Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 5 October 2018

Fennel, The Herbal Remedy Which Protects Our Body Against The Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find

Kyle J. Norton

Fennel may process a strong anti-inflammatory activity in reducing the risk of tissue injury and cell apoptosis, some scientists suggested.

Acute inflammation is a natural and systematic immune response to protect our body against invasion of foreign bacteria and virus by the initiated production of inflammatory cytokines to the site of infection.

However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cells damage and sometimes death of the healthy cells in the infectious site and nearby cells.

These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs functioning, such as liver scars caused by hepatitis virus infection.

Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.

Furthermore, chronic inflammation occurred that lasts for months or years when the immune system response to the site of infection failure to eliminate agents that cause acute inflammation.

An autoimmune disorder that attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.
Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.

If you are presently taking anti-inflammatory medicine, please make sure that you discuss the adverse effects with your doctor.

Fennel (Foeniculum vulgare) is a plant species, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

According to study of BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h, researchers found that in anethole treatment group exerts a significant increase of numbers of mobile white blood cells macrophages and neutrophils, the first immune response to the infectious site.

Furthermore, application of LPS also induced production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) all systematic inflammatory cytokines in response to cellular damage and tissue injury.

Moreover, LPS also exhibited overproduction of nitric oxide (NO) observed in bronchoalveolar lavage fluid in facilitated cellular cytotoxicity.

In the compared nontreatment group, injection anethole group demonstrated a strong anti-inflammatory effect through decrease activities of proinflammatory factors without affecting the immune activity in protects against infection.

Additional analysis also found that treatment group reduced acute lung injury caused by injection LPS through its antioxidants and induced production of host natural antioxidant in the body tissue.

The inhibited LPS results according to were attributed to anethole effect in suppressed the activation of NF-κB in signaling production of inflammatory cytokines by blocking the initiation of IκB-α degradation by inhibited TRAF2 in the induction of inflammation through TNF receptor superfamily members and NIK, a key signaling molecule of the noncanonical NF-κB.

Interestingly, further investigation of anethole as an inhibitor of TNF-induced NF-kB activation (an early response) as monitored by electrophoretic mobility shift assay, by suppression of IkBa phosphorylation and NF-kB reporter gene, researchers also indicated that

* Anethole also suppressed TNF-induced activation of the transcription factor AP-1 in regulated gene expression in response to a variety of stimuli, including LPS application.

*c-Jun N-terminal kinases (JNKs) with function in response to stress stimuli, such as cytokines,
And

* MAPKkinase in signal inflammatory response through transmitting information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

* Application of anethole also suppressed TNF-induced both lipid peroxidation and ROS generation, through the stimulated production of natural antioxidant in the host and itself, resulting in balancing the ratio of antioxidant and ROS expression.

The illustration and differentiation were elite by the experiment in the application of TNF (100 pM) with the cells pretreated for 240 and 120 min with anethole, NF-kB activation was almost completely inhibited.

However, the inhibition decreased gradually with decreased pre-incubation time.

Taken together, fennel and its bioactive anethole may be considered as a functional food in reduced risk and treatment in acute and chronic inflammatory related-diseases through the properties like a pro antioxidant and anti-inflammatory agent.

Sources
(1) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
by PurumKanga1Ka YoungKima1Hui SuLeea1Sun SeekMinbGeun HeeSeol(PubMed)

(2) Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: e€ffect on NF-kB, AP-1, JNK, MAPKK and apoptosis by Gagan BN Chainy1,2, Sunil K Manna1,2, Madan M Chaturvedi1 and Bharat B Aggarwal by Oncogene (2000) 19, 2943 ± 2950 ã 2000 Macmillan Publishers Ltd All rights reserved 0950 ± 9232/00 $15.00

Topical Arnica Gel, The Potent Herbal Product Which Alleviates Symptoms and Treatment of Osteoarthritis

By Kyle J. Norton, Master of Nutrition

Herbal Arnica may have a therapeutic potential in ameliorating the symptoms and treatment of osteoarthritis, some scientist suggested.

The results of this investigation were carried out in form of studies by some respectable institutes such as Rheumatology Clinic Sweden, and Valens Clinic for Rheumatism published online medical literature.

Arthritis is a chronic condition characterized by severe inflammatory pain and stiffness of the joints. affecting over 1.3 million Americans and as much as 1% of the worldwide population, according to statistics. The disease induced an average direct cost about $2,800 per patient annually.

