Coffee, the Beverage Is Associated to the Incidence of Laryngeal Cancer, Scientists Suggest

Kyle J. Norton, Master of Nutrients

 Coffee and coffee caffeine may have potential in reducing risk and treatment of laryngeal cancer, some scientists suggested.

Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.

The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, some are susceptible to the onset of the disease while others do not.

However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.

Genetic mutation inherited from the parents, such as TP53, GSTM3 and NAT2 and long-term use of some medication, such as immune-suppressive drugs to fight off infection such as HIV or AID is considered the prevalent risk factors for the disease development.

According to the statistic provided by the study of  A genetic view of laryngeal cancer heterogeneity
by Dr. María José de Miguel-Luken and colleagues, Out of over 500.000 new cases squamous cell carcinoma of the head and neck (SCCHN) diagnosed in 2008 worldwide,  151.000 cases (130.000 men and 21.000 women) were laryngeal cancer.

Sadly, the world mortality rate is 2.3/100.000 for all people who are diagnosed with  laryngeal cancer,, causing over 82.000 deaths in 2008.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the concerns of the effect of coffee in the risk of laryngeal cancer, researchers at the Central South University Affiliated The Third Xiangya Hospital conducted a review by searching the medical literature database of Medline and EMBASE for the relevant articles published up to Oct. 2013.

A total of 2,803 cases and 503,234 controls in 10 independent studies satisfied the criteria and guidelines were identified.

After taking into account co and confounders the selected studies,  researchers found that incidence of laryngeal cancer was associated with coffee consumption, compared to non drinkers. 

The relative risk of coffee drinkers was 1.47 compared to baseline.

Additionally, according to genetic assay used in the study, researchers also discovered that genetic influence plays an important role in increasing the risk of laryngeal cancer in the coffee consumed population.

Dr. said, "The significant heterogeneity was detected when the association between tea and coffee consumption and the laryngeal carcinoma".

Moreover, researchers found no statistically significant association of cancer incident difference in comparison between moderate and low coffee drinking.

 In another word, regardless of volumes, intake of coffee is associated with the risk of the disease.

Additional 1 pack of coffee consumption conferred an RR of 1.22.

Dr. Chen J, the lead researcher said, " A dose-response relationship between coffee intake and laryngeal carcinoma was detected" and "this meta-analysis of observational studies demonstrate that coffee consumption would increase the laryngeal cancer risk".

However,  among the 6 studies that reported the association between coffee consumption and laryngeal carcinoma, only one study was a prospective population-based cohort study, while the rest 5 studies were retrospective hospital based case-control studies using observation of returned survey from participants.

The findings firmly suggested that coffee consumption would increase the laryngeal cancer risk, therefore people who are at a higher risk of laryngeal cancer incidence may want to reduce or completely withdraw from coffee consumption.

Taking all together, coffee and coffee caffeine intake may have a negative effect in increasing risk laryngeal cancer but researchers suggested that genetic and environmental factors such as alcohol intake, human papillomaviruses infection, and silica exposure should be also taken into account. which were excluded in some studies.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tea and coffee consumption and risk of laryngeal cancer: a systematic review meta-analysis by Chen J1, Long S1.(PMC)

Catnip, the Natural Dopamine for Penile Erection and Male Sexual Desire

By Kyle J. Norton, Master of Nutrition

Herbal catnip processed a high amount of dopamine may be considered a functional herb used to prevent and treat penile erection and increase male sexual desire, some scientists suggested.

Dopamine, a neurotransmitter plays an important role in the brain of the human body, including sexual behavior.

Besides in regulation of cognitive, integrative and reward processes, the organic chemical of catecholamine and phenethylamine also can trigger penile erection and control of sexual function by acting on oxytocinergic neurons.

Erectile dysfunction (ED) or impotence is a condition of a male who can not get or maintain an erection firm enough to have sexual intercourse.

Most cases of erectile dysfunction (ED) are associated with medical conditions such as heart disease, diabetes, and obesity. However, according to the statistics, the incidence also is associated with

 the psychological problems in some men.

Some researchers suggested that certain risk factors such as increased age, stress, anxiety, drug abuse, excessive alcohol drinking, smoking and particularly in people with the long-term use of certain medication such as diuretics and beta-blockers can facilitate the early onset of the conditions.

