Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 10 October 2018

Fennel, the Functional Herb Which Stimulates Free Radical Cytotoxicity Against Cancer Cells, Scientists Show

Kyle J. Norton

Fennel may be considered secondary theoretical and natural agent for prevention and treatment of cancers, some scientists suggested.

Cytotoxicity is an action that can cause cell death. Substances with cytotoxic function processed the capability to induce apoptosis by binding to Fas expressed with an anti-apoptotic function to some target cells.

Some researchers suggested that some plants pigment, including herbal medicine lipophilic secondary metabolites, process antioxidant properties in protecting healthy cells against cytotoxicity but also stimulating the expression of free radical cytotoxicity against cancer cells.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the study to examine cytotoxic effects of some plants selection based on existing ethnobotanical information by interviewing the local healers and tested on the murine fibrosarcoma L929sA cells and on the human breast cancer cells MDA-MB231 and MCF7, researchers found that organic extracts from fennel exert a significant activity on an IC (50) value at 24 h of 700 and 500 μg/mL, on L929sA and MCF7 cells, respectively, through their cytotoxicity.

Further analysis, researchers also discovered, the extracts with different concentration limit the range of genes activated by NF-κB, in the regulation of the expression of various genes by allowing the only expression of genes, that contribute to an effective immune response.

Also, in vitro, acetone extracts of F. vulgare demonstrated a strong cytotoxic effect against kidney (Vero) cell line and an adenocarcinoma cervical cancer (HeLa) cell line.

Additionally, according to the investigation of the essential oil of fennel (Foeniculum vulgare) which is found to process a rich in lipophilic secondary metabolites, researchers found that the main components of F. vulgare oil, trans-anethole presented 36.8% in the oil demonstrated a significant antioxidant activity in the protection of healthy cells and cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukaemia) and CEM/ADR5000 (adriamycin resistant leukaemia) cancer cell lines.

Moreover, at the IC50 values between 30-210 mg L-1 and thus the essential oil exhibited low cytotoxicity compared to cytotoxic reference compound (trans-anethole).

Interestingly, in the study carried out to determine the cytotoxic effect of seven plant extracts and the isolated compounds - syringin and 4-methoxycinnamyl alcohol - on cancerous and non-cancerous cells by the University of Pretoria, researchers showed that the ethanol extract of Foeniculum vulgare exhibits the most significant toxicity with an IC50 value of 19.97 μg/mL on HeLa cells.

4-methoxycinnamyl alcohol compound isolated from fennel only showed toxicity against MCF-7, HeLa and DU145 cancer cell line but also inhibited all cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL

The DNA fragmentation study also revealed that application of 4-methoxycinnamyl alcohol takes place at a concentration of 10 μg/mL after 48 h exposure.

Taken all together, fennel extracts and essential oil may be considered a secondary therapeutic treatment for prevention and treatment of cancers through its antioxidant and cytotoxicity effects.

Since all experiments were only taking place in vivo and vitro, further data collection on large example size and multi-centers studies performed human during the course of the disease will be necessary to complete the picture of anti-cancers possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M(PubMed)
(3) Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines by Lall N1, Kishore N, Binneman B, Twilley D, van de Venter M, du Plessis-Stoman D, Boukes G, Hussein A.(PubMed)

Maternal Coffee Intake > 4 Cups/Day May Increase Risk of Miscarriage, Scientists Suggest

By Kyle J. Norton (Master of Nutrition, All right reserved)

The risk of miscarrying is increased substantially in excessive (over 4 cups/day) coffee drinkers during pregnancy, an Asian study suggested.

A miscarriage, according to the definition is the loss of a fetus before the 20th week of pregnancy.

Believe or not, according to medical literature, as many as many as 50% of all pregnancies end in miscarriage and over 80% of miscarriages are occurring within the first three months of pregnancy.

Some researchers suggested that women who carry mutation genes associated with chromosome gains and losses during embryonic development can lead to miscarriage or the failure of IVF treatments.

Other risk factors associated with an increased risk of miscarriage include aging Age. Women who are older than age 35, previous miscarriages. smoking and excessive alcohol drinking before and during pregnancy have a higher risk of miscarriage compared to younger women,

Chronic medical health conditions such as obesity and uterine or cervical problems can also substantially increase the miscarriage risk.