Osteoarthritis is a type of degenerative joint disease or “wear and tear” arthritis, affecting the joint commonly.

The exact causes of osteoarthritis are unknown. Researchers do not understand why, people with the same health and risk conditions, some are susceptible to the onset of the disease while others do not.

However, researchers do know that certain risk factors are associated to the early onset of the disease, including age, family history, gender, injured from the past that did not heal properly, such as torn cartilage, dislocated joints, ligament injuries, occupations and overweight.

Some scientists also suggested that mutation of genes involved develop cartilage are also having a strong implication in inducing early onset of the disease.

Dr.Mercedes Fernández-Moreno, the lead authors in the expression of Genetics in Osteoarthritis, wrote, "The genetic bases of this disease do not follow the typical patterns of Mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease".

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the randomized, double-blind study to compare the effective of topical preparation of arnica(50 g tincture/100 g, DER 1:20), and ibuprofen (5%) and in 204 patients, to ascertain differences in pain relief and hand function after 21 days' treatment, scientists showed that topical Arnica exerts a similar effect as of ibuprofen (5%) in pain and hand function improvements, or in any secondary endpoints.

There were no differences between the two groups in pain relief and improvement of hand stiffness.

However, compared to 2 groups, researchers found that adverse effects were reported by six patients (6.1%) on ibuprofen and by five patients (4.8%) on arnica.

These result suggested that Arnica topical preparation is compatible with those of ibuprofen for the treatment of patients with osteoarthritis, particularly in the patients with hand's osteoarthritis.

Further analysis of the safety and efficacy of an Arnica montana fresh plant gel, applied twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee, after 3 and weeks of application, researchers indicated that
* All groups (treatment with 3 and 6 weeks) display a significant improvement of scores on the pain, stiffness, and function subscales.

* The topical application also shows significant reductions at these time points.

* Total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) are decreased substantially in all patients.

* According to the returned questionnaire, 69 patients (87%) rate the tolerability of the topical gel as "good" or "fairly good,"

However, the overall local adverse-event rate is 7.6% included only one allergic reaction.

Although the topical gel may be effective, it has certain limitations as only patients with mild to moderate OA of the knee were included in the study.

The above differentiation of topical Arnica gel was supported by the publication lead by the Dr. Morris M, in the investigation of the efficacy of a homeopathic complex included Arnica montana, Bryonia alba, Causticum, Kalmia latifolia, Rhus Toxicodendron, and Calcarea fluorica. in combination with physiotherapy in treating chronic lower back pain (CLBP) due to OA.

In a 6-wk, randomized, double-blind, placebo-controlled pilot study took place in a private physiotherapy practice in Gauteng, South Africa of a total of 30 males and females, aged 45-75 y, who were receiving physiotherapy treatment for OA of the lumbar spine from a therapist in private practice, according to the observation of the visual analogue scale (VAS) for pain. Secondary outcome measures, complex application showed a incredible effectiveness in reduced pain, promoted daily functioning, and range of motion (ROM) of the lumbar spine in compared to placebo.

After taking into account of other co and confounders, Dr. Morris M, the lead scientist said, "homeopathic complex, together with physiotherapy, can significantly improve symptoms associated with CLBP due to OA" and "(but) the study was too small to be conclusive".

Taken together, topical Arnica gel with certain concentration may be considered a functional herb for alleviated symptoms and treatment of osteoarthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) Physiotherapy and a Homeopathic Complex for Chronic Low-back Pain Due to Osteoarthritis: A Randomized, Controlled Pilot Study by Morris M, Pellow J, Solomon EM, Tsele-Tebakang T.(PubMed)
(4) Genetics in Osteoarthritis by Mercedes Fernández-Moreno, Ignacio Rego, Vanessa Carreira-Garcia, and Francisco J Blanco. (PMC)

Thursday, 4 October 2018

The Cruciferous Vegetables' Phytochemical Indole-3-Carbinol Which Kills Cancer Cells in Vitro, Scientists Suggest

By Kyle J. Norton, Master of Nutrition

Intake of cruciferous vegetables may reduce the risk of cancers, some scientists suggested.

Cancers are a group of chronic and medical diseases characterized by irregular cells growth in the body tissue caused by the change of DNA transcription of healthy cells.

