Green tea Polyphenols, the Potential Candidate for Treatment of Spinal Muscular Atrophy, Scientists Find

Kyle J. Norton

Scientists may have found a beverage which processes the ability to protect the central nervous system against the onset of spinal muscular atrophy, some studies suggested.
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder affected the part of the nervous system that controls voluntary muscle movement due to loss of motor neurons and progressive muscle wasting.

The disease is caused by a mutation in the SMN1 gene on chromosome 5. In some cases, the disease is also associated with a mutation in an X-chromosome gene called UBE1 causes X-linked SMA.

Depending on the disease severity, patients with SMA may experience symptoms of muscle weakness and decreased muscle tone,  limited mobility, breathing problem, problems eating and swallowing, delayed gross motor skill and the spontaneous tongue movements.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In the investigation to reexamine, the laboratory-based evidence suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy, researchers at the RJAH Orthopaedic Hospital launched an investigation to evaluate the scientific evidence related to the known molecular effects that these polyphenols have on different models of inherited neuromuscular disease, with particular attention to problems with the validity of in vitro evidence. 

Application of polyphenols demonstrated the molecular effects on different models of inherited neuromuscular disease,

Polyphenols, in vitro, exerts a significant effect on cells through metal ion chelation in cell-culture media.

Dr. Fuller HR, the lead author after taking into account co and confounders said, "Polyphenols could be an attractive approach to therapy for the inherited neuromuscular disease, especially since they may be safer to use on young children, compared with some of the other drug candidates".

Additionally, in the assessment of Epigallocatechin-3-gallate (EGCG), a major component of green tea polyphenols effect on neuroprotection, researchers at The Second Hospital of Hebei Medical University found that injection of EGCG exerts substantial protection of motor neuron by regulating glutamate level in organotypic culture of rat spinal cord.

Further analysis suggested EGCG blocks the glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter not by its antioxidant activity but other unknown mechanisms. As another antioxidant could not regulate the glutamate level under the same condition in another study.

These results suggested that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity, including SMA.

Taken altogether, green tea purified polyphenols may be considered an adjunct therapy combined with conventional medicine for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases by Fuller HR1, Humphrey EL, Morris GE. (PubMed)
(3) Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level by Yu J1, Jia Y, Guo Y, Chang G, Duan W, Sun M, Li B, Li C.(PubMed)

Asparagus, The Potent Anti Liver Cancer Functional Food, Scientists Say

By Kyle J. Norton, Master of Nutrition

Asparagus May be considered an adjunct therapy combined with conventional medicine for the treatment of liver cancer, some scientists suggested.age

Liver cancer is a medical condition in which a group of cells growing and multiplying disordered and uncontrollable way in the liver tissue.

At the advanced stage, the cancerous cells can travel a distance away from the liver to infect other healthy tissue and organ via lymph or blood.

Secondary liver cancer or metastatic liver disease. are cancer started in another part of the body and spread to the liver.

Most common cancers are likely to spread to the liver including colorectal, lung and breast cancers.

The exact causes p[rimary liver cancer are unknown. Researchers also can not understand that people with the same health conditions, gender and family history, some are susceptible to the onset of liver cancer while others do not.

However, researchers do know that certain risk factors are associated with the development of the disease, such as long-term alcohol abuse, or chronic infection associated with hepatitis B and C and cirrhosis.

Some genetic mutations and liver damaged by birth defects are also elevating the risk of liver cancer.

Dr. Rao CV. the lead author in the study "Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer" wrote, "About 80-90% of liver cancers are hepatocellular carcinoma (HCC), and recent cancer genome sequencing studies have revealed frequently mutated genes in HCC".

These types of mutation are most likely are the results of oxidative stress in facilitating the accumulation of DNA damage and further mutations.

The John Hopskin Medicine, liver damage caused by birth defects includes
*Biliary atresia. A life-threatening condition in infants where the bile ducts are blocked or have developed abnormally. This blocks the flow of bile from the liver.

*Biliary (choledochal) cyst. A condition where the hepatic duct forms abnormally. This can also block the flow of bile.

*Alagille syndrome. Too few bile ducts associated with other abnormalities including heart, bone, facial features, eye, and others.

According to the statistic, in the US, every year, approximately over 40,000 adults are diagnosed with primary liver cancer, causing over 30,200 deaths.

Sadly, men are about 3 times more likely than women to be diagnosed with liver cancer.

