctor to rule out the possibility.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic inflammatory diseases, researchers examined the causal relationship between decreased intake of fish oil in modernized diets and an increasing number of individuals with asthma or other allergic diseases.

According to the tested differentiation, the pro-resolving mediators (SPM: protectins, resolvins, and maresins) generated from omega-3 fatty acids such as EPA and DHA via several enzymatic reactions showed a strong impact in the regulation of the airway eosinophilic inflammation and promotion of the resolution of inflammation in vivo.

The efficacy of the mediator in the inhibition of allergic diseases associated with inflammation was attributed to the improvement of the impairment of the biosynthesis of SPM.

The clinical lipidology wrote, "Defects in anti-inflammatory/pro-resolution lipid mediators can contribute to inflammatory disease severity. Anti-inflammatory/pro-resolution lipid mediators can be used to develop therapeutics that enhance rather than block the endogenous regulation of inflammation".

In other words, diseases associated with chronic inflammation in the lung might be a result of a resolution defect.

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of allergic diseases caused by SPM defect, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases by Miyata J1, Arita M. (PubMed)
(2) Proresolving mediators: new therapies to treat inflammatory diseases by Urszula Stopka-Farooqui & Oliver Haworth (Clinical Lipidology)

Red Cabbage May Process a Significant Antioxidant and Cytotoxic Activity

By Kyle J. Norton

Cytotoxicity is the process in the induction of cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals to destroy living cells.

In general, cytotoxicity can cause the death of healthy cells

In cancers, cytotoxicity can be benefits to humans by destroying the cancer cells and prevent them from proliferation.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

More precisely, most cases of cancer cell cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.

The aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.

Before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and Vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.

However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells. 

Many herbal medicines and foods such as fennel (*) , Onion (*), and tomato(*) have been found not only to promote the chemo drug cytotoxic activity against target tumors, but also protect the healthy cells against the chemo drugs side effects.

With an aim to find a natural food for the treatment of cancers, researchers the roles of zeatin (2 mg/L) on antioxidants and cytotoxic activity in regenerated shoots of red cabbage.  

Red cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded with a mass of leaves.

Based on the results of differentiation,

* The extract of a plant treated by 2 mg/L zeatin gives the highest content of total phenolics (5.18 mg gallic acid equivalent/g dry weight) and flavonoids (1.52 mg rutin equivalent/g dry weight).

* Furthermore, various bioactive compounds in red cabbage are significantly enhanced with increasing zeatin concentration.

* In vitro shooting culture using 2 mg/L zeatin displayed higher antioxidant activity in all assays (DPPH, FRAP, and ABTS) compared to control with respective values of 68.12%, 73.28%, and 54.1%, respectively.

* Moreover, the extracts of red cabbage explant treated by 2 mg/L zeatin exhibited the strongest cytotoxic effect towards cancer cells compared to control.

Taken altogether, red cabbage combined with Zeatin may be considered a functional food that processes antioxidant and cytotoxic capacity, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Enhancement of phenolic and flavonoids compounds, antioxidant and cytotoxic effects in regenerated red cabbage by application of Zeatin by Ravanfar SA1, Karimi E2, Mehrabanjoubani P3, Ebrahimi M. (PubMed)