Sexual desire is a motivational state and an interest in “sexual objects or activities, or as a wish, or drive to seek out sexual objects or to engage in sexual activities, according to the definition provided by the study of SEX DIFFERENCES AND SIMILARITIES IN FREQUENCY AND INTENSITY OF SEXUAL DESIRE conducted by Dr. Regan, Pamela C.;and Dr. Atkins, Leah

According to the self-reported frequency and intensity of sexual desire among an ethnically diverse sample of 676 men and women, the doctors found that men are experiencing a higher overall level of sexual desire than did women. and in the sex differences with respect to the frequency of sexual desire, Men also are experiencing sexual desire more often than did women.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The common herb has been used in herbal medicine as an insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc.

In the study to evaluate the effect of Nepeta cataria (NC), catnip on sexual behavior and penile erection researchers at the Paulista University, launched an investigation with male rats acutely fed chow enriched with 10% NC leaves.

All tested rats are randomly divided into 2 groups, the NC group is received for a 4h period the chow enriched with 10% NC leaves while the control groups are received regular chow.

Researchers found that in compared to control groups, NS fed group demonstrates an apomorphine-induced penile erection and motor coordination observed by the general activity in the open field that was assessed 0, 15, 30 and 60 min after treatment.

Dr. Bernardi MM, the lead scientist after considering all co and confounders said, "NC treatment increased male rat's penile erection. A slight facilitation on male rat sexual behavior and a decreased in general activity of NC treated rats were observed. No effects on motor coordination and yawning episodes were detected by the NC treatment".

The findings suggested that NC application may increase penile erection and improve male rat sexual behavior by an action on dopaminergic systems.

In fact, the effect of a pro-erectile dose of apomorphine, a mixed dopamine receptor agonist, also showed a stimulation of dopamine receptors, induced the release of oxytocin in brain to mediating and reinforcing effects of sexual activity in regulating the sexual behaviour (e.g., penile erection) with those controlling sexual motivation and sexual arousal.

Physically, dopamine can trigger penile erection by acting on oxytocinergic neurons located in the paraventricular nucleus of the hypothalamus and perhaps on the pro-erectile sacral parasympathetic nucleus within the spinal cord.

Dr. Baskerville TA said," dopamine demonstrates the potential existence of an interaction between central dopamine and hormone in controlling sexual reproduction during penile erection.

Several studies suggested that dopamine is a neurotransmitter which processes the potency in regulating and controlling penile erection and sexual behavior, but the use of the herbal medicine should only be prescribed by herbalist to prevent depression.

Taken all together, Herbal catnip may be considered a functional herb to improve erectile dysfunction and sexual desire, without inducing side effects compared to conventional medicine such as Avanafil (Stendra) Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra, Staxyn).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nepeta cataria L. var. citriodora (Becker) increases penile erection in rats by Bernardi MM1, Kirsten TB, Lago JH, Giovani TM, Massoco Cde O.(PubMed)
(2) Dopamine and male sexual function by Giuliano F1, Allard J.(PubMed)
(3) Dopamine-oxytocin interactions in penile erection by Baskerville TA1, Allard J, Wayman C, Douglas AJ. (PubMed)
(4) SEX DIFFERENCES AND SIMILARITIES IN FREQUENCY AND INTENSITY OF SEXUAL DESIRE by Dr. Regan, Pamela C, and Dr. Atkins, Leah

Green Tea and Its Bio-active Flavonoids That Process Anti Inflammatory Bowel Disease (IBD) Potency

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reducing risk and treatment of inflammatory bowel disease, some scientists suggested.

Inflammatory bowel disease (IBD) is a condition characterized by inflammation of the large intestine. The disease affects over 1.6 million American today.

The exact causes of inflammatory bowel disease are unknown. As of today, scientists do not know why, people with the same health conditions, some are susceptible to the onset of the disease, while others do not.

Some researchers suggested that the disease may be caused by the immune response failing to kill off the invasion of infectious micro-organisms in the acute phase of digestive tissue injury and damage or immune dysfunction mistakenly attacking the digestive tract, a case of autoimmune disease.

