Phytochemical Sulforaphane, The Potential Anti Colon cancer Bioactive Compound, Scientists Say

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of colon cancer with no side effects, according to studies.

Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Most cases primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.

The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.

According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The causes of colon cancer are unknown but certain risk factors, such as genetic preposition and chronic inflammation induced by colonic diseases are associated with the onset of the disease.

Some researchers suggested that the widespread of colon cancer over the past few decades probably associated with the promotion of the Western diet.

According to an article posted on WebMD By Salynn Boyles, the author said, "While there is no shortage of evidence linking the so-called Western diet to an increased risk for developing colon cancer, the study is among the first to examine the impact of such a diet on survival among patients treated for the disease".

 And,  "The findings must be confirmed, but Dana-Farber Cancer Center oncologist Jeffrey Meyerhardt, MD, a researcher on the team, says they cannot be ignored by colon cancer patients or their physicians".

The statement clearly suggested that by making a change to a healthy diet, the risk of colon cancer can be reduced substantially.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

On finding a natural bioactive compound for the treatment of colon cancer with no side effects, researchers looked into sulforaphane is an isothiocyanate that is present naturally in widely consumed vegetables and has a particularly high concentration in broccoli in the risk of colon cancer.

In rats, sulforaphane blocked the formation of tumors initiated by chemicals. The chemical compound inhibited the reinitiation of growth and decreases the cellular viability of quiescent human colon carcinoma cells (HT29).

Furthermore, sulforaphane-induced cell cycle arrest was correlated with an increased expression of a protein associated cell cycle division and cell death via an apoptotic process through cancer cells degradation.

Moreover, researchers found the anti-colon cancer cells line effect was not attributed to the proteins associated with programming cells death but activation of detoxifying enzymes.

Dr. after taking into account co and confounders, said, " (These) results strongly suggest that in addition to the activation of detoxifying enzymes, induction of apoptosis is also involved in the sulforaphane-associated chemoprevention of cancer.

Additionally, in the reaffirm the anticancer effect of the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly, researchers analyzed the formula activity against 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line).

The formula exerted a significant antiproliferative activity on all tested cancer cell lines (PC3, MCF7, and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner.

However, application of the formula at different concentrations did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts.

The result pointed out that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.

In the study to investigate the dietary isothiocyanates (ITCs) activity against HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells, researchers found that sulforaphane (SFN), a member of ITCs protect the colon tissue by inhibiting the HDAC activity and increase HDAC protein turnover.

Injection of sulforaphane (SFN) also induced colon cell growth arrest, autophagy, and apoptosis.

Further analysis of the results researcher also discovered that  ITC-induced DNA damage of colon cancer cells without causing harm to the non-cancer cells.

Taken  altogether, the findings suggested that phytochemical sulforaphane may be considered a bioactive compound for the prevention and treatment of colon cancer, pending to the  confirmation of the large sample size and multi-centers human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells by Gamet-Payrastre L1, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Tercé F.(PubMed)
(2) GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells by Okic-Djordjevic I1, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF, Terzic M, Vesovic D, Bugarski D.(PubMed)
(3) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates by Rajendran P1, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH.(PubMed)
(4) ‘Western’ Diet Tied to Colon Cancer By Salynn Boyles (WebMD)

Phytochemicals Phytic Acid, Inhibits the Risk and Progression of Alzheimer's disease (AD)

By Kyle J. Norton

Phytic acid, a bioactive compound found mostly in seeds and beans may have a strong and profound effect in protecting the aging brain against the onset of  Alzheimer's disease (AD), some scientists suggested.

Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.

Alzheimer's disease worsens over time and it is fatal.

As the disease progression, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.

In the elderly, age-related to the changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulated of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.

Dr. Pini L and colleagues in the study "Brain atrophy in Alzheimer's Disease and aging" said, "Disease progression has also been associated with changes in white matter tracts. Recent studies have investigated two areas often overlooked in AD, such as the striatum and basal forebrain, reporting significant atrophy".

