Beetroot, The Potent Function Food In Normalizing Your High Blood Pressure with No Side Effects

By Kyle J. Norton, Master of Nutrition

Beet juice with high in NO may be coaidered an therapy for prevention and treatment of high blood pressure with no side effects, some studies found.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.

The causes of high blood pressure are associated with some factors, including unhealthy lifestyle choices, lack of physical activity and poor diet.

Dr. Beilin LJ, in the update of on lifestyle and hypertension control, wrote, "lifestyle and blood pressure control will focus on complex dietary patterns, issues related to obesity, hypertension and dietary sodium, meta-analyses on exercise, alcohol, coffee consumption, and magnesium and some recent data on antioxidant vitamins".

Therefore, if you currently have high blood pressure, you can manage and treat the condition easily by the change of diet that recommends the high intake of fruits and vegetables and whole grain and reduces intake of saturated and trans fat and limits intake of red meats, and process foods, accompanied with limiting the use of alcohol, and salt intake.

Some researchers suggested that environmental factors such as long-term exposure to chronic stress are also the prevalent risk to the syndrome onset.

Dr. Tanya M. Spruill, at the Columbia University Medical Center, in the study of the connection between chronic psychological stress and hypertension, said, "Laboratory studies have provided convincing preliminary evidence that thinking about stressful events, in addition to experiencing them directly, can delay BP recovery, (leading to the persistent onset of hypertension)."

In the explanation of psychosocial factors that inflict the onset of hypertension. If your hypertension is a result of long-term psychological stress, biofeedback, progressive muscle relaxation, stress management training, and transcendental meditation, can be helpful.

Beet is best known as the beetroot or garden beet and belong to the amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.

Besides the major chemical constituents betalains and phenolics, it also contains a lesser amount of isobetanin, probetanin, neobetanin, indicaxanthin, vulgaxanthins, etc.



Dr. Coles LT, the lead scientist in the research team of the heart and diabetes program at the Baker IDI Heart & Diabetes Institute, Melbourne showed that consumption of beetroot juice on a low nitrate diet may lower blood pressure (BP)the major risk factor of cardiovascular events.

The results was based on a total of 50 women and 15 men participated in a double-blind, randomized, placebo-controlled, crossover study.

Particpants were randomized to receive 500 g of beetroot and apple juice (BJ) or a placebo juice (PL).

Volunteers also had BP measured at baseline and at least hourly for 24-h following juice consumption using an ambulatory blood pressure monitor (ABPM).

Volunteers remained at the clinic for 1-h before resuming normal non-strenuous daily activities and The identical procedure was repeated 2-wk later with the drink (BJ or PL) not consumed on the first visit.

At the end of the final phase, researchers discovered that there was a trend (P=0.064) to lower systolic blood pressure (SBP) at 6-h after drinking BJ relative to PL.

Analysis in men only (n=13) after adjustment for baseline differences demonstrated a significant (P<0.05) reduction in SBP of 4 - 5 mmHg at 6-h after drinking BJ.

These results indicated, beetroot juice will lower BP when consumed as part of a normal diet in free-living healthy adults.

Additionally, in the examining of the impact of beetroot on lower blood pressure, researchers conducted an experiment to investigate the acute effects of beetroot bread (BB) on microvascular vasodilation, arterial stiffness, and BP in healthy participants.

The acute, randomized, open-label, controlled crossover trial. included 23 healthy men received 200 g bread containing 100 g beetroot (1.1 mmol nitrate) or 200 g control white bread (CB; 0 g beetroot, 0.01 mmol nitrate).

The incremental area under the curve (0-6 h after ingestion of bread) for endothelium-independent vasodilation was greater and lower for diastolic BP (DBP; P = 0.032) but not systolic (P = 0.99) BP after BB compared with CB.

The above effects occurred in conjunction with increases in plasma and urinary nitrate (P < 0.000 1) and nitrite.

BB acutely increased endothelium-independent vasodilation and decreased DBP,

These results suggested beetroot bread (BB) lower the blood pressure by widening the micro blood vessels and decreasing the levels of  DBP, without affecting the SBP.