Furthermore, prolonged periods of imbalance of ratio of good and bad bacteria in the colon, long-term intake of certain medicines, age, family history, ethnicity, parasite, unhealthy diet, and smoking are some prevalent risk factors which can lead to the onset of inflammatory bowel disease.

Moreover, if you are living in the Western world, you are also at a higher risk of the onset of the disease.

For example, people who live in Western countries such as the United States and Europe have a higher IBD risk than those in other parts of the world. 

Genetic mutation inherited from the parents such as NOD2, ATG16L1and IL23R involved in innate immunity, in the autophagy, and in the inflammatory response may elevate the risk of IBD

Most common symptoms of inflammatory bowel disease are severe diarrhea, abdominal pain, fatigue, and weight loss. If you are experiencing the above symptoms, please make sure that you check with your doctor to rule the possibility.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

According to the evaluation of the effect of tea and other sources of flavonoids in reducing inflammatory process in the development and progression of numerous pathological situations, including inflammatory bowel disease (IBD), application of the chemical compound exerted a significant effect in the decrease of  expression of the reactive oxygen species (ROS) that initiates inflammation and inflammatory process through its antioxidant and free radical scavenging activities. 

Furthermore, oral administration of flavonoid also decreased the inflammatory factors in the production of cytokines by inhibiting the synthesis and activities of different pro-inflammatory mediators.

Some researchers suggested, the result of flavonoid in reducing inflammation in the intestines may be attributed to the antioxidant activity in inhibition of tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, a cytokine or signaling protein with functions involving systemic inflammation in the response to the acute phase of infection.

The benefits of flavonoids in IDB are also found to associate with the preserving of intestinal function and the ability to interfere simultaneously every step in the inflammatory process, including the steps in the production of ROS and pro-inflammatory cytokines.

Additional differentiation of the DNA damage induced in vitro in lymphocytes from IBD patients caused by oxidative stress, plant flavonoids, quercetin and epicatechin found in green tea and other sources such as fruits, tea, and soybeans demonstrated a huge effect in inhibiting oxidative stress caused by the toxic chemical injection.

Compared to the lymphocytes from IBD patients and healthy volunteers, treatment of 50 microg/ml H(2)O(2) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the presence of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) and flavonoid supplementation (250 microM quercetin or 100 microM epicatechins) displays an impressive inhibition of both oxidative substances in the induction of free radical expression.

Overall, applications of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) demonstrated significant effects in decreasing DNA damage by 48.6%  in the group treated with H(2)O(2) and a 43% in IQ group, compared to healthy group of 35.2 and 57.1%, respectively

However, after taking into account other confounders, researchers indicated that compared to patients from ulcerative colitis (UC) and Crohn's disease (CD), quercetin, IQ and epicatechin reduce DNA damage within lymphocytes from UC patients, compared to CD patients.

Dr. Najafzadeh M, the lead author said, " flavonoids dramatically reduced oxidative stress in vitro in lymphocytes from IBD patients and healthy individuals. Thus, flavonoids could be very effective in the treatment of oxidative stress and encouraged in the diet of IBD patients".

Taken all together, green tea with abundant bioactive flavonoids may be considered a functional food for reducing the prevalence risk factors of IBD and used combined with the standard medicine for the treatment of the disease.

Intake of green supplement should be taken with great care as toxicity was reported in some medical literature.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Flavonoids inhibit the genotoxicity of hydrogen peroxide (H(2)O(2)) and of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD) by Najafzadeh M1, Reynolds PD, Baumgartner A, Anderson D.(PubMed)
(2) Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies by Triantafillidis JK1, Triantafyllidi A1, Vagianos C2, Papalois A3. (PubMed)
(3) Studies in Natural Products Chemistry: Bioactive Natural Products (Part F) by Atta-ur-Rahman

Fennel, the Functional Herb Which Stimulates Free Radical Cytotoxicity Against Cancer Cells, Scientists Show

Kyle J. Norton

Fennel may be considered secondary theoretical and natural agent for prevention and treatment of cancers, some scientists suggested.

Cytotoxicity is an action that can cause cell death. Substances with cytotoxic function processed the capability to induce apoptosis by binding to Fas expressed with an anti-apoptotic function to some target cells.