Normal cells have the division of a limited cell cycle compared to a cancerous cell which can grow unlimitedly.

If an invasive tumor is growing too large, it can suppress the nerves and muscles surrounding them, leading persistent pain and other symptoms, depending on the locations.

The exact causes of cancer are unknown. Researchers do not know why people with the same health condition, some are susceptible to the onset of the diseases, while others do not.

However, an unhealthy diet, such as eating processed foods and fast foods and lifestyles such as smoking, overweight, physical inactivity, and excessive alcohol drinking are some of the major causes of cancer.

Truly, according to the article written by the Telegraph, an unhealthy lifestyle is responsible for half of the onset of the cancers. And overweight or obese is a cause of 12 types of cancer.

Other prevalent risk factors of cancer are genetic mutation inherited from the parents, environment toxic chemicals, radiation, virus, hormone imbalance,... and chronic inflammatory diseases.

Besides the general symptoms such as lumps, loss of appetite, fatigue, tiredness, unintended weight loss, patients with cancers also experience some symptoms totally depended to the location, types, and grade of infected tissues and organs,

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

According to the recent study, indole-3-carbinol (I3C), a substance presented in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.

Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may be attributed to the interference of cancer cell cycle division and expression of a diverse set of genes involved cell differentiation.

Dr. Aggarwal BB and Dr. Ichikawa H. in the additional examination of the function of indole-3-carbinol (I3C) also found that application of the phytochemical also inhibited DNA-carcinogen abducted and new blood vessels involved cancer cell survival formation, suppressed free-radical production, and stimulated 2-hydroxylation of estradiol in the reduction of cell proliferative and estrogenic activity and

Furthermore, indole-3-carbinol and its derivatives not only exerted the anti-cancer effects through restoring original gene formation but also inhibited free radicals production, ... but also interfered with cancer cell cycle division phase to induce apoptosis.

Other chemical compounds found in the cruciferous vegetables, showed to possess potent antitumor and chemopreventive activity are sulforaphane (SFN), an isothiocyanate and Allyl nitrile (3-butenenitrile).

Taking together, there is no doubt, cruciferous vegetables have exhibited anticancer activities, through many aspects.

Intake of cruciferous vegetables regularly is associated with the reduced risk and treatment of various types of cancer.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food of cruciferous vegetables during the course of the disease will be necessary to complete the picture of cruciferous vegetables anti-cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5. (PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10. (PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)

Carrot, The Veggie Which Normalizes Your High Blood Pressure With No Side Effects, Suggested By MEDLINE Studies

Kyle J. Norton, Master of Nutrition

Carrots may have a profound and positive effect in reduced risk and treatment of hypertension, some scientists suggested.

Hypertension is a common syndrome characterized by abnormally high blood pressure.

High blood pressure (HBP or hypertension) induced narrowing and blocking of blood vessels were associated with increased risk of developing heart failure.

Truly, in hypertensive individuals, the heart must work harder to pump and to circulate the blood to the entire body.

Prolonged and unchecked high blood pressure can increase the force of the blood pushing against the artery walls, leading to a substantial risk of heart attack and stroke.

Usually, high blood pressure has no signs or symptoms, if your blood pressure is persistently high, you must check with your family doctors for preventive pressure.

In some cases, medication may prescribe by your doctor, if your blood pressure is 160/100 or higher.

The exacted causes of high blood pressure are unknown. However, some researchers suggested that unhealthy lifestyle and diet and physical inactivities are the major contributors to the onset of the syndrome.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Epidemiological studies strongly suggested that increased fruit and vegetable intake daily and regularly is assowithated to lower blood pressure.

However, according to the searching of the medical literature data bases, most studies were found to engage in short-term intervention.

Therefore, a long term study with a large example size study to reaffirm the possibility is necessary.

In a prospective study to examine the independent association of whole fruit (excluding juices) and vegetable intake, as well as the change in consumption of whole fruits and vegetables, with incident hypertension in 3 large longitudinal cohort studies: Nurses' Health Study (n=62 175), Nurses' Health Study II (n=88 475), and Health Professionals Follow-up Study (n=36 803) conducted by the joint investigation lead by the Brigham and Women's Hospital and Harvard Medical School, researchers found that

* The risk of high blood pressure in compared participants whose consumped ≤4 servings/week, and those whose intake ≥4 servings/day were 0.92 for total whole fruit intake and 0.95 total vegetable intake.

