Carrot, The Best Food to Protect Your Brain Against Cognitive Impairment, Scientists Say

Kyle J. Norton

Carrots may have a profound and positive effect in improving cognitive impairment, some scientists suggested.

Cognitive impairment is a condition characterized by a decline in cognitive abilities, including memory and thinking skills.

People with mild cognitive impairment (MCI) are at greater risk in the development of dementia, including Alzheimer's Disease.

According to the statistic provided by the center of Diseases Control and Prevention, more than 16 million people in the United States are living with cognitive impairment and these numbers are increasing in the alarming rate.

Sadly, the CDC continued,  "An estimated 5.1 million Americans aged 65 years or older may currently have Alzheimer’s disease, the most well-known form of cognitive impairment; this number may rise to 13.2 million by 2050".

The causes of cognitive impairment are unknown. However, researchers suggested that aging, genetically mutated gene inherited from parents, such as Down's Syndrome, Fetal Alcohol Syndrome (FAS), autism, persistent mental health problems, together with unhealthy diet and lifestyle are associated to the onset of cognitive impairment.

Furthermore, hormonal imbalances, physical damage to the portion of the brain that is responsible for controlling cognitive function and substance abuse are also some major cause of development of the condition.

If you experience some of the symptoms such as confusion, poor motor coordination, loss of short-term or long-term memory, identity confusion,..... impaired judgment, you may have cognitive impairment. Please make sure that you check with your doctor to rule out the possibility.

Carrot, a root vegetable with an orange color is a subspicies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

A. Oxidative Stress
In the investigation of cognitive and memory impairment triggered by oxidative stress, researchers at the Northwest A&F University launched a study of carrot 's major bioactive compound lycopene effect in cognitive defects, using the experiment in the animal model.

The analysis of the results was measured by behavioral tests, including the Y-maze test, locomotor activity and Morris water maze test.

In d-galactose induced CD-1 male mice cognitive impairments, researchers found that chronic lycopene (LYC) supplementation (50 mg/kg body weight per day) alleviates histopathological damage and restored brain derived neurotrophic factor (BDNF) levels in the hippocampus.

These results may be associated with the reduced oxidative stress in the brain of tested subjects through increasing the antioxidants of the supplementation and stimulated production of antioxidants from the body of host tissue as well as decreasing levels of proinfammatory cytokines via activated the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited inflammatory cytokines IL-1β and TNF-α in mice hippocampus.

Observation of the oxidative status, indicated that application of LYC also significantly elevates antioxidant enzymes activities and reduces levels of inflammatory cytokines in the d-galactose-treated mice serum.

Further differentiation also suggested that the anti inflammatory effect is expressed by restoring the
glial cells inflammatory makers which have a strong implication in regulating neurotransmission, inflammatory and neuroprotective pathways, and blood-brain barrier functions.

Additionally, application LYC also attenuated neuronal oxidative damage through activation of Nrf2 signaling incontribution to the anti-inflammatory process and inactivation of NF-κB translocation in hydrogen peroxide H2O2(free radicals) in stimulated inflammatory process.

Of the results, Dr.  Zhao B, the lead author after taking into account of other co and confounders concluded, " LYC could ameliorate oxidative stress induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".

B. Diet

In the evaluation of the effects of A Western diet, high in saturated fats in the contribution of the development of cognitive impairment, researchers at the The Third Military Medical University, Chongqing conducted a study with several models to test the effect of lycopene neuroprotective properties.

The results of differentiation were measured through behavior testing including the Morris water maze (MWM), object recognition task (ORT), and anxiety-like behavior in an open field (OF) at the end of the experiment period.

Behavioural testing is a testing of the external behavior of the tested subjects.

On One-month-old male rats fed different diets for 16 weeks (n=12 per group), including a standard chow diet (CD), an HFD, or an HFD plus lycopene (4mg/kg, oral gavage in the last three weeks), researchers found that

* Mice fed with HFD consumption for 16 weeks demonstrated a significantly impaired central nervous system including spatial memory, working memory, and object recognition memory, decreased the dendritic spine density, damaged pyramidal neurons in the CA1 subfield (P<0.001),  compared with the chow diet group.