Some researchers suggested that some plants pigment, including herbal medicine lipophilic secondary metabolites, process antioxidant properties in protecting healthy cells against cytotoxicity but also stimulating the expression of free radical cytotoxicity against cancer cells.


Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...


In the study to examine cytotoxic effects of some plants selection based on existing ethnobotanical information by interviewing the local healers and tested on the murine fibrosarcoma L929sA cells and on the human breast cancer cells MDA-MB231 and MCF7, researchers found that organic extracts from fennel exert a significant activity on an IC (50) value at 24 h of 700 and 500  μg/mL, on L929sA and MCF7 cells, respectively, through their cytotoxicity.

Further analysis, researchers also discovered, the extracts with different concentration limit the range of genes activated by NF-κB, in the regulation of the expression of various genes by allowing the only expression of genes, that contribute to an effective immune response.

Also, in vitro, acetone extracts of F. vulgare demonstrated a strong cytotoxic effect against kidney (Vero) cell line and an adenocarcinoma cervical cancer (HeLa) cell line.

Additionally, according to the investigation of the essential oil of fennel (Foeniculum vulgare) which is found to process a rich in lipophilic secondary metabolites, researchers found that the main components of F. vulgare oil, trans-anethole presented 36.8% in the oil demonstrated a significant antioxidant activity in the protection of healthy cells and cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukaemia) and CEM/ADR5000 (adriamycin resistant leukaemia) cancer cell lines.

Moreover, at the IC50 values between 30-210 mg L-1 and thus the essential oil exhibited low cytotoxicity compared to cytotoxic reference compound (trans-anethole).

Interestingly, in the study carried out to determine the cytotoxic effect of seven plant extracts and the isolated compounds - syringin and 4-methoxycinnamyl alcohol - on cancerous and non-cancerous cells by the University of Pretoria, researchers showed that the ethanol extract of Foeniculum vulgare exhibits the most significant toxicity with an IC50 value of 19.97 μg/mL on HeLa cells.

4-methoxycinnamyl alcohol compound isolated from fennel only showed toxicity against MCF-7, HeLa and DU145 cancer cell line but also inhibited all cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL

The DNA fragmentation study also revealed that application of 4-methoxycinnamyl alcohol takes place at a concentration of 10 μg/mL after 48 h exposure.

Taken all together, fennel extracts and essential oil may be considered a secondary therapeutic treatment for prevention and treatment of cancers through its antioxidant and cytotoxicity effects.

Since all experiments were only taking place in vivo and vitro, further data collection on large example size and multi-centers studies performed human during the course of the disease will be necessary to complete the picture of anti-cancers possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M(PubMed)
(3) Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines by Lall N1, Kishore N, Binneman B, Twilley D, van de Venter M, du Plessis-Stoman D, Boukes G, Hussein A.(PubMed)

Maternal Coffee Intake > 4 Cups/Day May Increase Risk of Miscarriage, Scientists Suggest

By Kyle J. Norton (Master of Nutrition, All right reserved)

The risk of miscarrying is increased substantially in excessive (over 4 cups/day) coffee drinkers during pregnancy, an Asian study suggested.

A miscarriage, according to the definition is the loss of a fetus before the 20th week of pregnancy.

Believe or not, according to medical literature, as many as many as 50% of all pregnancies end in miscarriage and over 80% of miscarriages are occurring within the first three months of pregnancy. 

Some researchers suggested that women who carry mutation genes associated with chromosome gains and losses during embryonic development can lead to miscarriage or the failure of IVF treatments.

Other risk factors associated with an increased risk of miscarriage include aging Age. Women who are older than age 35, previous miscarriages. smoking and excessive alcohol drinking before and during pregnancy have a higher risk of miscarriage compared to younger women,

Chronic medical health conditions such as obesity and uterine or cervical problems can also substantially increase the miscarriage risk.

Coffee, one of the most popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a case-controlled study conducted in Milan of 561 (72%) cases of spontaneous abortion and 877 (57%) controls, coffee drinking during the first trimester of the index pregnancy with healthy women who gave birth at term (> 37 weeks gestation) to healthy infants as control, researchers reported that the risk of miscarry is classified as follows
* Coffee intake of 1, 2 or 3, and 4 or more cups of coffee per day are associated with an increased risk of 1.2, 1.8 and 4.0, respectively, compared to nondrinkers.