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.

The plant has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

Chemical constituents of the vegetable include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.

In the finding of natural ingredients with potential in preventing the onset of hepatocellular carcinoma (HCC), one of the most aggressive malignancies in the world, researchers conducted a study to examine the anticancer effects of the deproteinized asparagus polysaccharide on the hepatocellular carcinoma cells, using the in vitro and in vivo experimental model. 

The assessment of the experimental data suggested that the selected ingredient exert an effective inhibitor on cell growth in vitro and in vivo and potent selective cytotoxicity against human hepatocellular carcinoma Hep3B and HepG2 cells.

Further analysis showed that deproteinized asparagus polysaccharide potently induce cell apoptosis and G2/M cell cycle arrest in the more sensitive Hep3B and HepG2 cell lines.

Deproteinized asparagus polysaccharide potentiated the effects of mitomycin, a chemo drug both in vitro and in vivo.

The efficacy of the deproteinized asparagus polysaccharide was attributed to the ingredients in modulating the expression of Bax, Bcl-2, and caspase-3 apoptotic-associated pathways.

In other words, the deproteinized asparagus polysaccharide induce liver cancer cell apoptosis through numbers of cell death pathways.

Dr. Xiang J the lead scientists said, " deproteinized asparagus polysaccharide exhibited significant anticancer activity against hepatocellular carcinoma cells and could sensitize the tumoricidal effects of mitomycin".
Moreover, in the evaluation of the anti-liver cancer activity of Asparagus racemosus (Wild) through the role of dietary patterns and specific food groups, researchers launched a review of Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS), two cohort studies.

Total of 132 837 Chinese women and men, were evaluated the relationship between dietary patterns, food groups, and liver cancer risk.

Data were collected through in-person interviews and dietary information intake over the preceding year was collected by using a validated food-frequency questionnaire.

During an average follow-up of 10.9 (SWHS) or 5.5 (SMHS) years, researchers found that
* 267 incident liver cancer cases are identified after the first 2 years of study enrolment.

* A vegetable-based dietary pattern was inversely associated with liver cancer; hazard ratios (95% confidence intervals) for the lowest to highest quartiles were: 1.00; 0.98 (0.71-1.35); 0.93 (0.67-1.29); and 0.58 (0.40-0.84).

* The association was stronger among participants with a history of the chronic liver disease

* High intakes of celery, mushrooms, allium vegetables, composite vegetables (including asparagus lettuce and garland chrysanthemum), legumes and legume products were associated with reduced liver cancer risk.

The findings suggested that adding some portions of vegetables, including asparagus, are associated to reduce the risk of liver cancer, regardless of patients health condition.

Taken all together, there is no doubt that asparagus and its bioactive compound may be considered an adjunct therapy for the prevention and combined with conventional medicine for treatment of liver cancer.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo. by Xiang J, Xiang Y, Lin S, Xin D, Liu X, Weng L, Chen T, Zhang M.(PubMed)
(3) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies. by Zhang W, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO. (PubMed)
(4) What are congenital liver defects? by John Hopskin Medicine

Cinnamon: The Wholefood Medicine May Process Anti Cervical Cancer Potency, Studies Found

Kyle J. Norton, Master of Nutrition

Whole food(herbal medicine), linking health benefits in the prevention, management, and treatment of diseases has placed an important role in human history over many centuries.

The finding of whole food medication by renowned scientists all over the world for the replacement of the single ingredient of the Western medicine with little or no side effect has been difficult due to no commercial benefit and patent right to producers.

Cinnamon may be the best wholefood medicine for the prevention, management, and treatment of cervical cancer, some scientists suggested.

Cervical cancer is a chronic and medical condition characterized by irregular and disorder cells growth in the cervical tissue. In the beginning, cancer starts in the cell of the cervical lining. After completely colonizing the cervix, malignant cells may travel a distance away through lymph and blood to infect other healthy tissue and organs.

According to the statistic, every year approximately, over 13,000 women in the United States are diagnosed with invasive cervical cancer.

Although the incidence rates for the disease dropped by 50% between 1975 and 2014 due to an increase in screening, cervical cancer still causes over 4,170 deaths this year.

The 5 years survival rate for women diagnosed in the early stage of invasive cervical cancer is 92%. However, in the advanced stage, when cervical cancer has spread to a distant part of the body, the 5-year survival rate is 17%.

