Turmeric Protects Chemo Patients Against the Hand-Foot Syndrome

By Kyle J. Norton

Hand-foot syndrome also known as palmar-plantar erythrodysesthesia is side effects in some patients undergoing cancer treatments.

Redness, swelling, and pain on the palms of the hands and/or the soles of the feet are some of the most common symptoms of hand-foot syndrome patients.

In severe cases, patients may also experience symptoms of cracked, flaking, or peeling skin, blisters, ulcers, or sores on the skin and difficulty walking or using your hands.

The leading cause of chemotherapy-induced hand and foot syndrome was attributed to damage the growth of skin cells or small blood vessels in the hands and feet once the drug including Capecitabine (Xeloda) Cytarabine (Cytosar-U) Docetaxel (Docefrez, Taxotere) Doxorubicin (Adriamycin) is circulating in the bloodstream.

Most cases of hand and foot syndromes occur in the first 6 weeks of chemo-target drug treatment. In some cases, the syndrome can occur in the 2nd to 3rd months after chemotherapy.

Conventionally, treatment of hand and foot syndrome by identifying the chemo drug that causes of the condition and focusing to reduce inflammation with the use of anti-inflammatory medication such as corticosteroids.

The experts in the chemo care suggested reducing friction and heat exposure to your hands and feet such as hot water, short showers, avoid increased pressure, on the soles of the feet or palms of hands, reducing exercise that affects the food and hand.and avoid any activity that causes excessive pressure and friction on the palms may reduce the severity of hand and foot syndrome.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings, a potential compound for the treatment of complications in the first cycle of treatment in approximately 40% to 50% of patients who received capecitabine, researchers examined the efficacy of curcumin on hand-foot syndrome (HFS).

The study included 40 patients whose mean age was 62 years inclduing female (80%) with 52% had breast cancer, and 47.5% had GI tumors.

According to the analysis before and after treament of turmeric at a dose of 4 g/day (2 pills 12 hours apart) starting at the beginning of capecitabine treatment and lasting six weeks of the enrolled patients, 11 of 40 patients with capecitabine developed HFS whereas four patients developed HFS equal or superior to grade 2.

The inflammatory markers such as interleukin-6 (IL-6) showed no correlations in patients with HFS.

Co admiration of turmeric and capecitabine displays a lower rate of HFS, especially in grade 2 or higher.patients.

Taken altogether, turmeric may be considered supplements and adjunct therapy combined with conventional medicine for the prevention of hand and foot syndrome induced by capecitabine, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcuma longa (Turmeric) for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Pilot Study by Scontre VA1, Martins JC2, de Melo Sette CV2, Mutti H2, Cubero D2, Fonseca F2, Del Giglio A. (PubMed)
(2) What Is Hand-Foot Syndrome? by Chemocare

Red Cabbage, the Potential Anti-Mammalian Cancer Healthy Food

By Kyle J. Norton

Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.

There are many types of cancer, depending on the location where cancer begins.

As of today, researchers do not know what are the exact cause of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.

Genetic mutation od BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and alternation of gene PTEN.that suppress the growth of tumors also increase the risk of cancers.

According to the statistic provided by the UK Cancers research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.

Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of the Human Development Index (HDI).

The four most common types of human cancer, occurring worldwide are 

* Lung Cancer

Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistics, In 2015, approximately 26,600 Canadians will be diagnosed with lung cancer and 20,900 will die of it.

* Female breast cancer
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

* Colorectal cancer
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

Colorectal cancer is relatively very common and slowly growing and progressing cancer.

The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.

* Prostate cancer
Prostate cancer is defined as a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe. The veggie leave is highly nutritious cultivated as foods in most parts of Europe.

On finding a potent compound for the prevention and treatment of cancers, researchers examined, in vitro cytotoxic effects and the mode of interaction of biologically synthesized Ag and Au nanoparticles (NPs) using Brassica oleracea L. var. capitata f. Rubra (BOL) against HT-1080 cancer cells and bacterial cells.

According to the tested analysis,

* The Ag NPs showed a stronger free radical scavenging activity in vitro compared to the Au NPs.

* Both nanoparticles (NPs) exerted the cytotoxic effects are mediated through nuclear morphological changes and DNA damage.

* Intracellular localization of Ag and Au NPs induced HT-1080 cancer cells apoptosis.

These results strongly suggested that the Ag and Au NPs have easily entered and accumulated into the cytosol and nucleus to activate the inflammatory and apoptosis pathways to induce damage in cancer cell DNA. 