Coffee, one of the most popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a case-controlled study conducted in Milan of 561 (72%) cases of spontaneous abortion and 877 (57%) controls, coffee drinking during the first trimester of the index pregnancy with healthy women who gave birth at term (> 37 weeks gestation) to healthy infants as control, researchers reported that the risk of miscarry is classified as follows
* Coffee intake of 1, 2 or 3, and 4 or more cups of coffee per day are associated with an increased risk of 1.2, 1.8 and 4.0, respectively, compared to nondrinkers.

* The risk of pregnancy loss also is associated with the duration in years of coffee drinking. The estimated multivariate odds ratios of spontaneous abortion were 1.1 in comparison to non-coffee intake group.

Furthermore, in the evaluated effect of caffeine in influence of miscarriage researchers at the Boston University School of Public Health, conducted a prospective cohort study included 5132 Danish women planning pregnancy, enrolled from 2007 to 2010, after carefully assessed the returned beverage consumption on questionnaires, researcher found that a significantly miscarried risk is 1.62 higher in women consuming more than 300 mg/day of caffeine per day, in compared to 1.09 in women who consume <100 mg/day. Specifically, women with daily intake of caffeine of
* <100 mg/day showed a materially associated with SAB risk of 1.09.

* 100-199mg/day showed a materially associated with SAB risk of 0,89.

* 200-299mg/day showed a materially associated with SAB risk of 1.33

Additionally, in prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009) with beverage intake assessed every 4 years using a validated questionnaire in case pregnancies lost spontaneously at <20 weeks gestation, total coffee intake had a positive, linear association with SAB.

In compared to non-pre-pregnancy coffee intake, the risk of SAB increased by 20% for women consuming ≥4 servings/day.

More importantly, Dr. Gaskins AJ, the lead author said, "Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with the increased risk of SAB, particularly at weeks 8-19".

Taking together, there is no doubt that coffee may contribute to a relative risk of miscarrying for women consuming more than 4 cups per day.

Women who are pregnant between 12 to 28 weeks of gestation with excessive coffee intake habit are recommended to consult with their doctors.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation by Parazzini F1, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G.(PubMed)
(2) Caffeine and caffeinated beverage consumption and risk of spontaneous abortion by Hahn KA1, Wise LA2, Rothman KJ3, Mikkelsen EM4, Brogly SB5, Sørensen HT6, Riis AH4, Hatch EE5.(PubMed)
(3) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion by Gaskins AJ1,2, Rich-Edwards JW3,4,5, Williams PL3,6, Toth TL7, Missmer SA3,4,8,9, Chavarro JE10,3,4.(PubMed)

Sunday, 7 October 2018

Fennel,The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest

Kyle J. Norton

Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.

Cognitive function is a mental process of the brain, with an aim to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.

On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.

In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and longterm use of medication, including Alzheimer's;s disease.

However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.

Some researchers suggested that people who have metabolic syndrome (abnormally high blood pressure, and high blood sugar, obesity and abnormal cholesterol or triglyceride level), mental illness and previously disturbed the state of mind due to fever, intoxication are also at a higher risk of the condition develops.

Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"

And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle in cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, may be highly informative for the development of interventions to reduce or delay age-related cognitive decline".

These explanations strongly agreed that following a healthy diet plenty of fruits and vegetable and less in saturated and trans fat, processed meat, refined products,...... salt and sugar, and lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.

Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the neurons degeneration, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.

In the inflammatory expression, application of anethole exerted a significant effect in mediated NF-kB in the systematically inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production inflammatory factors in the acute phase of infection.

The initiation of the pro-inflammatory cytokine in case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and virus. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.

In oxidative perspective, application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which cause the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.

Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk in the initiated production of pro-inflammatory cytokines in the precipitation of the death of brain cell that controls memory or other cognitive functions.

Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against the progressive degeneration.

The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.

In acetylcholinesterase AChE induced neurotoxicity in mice, application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.

Dr. Preksha Dwivedi, the lead authors, after taking into account of other co and confounders said, "Foeniculum vulgare Linn. The extract used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".

Taken together, fennel, fennel extracts or its bioactive anethole may be considered a functional food for enhancing the memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.

Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)

Carrot and its Bioactive Compounds In Reducing Risk, Progression and Treatment of Gastric Cancer

Kyle J. Norton

Carrots may have a therapeutic and positive effect in reducing risk, progression, and treatment of gastric/stomach cancer, some scientists suggested.