The exact causes of cervical cancer are unknown, However, infected by human papillomavirus (HPV) infection due to having sex with men who carry the virus is a major cause of the disease.

 Furthermore, women who have many sexual partners, are smoking, use birth control pills (oral contraceptives) for the long-term and engaging in early sexual contact are associated with the increased risk of cervical cancer.

Women, on the early stage of cervical cancer, may not experience any symptoms. If you are having persistent symptoms of abnormal vaginal bleeding, increased vaginal discharge, bleeding after menopause and severe pain during sex and pelvic pain, please check with your doctor to rule out the possibility of cervical cancer.

Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the family Lauraceae.

The spicy herb has been used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

According to the Manipal University, Eugenol, a potential chemopreventive agent, one of the components of cinnamon possesses antiseptic, analgesic, antibacterial, and anticancer properties in the expression of apoptosis and inflammation against cervical cancer cell lines.

In SiHa cancer cell line, established from cancerous tissues of the cervix uteri, methanol extracts of Gymnema sylvestre (GS) leave and Cinnamomum zeylanicum (CZ) bark exhibited dose-dependent cytotoxicity in inducing apoptosis.

Other researchers suggested that the effects of cinnamon against tumor activity, particularly in cervical cancer cell line SiHa may be the result in the reduced number of colonies, the risk of migration potential through down-regulated normal physiological processes.

Dr. Kwon HK, the lead researcher at the Gwangju Institute of Science and Technology, insisted, Cinnamomum cassia bark,.. containing several active components such as essential oils, expressed anti-tumor effect via enhanced pro-apoptotic and inhibited pro-inflammatory activities, in vitro, and in vivo mouse melanoma model.

In fact, the potential anti-tumor effects of cinnamon may be due to the activities that suppress the cancer progression by increasing the levels of cytolytic molecules and functioning.

Although the whole herb medicine may be a potential agent for reduced risk and treatment of cervical cancer, oral use of cinnamon should be taken with care and only prescribed by a herbalist.

Additional data collection on large example size and multi-centers studies performed with human consumption of the whole food cinnamon during the course of the disease will be necessary to complete the picture of the spicy herb anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells by Hussain A1, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C.(PubMed)
(2) Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa) by Sujima Anbu A1, Velmurugan P2, Lee JH3, Oh BT4, Venkatachalam P5. (PubMed)
(3) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential by Koppikar SJ1, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R.(PubMed)
(4) Cinnamon extract induces tumor cell death through inhibition of NF-kappaB and AP1 by Kwon HK1, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. (PubMed)
(5) Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells by Kwon HK1, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.(PubMed)

Green Tea, The Beverage, Which Improves The Brain Functions in All Aspects, Studies Show

Kyle J. Norton, Master of Nutrition

Green tea intake regularly may have a potential influence of many aspects of the brain functions some scientists suggested.

The brain and the spinal cord form a central nervous system that consists of the ability to control our thoughts, memory, and speech, muscles, and the function of many organs.

People with brain impairment caused by a disease or injury may experience the decline of some conscious mental activity, including speech, learning, and memory. In severe cases, patients may also have a reduced daily function and independence.

In neurodegenerative disease, the progressive death, and loss of neurons function that affects the different regions of the brain may facilitate memory loss, forgetfulness, apathy, anxiety, agitation. a loss of inhibition and mood changes. In severe cases, the disease can cause a substantial reduction of the quality of life.

As of today, the treatment of neurodegenerative disease in conventional medicine is limited only to the symptoms. None of the currently available therapies slow or stop the continued loss of neurons.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

With an aim to find a natural and potential source which processes the ability in enhancing brain function, researchers at the University of South Australia conducted a review of the association between two dietary components of tea, caffeine, and L-theanine, and the psychological outcomes of consumption.

After taking an assessment of the all the selected studies, researchers found that caffeinated tea, injecting at regular intervals, maintains alertness, focused attention, and accuracy and may modulate the more acute effects of higher doses of caffeine.

The interaction of L-theanine on the brain and caffeine exerted the neurochemical effects to enhance performance in terms of attention switching and the ability to ignore the distraction,

However, although, injection of tea stimulated a higher-level cognitive activity, caffeinated tea can cause the detrimental effects to the brain as a result of overstimulation

Additionally, the in-depth differentiation of L-theanine in the modulation of the aspects of brain function suggested

* L-theanine found in tea has a direct effect on the brain.
* L-theanine significantly increases activity in the alpha frequency band which indicates the relaxation of the mind without inducing drowsiness.

