Broccoli Protects the Prostate Gland Cells Against the Risk of Prostate Cancer

By Kyle J. Norton

The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.

The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.

Prostate cancer is a medical and chronic condition caused by cell growth irregular in the prostate gland. Most cases of prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Most cases of prostate cancer begin in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper layers to induce colonization.

At the advanced stage, the prostate cancer cells can spread to the distant parts of the body, leading to secondary metastasis.

According to the statistics, prostate cancer is the most common cancer among men particularly in older over 65, after skin cancer. In 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer.

The average age of diagnosis is 66.

The 5 years survival rate of localized prostate cancer is 100% and 98% of that of survivors are alive after 10 years compared to the advanced stage of only 31%.

A most common risk factor is the increase of age as more than 80% of prostate cancers diagnosed in men who are 65 or older. The average age of diagnosis is 66.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential wholefood for the treatment of cancer, researchers examined the effect of Sulforaphane (SFN) is a metabolic by-product of broccoli against prostate cancer.

SFN and other notable isothiocyanates, including phenethyl isothiocyanate and benzyl isothiocyanate found in various cruciferous vegetables, also demonstrated a significantly chemopreventive role for the treatment of breast, colon and prostate cancer.

According to the experient, SFN showed a strong chemopreventive and antineoplastic activity against prostate cancer.

In other words, SFN used alone or a combination of other phytochemicals found in broccoli may be a promising chemopreventive nutraceutical in the context of mechanisms of prostate carcinogenesis.

Taken altogether, broccoli processed high amounts of SFN and phenethyl isothiocyanate and benzyl isothiocyanatemay be considered a functional food for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside by Amjad AI1, Parikh RA1, Appleman LJ1, Hahm ER2, Singh K3, Singh SV. (PubMed)

Cranberry Inhibits the Formation of Advanced Glycation End-Products Induced-Oxidative Stress

By Kyle J. Norton

Advanced glycation end is byproduces formed by protein or fat combine with sugar caused by cooking meat at high temperatures.

The products have been found to affect metabolic health.

The most common causes of AGEs are from the diet, particularly in people who follow the Western diet with high saturated and trans fat, a lot of red meats and processed foods.

Low levels of AGEs may not be a problem, however, overexpression of AGEs can induce oxidative stress, leading to inflammation and damage proteins, lipid and sometimes alternation of cells DNA.

In other words, AGEs initiate the production and free radicals and free radical a chain reaction in inducing oxidative stress that can not be stopped until all electrons in the outer ring paired or inhibited by antioxidants.

Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

Accelerated formation and accumulation of advanced glycation end-products have been found to increased hyperglycemia or oxidative stress, leading to age-related and chronic diseases such as diabetes mellitus, chronic renal failure, neurodegenerative diseases, osteoarthritis and also non-diabetic atherosclerosis and chronic heart failure.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers investigated the ligosaccharide-enriched fraction purified from the North American cranberry anti-AGEs and free radical scavenging effects.

According to the DPPH free radical scavenging assay, Cranf1b-CL isolated from the fraction showed superior activity to the synthetic commercial antioxidant, butylated hydroxytoluene, compared to the positive control (IC50 = 680 vs. 2200μg/mL, respectively).

Cranf1b-CL was found to inhibit AGEs formation in a concentration-dependent manner with comparable activity to the synthetic anti-glycating agent, aminoguanidine, used as the positive control (57 vs. 75%; both at 500μg/mL).

Furthermore, Cranf1b-CL showed superior activity to the synthetic commercial antioxidant, butylated hydroxytoluene, used as the positive control (IC50 = 680 vs. 2200μg/mL, respectively).

Based on the findings, researchers said, "in vitro anti-AGEs and free radical scavenging effects of cranberry oligosaccharides support previous data suggesting that these constituents may also contribute to biological effects of the whole fruit beyond its phenolic constituents alone.".

Taken altogether, cranberry combined with other herbal medicine may be considered a remedy for the inhibition of AGE in the contribution of free radical expression, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of cranberry (Vaccinium macrocarpon) oligosaccharides on the formation of advanced glycation end-products by Sun J1, Liu W2, Ma H1, Marais JPJ3, Khoo C3, Dain JA2, Rowley DC1, Seeram NP. (PubMed)

Tocopherols Promote Cytotoxicity in the Sensitive and Drug-Resistant Cancer Cells

By Kyle J. Norton


Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Drug-resistant cancer is a type of cancer that process chemotherapy resistance ability.