Most importantly, Ag and Au NPs showed no clear toxic effects and no nuclear abnormalities in peripheral blood cells

Taken altogether, red cabbage may be considered a functional food for the treatment of mammalian cancer, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Interaction of silver and gold nanoparticles in mammalian cancer: as real topical bullet for wound healing- A comparative study by Sivakumar AS1, Krishnaraj C2, Sheet S3, Rampa DR4, Kang DR1, Belal SA1, Kumar A5, Hwang IH6, Yun SI2, Lee YS3, Shim KS. (PubMed)

Herbal Angelica Offsets the Anticoagulant Activity of Dual Antiplatelet Therapy (DAPT)

By Kyle J. Norton

Platelets are tiny blood cells that prevent injury and infection by forming clots to stop bleeding.

Antiplatelet activity is an action that prevents and treats blood clots.

Anticoagulants, commonly known as blood thinners, are conventional medicines used to reduce the coagulation of blood, prolong the clotting time.

Anticoagulants have been used widely for people with a high risk of heart diseases and stroke due to narrowing arteries associated with plaque accumulation on the arterial walls.

Platelets are made in the bone marrow that also produces white and red blood cells.

Diseases associated with low and abnormal blood platelet include
* Thrombocytopenia is a condition characterized by low blood platelet due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, nosebleed.

Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.

* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.

* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of platelet aggression, the researchers examined the impact of these four commonly used Chinese medicinal herbs on the pharmacokinetics and pharmacodynamics of the combination therapy with clopidogrel and aspirin.

In order to mimic the standard dosing regimen for dual antiplatelet therapy (DAPT) in human, Sprague-Dawley rats treatment groups were received a bolus oral dose of DAPT on day 1 followed by DAPT for consecutive 13 days in absence and presence of orally co-administered four TCM herbs (Danshen, Gegen, Danggui, and Chuanxiong) at their low and high doses.

According to the results at day 14, and observed the plasma concentrations of aspirin (ASA) and clopidogrel (CLP) and their corresponding metabolites,

* Co-administration of Gegen and Danggui significantly altered the pharmacokinetics of ASA and CLP in DAPT with increased systemic exposure of ASA and CLP respectively.

Furthermore, DAPT with Danshen, Gegen and Danggui co-treatment. significant inhibition on rCyp2c11 that enzymes mediating metabolism of ASA and carboxylesterase activities in drug metabolism, compared to a minimal impact on aspirin esterase activity in all co-administered herbs.

Moreover. all DAPT treatment groups showed a significantly longer prothrombin time (PT) compared to a decrease of the DAPT group in presence of Gegen, Danggui, and Chuanxiong with no change to other coagulative expressions.

Taken altogether, Herbal Angelica used combined with other herbal medicine may be used as a remedy to offset the anticoagulant activity of DAPT, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats by Xiao M1, Qian C2, Luo X3, Yang M4, Zhang Y5, Wu C6, Mok C7, Lee P8, Zuo Z. (PubMed)

The Natural Anti-Helicobacter Pylori Infection Functional Foods

By Kyle J. Norton

Infection is a condition caused by a harmful microbial invasion of the body tissues

Most cases of bacterial infection are treated with antibiotics. However, bacterias are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.

Out of trillions of strains of bacteria in the world, only a few cause diseases in humans. Believe it or not, our gut contains trillion microorganisms, most of them are bacteria.

The most common symptoms of bacterial infection are redness and heat, swelling, fever, pain at the site of infection.

In severe cases, the patient may also experience symptoms of swollen lymph glands.

Most cases of bacterial infection are treated successfully if the types of bacteria that cause the infection are identified.

Helicobacter pylori (H. pylori) is a type of bacteria that cause ulcers, in the lining of your stomach or the upper part of your small intestine. For some people, an infection can lead to stomach cancer.

Gastritis is a condition of inflammation, irritation, or erosion of stomach lining caused by bacteria Helicobacter pylori (H. pylori) overexpression located at the lining of the stomach.

The most common cause of chronic gastritis is infection by Helicobacter pylori bacteria

Chronic gastritis can be caused by the immune system which mistakenly attacks the cells in the stomach lining and long term intake of conventional medicine, such as NSAIDs, aspirin, ibuprofen.

Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe. The veggie's leave is highly nutritious cultivated as foods in most parts of Europe.

On finding a potent compound for the prevention and treatment-induced potentially undesirable increasing resistance of H. pylori with the use of antibiotics, researchers examined the effects of natural compounds' anti-bacterial activity.