Gastric (Stomach) cancer is a condition characterized by cell growth disorderly and uncontrollably in breast tissue.

At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

The exact causes of gastric cancer are unknown. Researchers do not know why people with the same health conditions and eating habits in the same family, some are susceptible to the onset of the disease while others do not.

However, scientists do know that certain risk factors such as Helicobacter pylori infection, smoking family history, mutated gene inherited from the parents, some stomach conditions and previous stomach surgery are at the elevated risk of gastric cancer.

Moreover, people who have exposed to ionizing radiation, are smokers with type A blood and eating lots of processed meats are also at a higher risk of gastric cancer.

The American Cancer Association in the article of Can Gastric Cancer Be Prevented? wrote. "A diet high in fresh fruits and vegetables can also lower stomach cancer risk. Citrus fruits (such as oranges, lemons, and grapefruit) may be especially helpful" and ".. eating at least 2½ cups of vegetables and fruits every day. Choosing whole-grain bread, pasta, and cereals instead of refined grains, and eating fish, poultry, or beans instead of processed meat and red meat may also help lower your risk of cancer".

These suggestions strongly agreed that by following a healthy diet and lifestyle with moderate physical activity, the risk of gastric cancers can be reduced substantially and effectively.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the evaluation of carrot intake and risk of gastric cancer, by searching the database of medical
literature from PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx, researchers found that out of 81 articles collected with 5 selected to the study, carrot consumption exerts a reduced gastric cancer risk by 26% with an odds ratio of .74 compared to nonconsumers.

Some researchers suggested that lycopene isolated from the carrot and tomato may have a substantial inhibitory effect in reducing the risk of gastric cancer caused by oxidative stress, DNA damage, and Helicobacter pylori infection.

Overproduction of ROS, the reactive oxygen species may induce a chain reaction in stimulating more production of free radicals, causing cells and tissues damage and alternated DNA of healthy cells.

Lycopene, a bioactive compound antioxidant found in carrot showed a strong implication of on iron metabolism, thus reducing iron-mediated oxidative stress in the induction of cancer cells proliferation and initiation.

Furthermore, application of lycopene also expressed an inhibition of iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level and enhancing the production of natural antioxidants superoxide dismutase activities in serum and tissues.

These results indicated that administration of lycopene not only inhibits overproduction of ROS through its antioxidant activity but also stimulates the expression of natural antioxidants in the host body tissue in preventing DNA damage of healthy cell.

With H. pylori-induced chronic inflammation in facilitating risk of gastric cancer, researchers at the Yonsei University found that injection lycopene exerts a significant effect in inhibiting the increase of ROS, apoptosis, alterations in cell-cycle distribution in human gastric carcinoma AGS cells.

The results of above differentiation were supported by the study from the period 1997-1999 with 120 incident and histologically verified cases of stomach cancer, matched on age, sex, residence, and urban/rural status and 360 controls conducted by the Jiangsu Cancer Hospital and Research Institute.

According to the study, vitamin A, alpha-carotene and lycopene found in carrot and tomato were associated with strongly inverse relationships with stomach cancer with alpha-carotene scored the highest odds ratio of .34.

The joint exposure to high intakes of alpha-carotene and vitamin C was associated with an even higher reduction of gastric cancer risk with the odds ratio of only 0.11.

The findings strongly suggested that long-term intake of carrot in moderate amounts may have substantial implication in the prevention and treatment of gastric cancer. But Intake of carrot supplement should be taken with care to prevent acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Float ers
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3(PubMed)
(2) Dietary carotenoids and risk of gastric cancer: a case-control study in Uruguay by De Stefani E1, Boffetta P, Brennan P, Deneo-Pellegrini H, Carzoglio JC, Ronco A, Mendilaharsu M.(PubMed)
(3) Anticancer Effect of Lycopene in Gastric Carcinogenesis by Mi Jung Kim and Hyeyoung Kim(PMC)
(4) Protective effects of lycopene on oxidative stress, proliferation, and autophagy in iron supplementation rats by Liu C1, Wang R, Zhang B, Hu C, Zhang H.(PubMed)
(5) Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells by Jang SH1, Lim JW1, Morio T2, Kim H3. (PubMed)

Fennel, The Functional Herb Which Processes Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find

Kyle J. Norton, Master of Nutrition

Fennel may have a therapeutic effect in reducing risk and treatment of anxiety, some scientists suggested.