The results suggested the loss of white matter tracts in the striatum and basal forebrain may be the culprits that brain shrinking in the aging population.

In the free radicals analysis, researchers suggested that free radicals overexpression cause the reduced levels of antioxidant enzymes produced by the elderly initiates the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cells damage and development of AD.

Dr. Tuppo EE, the lead author in the study of oxidative stress and AD, said, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants" and "Evidence for oxidative damage has been obtained from postmortem brain tissue as well as from living patients with Alzheimer's disease. Antioxidants such as vitamin E show promise that they may help in treating the disease.

Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medications for the treatment of diseases with little or no side effects.

In the finding of a novel protective treatment for AD pathology, researchers at the Oregon Health & Science University, Portland conducted an investigation to evaluate the phytic acid(inositol hexakisphosphate), a phytochemical found in food grains and a key signaling molecule in mammalian cells.

The experiment is to examine the protective and beneficial effects of phytic acid against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model.

In MC65 cells, after 48-72-hour treatment with phytic acid researchers showed that phytic acid provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by reducing the levels of calcium present, free radicals, and plaques accumulation.

Furthermore, injection of phytic acid significantly increased brain levels of cytochrome oxidase which is found in low levels in AD patients and decreased the lipid peroxidation.

The phytic acid was well tolerated with little side effects.

Additionally, in the finding a composition and method for the treatment of Alzheimer's disease, researcher showed that phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination administered to a person in an amount from about 0.5 grams to about 18.75 grams per day, demonstrated a potential effect in reducing amyloid plaque development.

At the experiment, researchers also discovered that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta-amyloid proteins as are commonly seen in the brains of Alzheimer's patients.

Taken altogether, the phytic acid found abundant in nuts and seeds may be considered a functional supplement for the prevention of AD and an adjunct therapy combined with conventional medicine for the treatment of neurodegenerative diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)
(3) Brain atrophy in Alzheimer's Disease and aging by Pini L1, Pievani M2, Bocchetta M3, Altomare D1, Bosco P2, Cavedo E4, Galluzzi S2, Marizzoni M2, Frisoni GB. (PubMed)
(4) Free radical oxidative damage and Alzheimer's disease by Tuppo EE1, Forman LJ. (PubMed)

Avocado, The Anti High Blood Cholesterol Functional Fruit

By Kyle J. Norton

Avocado may process certain bioactive compounds with function in inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.

Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membranes walls and stimulated the production of steroid hormone and aided the digestive tract in absorbing the nutrients for our body need.

However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque building up on the arterial wall, leading to heart diseases and stroke.

Depending on the choice of diet,  your risk of high blood cholesterol can be increased or decreased.

People who follow the Western diet with high in saturated and trans fat, red meat, processed food and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy and salt put people at higher risk of heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".

These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at the lower risk of high blood cholesterol some in the future (weeks or months, depending to the levels of blood cholesterol today).

The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).

If your ratio is lower than 4, you are considered to have a healthy blood cholesterol ratio.

Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.

 It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Researchers in the examine of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.

The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.

Rat group treated with additional HAEPA showed a significantly decreased the body mass index (BMI), total fat pad mass and adiposity index, compared to HFD-fed rats.

The LDL and lipid peroxidation levels of HFD+HAEPA group were significantly lower compared to HFD group.

Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ and protein expression of PPAR-γ in mediating expression of fat-specific genes and in activating the program of adipocyte differentiation were found to be increased in HFD+HAEPA group than in HFD group.

The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduce the risk of hyperlipidemia and obesity.

In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion with 25 rats divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.

* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.

* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.

Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".

Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)

Cruciferous Vegetables in The Prevention and Treatment of Cancers

By Kyle J. Norton

Cruciferous vegetables may be the next pharmaceutical target to find the effective ingredients for the treatment of cancers, some scientists suggested.

Cancers are the class of medical condition caused by the irregular cell growth with the alternation of DNA.

Primary cancers are cancers that start at the original site. What causes the cells of the tissue or organs to become cancerous are unknown. Researchers do not know why people with the same health conditions, family history, and diet some are susceptible to the cell DNA alternation while most do not.

