Beta-Sitosterol Reduces the Risk of Liver Injury

By Kyle J. Norton

The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.

The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.

Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.

The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.

In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swelling, and tenderness.

Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.

Out of many risk factors, an overdose of medicine has been found to be the number 1 factor involved in liver injury.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the hepatoprotective effects of Beta-sitosterol (Sit) and its derivatives on acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/GalN) in mice.

According to the chemical analysis,
* Among its derivatives, 2-naphthoyl Sit ester (Sit-N) (50 mg/kg) showed the strongest activities against acute liver injury.

* More precisely, Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT) associated with liver injury

* Sit-N also markedly reduced tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels involved in liver inflammation.

* Sit-N drastically improved the activities of antioxidant enzymes such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) and suppressed the expression of malondialdehyde (MDA), liver oxidative stress marker by increasing the expression of nuclear respiratory factor2 (Nrf2) and heme oxygenase-1 (HO-1).

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of liver injury, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beta-sitosterol and its derivatives repress lipopolysaccharide/d-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice by Yin Y1, Liu X2, Liu J3, Cai E1, Zhu H4, Li H3, Zhang L1, Li P3, Zhao Y. (PubMed)
(2) Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats by Mondal A1, Maity TK, Pal D, Sannigrahi S, Singh J. (PubMed)

Cruciferous Vegetables Protect the Stomach Against Stomach Cancer

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Most patients with stomach cancer in the early stage are asymptomatic. 

However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

Localized stomach cancer has a 5-year survival rate of 68%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the 5-year survival rate is 31%.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods for the prevention and treatment of cancer, researchers investigated the risk of regular cruciferous vegetable intake on stomach cancer.

The hospital-based, case-control study conducted at Roswell Park Comprehensive Cancer Center in Buffalo, NY, included 292 stomach cancer patients and 1168 cancer-free controls recruited between 1992 and 1998 as part of the Patient Epidemiology Data System (PEDS).

According to the dietary and other epidemiologic and confounding variables collected by the questionnaire, there were strong inverse associations between stomach cancer and the highest versus lowest intakes of total cruciferous vegetables with the odds ratio (OR) of 0.59.

In the comparison test assay, raw cruciferous vegetables have an OR = 0.53, compared to raw broccoli with an OR = 0.61, raw cauliflower with an OR = 0.51, and Brussels sprouts with an OR = 0.66.

Increased portions of total cruciferous vegetable intake are associated linearly to a reduced risk of stomach cancer.

After taking other factors into account, researchers wrote, "These data suggest that consuming raw cruciferous vegetables may be associated with a lower odds of stomach cancer, even after considering other dietary characteristics".

Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the prevention of stomach cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous Vegetable Consumption and Stomach Cancer: A Case-Control Study by Morrison MEW1, Joseph JM2, McCann SE2, Tang L2, Almohanna HM2, Moysich KB. (PubMed)

Tocopherols Promote Cytotoxic Activity Against Cancer Cells

By Kyle J. Norton


Cytotoxicity is the process that induces cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy the living cells.

In normal, cytotoxicity can cause the death of healthy cells

In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and preventing them from proliferation.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

However, stimulation of ROS expression to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

Scientifically, most cases of cancer cell cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.

Chemotherapy is a type of cancer treatment that uses one or more toxic chemicals to kill cancer cells.

Chemotherapeutic cytotoxicity is the process that interferes with cell division (mitosis) through cell cycle arrest to include apoptosis.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer researchers examined protective effects of α- and γ-tocopherols and α- and γ-tocotrienols on the oxidative stress induced by LPS on human lung carcinoma A549 cells.

Application of α- and γ-tocopherols and α- and γ-tocotrienols showed strong suppression of the intracellular reactive oxygen formation, lipid peroxidation, and induction of inflammatory mediator cytokines, and cell death.

More precisely, the application of tocopherols incorporated into cultured cells could suppress LPS-induced oxidative stress at much lower intracellular concentration than tocotrienols compared to the much slower tocotrienols.

In other words, tocopherols demonstrated the strongest cytotoxicity against the tested cancer cells compared to that of tocotrienols.

Collectively, researchers wrote, "α-tocopherol may exhibit the highest protective capacity among the vitamin E isoforms against LPS-induced oxidative stress".