Anxiety is a psychological problem caused by significant feelings of anxiety and fear of present and future events.

In conventional medicine, an anxiolytic also known as antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.

Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.

Other causes of anxiety include the longterm use of illicit drugs, medication intake and medical condition and diseases associated with reduced lung functioning

Although the medicine may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.

In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.

If you are taking the above medicine, please make sure that you understand all the side effects.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the investigate the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.

This result was observed by the increased number of entries and time spent in the open arm in the elevated plus maze apparatus.

And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.

Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.

Additionally, in the experiment of elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.

* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing and head dipping.

* Fennel extract treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.

These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents whose were placed in the environment with an expression of anxiety and fear in the first study.

Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).

According to the results of analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.

Compared to a higher dose of 400 mg/kg and lower dose treatment group, application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease of anxiety through increased percent number of entries and time spent in open arms.

Compared to other doses of treatment group, administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.

Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.

The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.

"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.

Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.

However, intake of fennel supplement should be taken with extreme care in the prevention of toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

Green Tea, The Potent Functional Beverage Inhibits the Pathogens That Cause Pneumonia, Scientists Say

By Kyle J. Norton

Green tea may have a therapeutic and positive effect in reducing the risk and progression and treatment of pneumonia, some scientists suggested.

Pneumonia is a lung infection caused by bacteria, viruses, or fungi. Bacterial pneumonia is the most common type in adults.

Researchers do not know why people with the same health condition, some are susceptible to the onset of the disease while others do not.

However, according to the studies, certain groups of people are at a higher prevalent risk, including babies and toddlers, who have an immature immune system, people who have had a recent viral infection and people with chronic lung conditions such as asthma, bronchitis or bronchiectasis.

Additionally, people with suppressed immune systems, excessive alcohol drinking and smoking habit and the elderly are also associated with the increased risk of lung infection.

Most common symptoms of include fever and chill caused overexpression of inflammatory cytokines, shortness of breath and increased breathing rate, caused by reduced lung function.

Some patients with pneumonia also have serious symptoms of persistent coughing with phlegm, that does not disappear itself and chest pain.

If you experience some of the above symptoms, you may have pneumonia. Please check with your doctor to rule out the possibility.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.

In a population-based cohort study, with the follow-up from 1995 to 2006 conducted by Tohoku University Graduate School of Medicine using data of participants in National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y), researchers wrote at the end of the experiment,

* Over 12 y of follow-up, 406 deaths from pneumonia, according to the reported documents.

* According to the hazard ratios (HRs), injection of green tea demonstrated a significant reduction of death from pneumonia, (<1 cup/d, HRs

Injection of green tea <1 cup/d, with HRs of 1, 1-2 cups/d with HRs of 0.59, 3-4 cups/d, HRs of 0.55 and > or =5 cups/d with Hrs of .53, respectively in women.

Interestingly, in men, green tea injection regardless of volumes displays no significant association in the risk of death from pneumonia.

These results suggested that green tea intake daily and regularly may have a strong effect in reducing risk, progression, treatment of lung infection, particularly, in the reduced rate of motility in women.

Furthermore, in the evaluate epigallocatechin gallate (EGCG) effect in influenza A virus in the induction of pneumonia in Madin-Darby canine kidney (MDCK) cells of BALB/c mice treated with EGCG (10, 20 or 40 mg·kg(-1)·d(-1), po) for 5 days. and on the 3rd day of the treatment, the mice were infected with influenza A virus., researcher indicated that

* EGCG treatment group exerts a significant inhibition of the expression of influenza A virus in elevating production of reactive oxygen species.

* EGCG also inhibits the influenza A replication at a concentration-dependent manner (the ED(50) value of 8.71±1.11 nmol/L).

* Importantly, oral administration of green tea EGCG dramatically improves the survival rate, decreases the mean virus yields and mitigates viral pneumonia in the lungs, compared to conventional medicine at oseltamivir (40 mg·kg(-1)·d(-1)).

These results were supported by the investigation to examine, whether green tea by-products could function as an alternative to common antivirals in animals, conducted by the Konkuk University.

According to the experiment, both applications demonstrated a significantly inhibited influenza activity with green tea by-products (EC₅₀ = 6.36 µg/mL) to be equivalent to that of original green tea (EC₅₀= 6.72 µg/mL)

In against the H1N1 virus A/NWS/33, anti-influenza activity of green tea by-products (EC₅₀ = 6.36 µg/mL) is equivalent to that of original green tea (EC₅₀= 6.72 µg/mL).