According to studies selected to the research
*  Broccoli sprouts cruciferous vegetables include kale, cabbage, cauliflower, brussels sprouts, red-headed cabbage, and radishes (high in isothiocyanates) with a rich in sulforaphane, can diminish the H. pylori growth (6). 
* Apples containing flavonoids have been found to defend the lining materials of the stomach against H.pylori infection (7).

* Honey exhibits potent in vitro bacteriostatic activity against H. pylori and inhibits urease activity. The antibacterial activity of honey is attributable to its hydrogen peroxide content (5).

*Probiotic bacteria can modulate H. pylori activity by either immunological (reduction of IL-1 and IL-6) or non-immunological mechanisms (competition with potential microorganisms) (3). 

In other words, the medicinal properties of some foods and compounds aforementioned may be used as a new adjuvant therapy for H.pylori eradication.

Taken altogether, planted based compounds may be considered a functional food for the promotion of bile acid-binding, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Food bioactive compounds, a possible adjuvant for H.pylori eradication by Soheil Ebrahimpour, PhD,1 Haleh Esmaeili, MSc,2 and Reza Ghadimi, MD, PhD. (PMC)

Herbal Angelica Promotes Colon Functioning in Vivo

By Kyle J. Norton

The colon also known as the large bowel or large intestine, is part of the digestive system in our body which plays a critical role to reabsorb fluids and process waste products from the body and prepare for its elimination.

The mucosa is the inner lining of the colon and rectum made up of a thin layer of epithelial cells (called the epithelium) a layer of connective tissue (called the lamina propria) with a function to promote the moving of stool easily through the colon and rectum.

Most common diseases associated with the colon are

* Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

* Colonic polyps are a small clump of cells that forms on the lining of the colon. Most colon polyps are harmless

* Ulcerative colitis or ulcers of the colon and rectum is a  condition of inflammation of the small, bulging sacs or pouches of the inner lining of the intestine that bulge outward through weak spots as a result of small pieces of stool (feces) trapped in these pouches. 

 According to the statistic, approximately, About 10 percent of Americans older than 40 have diverticulosis.

 *Diverticulitis - inflammation or infection of pouches in the colon.

* Irritable bowel syndrome is a condition in which a patient is diagnosed with abdominal pain or discomfort, bloating, and alteration of bowel habits at least three times a month for the last 3 months without the preexistence of another disease.

Secreted of colonic mucus by the colon not only protected mucosal surfaces in the gut, airways, and urinogenital tract but also softened stool and promoted to discharge.porlongs stool.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of colonic diseases, researchers examined the effects of Angelicaesinensis radix (Danggui) decoction on the therapeutic action and the colonic morphology and mucus secretion in XuexuBianmi model mice.

A total of 60 Kunming mice, containing 1/2 males and females were randomly divided into six groups according to gender and weight (n=10): normal control group, XuexuBianmi model group, positive control group, and high-dose, middle-dose and low-dose Danggui groups.

Except for the normal control group, all other groups were orally administrated with diphenoxylate (DPN) and subcutaneously injected with acetyl phenylhydrazine (APH) and intraperitoneally injected with cyclophosphamide (CPA) to copy XuexuBianmi model.

From the 14th day, the mice in Danggui groups were orally administered with different doses of Danggui decoction (16.67、8.33、4.17 g/kg), and the mice in the positive control group were orally administered with Changtongshu granule (5 g/kg),

Furthermore, the mice in the XuexuBianmi model group were administered with normal saline (NS) at the same volume (10 ml/kg), once a day for consecutive 28 days.

Based on the experimental analysis, 

* Compared with the normal control group, the XuexuBianmi syndromes in the model group showed a significantly prolonged defecation time (FBDT), decrease of the water content in stool and in the colon were decreased (P<0.01), atrophy of the colonic mucosa and gland and decrease and thinning of the mucous membrane layer.

* Compared with the XuexuBianmimodel group, the Xuexu and Bianmi syndromes were improved.

* Danggui decoction treatment groups demonstrated the significant shorten of the first black defecation time (FBDT), increase of the water content of colon, improvement of the atrophy of colon mucosa and gland and colon lubrication function and mucus secretion in the colon.

Collectively, researchers said, "Dangguican improve the mucosal atrophy, and increase the secretion of colonic mucus, then the stool is softened and promoted to discharge".

Taken altogether, Herbal Angelica may be considered a remedy for the protection of the colonic functioning pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Effect of Angelica sinensis radix on colonic morphology and mucus secretion of experimental XuexuBianmi model mice].[Article in Chinese] by Du LD1,2, Ren Y1,2, Wu GT1,2, Niu TH1, Wang ZW1,2, Shao J. (PubMed)

Herbal Ashwagandha, a Natural Prevention and Treatment of Insomnia

By Kyle J. Norton

Most of us experience sleep disturbance sometimes. However, chronic sleep disorders are the changes in the way that you sleep.