In other words, rug-resistant cancer processes the ability to survive and grow despite anti-cancer therapies. In some cases, cancers can evolve resistance to multiple drugs, called multiple drug resistance.

Cancer that responds to treatment with anticancer drugs is called sensitive-drug cancer.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer, researchers examined the effect of the encapsulated tocopheryl succinate (PTX) loaded with PSST micelles (PTX/PSST-M) which are designed to display synergistic functions in anticancer activities.

According to the analysis,
* PTX/PSST-M showed significantly increased cytotoxicity against PTX-resistant human ovarian cancer A2780/PTX cells for 48 h,
* The efficacy was attributed to the equivalent IC50 value of PTX that was reduced from 61.51 to 0.49 μmol/L.

* Other contributors to the cytotoxic activity also included reducing the mitochondrial transmembrane potential, ATP depletion, ROS production, and activation of apoptotic pathways.

Additionally, researchers also found that the administration of PTX/PSST-M significantly increased cell apoptosis/necrosis and cell cycle arrest at the G2/M phase in A2780/PTX cells.

After talking about other factors into account, researchers said, " These results demonstrate that the redox-responsive PSST micelles inhibit P-gp activity and have a good potential to effectively reverse PTX resistance in human ovarian carcinoma cells by activating intrinsic apoptotic pathways".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of drug-resistant cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of α-tocopheryl succinate-based polyphosphoester copolymers by Chen FQ1, Zhang JM1,2, Fang XF3, Yu H1, Liu YL4, Li H4, Wang YT1, Chen MW. (PubMed)

Beta-Sitosterol, the Potential Anti-Metabolic Dysfunction Antioxidant

By Kyle J. Norton

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndromes, you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in a high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.


Most people with metabolic syndrome do not experience any symptoms, until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.

Other risk factors that increased the risk of metabolic syndrome include aging, race, family history, long-term hormone imbalance such as polycystic ovary syndrome (PCOS), gestational diabetes.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of cardiovascular diseases and diabetes, researchers investigated the potential protective effect of β-sitosterol against the development of metabolic dysfunction.
The study included 35 21-day-old female Sprague Dawley rat pups randomly allocated to and administered the following treatments: group 1-standard rat chow (SRC) + plain drinking water (PW) + plain gelatine cube (PC); group 2-SRC + 20% w/w fructose solution (FS) as drinking fluid + PC; group 3-SRC + FS + 100 mg/kg fenofibrate in gelatine cubes; group 4-SRC + FS + 20 mg/kg β-sitosterol gelatine cube (Bst); and group 5-SRC + PW + Bst.

According to the results after 12 weeks of feeding,
* The high-fructose diet group showed an increase of visceral adiposity and plasma triglyceride concentration but decreased (P < .05) plasma adiponectin concentration associated with return cholesterol in the blood.

* β-sitosterol treatment prevented the high-fructose diet-induced visceral obesity, hypertriglyceridemia, and hypoadiponectinemia.

* Furthermore, β-sitosterol alone increased plasma adiponectin concentration and reduced plasma insulin concentration and homeostatic model assessment index.

Based on the results, researchers concluded, "β-sitosterol could be potentially used to prevent high-fructose diet-induced metabolic dysfunction".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of diseases associated with metabolic dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) β-Sitosterol Shows Potential to Protect Against the Development of High-Fructose Diet-Induced Metabolic Dysfunction in Female Rats by Gumede NM1, Lembede BW1, Brooksbank RL1, Erlwanger KH1, Chivandi E. (PubMed)

Antioxidant Ursolic acid Shows a Strong Effect on Muscle Atrophy in Vivo, Researchers Find

By Kyle J. Norton

Muscle atrophy is a condition associated with a lack of physical activity, inducing loss of muscle mass due to the muscles weakening and shrinking.

A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role to process and transmit information.

The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses.

*The motor neurons transmit impulses from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.

* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.

The most common diseases associated with neuron dysfunction are amyotrophic lateral sclerosis (ALS). Lou Gehrig's disease or classical motor neuron disease disrupts signals to all voluntary muscles on both sides of the body.

The most common disease involved in muscle atrophy is amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Amyotrophic lateral sclerosis (ALS) is a type of dementia associated with neurodegeneration syndrome among elders, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment.

Over 47 million worldwide populations are affected by the disease, mostly in the West.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of neurodegenerative diseases, researchers examined the ursolic acid (UA) activity on the alleviation of the deleterious effect of skeletal muscle atrophy on bone health.

