Beet (Beta Vulgaris), the Potent Free Radicals Scavenger Functional Food

By Kyle J. Norton

Beet or beetroot may be considered a functional food in protecting the body against the onset of diseases caused by oxidative stress, some scientists suggested.

Oxidative stress in the result of the imbalance of the ratio of free radicals and antioxidants in the body.

In other words, it is caused either by overexpression of free radicals or depletion of antioxidant enzymes produced by the host body.

Free radical is an unstable molecule with the unpaired electrons in the outer ring formed when oxygen interacts with certain molecules. The highly reactive radicals once formed can start a chain reaction, like dominoes that may not stop until they are inhibited by antioxidant.

According to the free radical theory, organisms age and sick are associated with the accumulation of free radicals that cause damage to the cells over time.

An antioxidant is a stable molecule that inhibits oxidation.

Long-term expression of oxidative stress in the body can induce aging and chronic diseases.

Dr. the lead author in the concerns of overexpression of free radical in the risk aging and illness launched an investigation to examine the negative effect of ROS in the risk of the depletion of antioxidant defenses. 

The differentiation found that oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer). 

There is a significant association between oxLDL and higher arterial stiffness, independent of other traditional CVD risk factors and link atherosclerosis with oxidized LDL-cholesterol (oxLDL) as the compound mainly responsible for its production in elderly.

In diabetes mellitus (type 1 and 2), there is the association of increased formation of free radicals and decreased antioxidant potential, leading to macro- and microvascular complications.

And, oxidative stress plays a pivotal role in the progression of CKD, through glomerular damage and renal ischemia and, indirectly, with inflammation, hypertension, and endothelial dysfunction.

All these results found in the differentiation suggested that by identifying different types of oxidative stress biomarkers in the facilitation of chronic illness may provide important information about the efficacy of the type of treatment, the guiding selection of the most effective drugs/dose regimens for patients. 

Beet is best known as the beetroot or garden beet and belong to the amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.

The widespread of oxidative stress-related chronic diseases has been a burden to health care systems such as diabetes, cardiovascular disease, and cancer and concerns of the many scientists.

Particularly, the medication used for the treatment of these diseases have been found to induce numbers of serious side effects.

Researchers at the Poznań University of Medical Sciences in the finding the natural ingredient which processes a potential for the treatment without inducing any adverse effects launched an evaluation to analyze the effect of beetroot juice against N-nitrosodimethylamine (NDEA)-induced liver injury.

In two hepatic cell lines: non-tumour THLE-2 and hepatoma-derived HepG2 cell lines, treatment of with 2, 10 and 20 μm of BET resulted in the translocation of Nrf2 from the cytosol to the nucleus., thus inhibiting the Nrf2 function  that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

These initiation caused by beet juice was application of accompanied by the phosphorylation of serine/threonine kinase (AKT) in the mediation of carcinogenesis, JNK (c-Jun N-terminal kinase) in the regulation of that regulates the biological processes implicated in tumorigenesis, and extracellular signal-regulated kinase (ERK) in the mediation of cancer cell stages of division.

Additionally, beet juice also increased the expression of antioxidant in the gastric cell lines through significantly increased the mRNA and protein levels of GSTP, GSTT, GSTM and NQO1, the groups of protein which play an important role in cellular protection against oxidative stress and toxic foreign chemicals, in these cells. 

Interestingly, BET did not modulate any of the other parameters measured in the HepG2 cells and did not change the methylation of GSTP1 in these cells either.

The finding led us to believe that BET through the activation of Nrf2 and subsequent induction of the expression of genes controlled by this factor may exert its hepatoprotective and anticarcinogenic effects.

In other words, BET increased the levels of antioxidants by reducing the oxidative stress triggered by injury and inflammation through protection of cell DNA against cancer initiation and liver against the expression of chemical toxins.

Taken altogether beet juice may be considered a functional liquid for the inhibition of oxidative stress and adjunct therapy for treatment of oxidative stress-related diseases, depending to the confirmation of large sample size and multi-center study in human

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) What is NRF2?
(2) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines by Krajka-Kuźniak V, Paluszczak J, Szaefer H, Baer-Dubowska W.(PubMed)

Papaya, The Fruit Which Normalizes Your Blood Pressure with No Side Effects

By Kyle J. Norton

Papaya may be considered a natural whole food for the prevention and treatment of hypertension, some scientists suggested.

Hypertension is another term of abnormally high blood pressure in the arteries.