Dr. Hobbs DA, the lead scientists said, after taking into of co and confounders " enriching bread with beetroot may be a suitable vehicle to increase intakes of cardioprotective beetroot in the diet and may provide new therapeutic perspectives in the management of hypertension".

taken altogether, beetroot may be considered a functional food for the prevention and therapeutic agent for the treatment of hypertension without inducing any side effects.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial by Coles LT, Clifton PM.(PubMed)
(2) Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial by Hobbs DA, Goulding MG, Nguyen A, Malaver T, Walker CF, George TW, Methven L, Lovegrove JA. (PubMed)
(3) Update on lifestyle and hypertension control by Beilin LJ. (PubMed)
(4) Chronic Psychosocial Stress and Hypertension by Tanya M. Spruill. (PubMed)

White Button Mushroom, the Potential Anti Breast Cancer Functional Foods, According to the Studies

By Kyle J. Norton, Master of Nutrition

Mushroom may be the next generation of vegetable processing pharmaceutical value for the finding of single ingredients that process anti-breast cancer potency, some studies suggested.

Breast cancer is a primary medical and chronic condition that starts with the irregular cells growth due to DNA alternation on the surface the inner lining of the breast tissue.

At the advanced stage, breast cancer cells can travel a distance away to infect other healthy tissue and organ.

According to the statistic, the risk of a woman to develop breast cancer in her lifetime is 12.4%.

In 2018, approximately over 260,000 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with over 63,000 new cases of non-invasive (in situ) breast cancer.
The exact causes of breast cancer are unknown, Women who carry the mutated gene BRAC1 and 2 are associated with the increased risk of the disease.

In the concerns of breast cancer risk among women in both developed and less-developed countries and the increasing rates of breast cancer worldwide, particularly in postmenopausal and estrogen receptor-positive cases, researchers at the University Hospital of South Manchester NHS Foundation Trust, launched an investigation to evaluate whether diet and lifestyle can prevent breast cancer.

At the final report, they discovered, "successful lifestyle changes could prevent 25% to 30% of cases of breast cancer" and "breast cancer) reductions will only be achieved if we can implement targeted prevention programs for high-risk women and women in population-based breast screening programs during childhood, adolescence, and early adulthood when the rapidly developing breast is particularly susceptible to carcinogenesis".

"Adherence to a healthy dietary pattern does not have specific effects on breast cancer risk but remains important as it reduces the risk for other common diseases, such as cardiovascular disease (CVD), diabetes, and dementia".

In menopausal women, researchers said, "Weight control throughout life appears to prevent cases (of breast cancer) after menopause".

These results clearly suggested that maintaining the healthy weight and active changing the unhealthy lifestyle and having mammograms taken every year in high-risk women are the best approaches to prevent the onset of breast cancer.




Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

The vegetable is a genus A. Muscaria and belonging to the family Amanitaceae and cultivated in many cultures all over the world for foods and health benefits.

Chemical constituents of white button mushroom include astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

In the assessment of white button mushroom (WBM), widely consumed in most countries intake in the protection of breast cancer, researchers launched an investigation to examine mushroom polysaccharides for their immunomodulating and antitumor properties.

Two polysaccharide fractions, ABP-1 and ABP-2, exerted a potential antitumor activity through inhibiting the production of proinflammatory cytokines such as nitric oxide, interleukin-6, and tumor necrosis factor-α. via modulation of macrophage, (the immune first line of defense) function by that is mediated in part through activation of nuclear factor-κB in the induction of tumor cell apoptosis.

In compared to other cancer cell lines, ABP-1 and ABP-2 demonstrated the ability to inhibit the growth of human breast cancer MCF-7 cells.

Particularly, when murine Sarcoma 180 cells exposed ABP-1 or ABP-2 were implanted subcutaneously into mice, two polysaccharide fractions reduce tumor growth substantially compared to those of control mice.

These result suggested that white button mushroom may exhibit the antitumor effect through stimulating the function of immune macrophages.

Additionally, PAP-3, an acidic polysaccharide fraction in the testing against breast cancer cell line MCF-7 cancer cells with an IC50 of 193 µg/mL, displays a strong apoptotic activity through inducing the loss of mitochondrial membrane and increase of Bax/Bcl-2 ratio via cytotoxicity.

PAP-3 also exhibited the pro-apoptotic function of p53, and cell cycle arrest at the S phase.

Antioxidants produced by the incubation of MCF-7 cells such as superoxide dismutase (SOD) and N-acetylcysteine (NAC) was significantly attenuated by the ROS generation and apoptosis by PAP-3.