Genetic mutation inherited from the parents is one of the major risk factors have been found to some of the cancer patients. According to the statistic, gene mutations are associated with 7% of all cancer cases in the US.

By targeting the gene that initiates the onset of cancer and its specific dysregulated molecular pathways patients may have a higher chance to inhibit the growth and spread of a tumor.
However, most people who carry the cancerous gene do not know they have them. Dr. Jain Rin the study " The Relevance of Hereditary Cancer Risks to Precision Oncology: What Should Providers Consider When Conducting Tumor Genomic Profiling?" said, "Through tumor genomic profiling (TGP), existing and novel treatments can be selected to better target the specific dysregulated molecular pathways that drive growth and spread of a patient's tumor"

" Although the primary purpose of TGP is to detect targetable somatic mutations for treatment, TGP may also uncover germline mutations with important implications for patients and family members. Oncology care providers should be aware of the hereditary cancer risks associated with genes commonly tested by TGP.".

And, "Patients should be informed about the possible discovery of hereditary cancer risk information and the relevance of this information to their health and that of family members, and should have their preferences toward further evaluation of hereditary risk information that could be revealed by TGP documented in the medical record and followed".

Types of mutated gene facilitated the risk of cancer include BAG3, 10q26.11, BAG3 (Bcl- BLCAP, 20q11.23, BLCAP,...

Furthermore, unhealthy lifestyle choices also have a substantial effect on the increased risk of cancers.

"Seventy-one percent(71%) of lung cancer deaths are caused by tobacco use (lung cancer is the leading cause of cancer death globally). The combined effects of tobacco use, low fruit and vegetable intake, urban air pollution, and indoor smoke from household use of solid fuels cause 76% of lung cancer deaths. Exposure to these behavioral and environmental factors is preventable; modifications in lifestyle could have a large impact in reducing the cancer burden worldwide (WHO, 2009)". Dr, Weiderpass E at the Karolinska Institutet, wrote in the study " Lifestyle and cancer risk"

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Its chemical constituents include glucosinolates, dithiolthiones, indoles, glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..

In the study to evaluate the naturally occurring sulforaphane (SF) anti-cancer effects, researchers at the Roswell Park Cancer Institute launched an investigation to examine the SF isolated from cruciferous vegetables administered to rats orally either in a single dose or once daily for 7 days.

Application of SF exerts a significant effect in the stimulation fo the production of antioxidant enzymes GST and NQO1 varied by 3- to 6-fold among the organs of SF-treated rats.

Tissue uptake of SF was the greatest in the stomach, declining rapidly in the descending gastro-intestinal tract,

Particularly, tissue uptake level of SF in the bladder was second only to that in the stomach. Tissue levels of SF in the colon, prostate and several other organs were very low, compared to those in the bladder and stomach.

These results suggested according to the levels and organs uptakes and antioxidants enzymes produced during the course of the experiment, dietary SF, a potential chemopreventive benefit for the treatment of cancer.

Furthermore, in the searching for the effects of sulforaphane on cancer stem cells (CSCs), researchers launched a review of some medical literature found on the medical database.

Where CSCs are suggested to be responsible for initiating and maintaining cancer, and to contribute to recurrence and drug resistance.

A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-κB, a cellar apoptotic protein, SHH present in various human tumors. epithelial-mesenchymal transition, in the expression of tumor progression and malignant transformation and Wnt/β-catenin pathways in the cancer stem cells regeneration and organogenesis.

Dr. Li Y, the lead author at the final report said, "Combination therapy with sulforaphane and chemotherapy in preclinical settings has shown promising results".