According to the analysis of the immobilization (IM) method used on the left hindlimb of Sprague Dawley (SD) rats for 10 days to induce muscle atrophy, divided into two groups, SED (sedentary, n=6) and UA (n=6) to demonstrate the effect of UA on atrophic skeletal muscles.
* Before UA treatment, muscle atrophy was induced and bone mineral density (BMD) decreased significantly in experimental rats.

* The 8-week UA treatment significantly increased the gastrocnemius muscle mass compared to the SED group.

* UA treatment showed negative results of a decrease in BMD, trabecular bone volume fraction, and trabecular number, and an increase in trabecular separation in the SED group.

* No significant difference was observed in atrophic hindlimbs between SED and UA groups.

After talking about other factors into account, researchers said, "These results alone are insufficient to suggest that UA is a potential resistance exercise mimetic for atrophic skeletal muscle and weakened bone. However, this study will help determine the potential of UA as a resistance exercise mimetic".

Taken altogether, ursolic acid, may have an effect on muscle atrophy, pending the confirmation of the larger sample size and multicenter human study.

Intake of ursolic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of ursolic acid on muscle mass and bone microstructure in rats with casting-induced muscle atrophy by Kang YS, Noh EB, Kim SH. (PubMed)

Queen Herb Chaste Tree Berry Shows a Valuable Chemotherapeutic Property for the Treatment of Cancers in Vitros, Researchers Say

Kyle J. Norton.

Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable ways in our body. In the late stage, the cancer cells may travel away from the originated site
to infect other tissues and organs.


According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under a light microscope, flow cytometric analysis, and agarose gel electrophoresis, Vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria(in regulated cell metabolism)-controlled apoptotic pathway".


In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits exerted strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for the treatment of various types of cancer, depending on further evaluation.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF.(PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y.(PubMed)

Coffee and Coffee's Caffeine May Reduce The Risk of Colon Cancer, Researchers Say

By Kyle J. Norton

Good news for coffee drinkers, coffee consumption regularly is associated with reduced risk of colon cancer, a renowned institute study suggested.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

Colon Cancer is a disease characterized by irregular cell growth in the colon, with the tendency in spreading to distant parts of the body, depending on the stage.

According to the Federico II University of Naples, the efficacy of coffee consumption in attenuated risk of the colon may be attributed to its bioactive components, such as polyphenols, melanoidins, carbohydrates, diterpenes,...

Dr. Vitaglione P, the lead author said, " ...metabolism and composition, both coffee chlorogenic acids and dietary fiber, including melanoidins, may reduce CRC risk, increasing colon motility and antioxidant status".

However, phytochemicals found in coffee may be different that depends on the amount and type of compounds ingested with the beverage, the variety of coffee used, the roasting degree, the type of brewing method as well as the serving size.


Additionally, in the investigated the protective action of coffee against Caco-2 human colon carcinoma cells. researchers filed the following results
1. Even with low concentrations, coffee (<5%) inhibited the proliferation of Caco-2 cells without affecting normal cell viability.
2. . Increasing the duration of coffee bean roasting showed a significant in reduction the mutative risk of gene KRAS expression.

3 Coffee reduces risk colon cancer through suppressed miR-30c and miR-96, in promoted cell proliferation, migration and invasion, and enhanced tumor growth.

Interestingly, in the examine of the association between coffee consumption and CRC risk as well as a risk by anatomic subsite among Japanese, using data from the Hospital-based Epidemiological Research Program at Aichi CancerCenter I and II (HERPACC-I and II) with subjects enrolled in HERPACC-I between 1988 and 2000 and in HERPACC-II between 2001 and 2005, scientists found that returned self-administered questionnaire from participants, coffee consumption in reduced risk of colon cancer is associated to numbers of cup intake daily, in compared to non-drinker.

The relative odd ratio of less than 1 cup/day, 1-2 cups/day, and 3 or more cups/day for CRC were 0.88, 0.90, and 0.78 respectively.

Dr. Senda Nakagawa H, the lead author said, " Subsite-specific analysis revealed a significant inverse linear trend between coffee consumption and distal colon cancer (p-trend = 0.048), and a tendency toward a lower risk of rectal cancer (p-trend = 0.068)".

The finding evidence suggested that coffee and coffee caffeine may have a profound effect in reduced risk of cancer linearly.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee, colon function and colorectal cancer by Vitaglione P1, Fogliano V, Pellegrini N.(PubMed)
(2) Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs by Nakayama T1, Funakoshi-Tago M1, Tamura H1.(PubMed)