Polysaccharides from the white button mushroom, especially acidic PAP-3, not only are very important nutritional ingredients, but also at least in part, exerts anti-cancer health benefits through the ROS-mediated mitochondrial apoptotic pathway.

Interestingly, in the study to investigate the evidence of consumption of dietary mushrooms can protect against breast cancer, researchers found that MCF-7 cellular proliferation was significantly (P < 0.05) reduces up to 33% by all mushrooms and Hot water extracts (MT) from white button mushroom significantly increases apoptosis, or programmed cell death.

The results strongly indicated mushrooms processes significantly suppressed cellular proliferation property, with MT further significantly inducing apoptosis and cytotoxicity in human breast cancer cells.

Taken all together, white button mushroom may be considered a functional food for the prevention and combined with the primary therapy for the treatment of breast cancer., depending on the confirmation of further data collection from the large example size and multi-center studies in human.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms by Jeong SC1, Koyyalamudi SR, Jeong YT, Song CH, Pang G.(PubMed)
(2) ROS-dependent mitochondria molecular mechanisms underlying antitumor activity of Pleurotus abalonus acidic polysaccharides in human breast cancer MCF-7 cells by Shi X1, Zhao Y, Jiao Y, Shi T, Yang X.(PubMed)
(2) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR1, Brophy SK.(PubMed)
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)

Phytochemical Piperine, A Potent Anti Allergy Bioactive Ingredient, Researchers Say

By Kyle J. Norton

Scientists may have found a bioactive compound in the prevention and treatment of allergy with no side effects, according to studies.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

Allergies are the result of the abnormally immune systematic response to typically harmless substances in the environment, leading to the symptoms and reaction in the nose, lungs, throat, sinuses, ears, lining of the stomach or on the skin.

Believe or not, the diseases associated with the hyperactivity of the immune system include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis.

According to the Centers for Disease Control and Prevention (CDC), Over 20 million Americans 18 and older and more than 6.1 million children were diagnosed with allergic rhinitis, commonly known as hay fever, in 2015. Another 20 million Americans were diagnosed with respiratory, food, or skin allergies.

In the comparison the allergic effect in the school today and the past, it often feels like food allergies are far more common today than in their youth, the incidence rarely happened in the past school days.

What contributes to the hyperactivity of the immune system in triggering the food allergy today compared to the past. No one knows.

However, researchers do know that certain risk factors including children, adults younger than 18 years old, family history of allergy and having asthma, particularly in people with a genetic preposition are associated to the onset of allergy.

Dr. Romina A. Ortiz, the lead scientist in the immunity team at the The Johns Hopkins Asthma & Allergy Center, said, " Genome-wide association studies (GWAS) has been widely employed in the field of allergic disease, and to date significant associations have been published for nearly 100 asthma genes/loci, in addition to multiple genes/loci for AD, AR and IgE levels".

And, " Molecular genetics has undergone a technological revolution, leading to next-generation sequencing (NGS) strategies that are increasingly employed to hone in on the causal variants associated with allergic diseases".

These result clearly indicated that people inherited the mutated gene from the parent that causes over-reactivity of the immune system are at the increased risk of allergy

On finding a natural constituent or wholefood for the prevention and treatment of allergy with no side effect, researchers at the Kinki University investigated the anti-allergy effect of the extract of the Piper nigrum leaf.

The extracts at a different dose of 50, 200 and 500 mg/kg exerted a significant activity in inhibiting the cutaneous reaction at the early phase and later phase in dinitrofluorobenzene (DNFB) induced allergic mice.

Allergic effect of ear swelling also was inhibited by the PN-ext (50, 200 and 500 mg/kg, per os (p.o.)). But this effect on very late phase response (vLPR) in the model mice was significant but weaker than that on IPR.

At day 7, administration of PN-ext (50, 200 and 500 mg/kg for 7 d) completely inhibited picryl chloride (PC)-induced ear swelling in PC sensitized mice.

The results were attributed to the extract inhibitory effect on compound 48/80-induced histamine release from rat peritoneal mast cells.

The in-depth analysis of the result suggested that 2 Two lignans of PN-ext, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), from the piperine found in the extract, were identified as major active principles having histamine release-inhibitory activity.

Additional evaluation of the piperine antiallergic effect, researchers launched a study of Balb/c mice to test the effect of piperine on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes.