The findings suggested that cruciferous vegetables processed a high level of sulforaphane (SF) may be considered a functional food for the prevention and combined with other primary therapy for the treatment of cancer, depending to the uptake organ's tissue and further large and multi-centre human studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention by Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.(PubMed)
(2) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts by Li Y, Zhang T.(PubMed)
(3) The Relevance of Hereditary Cancer Risks to Precision Oncology: What Should Providers Consider When Conducting Tumor Genomic Profiling? by Jain R1, Savage MJ1, Forman AD1, Mukherji R1, Hall MJ. (PubMed)

Eggplant, the Potential Anti Diabetes Functional Food

By Kyle J. Norton

Eggplant may be considered a functional food for the prevention and treatment of type 2 diabetes, some scientists suggested.
Diabetes is a chronic and medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Insulin resistance, a hallmark for the early onset of the diseases is caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

People with insulin resistance, the pancreas has to work overtime to deploy greater amounts of the hormone to keep cells energized and blood glucose levels under control. However, al longterm overworked pancreas can lead to reduced function of pancreatic beta cells in making insulin. These results eventually cause damage to the pancreas impaired function that no longer produces enough insulin to overcome the cells' resistance.

Cholesterol may be necessary for the body to function properly, however, the impaired ratio of lower density and high-density lipoprotein only cause cholesterol plague built upon the walls of arteries but also can clog up the insulin receptor sites, leading to the spike of blood glucose.

People who follow the Western diet with high on saturated and trans fat, red meat, processed food and less in fruits and vegetables and whole grains are associated with increased risk of type 2 diabetes caused by clogging up on the insulin receptors.

Please make sure that you maintain a healthy total blood cholesterol ratio of 4 (low-density lipoprotein, LDL) to 1 (high-density lipoprotein, HDL).

In other words, insulin produced by the pancreas still binds to the receptor normally, but the signal is not sent into the cell, the cells do not take up glucose and the resulting high blood glucose levels cause organ damage over time.

In some cases, acute high blood glucose can also be caused by an allergic reaction of the cells in the immune system.

Some researchers suggested that these may be a result associated with the use of  OTC or prescription nasal spray, containing steroids. People with diabetes should be aware that steroids can stimulate the liver to make more glucose.

Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in season.

In the reaffirming of the National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association recommendation that eggplant-based diet as a choice for management of type 2 diabetes, researchers launched an investigation to examine the phenolic-linked antioxidant activity and alpha-glucosidase inhibitory potential of eggplant which could reduce hyperglycemia-induced pathogenesis.
At the end of the experiment, researchers found that

* Phenolic-enriched extracts of eggplant process a moderate free radical scavenging-linked antioxidant activity and high angiotensin I-converting enzyme (ACE) inhibitory activity that plays an essential role not only prevent high blood pressure but also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.

* The extracts also had a high alpha-glucosidase inhibitory activity which prevents the digestion of carbohydrates

Inhibition of these enzymes provides a strong biochemical basis for management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively. 

Dr. the lead author wrote, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".

Additionally, in the examine the anti-diabetes effect of chlorogenic acids (CGAs) received considerable attention for their wide distribution and part of the human diet with potential biological effects, researchers launched an investigation to examine CGAs found in eggplant.

At the end of the experiment, researchers found that

* Coffee is among the highest found in plants, ranging from 4 to 14%.of chlorogenic acids (CGAs) compared to eggplant
* CGA besides processes strong antioxidant and anti-inflammatory effects, it also plays an important role on glucose and lipid metabolism regulation and on the related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.

Dr. the lead author after taking into account ac and confounders said, " The wide range of potential health benefits of CGA, including its anti-diabetic, anti-carcinogenic, anti-inflammatory and anti-obesity impacts, may provide a non-pharmacological and non-invasive approach for treatment or prevention of some chronic diseases".

Taken altogether, eggplant may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of diabetes without inducing adverse effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the eggplant or its bioactive compounds during the course of the disease will be necessary to complete the picture of eggplant anti-diabetes possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ. (PubMed)

(3) The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature by Tajik N1, Tajik M2, Mack I1, Enck P. (PubMed)

Apricot, the Potential Anti Breast Cancer Remedy, Scientists Say

By Kyle J. Norton

Finding a cure for breast cancer from the botanical plants without inducing side effects has been a lifetime dream of many scientists. Unfortunately, as of today, the finding is still ongoing without much success.