Blood pressure of fruits intake participants displayed a much lower pooled hazard ratios, compared to the same volume of vegetables.

* In compared to participants who did not increase their fruit or vegetable consumption, the pooled hazard ratios for those whose intake increased by ≥7 servings/week were 0.94(0.90-0.97) for total whole fruit intake and 0.98(0.94-1.01) for a total vegetable.

Further differentiation of all fruits and vegetables intake by participants scientist surprisingly found that only consumption levels of ≥4 servings/week, in numbers of specific vegetables were associated with lower hypertension risk in compared to whole fruits.

Dr. Borgi L the lead author, after taking into account of other confounders, said, " greater long-term intake and increased consumption of whole fruits may reduce the risk of developing hypertension".

These results indicated that only daily and regular and increased intake of fruits and certain vegetables may reduce the risk of hypertension in a longer term.

In the investigation of dried purple carrot effect in reduced risk of hypertension in obese individuals, researchers at the The University of Queensland conducted a study containing 16 males (aged 53.1 ± 7.6 years with a mean BMI of 32.8 ± 4.6 kg/m(2)) with normal lipid and inflammatory markers.

Application of 118.5 mg/day of anthocyanins and 259.2 mg/day of phenolic acids for 4 weeks to participants showed an statistically insignificant changes in hypertension.

However, sub-sequenced study with anthocyanins, phenolic acids and carotenoids, the predominant phytochemicals isolated from purple carrots in hypertensive rats induced by a high fat diet, researchers found

* Rat fed with high fat diet developed an elevated hypertension

* Rat fed with a high fat diet with an injection of whole food purple carrot juice showed a significant reduced blood pressure in compared to untreated group.

In compared to isolated phytochemicals researchers suggested that not all bioactive compounds exert a protective effect against the onset of hypertension, it is likely that the anthocyanins are responsible for the antioxidant activity in inhibited excessive reactive oxygen species (ROS) in initiated and exacerbated hypertension.

The findings suggested that whole food carrot may be considered as functional food in reduced risk of hypertension if it is taken daily and regularly over a long term period.

Therefore, people who want to optimize the blood pressure level may want to add some portions of carrot in their diet.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(2) A randomized, double-blind, placebo-controlled trial of the effect of dried purple carrot on body mass, lipids, blood pressure, body composition, and inflammatory markers in overweight and obese adults: the QUENCH trial BY Wright OR1, Netzel GA, Sakzewski AR. (PubMed)
(3) Comparison of purple carrot juice and β-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome by Poudyal H1, Panchal S, Brown L.(PubMed)
(4) Natural Antioxidants and Hypertension: Promise and Challenges by Tinoy J. Kizhakekuttu, MD and Michael E. Widlansky, MD, MPH (PMC)

Beetroot and Its Bioactive Chemical Ingredient Which Kill Cancer Cells Compared to Chemo Drug Doxorubicin (Adriamycin) with No Side Effects, Scientists Reveal

By Kyle J. Norton, Master of Nutrition

Scientists may have found a vegetable which processes a potency in killing cancer cells before spreading, some studies suggested.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body.

At the advanced stage, the invasive cancer cell can travel a distance away from the original site to infect other healthy tissues and organs via lymph or/and blood.

According to the statistic provided by the UK Cancers research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.

Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of Human Development Index (HDI).

The Human Development Index (HDI) is a statistic composite index of life expectancy, education, and per capita income indicators, according to the definition.

In 2018, over 1,7 millions of new cases of cancer are diagnosed in the US, and approximately over 600,000 patients will die from the diseases.

The four most common types of cancer, occurring worldwide are lung, female breast, bowel and prostate cancer.

Early diagnosis as always is the best way to improve survival rate. Depending on types of cancer, most cancers have a 100% 5 years survival rate, if they are diagnosed at the stage of 0 and 1.

Beet is best known as the beetroot or garden beet and belong to the amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.

Nutrients and Chemicall Constituents
1. Energy
2. Carbohydrates
3. fiber
4. Protein
5. Vitamin A
6. Beta-carotene
7. Trytophan
8. Thiamine (Vitamin B1)
9. Riboflavin (Vitamin B2)
10. Niacin (Vitamin B3)
11. Pantothenic acid (Vitamin B5)
12. Vitamin B6
13. Folate (Vitamin B9)
14. Vitamin C
15. Calcium
16. Iron
17. Magnesium
18. Copper
19. Phosphorus
20. Potassium
21. Zinc
22. Magnesium
23. Betacyanin
24. Betaine
25. Etc.