Taken altogether, tocopherols may process cytotoxicity against the onset of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols by Nishio K1, Horie M, Akazawa Y, Shichiri M, Iwahashi H, Hagihara Y, Yoshida Y, Niki E. (PubMed)

Antioxidant Alliin Isolated From Garlic May Processes Immunomodulatory Effects

By Kyle J. Norton

The immunomodulatory effect is an action in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including the spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, which is the body's defense against infectious organisms and foreign invaders.

In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of a blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Out of many low-grade inflammatory risk factors, some researchers suggested that an unhealthy diet may be one of the major culprits involved in facilitating the onset of the diseases.

Dr. Casas R, Sacanella E, the lead scientist wrote, "Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from fruits, vegetables, and whole grains, and poor in omega-3 fatty acids may cause an activation of the innate immune system, most likely by excessive production of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines".

In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.


Before being treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, production of proinflammatory cytokines, including IL-1beta and TNF-alpha.

Furthermore, the pokeweed mitogen (PWM) treated group also showed reduced levels of both percentage of phagocyting cells and the number of latex particles associated with the immune functions of phagocytosis.

Administration of garlic derivative alliin not only decreased the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.


In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.


In order to reveal more information of alliin effect on the immune system, researchers investigated whether different plant-derived components with similar anti-oxidative and anti-inflammatory function such as quercetin and alliin in traditional Asian diet consumed in an alternate style cooperatively affect health including the growth of host and the status of the gut microbiota and colonic epithelial immunity.

Compared to the traditional Asian diet significantly increased the rat body weight and reshaped the gut microbiota composition by significantly increasing the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health, the consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways of complement and coagulation cascades and hematopoietic cell lineage to improve the gut immunity.

In other words, the alternate consumption of quercetin and alliin can contribute beneficial metabolic effects by optimizing gut microbiota and altering the immunologic function of colonic epithelial cells.

Taken altogether, alliin may be considered supplements for the immune-modulatory activity depending on the body needs, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of a garlic derivative (alliin) on peripheral blood cell immune responses by Salman H1, Bergman M, Bessler H, Punsky I, Djaldetti M. (PubMed)
(2) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(3) The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases by Casas R, Sacanella E, Estruch R. (PubMed)

Cruciferous vegetables Kill Non-Small Cell Lung Cancer in Vitro

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Cancer is a class of disease characterized by cell growth disorderly and uncontrollably in the tissues and organs.

Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancers is derived from epithelial cells.

According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.

In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.

In other words, 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime. Approximately over 220,000 people in the US will be diagnosed with lung cancer this year.

Believe it or not, 60% to 65% of all new lung cancer diagnosed are among people who have never smoked or are former smokers.

Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.

The most common risk factors of non-small cell lung cancer (NSCLC) are long term smoking and people exposed to long-term second-hand smoke.

The most common symptoms of lung cancer are shortness of breath, cough up blood, pain, fluid in the chest, wheezing and hoarseness accompanied by general symptoms shared by other types of cancer.


Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the prevention and treatment of cancer, researchers examined
the effect of the combination of two isothiocyanates, i.e. allyl isothiocyanate and sulforaphane on A549 lung cancer cells.

According to the results of the experiment, the combination treatment worked synergistically to induce stronger growth inhibition of the cancer cells compared to the singular treatment.

The combination treatment caused cell cycle arrest, suppressed cell migration and apoptosis compared to a singular treatment by modifying the expression of key proteins associated with the cellular processes.

Most importantly, the combined treatment also exhibited the expression of ROS to induce the cytotoxic activity against the tested cell line.

Based on the findings, researchers said, "our results have demonstrated the potential of different isothiocyanates used in combination to produce enhanced protective effects against carcinogenesis".

Taken altogether, cruciferous vegetables processed a high amount of allyl isothiocyanate and sulforaphane may be considered functional foods for the prevention of non-small cell lung cancer pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Synergistic chemopreventive effect of allyl isothiocyanate and sulforaphane on non-small cell lung carcinoma cells by Rakariyatham K 1, Yang X, Gao Z, Song M, Han Y, Chen X, Xiao H. (PubMed)

Healthy Food Potatoes (Solanum) May Process Antibacterial Activities

By Kyle J. Norton

Infectious diseases are a class of conditions caused by the invasion of pathogenic microorganisms, such as bacteria, viruses, parasites, or fungi.