Although h blood pressure usually does not cause symptoms some patients with the syndrome may experience dizziness and light head.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

Underlying medical conditions such as kidney disease and long=term stress are associated with high blood pressure. Epidemiological studies strongly suggested that poor lifestyle habits, such as an unhealthy diet, obesity and lack of exercise, are some major risk factors which can contribute to the early onset of high blood pressure.

Some researchers also found that excessive energy intake and obesity are major causes of hypertension. Dr. Savica V, the lead author in the study "The effect of nutrition on blood pressure" wrote, "Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralocorticoid activity, insulin resistance, salt-sensitive hypertension, and excess salt intake, and reduced kidney function".

High sodium chloride intake strongly predisposes to hypertension".

"Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure".

In the review of all the causable risk factors, you may find that the only natural way to prevent and treat hypertension is to follow a diet with a high intake of fruits and vegetable and whole grain and less in saturated and trans fat, red meat and processed food accompanied with a healthy lifestyle and moderate exercise.

Conventional hypertensive medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.

If you current taking hypertensive medicine, please make sure you know all the side effects for the preventive measure.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents

Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)

Malaysian plants pucuk ubi (Manihot esculenta), pucuk betik (Carica papaya), Ulam Raja (Cosmos caudatus), pegaga (Centella asiatica) and kacang botol (Psophocarpus tetragonolobus) was selected to the examine their effects on key enzymes related to type 2 diabetes and hypertension.

The hexane extract of pucuk ubi (95.01%) and dichloromethane extract of kacang botol (38.94%) showed the highest inhibitory potential against alpha-glucosidase in the alpha-glucosidase inhibition assay.

Furthermore, in the iACE inhibition assay, the inhibitory potential was highest in hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik (59.77%).

These results suggested that papaya may have a nutraceutical potential for hyperglycemia and hypertension prevention associated with type 2 diabetes.

Male albino Wistar rats randomly were divided into three batches (15 rats per batch)-renal, DOCA-salt hypertensives, and normotensives.in the study to examine the antihypertensive effect of crude ethanol extract from the unripened fruit of Carica papaya.

Each batch was further divided into three groups-the untreated, hydrallazine and extract treated groups.

Before injection of crude ethanol extract, the basal (control) The mean arterial blood pressure (MAP) was 93.8 +/- 4.5, 175.2 +/- 5. 1 and 181.3 +/- 6.2 mmHg in the normotensive, renal and DOCA-salt hypertensives, respectively.

Groups treated with extract produced about 28% more depression of MAP than hydrallazine in the hypertensive groups treated with hydrallazine (200 microg/100 g i. v) and extract (20 mg/kg.i.v).

In vitro, using isolated rabbit arterial (aorta, renal and vertebral) strips showed that the papaya extract (10 microg/mL) produced relaxation of vascular muscle tone.

According to the findings, the fruit juice of C. papaya probably processes antihypertensive agent(s) which exhibits mainly alpha-adrenoceptor activity.

Taken all together, unripe fruit of papaya may have a significant effect in reducing the risk of hypertension and treatment of hypertension with no side effect.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension by Loh SP1, Hadira O.(PubMed)
(2) Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat by Eno AE1, Owo OI, Itam EH, Konya RS.(PubMed)
(3) The effect of nutrition on blood pressure by Savica V1, Bellinghieri G, Kopple JD(PubMed)

Apricot, the Potential Anti Colon Cancer Functional Fruit, Scientists Find

 By Kyle J. Norton

Apricot maybe next generation of whole food medicine for the prevention and treatment of colon cancer, some studies suggested.

Colon cancer is the medical condition characterized by cell growth disorderly and irregularly in the tissue of the colon as a result of the alternation of DNA of the healthy cells.

Most case of colon cancer starts on the surfaced cells of the inner lining of the colon tissue. However, at the later stage, the cancerous cells of the colon can travel a distance away to infect other healthy tissue and organs.

The colon also known as the large bowel or large intestine is an organ which involves the absorption of water from the small bowel contents and breaks down of certain materials in the feces into substances in which some of them to be reabsorbed and reused by the body.

The causes of colon cancer are unknown, However, researchers do know that age, family history, ethnicity, overweight or obesity, excessive alcohol drinking and long-term use of tobacco are a most common risk factor of the colon cancer.

Some researchers suggested that good and poor choice of the diet may have potential effects to reduce and contribute to the risk of colon cancer.

People who follow the Western diet not only associated to higher risk but also the recurrent risk of colon cancer onset.

Dr. Alan Moss, the lead author in the study of "The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations" wrote, "processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage.5 Furthermore, red meat was declared as probably carcinogenic to humans, and red meat was listed as a group 2A substance.4 Red and processed meats are considered significant components of a “Western” diet. Other consumed substances that are associated with an increased risk of CRC include alcohol6 and tobacco".

