Herbal Chaste Tree Berry (Vitex Agnus-castus) May Process Anti-Leukemia Potency

By Kyle J. Norton

Scientists may have found a herbal ingredient for the treatment of leukemia with no side effects, some studies suggested.

Leukemia is a medical condition characterized by the production of high numbers of abnormal white blood cells. A disease is a group of cancers originating in the soft, inner part of the bones (bone marrow).

At the advanced stage, the cancerous cells can travel a distance away to infect other healthy cells of other tissue and organs, particularly, in the tissue of lymph nodes, spleen, liver, and central nervous system.


The exact causes of leukemia are unknown, however, researchers do know that smoking, and genetic disorders such as Down syndrome. blood disorders and previous treatment for cancer with chemotherapy or radiation are the most common risk factors associated with the onset of the disease.

Leukemia can be classified into acute and chronic leukemia. In acute and chronic leukemia, the abnormal cells can multiply quickly. On the other hand, chronic leukemia, progresses slowly and early symptoms may be very mild.

According to the statistic provided by the Leukemia and Lymphoma Society of Canada, in Canada, leukemia is the most common form of cancer in children 0-14 years of age and the 6th most common among young adults 15 to 29 years.


Every year over 900 children, 0-14 years of age are diagnosed with cancer, accounting for 11% of all childhood cancer.


The most common symptoms of leukemia include persistent fever or chills, fatigue, weakness, frequent or severe infections, unintentional weight loss, swollen lymph nodes, and enlarged liver or spleen.


If you are experiencing some of the above symptoms, please check with your doctor to rule out the possibility of leukemia.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region.

The tree has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time.

There was a report suggested that chaste tree berry stems and leaves can be used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,

Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids

In the study to reaffirm the extract from the ripe fruit of Vitex Angus-cactus (Vitex), may be considered an anticancer candidate, researchers at the joint investigation led by the Tokyo University of Pharmacy and Life Sciences conducted a study to provide a molecular rationale for clinical development in anticancer therapy(SB203580, an inhibitor for p38 MAPK), a detailed mechanism underlying the efficacy of Vitex against HL-60 cells.

* Vitex and the addition of SB203580 induced a dose- and time-dependent decreased cancer cell viability associated with induction of apoptosis and G(2)/M cell cycle arrest.


* SB203580 significantly suppressed Vitex-induced phosphorylation of histone H3, a downstream molecule of p38 MAPK involved in the induction of tumor cells.

* Vitex inhibited HL-60 cancer cells through, the mediation of cytotoxicity.

* A decline in ROS levels along with enhanced apoptosis was observed after treatment with Vitex.


These results suggested that chaste tree berry inhibited the HL 60 cells by increasing the expression of ROS in the facilitated cytotoxicity and inducing apoptosis through cell cycle arrest.

In the summary of the findings, Dr. Kikuchi H, the lead author said, "These results may have important implications for appropriate clinical uses of Vitex and provide novel insights into the interaction between Vitex and other conventional drugs capable of affecting intracellular redox status".



Further differentiation of the cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin against the leukemia cell lines, HL-60 and U-937, researchers found that Vitex and casticin induced cytotoxicity on both cell lines in a dose depended on manner. and HL-60 cells were more sensitive to the cytotoxicity of Vitex/casticin compared to U-937 cells.


Since the HL-60 cell line is more immature than the U-937 cell line, these results suggested that the levels of cytotoxicity of Vitex/casticin were largely attributed to the types of leukemia cells.


Taken altogether, Chaste tree berry may be considered a functional food and an adjunct therapy combined with conventional medicine for the treatment of leukemia without inducing any side effects.

However, due to the limitation of the studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of chaste tree berry anti-leukemia possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by chi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)
(2) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by chi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)

Healthy Food Broccoli Improves the Chemotherapeutic Drug Efficacy for the Treatment of Head and Neck Cancer

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Over time, after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.

The most common head and neck cancer metastases are secondary skin cancer.

Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.