Besides the major chemical constituents betalains and phenolics, beetroot also contains the lesser amount of isobetanin, probetanin, neobetanin, indicaxanthin, vulgaxanthins, etc.

In the study to reaffirm the effect of red beetroot (Beta vulgaris L.) extract (B), approved by Food and Drug Administration and European Union as red food color E162, in reducing multi-organ tumor formations in various animal models when administered in drinking water, researchers at the Howard University launched an investigation to examine whether a long-term daily exposure to low doses of B through diet would be safe and sufficient to produce cancer chemopreventive effect in humans.

Compared to the conventional chemo drugs doxorubicin (D) with different concentrations of range from 0.29-290 μg/ml in several human cancer cell lines, researchers found that

* Application of Red beetroot (Beta vulgaris L.) extract (B exerts a synergistic antiproliferative activity with against pancreatic (PaCa), breast (MCF-7) and prostate (PC-3) tumor cells of human origin.

* Red beetroot (Beta vulgaris L.) extract (B) is considered safe for human use with no known toxicity.

* Used combined with D demonstrates an overall positive reduction of concentration od D with the same cytotoxicity profile in the three human cancer cells. In other words, the synergistic cytotoxicity was best when the B:D ratio of 1:5 was used in PaCa cells at IC50, IC75, and IC90 dose levels and in MCF-7 cells at an IC90 dose level.

These results suggested that red beetroot extract used combined with doxorubicin may process a potency in treating human cancers.

Additionally, in the further testing of the anti-cancer effect of the red beetroot extract with the anticancer drug, doxorubicin (Adriamycin) in the androgen-independent human prostate cancer cells (PC-3) and in the well-established estrogen receptor-positive human breast cancer cells (MCF-7), researchers showed that
* Both doxorubicin and the beetroot extract exhibit a dose-dependent cytotoxic effect in the two tested cancer cell lines.

* The cytotoxicity of the beetroot extract is significantly lower, compared to doxorubicin. Application of beetroot continues to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) when tested at the concentration of 29 µg/ml in compared to doxorubicin completely inhibited the growth of the PC-3 cells in three days at the same concentration.

These results indicated lesser effects of the beetroot extract in inducing cytotoxicity, compared to doxorubicin (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period).

Further analysis of the results, researchers found that the anticancer activity may be attributed to its bioactive compound betanin, the major betacyanin constituent.

The findings suggested that beetroot and its extract with abundant phytochemicals may be considered a functional food used alone or combined with chemo drugs for the treatment of cancers without inducing any side effects.

However, further data collection on large example size and multi-centers studies performed with human consumption of the beer root extract during the course of the disease will be necessary to complete the picture of its anti-cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H.((PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines by Kapadia GJ, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

Black Tea, The Beverages That Block and Reverse the Onset of Dyspepsia, Naturally, Researchers Reveal

Kyle J. Norton

Black and green tea may have a therapeutic and positive effect on the prevention of dyspepsia, some scientists suggested.

Dyspepsia is a digestive condition of ingestion.

The exact causes of dyspepsia are unknown. However, researchers suggested that patients with the onset of a stomach ulcer or acid reflux disease are most susceptible to the condition.

Certain medication such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (metronidazole, macrolides) and diseases such as irritable bowel syndrome is associated with the increase risk of dyspepsia.

Some researchers also suggested that unhealthy choice of lifestyle such as smoking, excessive alcohol drinking also have a strong impact on the onset of the disease.

Dr. Umapati C. Baragi, the lead scientist in the study of diet and lifestyle in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) said, "dietary patterns, lifestyle choices, and physical activities play an important role in the etiopathogenesis of Urdhwaga Amlapitta, and it is important for patients to have access to diet and lifestyle modifications. Currently, research in this area is minimal"

Symptoms of dyspepsia include pain in the chest, stomach burning pain, bloating, heartburn, upset stomach,.... digestive discomforts.

If you experience the above symptoms, please check with your doctor to rule out the possibility.

Black tea is a beverage with more oxidization, compared to other teas such as oolong, green, and white teas.