Sleep disorders can be acute or chronic. Acute sleep disorder caused by specific or nonspecific events can resolve quickly in short times after the event is addressed.

Ignoring sleep disorders have been found to induce poor health, poor mood, and lethargy, and sometimes have a negative impact on motivation, relationships, and job performance in daily life.

Some people who use over the counter medicine or herbal medicine without consulting the experts may experience side effects and in some cases, worsening sleep problems.

Most people with chronic sleep disorder experience symptoms of excessive daytime sleepiness, irregular breathing or increased movement during sleep, and difficulty falling asleep.

Sleep quality can be measured by examing the.way that you sleep, including the time period that you need to fall to sleep and how many times you have awakened and drifted back to sleep during night sleep.

The National Sleep Foundation’s inaugural Sleep Health Index showed, 45 % of Americans have poor or insufficient sleep that affects their daily activities at least once in the past seven days.

Depending on the types of sleep disorder, the most common causes of chronic sleep disorder are caffeine consumption, lack of regular exercise, poor stress management and the increase in aging.

Insomnia, a common sleep disorder associated with trouble sleeping, including difficulty falling asleep or staying asleep. The condition has been found to induce symptoms of daytime sleepiness, low energy, and irritability.

Long term insomnia is associated with a neurological disorder of depressed mood.

According to the University of Pennsylvania School of Medicine, in 2018, 25% of the US population experience acute insomnia each year. and 6% of the population are living with chronic insomnia.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of sleep disorder, researchers examined the effects of the root or whole plant extract of Ashwagandha (Withania somnifera) on insomnia patients.

In vivo, the root or whole plant extract of Ashwagandha showed significant activity on mice sleep regulation.

Furthermore, the water extract containing the chemical constituents triethylene glycol as a major component induced a significant amount of non-rapid eye movement sleep with a slight change in rapid eye movement sleep in a dose-dependent (10-30 mg/mouse) manner. 

However, the alcoholic extract that contained a high amount of active withanolides showed the insignificant effect to induce sleep in mice.

Based on the findings, researchers said, " These results clearly demonstrated that triethylene glycol is an active sleep-inducing component of Ashwagandha leaves and could potentially be useful for insomnia therapy".

Taken altogether, Ashwagandha containing  triethylene glycol  may be considered a functional herb for the treatment of insomnia, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction by Kaushik MK1,2, Kaul SC3, Wadhwa R3, Yanagisawa M2, Urade Y. (PubMed)

Herbal Turmeric Exerts the Activity Similar to Cytostatic Drugs without Side Effects

By Kyle J. Norton

Cytostasis is the activity that inhibits cancer cell growth and multiplication.

Cytostatic drugs are medicines that inhibit cancer cell growth and division. Cytostatic drugs used in chemotherapy have been found to significant adverse effects.

Chemotherapy is a type of therapy that uses drugs to destroy cancer cells by keeping them from proliferation and migration.

Under normal circumstances, cell growth is a natural process. Every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells is back to a normal growth rate again.

Cancer cells are fast-growing cells ignored the cell cycle inhibitors that stop the cell from growing after certain cell cycle division compared to normal cells. 

According to the statistics provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes. In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

Conventionally, cytostatic drugs are powerful for the treatment of cancers.

The exact causes of cancer are unknown. Carcinoma accounting for over 90% of cancer diagnosed, is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands, including breast, prostate, lung, and colon.

Treatment of cancer conventionally is totally depending on types, grade and stage of cancer. Surgery, radiation and chemo drugs are used for the treatment in most cases of invasive cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of cancer-associated with cytostatic drug resistance, researchers examined numerous adverse effects of mitoxantrone on drug-resistant tumors.

Curcumin, a plant-derived biomolecule isolated from Curcuma longa showed significant activity on the neoplastic and invasive potential of carcinosarcoma cells in vitro.

On the Walker-256 cells, curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone.

However, curcumin only strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells tin a long-term mitoxantrone/curcumin treatment.

Based on the findings, curcumin only reduced the effective doses of mitoxantrone but also inhibits the invasive potential of drug-resistant carcinosarcoma cells.

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for reducing the side effects of chemo drug, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro by Luty M1, Kwiecień E1, Firlej M2, Łabędź-Masłowska A1, Paw M1, Madeja Z1, Czyż J. (PubMed)