The Balb/c mice were induced asthma by ovalbumin sensitization and inhalation. Piperine (4.5 and 2.25 mg/kg) was orally administered 5 times a week for 8 weeks.

Piperine-treated groups showed a strongly suppressed eosinophil infiltration, allergic airway inflammation, and airway hyperresponsiveness by inhibiting the proinflammatory cytokines and levels of immunoglobulin E and histamine.

In other words, the therapeutic mechanism by which piperine effectively treats asthma is based on a reduction of Th2 cytokines associated with the promotion of IgE and eosinophilic responses.

Taken altogether, piperine, a major bioactive compound found in black pepper may be used for the prevention and treatment of allergy caused by immune overreaction.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC. (PubMed)
(3) Genetics of Allergic Diseases by Romina A. Ortiz, MS, and Kathleen C. Barnes, Ph.D. (PubMed)

Phytochemical Polysulfides, a Plant Base Anti Bacterial and Fungal Infection Alternative

By Kyle J. Norton

Scientists may have found a natural antibiotic for the prevention and treatment of bacterial infection, according to the study.

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belongings to the group ofOrganosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

How the immune system protects against infection. As soon as sensing the physical injury in the body, the white blood cells of the immune first line of defense not only activates the protein associated with the coagulation to cover the wound but also stimulates the production of pro-inflammatory cytokines to kill off the foreign invaders.

However, in most cases, overexpression of proinflammatory cytokines can cause death and damage to nearby health, leading to abnormal tissue healing with the formation of scars.

For example overexpression of proinflammatory cytokines produced during the hepatitis infection can induce irreversible liver scars, leading to chronic liver disease, such as cirrhosis.

Some researchers in the examine the immune evolution history, suggested that the immune system must kill off the invaders with 3 to 8 weeks during the acute phase of infection, otherwise, it will adapt to the change, causing low-grade inflammation, such as type 1 diabetes mellitus, coeliac disease, inflammatory bowel disease, and rheumatoid arthritis.

According to the study by the Memorial University of Newfoundland, in the micronutrients perspectively, zinc; selenium; iron; copper; vitamins A, C, E, and B-6; and folic acid have important influences on immune responses" and "Overnutrition and obesity also reduce immunity and protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production".

These results indicated beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In order to understand the range of sulfur-containing natural products from plants in the inhibition of fungi, bacteria infection, researchers investigated the biological activity of these compounds that affect human immunity.

Polysulfides, one of the bioactive compound from the group, exerted a significant redox-activity through increasing the expression of antioxidants (catalysis, metal binding) enzymes in inhibiting the radical generation and protecting the integrity of DNA and cellular membranes.

Furthermore, in order to exert the maximum effect in immunity, the biological activity of polysulfides depends on initial antioxidant-enzymatic activation to be generated with high target selectivity.

Moreover, in examing the polysulfides activity against the increase in the number of systemic fungal diseases, researchers showed that polysulfides found in the garlic extracts or essential oils demonstrated a clinically significant effect in fungal infection. the bioactive compound was considered an alternative way of protection of foodstuffs from contamination.

In vitro and in vivo, polysulfide derivatives isolated by chemical reaction also exhibited a potent antifungal acti.vity against candidosis in the tested mice.

Taken altogether, Polysulfides isolated from garlic may have a therapeutic effect in improving the immune activity against the bacterial and fungal infection with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms by Jacob C.(PubMed)
(2) [Pharmaceutical significance of Allium sativum L. 4. Antifungal effects].[Article in Czech]by Sovová M1, Sova P.(PubMed)
(3) Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H- 1,2,4-triazol-1-yl)-2-butanol by Tasaka A1, Tamura N, Matsushita Y, Hayashi R, Okonogi K, Itoh K.(PubMed)
(4) Nutrition and the immune system: an introduction by Chandra RK. (PubMed)

Bioactive Sulforaphane (Isothiocyanates), the Anti-Obesity Plant Based Compound

Kyle J. Norton

Dithiolthiones, a bioactive ingredient found in cruciferous vegetables may have an effect on reducing the risk of obesity in chronic consumption, some scientists suggested.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Obesity is a medical condition caused by the excess body fat accumulated over time.

And,  overweight is a condition of excess body weight relative to the height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

Some researchers suggested that the prevalent and widespread of obesity in the Western world not only increased the burden of health care and economic cost but also induce a reduced quality of life of adults due to chronic ailments.