In the investigation of aqueous extract (BTE) and thearubigins isolated from green tea effects in sildenafnil-induced delay in gastric emptying (GE) and small intestinal transit (SIT) in total of 160 mice, randomly assigned to 20 groups with 8 in each group, treated by different or combination of doses of BTE, thearubigins (TRs), sildenafil (SLD), metoclopramide, L-NAME (hydrochloride) and black tea extract researchers found that pretreatment of certain doses of green tea aqueous extract (BTE) and thearubigins significantly reverse motility-delaying effects caused by injection of sildenafnil.

Further differentiation also indicated that additional injection of black tea at 3% and 4.5% increases function of thearubigins (50 and 60 mg/kg) dose-dependently in promoted dyspepsia in mice in compared to the insignificant effect of the combination of BTE at 6% and thearubigins 70 mg/kg.

Moreover, combination of metoclopramide, a medicine used mainly for treatment of ingestion in people with delayed stomach emptying, BTE 4.5%, thearubigins 60 or nω -Nitro-l-arginine methyl ester hydrochloride (l-NAME) with sildenafil (5 mg/kg) reversed its motility-delaying effects,

This improvement of dyspepsia was partially blocked by application of l-NAME through reducing function nitric oxide and improving gastrointestinal smooth muscle mobility by observation of the pretreatment of l-NAME followed by application of BTE alone or combination of thearubigins 60, BTE + sildenafil, and thearubigins + sildenafil.

Dr. Murad HA, the lead author, after taking into account of confounders said, "BTE 4.5% or TRs 60 mg/kg solution could be considered a reliever therapy for the sildenafil-induced dyspepsia".

Additional investigate the role of hot water extract of black tea [Camellia sinensis (L) in normalizing the changes in the intestinal transit and gastric emptying induced by various ulcerogenic agents in experimental rats found that application of black tea extract significant promotes the intestinal transit and gastric emptying caused by glutathione (GSH) depleting agents, diethyl maleate (DEM) in decreased mucosal content in aid of digestion, indoacetamide (IDA) in reduced stomach acid secretion, gastritis, and mucus thickness on gastric transfer and N-ethyl maleimide (NEM) with function of in significantly reduced the mucosal SH levels and the lesions.

Oral administration of black tea extract (BTE) at 20 ml/kg of a 10% solution once a day for 7 day also expressed a significantly increased the intestinal transit and gastric emptying similarly to those of conventional succimer (60 mg/kg, i.g.), the standard sulfhydryl containing an antiulcer agent

through the restoration of antioxidant of serum GSH level.

However, such increase of intestinal transit induced by BTE was reversed both by N-omega-nitro-L-arginine methyl ester (L-NAME) (25 mg/kg, i.p.) and N-omega-monomethyl-L-arginine (L-NMMA) (25 mg/kg, i.p.), in reduced levels of NO in the aided stomach in the production of gastric acid for digestive function.

Dr. Maity S, the lead author said, "restoration of intestinal nitric oxide synthase (NOS) activity was found to be associated with BTE treatment" and "These results provide evidence that nitric oxide may play a role in BTE-mediated movement of intestinal motility changes and gastric emptying induced by DEM, IDA, and NEM".

Taken together, black tea with plenty phytochemicals may be considered as functional food in reducing risk and treatment of dyspepsia.

However, intake of tea supplement should be taken with exceptional care to prevent acute liver toxicity.

Sources
(1) Black tea extract and its thearubigins relieve the sildenafil-induced delayed gut motility in mice: a possible role of nitric oxide by Murad HA1, Abdallah HM. (PubMed)
(2) Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats by Maity S1, Vedasiromoni JR, Chaudhuri L, Ganguly DK. (PubMed)
(3) Gastrointestinal transit during endotoxemia: the role of nitric oxide by Wirthlin DJ1, Cullen JJ, Spates ST, Conklin JL, Murray J, Caropreso DK, Ephgrave KS. (PubMed)
(4) Evaluation of diet and life style in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) by Umapati C. Baragi and Mahesh Kumar Vyas. (PubMed)

Yoga Intervention Alleviates Symptoms By Improving Lung Functions of Patients with Chronic Obstructive Pulmonary Disease

Yoga may be used as an integrated form of exercise in the treatment of chronic obstructive pulmonary disease, a randomized controlled study suggested.

Chronic obstructive pulmonary disease (COPD)) is the third leading cause of death in the United State, inducing symptoms of breathlessness and fatigue and making physical activity more challenging.