These results were provided by the final report of EEG recording in the study of young participants with rest at the baseline and 45, 60, 75, 90 and 105 minutes after ingestion of 50mg L-theanine (n=16) or placebo (n=19). The similar results also observed even when the subjects engaged in a passive activity. 

Benefits of the increase of Alpha Brain Waves are the deep relaxation of body and mind accompanied with no stresses and worries.

Intesterestly, in the study to examine whether L-theanine injection reduced stress by blocking the binding of L-glutamic acid to glutamate receptors in the brain, researchers launched an investigation including fourteen participants each underwent three separate trials, in which they orally took either L-theanine + placebo, caffeine + placebo, or placebo only.

All participants were assessed on mental task performance and physiological activities under conditions of physical or psychological stress in humans.

Application of L-theanine significantly inhibited the blood-pressure increase in a high-response group, which consisted of participants whose blood pressure increased more than average by a performance of a mental task after placebo intake.

Caffeine exerted a similar but smaller inhibition of the blood-pressure increase caused by the mental tasks.

Also, according to the Profile of Mood States after the mental tasks, L-theanine reduced the Tension-Anxiety scores as compared with placebo intake.

These results suggested that the application of green tea L-theanine not only reduces anxiety but also attenuates the increase in the levels of stress.

Taken altogether, there is no doubt that moderate consumption of green tea or tea with abundant of L-theanine processes a positive and profound effect in enhancing brain function in many aspects. However, excessive green tea and tea drinking may cause overstimulation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Psychological effects of dietary components of tea: caffeine and L-theanine by Bryan J1.(PubMed)
(2) L-theanine, a natural constituent in tea, and its effect on mental state by Nobre AC1, Rao A, Owen GN.(PubMed)
(3) Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses by Yoto A1, Motoki M, Murao S, Yokogoshi H.(PubMed)

Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find

Kyle J. Norton

Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.

Cell death is a natural process to warrant the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.

However, some microorganisms are found to process the activity in triggering cell death for their own survival.

Apoptosis, or programmed cell death, is a function of the immune system evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection

Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.

Some herbal medicine such as fennel was showed to induce the function of overexpression of levels of free radical in initiating cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.

Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the study to investigated several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukaemia, J-45.01—human acute T cell leukaemia, EOL—human eosinophilic leukaemia, HL-60—human Caucasian promyelocytic leukaemia, 1301—human T cell leukaemia lymphoblast, C-8166—human T cell leukaemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that

* The ethanol extract from fruit F. vulgare shows the highest mortality in Trypan blue test for J45 cell line with 4% of viable cells and a C8166 cell line with 100% of mortality.

* The extract also shows the highest viability in other cell lines, including the HL60 with 60%, EOLwith 48%, and ML1 with 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.

Furthermore, in the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.

Application of fennel showed to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.

Fennel induced a apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI-assay.

More importantly, application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promoted of MCF-7 cells death.experienment

Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".

Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.

* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.

Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.

Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for treatment of cancers

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)

Green Tea and its Bioactive Polyphenols Suppress the Onset and Progression of Osteoporosis, Medline Studies Find

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reducing the onset, progression, and treatment of osteoporosis, some scientists suggested.

Osteoporosis is a chronic condition characterized by progression in the reduction of bone mass and deterioration of bone tissue and considered a major health problem in both elderly men and women.

The diseases also affect all bone in the body, including the bones of the spine, hip, and wrist

Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is the common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,

*  Reduced hormone production, the drop of estrogen levels after menopause, can speeds up bone loss.

* Reduced production of bone mass and increased bone reabsorption.

These results suggested that osteoporosis can make bone more fragile and easier to break. In elderly, osteoporosis can be dangerous, as fractures can cause prolonged immobility, and required a longer healing process.

Some researchers suggested that fractures in the older population are the most common cause of blood clots or pneumonia, both of which can have fatal consequences.

Long-term use of certain medicines, such as anti-seizure drug Glucocorticoids and medical conditions such as kidney disease, Cushing's syndrome, and an overactive thyroid or parathyroid, can also increase the risk of osteoporosis.

Dr. Stephen P Tuck, the lead author in the study Osteoporosis in men said, "The incidence of osteoporotic fractures in elderly men, just as in aged women, increases exponentially with age; the rise in men, however, is some 5–10 years later than in women. Up to 50% of male osteoporosis have no identifiable etiology; however elderly males have a much higher likelihood of having an identifiable secondary cause than younger men".