* The risk of pregnancy loss also is associated with the duration in years of coffee drinking. The estimated multivariate odds ratios of spontaneous abortion were 1.1 in comparison to non-coffee intake group.

Furthermore, in the evaluated effect of caffeine in influence of miscarriage researchers at the Boston University School of Public Health, conducted a prospective cohort study included 5132 Danish women planning pregnancy, enrolled from 2007 to 2010, after carefully assessed the returned beverage consumption on questionnaires, researcher found that a significantly miscarried risk is 1.62 higher in women consuming more than 300 mg/day of caffeine per day, in compared to 1.09 in women who consume <100 mg/day. Specifically, women with daily intake of caffeine of
* <100 mg/day showed a materially associated with SAB risk of 1.09.

* 100-199mg/day showed a materially associated with SAB risk of 0,89.

* 200-299mg/day showed a materially associated with SAB risk of 1.33

Additionally, in prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009) with beverage intake assessed every 4 years using a validated questionnaire in case pregnancies lost spontaneously at <20 weeks gestation, total coffee intake had a positive, linear association with SAB.

In compared to non-pre-pregnancy coffee intake, the risk of SAB increased by 20% for women consuming ≥4 servings/day.

More importantly, Dr. Gaskins AJ, the lead author said, "Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with the increased risk of SAB, particularly at weeks 8-19".

Taking together, there is no doubt that coffee may contribute to a relative risk of miscarrying for women consuming more than 4 cups per day.

Women who are pregnant between 12 to 28 weeks of gestation with excessive coffee intake habit are recommended to consult with their doctors.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation by Parazzini F1, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G.(PubMed)
(2) Caffeine and caffeinated beverage consumption and risk of spontaneous abortion by Hahn KA1, Wise LA2, Rothman KJ3, Mikkelsen EM4, Brogly SB5, Sørensen HT6, Riis AH4, Hatch EE5.(PubMed)
(3) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion by Gaskins AJ1,2, Rich-Edwards JW3,4,5, Williams PL3,6, Toth TL7, Missmer SA3,4,8,9, Chavarro JE10,3,4.(PubMed)

Fennel,The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest

Kyle J. Norton

Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.

Cognitive function is a mental process of the brain, with an aim to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.

On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.

In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and longterm use of medication, including Alzheimer's;s disease.

However,  malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.

Some researchers suggested that people who have metabolic syndrome (abnormally high blood pressure, and high blood sugar, obesity and abnormal cholesterol or triglyceride level), mental illness and previously disturbed the state of mind due to fever, intoxication are also at a higher risk of the condition develops.

Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"

And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle in cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, may be highly informative for the development of interventions to reduce or delay age-related cognitive decline".

These explanations strongly agreed that following a healthy diet plenty of fruits and vegetable and less in saturated and trans fat, processed meat, refined products,...... salt and sugar, and lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.

Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
.
 Anethole, the main fragrance and bioactive compound of fennel, in the study of  20 other plant species was found to process nootropic activity in protecting the neurons degeneration, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.

In the inflammatory expression, application of anethole exerted a significant effect in mediated NF-kB in the systematically inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production inflammatory factors in the acute phase of infection.

The initiation of the pro-inflammatory cytokine in case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and virus. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death. 

In oxidative perspective, application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which cause the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.

Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk in the initiated production of pro-inflammatory cytokines in the precipitation of the death of brain cell that controls memory or other cognitive functions.

Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against the progressive degeneration.

The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.

In acetylcholinesterase AChE induced neurotoxicity in mice, application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.

Dr. Preksha Dwivedi, the lead authors, after taking into account of other co and confounders said, "Foeniculum vulgare Linn. The extract used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".

Taken together, fennel, fennel extracts or its bioactive anethole may be considered a functional food for enhancing the memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)

Carrot and its Bioactive Compounds In Reducing Risk, Progression and Treatment of Gastric Cancer

Kyle J. Norton

Carrots may have a therapeutic and positive effect in reducing risk, progression, and treatment of gastric/stomach cancer, some scientists suggested.