On the other hand in the support of the healthy diet choice in the reduction of colon cancer risk, Dr.Jessie A. Satia, the lead scientists said, "the fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk".

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae.

Apricot is classified with the family o the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

The chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

Dr. Fahima Rashid, the lead author in the finding a natural and bioactive from food sources with no side effect suggested that the butanolic extract may have a profound effect in reducing the risk of colon cancer by inhibiting the expression of Gram-positive and Gram-negative bacteria.

The antibacterial effect of the extract was attributed to the presence of bioactive Flavonoid glycoside.

Futhermore, in the investigation of the anti-neoplastic effects of MK615, an extract from the Japanese apricot (Prunus mume), against 3 colon cancer cell lines, SW480, COLO, and WiDr, cultured with MK615, researchers found that
* MK615 inhibited growth and lysed SW480, COLO and WiDr cells in a dose-dependent manner.

* MK615 induced apoptosis after 6 h incubation, at which point the occurrence of apoptotic cells was 68.0%, 65.7% and 64.7% for SW480, COLO, and WiDr cells, respectively.

* MK615 induced cells death through massive cytoplasmic vacuoles (autophagosomes) in all three cell lines.

Dr. Mori S, the lead author wrote at the final report, "MK615 has an anti-neoplastic effect against colon cancer cells. The effect may be exerted by the induction of apoptosis and autophagy".

Taken altogether, apricot may be considered a functional food for the prevention and treatment of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of apricot anti-colon cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Flavonoid glycosides from Prunus armeniaca and the antibacterial activity of a crude extract.Rashid F1, Ahmed R, Mahmood A, Ahmad Z, Bibi N, Kazmi SU. (PubMed)
(2) New anti-proliferative agent, MK615, from Japanese apricot "Prunusmume" induces striking autophagy in colon cancer cells in vitro by Mori S1, Sawada T, Okada T, Ohsawa T, Adachi M, Keiichi K.(PubMed)
(3)  The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
 Alan Moss and Kumanan Nalankilli. (Gastro enterology)

(4) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler (PMC)

Tualang Honey Protects the Oral Cells Against Cancer With No Side Effects

Kyle J. Norton

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at the increased risk of the disease.

The Canadian Cancer Society in the explanation of how weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".

Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"

If you experience symptoms of a sore that does heal  within a few days, a growth, lump or thickening of the skin or lining of your mouth, tongue and jaw pain that do not heal in weeks, persistent sore throat, difficult or  chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effect compared to surgery followed by chemo and.or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.

The study procedures include several concentrations of Tualang honey (1% - 20%) were applied directly on OSCC cell lines for 3, 6, 12, 24, 48 and 72 hours.

The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit.to detect the cell apoptosis.

Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.

In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.

The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.

The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.

The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.

Dr. Ghashm AA the lead scientist at the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".

Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.

Due to the limitation of the above study, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)

Avocado, the Anti Inflammatory Diseases Functional Food

By Kyle J. Norton

Intake avocado daily may have a strong effect in reducing the risk of acute and chronic inflammation, some researchers suggested.

Inflammation is a natural and systematic immune response with an aim to protect our body against the invasion of foreign pathogens.

Acute inflammation is caused by overproduction of proinflammatory cytokines which is activated the immune macrophages, a first line of the immune defense.

Chronic inflammation that lasts for several months and even year usually is the result of the immune system failing to eliminate all pathogenic invasion in the acute inflammation.

In some cases, chronic inflammation can also be caused by the immune white blood cells mistakenly attacks the body healthy tissue.

Some researchers suggested that long-term exposure to lower levels of irritants, such as industrial chemicals or polluted air may also cause chronic inflammation.

According to the statistic,  in 2000, nearly 125 million Americans were living with chronic conditions and 61 million (21%) had more than one. And these numbers are expected to increase substantially, 

More scarcely,  3 of 5 people die due to chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes, worldwide.

If you experience symptoms of depression, anxiety and mood disorders, persistent gastrointestinal complications like constipation, diarrhea, and acid reflux,  weight gain, and frequent infections, you may be at the early stage of the development of chronic inflammation. Please check with your doctor to rule out the possibility.

Dr. Roma Pahwa and Dr. Ishwarlal Jialal in the article of chronic inflammation suggested that many dietary and lifestyle changes may be helpful in removing inflammation triggers and reducing chronic inflammation as listed below. The most effective is weight loss.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

In the finding a natural ingredient for the treatment of skin inflammation caused by exposure to ultraviolet (UV) radiation without inducing side effects, researchers at the Granot Initiative Center conducted a study to test the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin.

Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6, and PGE(2), the proinflammatory cytokines and enhancing DNA repair.

In human skin explants, treating with PFA reduced significantly UV-induced cellular damage.

Furthermore, in the evaluation of the anti-inflammatory effect of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG) on cyclooxygenase-2 (COX-2) expression which is responsible for increase the inflammatory response and prostaglandin E(2) (PGE(2)) production in cytokine-activated equine chondrocytes, the cells harvested from normal or OA joints .

Before application of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG), equine chondrocytes responded to cytokine activation by up-regulated gene expression of COX-2 and increased PGE(2) production.

Application of ASU and EGCG marginally inhibited COX-2 expression and PGE(2) production in activated chondrocytes. 

The combination of ASU and EGCG reduced COX-2 expression close to non-activated control levels and significantly inhibited PGE(2) production. 

The inhibition of COX-2 expression and PGE(2) production was associated with the inhibition of NF-kappaB translocation in the regulation of cytokines and immune responses.

These results suggested that the combination may offer an attractive supplement or alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis, a chronic inflammatory disease.

Additional study on the effects of avocado soybean unsaponifiables (ASU) on proinflammatory mediators in chondrocytes and monocyte/macrophage-like cells, researchers also found that
* ASU reduced proinflammatory cytokines, TNF-alpha, IL-1beta, COX-2, and iNOS expression in LPS-activated chondrocytes to levels similar to nonactivated control levels.

* The suppression of COX-2 and iNOS expression was paralleled by a significant reduction in PGE(2) and nitrite, respectively.

Taken altogether, avocado processed a significant anti-inflammatory activity may be considered a functional food for the prevention of inflammatory disease and an adjunct therapy combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Polyhydroxylated fatty alcohols derived from avocado suppress the inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(2) Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate by Heinecke LF1, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG.(PubMed)
(3) Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages by Au RY1, Al-Talib TK, Au AY, Phan PV, Frondoza CG.(PubMed)
(4) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)

Phytochemical Allicin, Protects the Cardiovascular System With NO Side Effects, Scientists Find

By Kyle J, Norton

Allicin, a bioactive compound found abundantly in garlic and onion may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of cardiovascular disease, some scientists suggested.

Cardiovascular diseases are a class of chronic and medical conditions of heart and blood vessel disease related to the plaque build up in the walls of the arteries that cause the blockage of blood flow and reduced the oxygen and nutrients rich blood to reach the heart, leading to heart attack and stroke,

There are many causes of heart diseases. Most heart diseases are caused by high blood pressure that contributes to hardening of the arteries.
High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat.

All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Dr. P. Scarborough, the lead author in the study "An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation" wrote, "Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of an unhealthy lifestyle".

These result suggested that people who follow the Western diet with high consumption of saturated and trans fat, red meats and processed food accompanied physical inactivity are associated with the substantially increased risk of cardiovascular disease.

On the other hand, people who are nonsmokers and follow a traditional diet with high intake fruits and vegetables and whole grain and daily moderate exercise have a lower risk of the disease onset.

If you experience symptoms of chest pain, tightness, and chest discomfort (angina), shortness of breath and weakness or coldness in your legs or arms, please check with your doctor immediately, you may be at the early onset of cardiovascular disease.


Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

In the concerns of hyperlipidemia.cause of cardiovascular disease, researhcer at the Taishan Medical University, conducted an investigation to test the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats.

In the study, healthy male Wistar rats fed high-fat diet were treated with fenofibrate (80 mg/kg per day) alone, allicin (60 mg/kg per day) alone and a lower dosage of combined therapy (allicin 20 mg/kg per day and fenofibrate 30 mg/kg per day) respectively for 8 weeks.

At the final phase, compared with high fat diet control, fenofibrate alone or the combined therapy increased remarkably the levels of high-density lipoprotein respectively (P<0.05).

Both single and combined therapy of fenofibrate and allicin significantly enhanced the levels of NO (P<0.01 or P<0.05), but the combined therapy had the greatest high endothelial-dependent vascular relaxation (EDVR) responses. These suggested that both ingredients processed a significant effect in enhancing vascular relaxation.

Futhermore, the combined therapy also inhibited the levels of ALT and AST caused by infection of a high-fat diet in the stimulation of oxidative stress.

Additionally, in the search of chemicals that arise from natural food source with the potential to provide beneficial effects to the cardiovascular system, researchers at the heart team at The Hong Kong Polytechnic University launched a study to test the effect of allicin om heart diseases.

Application of Allicin demonstrated cardioprotective effects by inducing vasorelaxation and alleviating various pathological conditions of CVD, including cardiac hypertrophy, angiogenesis, platelet aggregation, hyperlipidemia, and hyperglycemia.