Truly, both male and female share the same conditions of the onset of osteoporosis, but the onset of the disease in men is about 10 years later, compared to a woman in the same age.

Interestingly, in the observation of hip fracture in the aging population, Dr. Eric Orwoll, a physician-researcher who studies osteoporosis at Oregon Health and Science University wrote, “A third of all hip fractures occur in men, yet the problem of osteoporosis in men is frequently downplayed or ignored.”

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that the applications exert significant activities in reducing the onset of osteoporosis, through their antioxidants and initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibiting the levels of ROS that facilitate the chain reaction.

Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroying the calcified tissue and inducing bone remodeling.

These results demonstrated that green tea and its bioactive components exhibit a significant decrease in the risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.

Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that the ingestions display an impressive osteoprotective impact on bone mass and microarchitecture in various bone loss models associated with aging, sex hormone deficiency, and chronic inflammation.

The implication of reduced onset and progression of osteoporosis in the aging population due to sex hormone deficiency may be attributed to green tea and its bioactive compound in increasing the levels of osteocalcin, a bone formation marker, decreasing serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improving the body in the absorption of calcium.

In fact, the serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) are considered effective measurements in the rate of bone turn over in patients with osteoporosis.

Interestingly, application of green tea and its bioactive compound also is found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibiting the production of C-reactive protein (CRP) in the liver in initiating inflammation and reducing levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.

These differentiation were supported by the study in the evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.

At the end of experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft, and decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.

The findings indicated a strong implication of green tea polyphenols in decreasing cortical and trabecular bone loss and increasing both bone density by stimulating the overexpression of bone formation and reducing bone resorption via antioxidant capacity.

Taken together, green tea and its bioactive polyphenols may be considered functional foods in ameliorating early onset, progression and combined with standard medicine for treatment of osteoporosis.

However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS. (PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS. (PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK. (PubMed)
(4) Osteoporosis in the aging male: Treatment option by Stephen P Tuck1 and Harish K Datta. (PubMed)

Papaya, The Fruit Which Protects Our Body Against Acute and Chronic Inflammatory Diseases

By Kyle J. Norton, Master of Nutrition

Papaya is found to process anti acute and chronic inflammatory activity that may be considered an adjunct therapy for treatment of several chronic diseases, some scientists suggested

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Truly, the main focus of inflammation is to repair damage and injury.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Chronic inflammation is the results of the immune system inability to kill off all the microorganism participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Inflammation is also can be caused by overexpression of free radical compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidant, the major cause of oxidative stress.

Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, DNA that initiate the development of numbers of chronic diseases, such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction.

Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries


Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)

In the reaffirm fruit and vegetables have therapeutic potential as they dampen inflammation with no known side-effects, researchers at the Universiti Putra Malaysia launched an evaluation to examine the effect of papaya on the activity of Th1 (IFN-γ(+) CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play in mediating inflammatory responses.
According to the flow cytometry methods. application of papaya exerted a potential effect in down-regulation of IFN-γ(+) CD4(+) (p=0.03, n=13) in the expression of inflammatory markers and up-regulation of IL-4(+) CD4(+) (p=0.04, n=13) T cells, CD3(+) CD4(+) CD25(+) CD127(-) in productiuon of anti inflammatroy sytokines.

Tregs, regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress the immune response in the production of the proteins related to inflammation, were found after papaya consumption.

In vitro cultures, papaya up-regulates Tregs in male subjects and was significantly associated with suppression of the levels of IL-1β and other inflammatory cytokines.

Dr. Abdullah M., the lead author said, "Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions".

Furthermore, in the reconfirmation of papaya anti-inflammatory effect in patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers found that pretreatment of mangiferin (MF), a natural glucosyl xanthone found in papaya inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, the mediators with function in stimulated the production of  in elevated inflammatory cytokines.

Moreover, MF dose-dependently also up-regulates the expression and activity of heme oxygenase (HO)-1 which plays a critical role in the prevention of vascular inflammation in the lung of septic mice, leading to the elimination of the septic lung injury.

The findings suggested that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators

Taken all together, papaya and its bioactive compound mangiferin (MF)  may be an adjunct therapy combined with conventional medicine for treatment in acute and chronic inflammatory diseases.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papayaincreases regulatory T cells, and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)