Bacteria is a type of biological cell consisting of a single cell with a simple internal structure.

Out of millions of bacteria present in this world, only a hundred of them cause infectious diseases. And, most bacteria that cause large-scale disease in human history may be closed to extinction.

In contrast to general belief, most bacteria live as independent cells, they share the basic characteristics of all living things, they breathe, metabolize, produce waste, and maintain a membrane potential.

However, bacteria do not process a nucleus in which their DNA is separated from the rest of the cell.


In the differentiation of bacteria, one must know that not all bacteria are bad. Some bacteria found in the digestive tract have been found to aid digestion and prevent the imbalance of bad and good bacteria. In other words, most bacteria are harmless.

The most common diseases caused by bacteria include strep throat, urinary tract infections, and tuberculosis.

Infection occurs when the bacteria successfully invade the body and start to multiply. Most cases of infectious diseases caused by bacteria are treated with antibiotics.

And, most cases of infectious disease are transmitted by airborne you can get sick if you breathe into the air that carries infectious bacteria in air particles, vector-borne if you are stunk by the insect that the bacteria and vehicle-borne if you are eating food or carrying the materials contaminated by the bacteria.


Potato is a genus Solanum, which belongs to the family Solanaceae. It is a good source of protein and according to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. It now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.

On finding a potential plant that processes anti-infectious properties, researchers evaluated the antibacterial and cytotoxic activity of a new experimental tooth based on Solanum tuberosum "Tocosh" on the cell lines 3T3 and DU145.

According to the tested analysis* Solanum tuberosum (toosh) was not cytotoxic because it only had one CC50 at the concentration of 0.26927 mg/mL and 0.26845 mg/mL for the cell lines 3T3 and DU145, respectively.

* However, tocosh toothpaste (TD) has an antibacterial effect against S. aureus and S. mutans.


In other words, Solanum tuberosum showed no effects to induce cell death in the tested cancer cell lines but exerted a strong activity against certain oral bacterial strains.

Collectively, researchers said, "This research has great potential for clinical use because this new dentifrice has antimicrobial activity against different oral germs".


Taken altogether, potatoes may be considered a functional food for the prevention and treatment of infectious diseases, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Development of New Experimental Dentifrice of Peruvian Solanum tuberosum (Tocosh) Fermented by Water Stress: Antibacterial and Cytotoxic Activity by Mayta-Tovalino F1, Sedano-Balbin G2, Romero-Tapia P2, Alvítez-Temoche D3, Álvarez-Paucar M4, Gálvez-Calla L5, Sacsaquispe-Contreras S. (PubMed)

Beta-Sitosterol Protects the Liver Against Liver Toxicity

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

If the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linked to increased mortality, extending to those with chronic liver disease.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.

Hepatotoxicity is a condition caused by the accumulation of toxins in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long-term use of certain medicines.

There are many causes associated with liver toxicity including chemical toxins, which normally induce acute liver toxicity, such as those used in laboratories and industries, natural chemicals, and long-term use of certain medication.

The most common signs and symptoms of liver toxicity include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

Beta-Sitosterol is a phytochemical in the class of phytosterols, belongings to the group of lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the pharmacological efficacy of the seed extracts, constituents of the seeds including unsaturated fatty acids linolenic and linoleic acids, and the sterol beta-sitosterol in the 70% EtOH and the MeOH extracts.

According to the chemical analysis, in rat experiment, the seed extracts orally administered attenuated the dimethylnitrosamine-induced hepatopathy, and blood L-aspartate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level.

From the liver perspective, the extracts decreased the levels of AST, ALT, and hydroxyproline levels involved in liver oxidative stress and the rate of liver fibrosis rates.

Hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed showed a higher retinoid level compared to water-treated control rats.

Based on the findings researchers suggested, " the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathy rats, thus exhibiting potent improvement".

And, " The unsaturated linolenic and linoleic acids and the sterol beta-sitosterol contained in these extracts may also contribute to the improvement of liver function".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of liver toxicity pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of extract derived from Eriobotrya japonica on liver function improvement in rats by Nishioka Y1, Yoshioka S, Kusunose M, Cui T, Hamada A, Ono M, Miyamura M, Kyotani S. (PubMed)