Allicin was also discovered to further protect the cardiovascular system by enhancing the antioxidant status by lowering the level of reactive oxygen species and stimulating the production of glutathione.

Dr. Chan JY, the lead author, said, "From the pharmacokinetic studies, allicin is known to be hydrophobic and can be readily absorbed through the cell membrane without inducing any damage to the phospholipid bilayer and then rapidly metabolized to exert pharmacological effects that are important to the cardiovascular system".

Taken all together, Allicin, the bioactive compound may be considered a functional supplement for the prevention and treatment of cardiovascular diseases, depending on the further differentiation in the human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(3) The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats BY Li W, Wang D, Song G, Zuo C, Qiao X, Qin S.(PubMed)
(4) A review of the cardiovascular benefits and antioxidant properties of allicin by Chan JY, Yuen AC, Chan RY, Chan SW.(PubMed)
(5) An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation by P. Scarborough,⁎ S. Allender, M. Rayner, and M. Goldacre. (PMC)

Anacardic Acids, The Potential Anti Breast Cancer Phytochemical

By Kyle J. Norton

Anacardic acids, a phytochemical found abundantly in the may process a potential effect in reducing risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a chronic condition associated with the irregular cell growth caused by the alternation of  DNA of breast cell.

Most cases of breast cancer start on the cells in the surface of the in the inner lining tissue of the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

However, after colonizing most of the breast tissue, the cancer cell at the later stage can travel a distance away to infect other healthy tissue and organs through the circulation of lymph and blood.

According to the statistic, every year, 75,000 and 234,000 patients are diagnosed with breast cancer (BC) in Germany and in the USA, respectively.

 In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Although genetic preposition such as mutated gene BRCA 1 and 2 are the best-known risk factor associated with the 60% increased the risk of breast cancer.

Unhealthy lifestyle including poor diet and physical inactivity are also the most mentioned risk factor by scientists.

Dr. Max Dieterich, the lead scientist in the study "Influence of Lifestyle Factors on Breast Cancer Risk" wrote, "epidemiological studies that lifestyle factors play an important role in the development of BC. For example, daughters of Asian women who have migrated to the USA revealed an increased risk of developing BC, which was attributed to the exposure to a different lifestyle and nutritional factors".

These results suggested regardless of ethical origin, if you follow the Western diet and lifestyle, you are at the higher levels of risk, compared to those who follow the traditional diet.

More precisely, if you are following the diet high saturated and trans fat, red meat and processed food, regardless of where you're from, you are at higher risk of breast cancer.

Therefore by modifying the lifestyle risk factors to develop a strategy for BC prevention is an urgency for the prevention of breast cancer.

Other risk factors associated with breast cancer are age, family history of BC, personal breast history (pre-malignant lesions), breast density, thorax radiation, and a number of menstrual cycles during the lifetime.

In order to understanding the effect of Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid), a dietary and medicinal phytochemical anticancer activity in cell and animal models, researchers at the cancer team program at the University of Louisville School of Medicine, conducted an experiment to test the mechanisms of the AnAc in the inhibition of breast cancer cell proliferation.

Application of the AnAc 24:1(omega5) purified from geranium (Pelargonium x hortorum) inhibited the proliferation of estrogen receptor alpha (ERalpha)-positive MCF-7 and endocrine-resistant LCC9 and LY2 breast cancer cells with greater efficacy than ERalpha-negative primary human breast epithelial cells, MCF-10A normal breast epithelial cells, and MDA-MB-231 basal-like breast cancer cells.

AnAc 24:1(omega5) inhibited cell cycle progression and induced apoptosis in a cell-specific manner.

AnAc 24:1(omega5) inhibited the breast cancer cell line was attributed to stimulation of proteins which are responsible for program cells death and anti-cell proliferation.

. 
Dr. Schultz DJ, the lead scientist at the end of the study said, "These data indicate that AnAc 24:1(omega5) inhibits cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner by reducing ER-DNA interaction and inhibiting ER-mediated transcriptional responses".

Furthermore, in examining the series of N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-alkyl (and alkenyl) benzamides related to the anacardic acid derivative CTPB prepared from 2,6-dihydroxybenzoic acid, researchers found that In U937 cells
* Derivatives labeled 7 c, 7 d, 7, and 7 j exerted a potential effect in inducing cell-cycle arrest in the G1 phase,

* The derivative also cause apoptosis in about 20 % of the cells and increased the acetylation of H3. Loss of acylation levels of H3 was associated with patients with breast cancer.

Taken together, Anacardic acids may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM. (PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)