However, in tested mice, oral administration of green tea by-products reduced viral titers in the lungs in the early phase of infection, but they could not protect these animals from disease and death compared to therapeutic administration of green tea by-products via feed or water supplement on a dose-dependent manner and the rate of motility at dose of 10 g/kg of feed.

These result unsurprisingly suggested that green tea bioactive compound as a single ingredient consist of a strong effect in reducing the death of pneumonia pathogens compared to the intake of green tea whole foods.

After taking into account other co and confounders, Dr. Lee HJ said, "Unidentified hexane-soluble fractions of green tea by-products possessed strong anti-influenza activity, in addition to ethyl acetate-soluble fractions, including catechins".

Taken together, green tea and its bioactive polyphenols catechin may be considered as functional foods in reducing risk, progression and treatment of pneumonia, particularly in the decrease of death ratio.

However, intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of the case.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea by Ling JX1, Wei F, Li N, Li JL, Chen LJ, Liu YY, Luo F, Xiong HR, Hou W, Yang ZQ.(PubMed)
(3) Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens by Lee HJ1, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS(PubMed).

Green tea, The Beverage Which Processes Anti Viral Activity Against Onset of Pneumonitis

By Kyle J. Norton, Master of Nutrition

Scientists may have found a beverage processed antivirus property for a cure of pneumonitis, some studies suggested.

Pneumonitis is an inflammatory disease that affects the walls of the alveoli in the lungs, in most cases, it is caused by a virus.

However, irritants, ranging from airborne molds to chemotherapy drugs, have been linked to the onset of the condition.

Most common symptoms of are difficulty breathing, often accompanied by a dry cough.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In the concerns of the widespread of some virus in the induction of pneumonitis, researchers at the Kobe University conducted an investigation to examine whether green tea Epigallocatechin-3-O-gallate (EGCG), the major catechin component of green tea possessed antiviral activities against a wide range of DNA viruses and RNA viruses, that cause pneumonitis.

At the final report of the experiment, researchers suggested that EGCG appears most likely to inhibits the early stage of infections, such as attachment, entry, and membrane fusion, by interfering with viral membrane proteins.

Also, according to the observation of the relationships between structure and antiviral activity of catechin derivatives, researchers found that the 3-galloyl and 5'-OH group of catechin derivatives appears critical to antiviral activities in the early phase of infection.

In addition of fatty acid derivative, the combination also exerts an increase viral and cellular membrane permeability.

These results suggested that EGCG-fatty acid monoesters improved greater antiviral activities against different types of viruses, probably due to their increased affinity for virus and cellular membranes, compared to the use of EGCG alone.

Dr. Kaihatsu K, the lead author said, after taking into account of other co and confounders, "(The) application of EGCG-fatty acid derivatives for the prevention and treatment of viral infections".

Furthermore, a study in the evaluation of epigallocatechin-3-gallate (EGCG), the main constituent of green tea, anti-infective properties.launched by the University of Duisburg-Essen, showed that application of EGCG demonstrated a significant activity on orthomyxoviridae and Flaviviridae and other human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus.through interfering with the replication cycle of DNA viruses like hepatitis B virus, herpes simplex virus,.... and adenovirus.

Additionally, in an experimental skin contact model for influenza virus transmission to evaluate the use of a green tea solution as a first-hand disinfectant, researchers strong agreed that green tea displays a strong antiviral effect in inhibiting the infectivity of the virus on the skin cell layer.

This result suggested that green tea may be used as a non-pharmaceutical washing solution in reducing human transmission of viral infection, including the virus that causes pneumonitis.

Taken all together, green tea and its bioactive EGCG may be considered a functional food in protecting the lung tissue against the onset of viral pneumonitis.

Intake of green tea supplement EGCG should be taken with extreme care as acute liver diseases have been reported in many instances.

Sources
(1) Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters by Kaihatsu K1, Yamabe M2, Ebara Y. (PubMed)

(2) Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea by Steinmann J1, Buer J, Pietschmann T, Steinmann E.(PubMed)

(3) Evaluation of the antiviral activity of a green tea solution as a hand-wash disinfectant by Shin WJ1, Kim YK, Lee KH, Seong BL. (PubMed)