In the comparison of the obesity rate today and 50 years ago, the Centers for Disease Control statistic showed that the obesity rate has skyrocketed by more than 185 percent among American adults over the last 50 years, and the rate of extreme obesity among children have tripled during the same time period.

These results clearly suggested that the adults today must have something different in their daily activity that contributes these significant change.

Some researchers suggested that lack of exercise may be one the most prevalent risk factor which induces the onset of obesity.

Dr. Petri, the lead scientist in the examine the role of physical activity and exercise in obesity and weight said, "obesity is caused by a consistent decline in daily energy expenditure is not supported either by objective measures of energy expenditure or physiological theory of weight gain alone. However, since voluntary exercise is the most important discretionary component of total daily energy expenditure, it can affect energy balance".

This conclusion indicated that lack of exercise and over nutrient consumption work together to facilitate the onset of overweight and obesity.

In the concern of obesity widespread in the American population, researchers examine the anti-obesity effect of sulforaphane in the animal model. C57BL/6N mice in the study. were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks.

According to the food efficiency ratios compared to untreated control, the sulforaphane treatment group showed a lower body weight. SFN attenuated HFD-induced visceral adiposity, adipocyte hypertrophy associated with increasing the store of fat within the abdominal cavity and fat accumulation in the liver.

Futhermore, Serum total cholesterol and leptin, and liver triglyceride levels were lower in HFD-SFN-fed mice than in HFD-fed mice.

The efficacy of SFN in the anti-fat deposit was attributed to the decreased expression of a protein which plays a critical in reducing triglyceride level and regulating the energy homeostasis and increased adiponectin expression in the modulation of glucose and fatty acid oxidation.
Taking foods containing sulforaphane may be effective in managing weight loss for obese patients accompanied by a change of lifestyle with more vegetables and fruits into a diet.

Futhermore, in a highly palatable (HP) diet male Wistar rats, injection of sulforaphane (SFN, 1 mg kg⁻¹, 4 months treatment)exerted some beneficial effects on obesity and insulin resistance.

Moreover, glucose tolerance was lower in the HP diet groups, especially in the HP group treated with SFN. Except for the liver triacylglycerols. 

Moreover, SFN at the specific dose was found to accentuate glucose intolerance and affect the GLUT3 protein in facilitating the transport of glucose across the plasma membranes of mammalian cells in the cerebral cortex and hypothalamus in the HP diet group treated with SFN.

 Taken altogether, plant base sulforaphane may be considered a bioactive compound for the prevention and treatment of obesity with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Choi KM1, Lee YS1, Kim W1, Kim SJ2, Shin KO1, Yu JY3, Lee MK1, Lee YM1, Hong JT1, Yun YP1, Yoo HS4. (PubMed)
(2) Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet by Souza CG1, Riboldi BP, Hansen F, Moreira JD, Souza DG, de Assis AM, Brum LM, Perry ML, Souza DO. (PubMed)
(3) Sulforaphane induced adipolysis via hormone-sensitive lipase activation, regulated by AMPK signaling pathway by Lee JH1, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY. (PubMed)
(4) The role of physical activity and exercise in obesity and weight management: Time for critical appraisal by PetriWiklund. (Research Gate)

Phytochemical Sulforaphane (Dithiolthiones), the Potent Anti-Liver Disease Bioactive Compound, According to Studies

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.

Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affecting everyone from infants to older adults, including infected viri such as hepatitis A, B, C, and medication overloaded.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.

According to the statistic provided by the Canadian Liver Foundation,  approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.

This incidences of liver disease not only lead to dismiss the quality of life and life expectancy but cause a financial burden of the health care system.

Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.

Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".

And,  "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".

With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.

Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein which plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.

And CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.

Application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.

SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.

The results strongly suggested that SFN inhibited liver disease by increasing expression of antioxidant enzymes and lowing the expression of free radical as well as reducing the liver fat deposits.

Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentration (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity

Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.

Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.

The University of Rhode Island, Kingston study also suggested that SF activate Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolising enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)

Eggplant, the Cardio-Protective Functional Veggie, Scientists Suggest

By Kyle J. Norton

Scientists may have found a whole fruit or vegetable with a potential to treat cardiovascular disease with no side effects, some studies found.