The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infection by the HPV virus, poor oral health, race, and long-term exposure to wood dust.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

Other risk factors such as prolonged sun exposure, infection by Epstein-Barr virus (EBV), poor oral and dental hygiene and occupational inhalants, long-term marijuana, tobacco use, and involuntary smoking are also associated with the onset of head and neck cancer.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential whole for the prevention and treatment of cancer, researchers examined the effect of sulforaphane (SFN) isolated from broccoli extract in the improvement of chemotherapeutic drug efficacy in the treatment of head and neck cancer.

According to the results of differentiation, SF improved the chemotherapeutic efficacies used in the combination with much lower doses of CIS or 5-FU against SCCHN cells, by reducing cytotoxicity to normal cells.

On SCCHN human cell lines (SCC12 and SCC38), titrations of SF standalone or in combination with CIS and 5-FU

* SF treatment alone reduced the SCCHN cell viability in a time- and dose-dependent manner.

* SF-combined treatment not only increased the cytotoxic activity of CIS by two folds and of 5-FU by tenfold against SCCHN but also inhibited SCCHN cell clonogenicity and post-treatment DNA repair with no effect on normal cells. 

Furthermore, SF increased SCCHN apoptosis by promoting the proteins associated with proapoptosis and inhibiting the proteins involved in the anti-apoptotic activity in the tested cell lines.

Based on the findings, researchers said, "Combining SF with low doses of CIS or 5-FU increased cytotoxicity against SCCHN cells while having minimal effects on normal cells".

Taken altogether, broccoli processed with high amounts of sulforaphane may be considered a functional food for reducing chemo drug side effects, pending the confirmation of the larger sample size and multicenter human study.

Intake of sulforaphane in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas by Elkashty OA1,2, Ashry R2, Elghanam GA1,3, Pham HM1, Su X1,4, Stegen C5,6, Tran SD. (PubMed)

Phytochemical Beta-Sitosterol Inhibits the Symptoms of Benign prostatic hyperplasia (BPH)

By Kyle J. Norton

The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.

The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.

Benign prostatic hyperplasia(BPH) is a condition that increases numbers of the cell of prostate tissues, causing partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistics, BPH commonly starts at the age of 30 and symptoms usually can not be realized until the age of 50.

More than half of men between the age of 60-70 experience symptoms of BPH and only 10% is required treatment.

Most symptoms of an enlarged prostate are related to bladder function in urinary excretion.  If you experience some of the symptoms of a weak stream of urine, difficulty starting urination, dribbling of urine, especially after urinating,..... and a sense of not fully emptying the bladder, you may develop enlarge prostate.

In severe cases, patients may also develop symptoms of night time frequent urination and a strong and sudden desire to urinate,.... and blood in the urine.

As the size of the prostate increase, the sex organ pressed on the urethra not only causes urinary problems but also induce urinary pain (dysuria or pain with urination).

Beta-Sitosterol is a phytochemical in the class of phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the protection of the prostate gland, researchers examined the effects of Azuprostat, a beta-sitosterol, in patients with symptoms of outlet obstruction caused by benign prostatic hyperplasia (BPH).

The randomized, double-blind and placebo-controlled clinical trial was conducted to assess the efficacy and safety of 130 mg free beta-sitosterol (phytosterol) daily, using the international prostate symptom score (IPSS) as the primary outcome variable in a total of 177 patients with BPH who were recruited for 6 months treatment in 13 study centers.

Treatment of beta-sitosterol showed a significant improvement of BPH symptoms over placebo.

The mean difference in the IPSS between placebo and beta-sitosterol, adjusted for the initial values, was 5.4 and the quality-of-life index was 0.9.

According to the secondary outcome variables, beta-sitosterol showed an increase in Qmax (4.5 mL/s) and a decrease in PVR (33.5 mL) after adjusting to the changes compared to the placebo.

Based on the findings, researchers said, "These results show that a beta-sitosterol is an effective option in the treatment of BPH".

Taken altogether, beta-Sitosterol may be considered a functional supplement for the prevention and treatment of benign prostatic hyperplasia (BPH), pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol(phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group by Klippel KF1, Hiltl DM, Schipp B. (PubMed)
(2) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)

Anthocyanin-Rich Red Cabbage Extract (ARCE) Processes Cardio-Protective Activity

By Kyle J. Norton

Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.

Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage to blood vessels and the heart.

More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,

According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.

The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight, and smoking.

Believe it or not, most patients who suffered from CVD are also associated with atherosclerosis, a condition caused by long-term plaque build-up on artery walls, that leads to narrowing the arteries and reducing blood flow through your arteries to the heart.


Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are the most common syndromes that have been found to promote CVD.

Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol, and potassium level in the bloodstream, respectively.

Dr. Gumbiner B, the lead scientist wrote, "Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder".

And, " Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl); (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women; or low-density lipoproteins of 160 or greater; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg; or diastolic above 90 mmHg)".

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings of a natural whole for the prevention of cardiovascular disease, researchers examined the effects of Brassica vegetables such as red cabbage on the alleviation of experimentally induced myocardial infarction.

H2O2 induced rat neonatal cardiomyoblasts (H9c2 cells) treatment associated with cytotoxicity (48-50%) and apoptosis (57.3%), were reduced by the application of anthocyanin-rich red cabbage extract (ARCE).

Furthermore, in the isoproterenol (ISO) induced rodent model of myocardial infarction, pretreated ARCE for 30 days recorded a significant increase in heart body weight ratio as compared to the ISO-treated group.

ARCE pretreatment also prevents the effect of ISO on the induction of the depletion of enzymatic antioxidants and apoptosis.

Moreover, ISO-induced infracted areas (10%) and derangement of the myocardium were also inhibited by the pretreatment of ARCE.

Additionally, ISO-induced heart cell membrane damage and heart calcium imbalance were also attenuated by the pretreatment of ARCE.

In other words, ARCE protected heart integrity against the isoproterenol (ISO) induced damage to the heart muscle.

Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".

Taken altogether, red cabbage may process cardioprotective activity, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)
(2) Metabolic risk factors for cardiovascular disease in a working population: a retrospective cohort study by Gumbiner B1, Andresen EM, Hearne FT, Michaelson TE, Bryson M, Lednar WM, Cass R. (PubMed)

Herbal Bilberry, an Anti-Psoriasis Remedy

Kyle J. Norton  

Psoriasis is an autoimmune disease caused by speeding up the life cycle of skin cells that leads to patches of abnormal skin.

Psoriasis may be localized which causes red, dry, itchy, and scaly skin patches in the affected area.

In cases of severity, psoriasis can cover the body completely.

Some patients also experience symptoms of thickened, pitted, or ridged nails and swollen and stiff joints.

If you experience some of the aforementioned symptoms, please check with your doctor for preventive measures.

The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causable factors that induce the onset of the condition.

Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long-term use of certain medicines such as oral steroids.

Some researchers suggested smoking that has a strong impact on the immune system and may also be one of the major causes of psoriasis in smokers.

Dr. wrote, "A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis".


And, " Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences".

The findings strongly suggested, that if you smoke, you are at a higher risk of psoriasis

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, and kidney disease, psoriasis, diabetes, etc.

With an aim to find a natural and therapeutic ingredient for the treatment of psoriasis, researchers
a cosmeceutical formulation based on boswellic acids and Vaccinium myrtillus seed oil in patients with psoriasis.


The double-blind study is to compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclature of Cosmetic Ingredients]: lecithin, Boswellia serrata resin extract) with a placebo formulation and a formulation of Vaccinium myrtillus (Bilberry) seed oil.

More precisely, patients with psoriasis or erythematous eczema were randomly assigned, in a 1:1:1 ratio, to Bosexil(®), V. myrtillus seed oil, or placebo.

During the experiment, Bosexil(®) and the V. myrtillus seed oil treatment significantly improved psoriasis, scales in comparison with placebo.

Formulation of Vaccinium myrtillus seed oil exerted a similar effect as those of Bosexil(®) without any case of worsening compared to placebo.

Furthermore, V. myrtillus seed oil improved itch and erythema in 66.7% and 77.8% of patients, respectively compared to the Bosexil(®) formulation (60% of cases) and erythema (60% of cases) without any case of worsening, respectively.

The results clearly suggested that V. myrtillus seed oil and Bosexil(®) formulation process a strong anti-psoriasis activity without side effects.