Gastric (Stomach)  cancer is a condition characterized by cell growth disorderly and uncontrollably in breast tissue.

At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

The exact causes of gastric cancer are unknown. Researchers do not know why people with the same health conditions and eating habits in the same family, some are susceptible to the onset of the disease while others do not.

However, scientists do know that certain risk factors such as Helicobacter pylori infection,  smoking family history, mutated gene inherited from the parents, some stomach conditions and previous stomach surgery are at the elevated risk of gastric cancer.

Moreover, people who have exposed to ionizing radiation, are smokers with type A blood and eating lots of processed meats are also at a higher risk of gastric cancer.

The American Cancer Association in the article of Can Gastric Cancer Be Prevented? wrote. "A diet high in fresh fruits and vegetables can also lower stomach cancer risk. Citrus fruits (such as oranges, lemons, and grapefruit) may be especially helpful" and ".. eating at least 2½ cups of vegetables and fruits every day. Choosing whole-grain bread, pasta, and cereals instead of refined grains, and eating fish, poultry, or beans instead of processed meat and red meat may also help lower your risk of cancer".

These suggestions strongly agreed that by following a healthy diet and lifestyle with moderate physical activity, the risk of gastric cancers can be reduced substantially and effectively.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the evaluation of carrot intake and risk of gastric cancer, by searching the database of medical
literature from PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx, researchers found that out of 81 articles collected with 5 selected to the study, carrot consumption exerts a reduced gastric cancer risk by 26% with an odds ratio of .74 compared to nonconsumers.

Some researchers suggested that lycopene isolated from the carrot and tomato may have a substantial inhibitory effect in reducing the risk of gastric cancer caused by oxidative stress, DNA damage, and Helicobacter pylori infection.

Overproduction of ROS, the reactive oxygen species may induce a chain reaction in stimulating more production of free radicals, causing cells and tissues damage and alternated DNA of healthy cells.

Lycopene, a bioactive compound antioxidant found in carrot showed a strong implication of on iron metabolism, thus reducing iron-mediated oxidative stress in the induction of cancer cells proliferation and initiation.

Furthermore, application of lycopene also expressed an inhibition of iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level and enhancing the production of natural antioxidants superoxide dismutase activities in serum and tissues.

These results indicated that administration of lycopene not only inhibits overproduction of ROS through its antioxidant activity but also stimulates the expression of natural antioxidants in the host body tissue in preventing DNA damage of healthy cell. 

With H. pylori-induced chronic inflammation in facilitating risk of gastric cancer, researchers at the Yonsei University found that injection lycopene exerts a significant effect in inhibiting the increase of ROS, apoptosis, alterations in cell-cycle distribution in human gastric carcinoma AGS cells.

The results of above differentiation were supported by the study from the period 1997-1999 with 120 incident and histologically verified cases of stomach cancer, matched on age, sex, residence, and urban/rural status and 360 controls conducted by the Jiangsu Cancer Hospital and Research Institute.

According to the study, vitamin A, alpha-carotene and lycopene found in carrot and tomato were associated with strongly inverse relationships with stomach cancer with alpha-carotene scored the highest odds ratio of .34.

The joint exposure to high intakes of alpha-carotene and vitamin C was associated with an even higher reduction of gastric cancer risk with the odds ratio of only 0.11. 

The findings strongly suggested that long-term intake of carrot in moderate amounts may have substantial implication in the prevention and treatment of gastric cancer. But Intake of carrot supplement should be taken with care to prevent acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3(PubMed)
(2) Dietary carotenoids and risk of gastric cancer: a case-control study in Uruguay by De Stefani E1, Boffetta P, Brennan P, Deneo-Pellegrini H, Carzoglio JC, Ronco A, Mendilaharsu M.(PubMed)
(3) Anticancer Effect of Lycopene in Gastric Carcinogenesis by Mi Jung Kim and Hyeyoung Kim(PMC)
(4) Protective effects of lycopene on oxidative stress, proliferation, and autophagy in iron supplementation rats by Liu C1, Wang R, Zhang B, Hu C, Zhang H.(PubMed)
(5) Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells by Jang SH1, Lim JW1, Morio T2, Kim H3. (PubMed)