Cardiovascular disease is a class of conditions associated with heart and blood vessels. Anything that affects the normal heart and blood vessel functionings is considered risk factors of the disease, including heart's muscle, valves or rhythm, and blockage of blood vessels.

According to the statistics, in the US, approximately, 610,000 people die of heart disease every year that's 1 in every 4 deaths. The disease is the leading cause of death for both men and women.

The causes of cardiovascular diseases are associated with the location that affects the functioning of the heart and blood vessels, including atherosclerosis is caused by the blockade of the blood vessel due to the accumulation of plaques in the arteries and arrhythmias caused by abnormal heart rhythms.

Epidemiological studies strongly suggested that most common cardiovascular disease that affects most of the heart disease patients are coronary artery disease (CAD).

Coronary artery disease (CAD) is the most common form of heart disease caused by one or more of the coronary arteries become narrow or blocked.

Some researchers suggested that the widespread of the diagnosis of coronary artery disease (CAD) in the Western world probably is a result of the promotion of the Western diet over the last few decades.

The diet high in bad cholesterol, salts and sugar and carcinogens associated with the accumulation of plaques on the arteries have been found to be a culprit of the onset of coronary artery disease in many studies.

Dr. Oikonomou E, the lead author in the joint study led by the National and Kapodistrian University of Athens in the concerns of CAD widespread in the Western world launched an investigation to examine the independent predictive value of an unhealthy diet on the severity of coronary artery disease (CAD).

In the total of 188 symptomatic stable patients with CAD. Patients were categorized as having severe CAD or nonsevere CAD by coronary angiography.

Among several demographics and clinical characteristics, all patients were tested using a semiquantitative food frequency questionnaire.

By analysing the 8 principal components in the 8 distinct dietary patterns found in the returned questionnaire, researchers found that The Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001).

These results not only suggested that the Western not only causes the onset of the disease but also increased the risk of severity of coronary artery lesions in patients with stable CAD.

The doctors in the study wrote the final report, "the findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.

The plant has been cultivated in southern and eastern Asia since prehistory. It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.

The chemical constituents of eggplant include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.

In the finding, a natural compound with the efficacy for the prevention and treatment of cardiovascular disease with no side effects, researchers at the University of Connecticut School of Medicine examines the role of raw and grilled eggplants on cardioprotection using an isolated perfusion heart model.

The animals were fed freeze-dried products of either raw or grilled eggplants for 30 days. After 30 days, isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion.

The medical assays suggested eggplants process potent cardioprotective compounds judging by their ability to increase left ventricular function, and reduce myocardial infarct size and cardiomyocyte apoptosis.

Interestingly, researchers found no difference in cardioprotective ability between the raw and grilled products.

Based on the antioxidant vitamins classification, researchers showed that vitamin A, vitamin C, and β-carotene, were lower and some of the polyphenolic components, especially nasunin content, were higher in grilled eggplants, These result indicated that there must be some other ingredient processed by both grill and raw eggplants that exert cardiovascular diseases not found in this study.

Moreover, in the study to analyze total phenolics and antioxidant capacity in the indigenous vegetables for cardioprotective effect researchers at the Tuskegee University conducted a group analysis including collard greens, mustard greens, kale, okra, green onion, butter beans, butter peas, purple hull peas, rutabagas, and eggplant.

At a concentration of 10.0 mg dried vegetable equivalent/ml, the extract of these vegetables exerted a significant antioxidant activity by reducing 13.2-88.5% DPPH(•) radical in 30 min.

The Oxygen Radical Absorbance Capacity. (ORAC) value ranged from 2.5 to 100.7 µmoles of Trolox equivalents per gram of dried sample.

The antioxidant capacity of the vegetable samples was highly related to their total phenolic content.

The evidence suggested these indigenous vegetables are good sources of the phenolic compounds, which might provide anti-oxidative protection against free radicals in inducing chronic diseases, such as cardiovascular disease.

Taken altogether, eggplant processed abundantly bioactive antioxidants may be considered a functional vegetable for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cardiovascular disease without inducing any adverse effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardioprotective properties of raw and cooked eggplant (Solanum melongena L) by Das S1, Raychaudhuri U, Falchi M, Bertelli A, Braga PC, Das DK. (PubMed)
(2) Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for CardiovascularEquality Project by Huang Z1, Wang B, Eaves DH, Shikany JM, Pace RD. (PubMed)
(3) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)