COPD is a chronic condition caused by lung inflammation that obstructs the airflow from the lungs.

Most common symptoms of COPD are breathing difficulty, cough, mucus (sputum) production,.... and wheezing.

According to the statistic, chronic obstructive pulmonary disease (COPD) affects about 32 million persons in the United States.

Conventional treatment of COPD focuses on the management to improve patients' functional status and quality of life by preserving remained lung function, according to Medscape

Yoga, the ancient practice for harmonized external and internal body well being, through breath control, meditation, bodily movement,.... and gesture.....

The technique is well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized trial with two study arms (yoga and control) of total of 81 coal miners enrolled, ranging from 36 to 60 years with stage II and III stable COPD, assigned either on conventional treatment or combination of conventional care with yoga program for 12 weeks, after review the returned questionnaire, researchers found that
* Compared to other groups, yoga group displays strong improvements of COPD on all scales.

*Also, Compared to the conventional treatment group, yoga group expresses significantly positive effects in both physical and mental health status.

Dr. Ranjita R, the led researchers said, "Yoga seems to be a safe, feasible, and effective treatment for patients with COPD".

More profoundly, in the evaluated 43 patients with symptomatic, moderate-to-severe COPD assigned to the 12 weeks of pranayama plus education versus education alone taught by 2 yoga professionals, researchers indicated the following results
* Yoga group shows a strong performance in the 6-min walk distance (6MWD), compared to education the only group.

* Yoga also displays small improvements in inspiratory capacity and air trapping.

Researchers, after adjusting to other risk factors said, "Both groups had significant improvements in various measures of symptoms, but no overall differences in respiratory system impedance or markers of oxidative stress or systemic inflammation".

Truly, yoga posture and breathing practices improve blood circulation to the lung and muscle of the organ function, thus increasing the air flow to the lung in the absorption of volumes of oxygen for the body needs.

With the additional supply of oxygen to the blood, patients with COPD not only can increase walking distance but also can perform other physical activity. Thus, enhancing the quality of life, including mental health.

In other words, yoga intervention significantly enhances inspiratory capacity and air trapping and improves the central nervous system in the regulation of certain hormones which have the functions in the stimulation of pro-inflammatory and anti-inflammatory expressions.

The efficacy of yoga mentioned on the above is also supported by the evaluated the effects of yoga training on the quality of life (QOL) and the parameters of lung function in patients with COPD of 33 patients with COPD satisfied with study criteria selected, after attending yoga exercises including breathing exercises, meditation, and yoga postures for 1 hour, thrice a week for 6 weeks by a certified yoga therapists.

Compared to conventional treatment
* Yoga intervention showed an impressive improvement of vital capacity (95% CI 2.53-7.65), maximal inspiratory pressure, and maximal expiratory pressure, observed for the St. George Respiratory Questionnaire.

* The intervention also expressed short-term benefits in enhancing QOL and lung function

Taking all together, yoga may be used as a secondary form of exercise combined with standard therapy for ameliorated symptoms and treatment for COPD patients.

Sources
(1) A randomized controlled study on assessment of health status, depression, and anxiety in coal miners with chronic obstructive pulmonary disease following yogatraining by Ranjita R1, Badhai S1, Hankey A1, Nagendra HR1.(PubMed)
(2) Effect of Yoga Breathing (Pranayama) on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Trial by Kaminsky DA1,2, Guntupalli KK3, Lippmann J2, Burns SM2, Brock MA3, Skelly J4, DeSarno M4, Pecott-Grimm H2, Mohsin A3, LaRock-McMahon C2, Warren P5, Whitney MC6, Hanania NA3.(PubMed)
(3) Yoga-based pulmonary rehabilitation for the management of dyspnea in coal miners with chronic obstructive pulmonary disease: A randomized controlled trial by Ranjita R1, Hankey A2, Nagendra HR2, Mohanty S2.(PubMed)
(4) Effect of yoga in chronic obstructive pulmonary disease by Fulambarker A1, Farooki B, Kheir F, Copur AS, Srinivasan L, Schultz S.(PubMed)
(5) Chronic Obstructive Pulmonary Disease (COPD) Treatment & Management
Updated: Jul 25, 2018, by Author: Zab Mosenifar, MD, FACP, FCCP; Chief Editor: John J Oppenheimer, MD more (Netscape)