Taken altogether, bilberry may be considered a functioning remedy for the treatment of psoriasis, pending the validation of larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis by Togni S1, Maramaldi G1, Di Pierro F2, Biondi M. (PubMed)
(2) Psoriasis and smoking: links and risks by Luigi Naldi. (PMC)

Phytochemical Tocopherols, the Potential Anti-Cancer Remedies

By Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.

At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.

Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.

According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results from cancer.

Furthermore, from the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.

The 3 most common types of cancer are
* Breast cancer, accounts for 25.4% of the total number of new cases diagnosed in 2018.

Breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that which breast cancer starts in other areas of the breast. The risk of getting invasive breast cancer during the lifetime of women is 1/8.

Luckily, the 5 years survival rate of localized breast cancer is about 100%.

* Colorectal cancer and lung cancers are the second and third most common cancers, accounting for 43.9% of all cancers, excluding non-melanoma skin cancer.

Colorectal cancer is cancer in the colon, rectum, or vermiform appendix. Colorectal cancer is relatively very common and slowly growing and progressing cancer.

The 5-year survival rate of the localized stage of colorectal cancer is about 90%.

* Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed, or nut oils, etc.


On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the effect of tocopherols (TOCs) on tocotrienols (TTs). γ-TT and δ-TT have the highest anti-cancer activities.

According to the tested analysis, tocopherols (TOCs) showed a strong anti-tumor proliferative activity by targeting the common molecular pathways involved in the inhibition of the cell cycle.

Furthermore, tocopherols (TOCs) activated the pathways associated with the induction of apoptosis and autophagy, and the inhibition of invasion, metastasis, and angiogenesis.

Moreover, γ-TT and δ-TT (solely or in combination) also induced anti-cancer molecular pathways when used in the combination with the conventional chemotherapeutic drugs

Taken altogether, tocopherols may process anti-cancer properties in Vitro and Vivo, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols by Constantinou C1, Charalambous C2, Kanakis D. (PubMed)

Healthy Food Green Beans Inhibit the Expression of Liver Oxidative Stress Markers, Researchers Say

By Kyle J. Norton

Oxidative stress is a condition characterized by overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.

A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radicals readily donate or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

Antioxidants are stable atoms with a function to inhibit oxidation, come either from dietary sources or are produced by the body.

In contrast to general belief, free radical is also needed in a moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

In a healthy person, oxidative stress is harmful because it not only induces cells lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.

Ozone, certain pesticides, cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.

Liver stress markers such as serum MDA refer to oxidative stress in the liver tissues caused by the overexpression of free radicals or reduced levels of antioxidant enzymes in the liver.


Dr. Halina Cichoż-Lach, the lead scientist said, "Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases.".

And, "Hepatocytic proteins, lipids, and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver".

In other words, liver oxidative stress over the long-term induced damage of proteins, and lipid and alternation of cell DNA can lead to liver diseases, including cancer.


Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belonging to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a natural compound for the prevention of liver stress, researchers examined the effect of cabbage, green beans, or seeds from sunflowers grown either on municipal sewage sludge-amended soil or soil alone fed to male and female Coturnix quail, as 50% of a complete diet, for 5 weeks.


Green beans fed male and female Coturnix quail exhibited liver GST activities significantly lower compared to those fed with sludge-grown cabbage.


Compared to the levels of liver glutathione S-transferase (GST) soil-grown cabbage demonstrated a two-fold activity increase in birds fed the other plants.

More precisely, the levels of glucosinolates present in the cabbage, are 3040 and 9253 ppm (dry basis) in the sludge-grown and soil-grown cabbage, respectively.

In other words, green beans showed a significant reduction of liver stress markers lesser than those of cabbage, regardless of soil cultivation.

Taken altogether, green beans may be considered a liver protective veggie, pending the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Changes in liver glutathione S-transferase activities in Coturnix quail fed municipal sludge-grown cabbage with reduced levels of glucosinolates by Stoewsand GS, Anderson JL, Lisk DJ. (PubMed)
(2) Oxidative stress as a crucial factor in liver diseases by Halina Cichoż-Lach and Agata Michalak (PMC)