However, according to some studies, apricot, the edible fruit may be a next pharmaceutical target to extract potential ingredients for the cure for breast cancer.

Breast cancer is a medical and chronic condition as the result of irregularly cell growth originated from the breast tissue. why women in the same health conditions, family history, and race, some are prone to develop the early onset of the disease while others do not.

Breast cancer is caused by the alternation of DNA  of the cells in the breast tissue. Epidemiologically, certain prevalent factors are associated with the increased risk of the disease.

According to the probability for women to develop or die from breast cancer provided by the Canadian Cancer Statistics publication, the lifetime risk of a woman to develop is 1/8 and 1/31 of them will die from the disease.

The 5 years survival rate of the early stage of breast cancer is 100% compared to much less in the advanced stage.

Therefore, women with higher risk such as genetic preposition of gene BRAC1 and 2 should have their breast mammogram taken every year.

More importantly, Dr. Zainab Taha, the lead author in the study "The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East" wrote, 

"There is an alarming epidemic of obesity among women in most of the EMR countries, especially Gulf Coopers action Council (GCC) countries. The rise in the new breast cancer cases among women could be attributed to excess body weight. Their dietary pattern, which correlates with obesity, can be an important factor in the etiology of cancer.".

These results\ strongly suggested that diet and lifestyle associated with the onset of obesity are major contributors in the early onset of breast cancer.

In other words, if you follow a healthy diet with a lot of fruits and vegetable, whole grain with less in saturated and trans fat, red meat and processed and lifestyle with moderate exercise, you are at the lower end in the risk factor scale of breast cancer.

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

Chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides, (b),

In the reaffirming the MK615, an extract mixture containing hydrophobic substances from Japanese apricot. anti-cancer possibility, researchers at the Dokkyo University School of Medicine conducted an evaluation to examine the antineoplastic effects of MK615 against breast cancer cells.
The experiment includes 2 breast cancer cell lines, MDA-MB-468 (MDA) and MCF7, were cultured with (600, 300, and 150 mug/mL) or without MK615.

After 72 hours of incubation, researchers showed that

* MK615 inhibited the growth of MDA and MCF7 in a dose-dependent manner.

* The percentage growth inhibition of MDA at dosages of 600, 300, and 150 mg/mL was 59.2%, 52.4%, and 23.3%, respectively, and that for MCF7 was 83.5%, 52.7%, and 16.6%, respectively.

* MK615 treatment included massive vacuolization in the cytoplasm and apoptotic changes in the nucleus.

* Cell cycle analysis showed that MK615 increased the proportion of cells in the G2-M phase in both MDA (7.8-11.7%) and MCF7 (8.1-18.7%), and finally both cell lines became apoptotic.

These results suggested MK615 effectively inhibits the growth of breast cancer cells in vitro, through cell cycle arrest and apoptosis.

Furthermore, in the concerns of breast cancer continued to cause high cancer death rates among women worldwide, researchers at the joint study led by the Universiti Sains Malaysia launched an evaluation to examine the plant-based products which have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth.

Out of the medical plants selected including Glycyrrhiza glabra, Uncaria tomentosa, Camellia sinensis, Panax ginseng, Prunus armenaica (apricot), Allium sativum, Arctium lappa and Curcuma longa, malic acid and quinic acid isolated from apricot exerted a significant activity in regulating the immune system potentially applicable in breast cancer treatment via anti-inflammatory and lymphocytes activation.

Taken all together, apricot may be considered a functional food for the prevention and a secondary therapy combined conventional medicine for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

 References
(a) [Studies on the chemical constituents of flowers of Prunus mume].[Article in Chinese] by Zhang QH1, Zhang L, Shang LX, Shao CL, Wu YX.(PubMed)
(1) New antineoplastic agent, MK615, from UME (a Variety of) Japanese apricot inhibits growth of breast cancer cells in vitro by Nakagawa A1, Sawada T, Okada T, Ohsawa T, Adachi M, Kubota K. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS. (PubMed)
(3) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East by Zainab Taha1 and Sakina E. Eltom. (PMC)

Fennel, the Function Food Which Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body

By Kyle J. Norton

Imbalancing the ratio of the free radicals and antioxidants in the facilitation of oxidative stress was associated with the increased risk of the early onset of many chronic diseases, scientists found.

Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), and native to the shores of the Mediterranean, may process a potential effect in improving the levels of antioxidant enzymes produced by the human body, therefore, adding a portion of fennel on your daily diet should be helpful in reducing the risk of diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke ...

Dr. Moylan JS, the lead author in the study "Oxidative stress, chronic disease, and muscle wasting", wrote, "If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensue. In some cases, oxidative stress is assigned a causal role in disease pathogenesis, whereas in others the link is less certain".

Free radicals are unstable molecules with unpaired electrons produced daily in our body, reactive oxygen species, and reactive nitrogen can induce a domino's effect by stealing an electron from other molecules, leading to a continued function that cannot stop until they are paired or inhibited by the presence of antioxidant molecules.

If the generation of free radicals exceeds the protective effects of antioxidants and some co-factors, the process can cause oxidative damage accumulated during the life cycle, leading to the disruption in the function of the cells.

There are many risk factors which can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, air pollutants.

Therefore by changing your diet pattern with more in fruits and vegetables, whole grains and less in red meat and processed foods and maintaining an active lifestyle, you can absolutely balance the ratio of free radicals and antioxidants in your body, thus decreasing the risk of many related chronic diseases.

In the review of traditional use of fennel essential oils (EO) possess antimicrobial, anti-inflammable oil and insect repellent, anti-cancer, and antioxidant properties, researchers launched a comparison of essential oil and their main constituents in Citrus aurantium, C. limon, Cupressus sempervirens, Eucalyptus globulus, Foeniculum vulgare and Thymus vulgaris.

EO of fennel showed the best free radicals scavenging capacity compared to others.

Fennel EO also was most effective against lipid peroxidation along with EO of C. limon.

Interestingly, after in-depth analysis, researchers discovered the antioxidant and anti-inflammatory activities of the EOs were plant species dependent and not always attributable to the EOs main components.

Additionally, in the evaluation of chemical constituents from essential oil from (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce and Foeniculum vulgare var. vulgare, researchers suggested
* trans-Anethole, estragole, fenchone and limonene found highly abundant in all of the examined oils demonstrated strong antioxidant activities in the DPPH radical scavenging, lipid peroxidation, and metal chelating assays

* All 3 tested essential display significant antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.

Finally, in the study to assess the efficacy of medicinal plants used traditionally in folk medicine as natural healing remedies with therapeutic effects as prevention of cardiovascular diseases, inflammation disorders, or reducing the risk of cancer, researchers found that fennel in comparison to other medical exerts a strong antioxidant effect through many of its bioactive compound such as phenolic compounds.

However, Dr. Škrovánková S, the lead scientist in the concerns of some condition which may affect the herbal quality, said, "The antioxidant properties of medicinal plants depend on the plant, its variety, environmental conditions, climatic and seasonal variations, geographical regions of growth, degree of ripeness, growing practices, and many other factors such as postharvest treatment and processing.

Taken all together, adding a portion of fennel into your diet may have a potential effect in increasing the levels of antioxidants in your body and countering the risk of overexpression of free radicals.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-oxidant, anti-inflammatory and anti-proliferative activities of Moroccan commercial essential oils by Aazza S, Lyoussi B, Megías C, Cortés-Giraldo I, Vioque J, Figueiredo AC, Miguel MG. (PubMed)
(4) Distillation time modifies essential oil yield, composition, and antioxidant capacity of fennel (Foeniculum vulgare Mill) by Zheljazkov VD1, Horgan T, Astatkie T, Schlegel V.(PubMed)
(3) Antioxidant activity and protecting health effects of common medicinal plants.
(4) Oxidative stress, chronic disease, and muscle wasting by Moylan JS1, Reid M. (PubMed)