The authors did not mention the cause of high fat diet in the induction of neuron dysfunction, but based on the analysis of  oxidative stress, one can suspect that these results may be associated to the overexpression of lipid peroxidation in reduced levels of antioxidant and precipitated production of proinflmmatory cytokines in the host.

* Application of lycopene in HFD group or HFD plus lycopene group displayed significantly attenuated learning and memory impairments and prevented the reduction in dendritic spine density.

Injection of lycopene only can delay the progression of the learning and memory impairments but cannot restore the function of the neurons already damage due to HFD.

Dr. Wang Z, the lead scientist of the study at the end of the experiment said, " lycopene helps to protect HFD induced cognitive dysfunction".

Taken together, Carrot and its bioactive lycopene may be considered as functional food in the protection of the central nervous system against cognitive impairment, an early sign of the development of dementia.

However, intake of supplementation should be taken with care to prevent the onset of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X(PubMed)
(2) Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats by Wang Z1, Fan J2, Wang J2, Li Y2, Xiao L2, Duan D2, Wang (PubMed)

Carrots, The Potent functional Food Which Protects the Brain Against Onset of Neuro-degenerative Disorders, Scientists Reveal

Kyle J. Norton

Carrots may have a profound and positive effect in reducing risk, progression, and treatment of the neurodegenerative disorder, some scientists suggested.

Neurodegeneration is the progressive loss of neurons including the death of neurons, characterized by structure loss induced reduction of brain function.

The exact causes of neurodegenerative disorders are unknown. Researchers also do not why people with the same health conditions, some are susceptible to certain neurodegenerative disorders such as
Huntington's disease. ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease,  Parkinson's disease or other forms of dementia, while others do not.

However, some researchers suggested that genetic mutation inherited from parents, certain illness and traumatic injury to the brain are some of the major causes of the onset of the disease.

According to Dr. Chaudhuri K, in the study of unhealthy diet and lifestyle on risk of neurodegenerative disorders, the onset of some neurodegenerative disorder was attributed to the unwholesome diet that disturbed mental health in initiating etiopathogenesis of senile dementia.

Further differentiation showed that psychological syndromes such as disturbed sleep, anxiety, tension, depression, difficulty in concentration, and memory, and the tendency to indulge in defective dietary habits, Kapha vitiating diets, and lifestyle are some predominant risk factors associated to the development of the disease.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the evaluate the neurodegenerative disorder such as Alzheimer and Parkinson's diseases affecting the central nervous system with debilitating effect to the patient, researchers at the University Technology of Mauritius launched a study to test the efficacy of flavonoids, found in many vegetables including carrot.

Flavonoids are phytochemicals containing numbers of the member, including curcumin, lycopene, ginsenoside, vitexin, and baicalin with a proven record of anti-cancer and antioxidant and immunomodulation properties in numbers of studies.

At the results of the analysis, researchers showed that application of flavonoid to the brain ischemia patient also exerts potential neuroprotective effects by increasing neuronal viability, tissue perfusion, and cerebral blood flow and reducing ischemic-related apoptosis.

Moreover, patients treated with flavonoid also demonstrated a significantly anti-amyloidogenic effect and reduced the loss of dopaminergic neurons in the brain that has a strong implication in patients with Pakistan's disease.

After taking into account of other co and confounders, researchers concluded that flavonoid found in numbers vegetables and fruits, including carrot, may be served as a potential therapeutic agent in brain disorders.

Further differentiation of the oxidative stress which causes neurodegenerative disorder, including oxidative damage to neuron in induction of mitochondrial dysfunction and apoptosis, scientists at the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region conducted a experiment to test the effect of lycopene, a polyunsaturated hydrocarbon with the highest antioxidant capacity compared to the other carotenoids against the expression of the diseases.

In rat model randomly divided into 5 groups: the sham group, the spinal cord injury (SCI) group and 3 SCI groups pre-treated with lycopene (5, 10, or 20mg/kg) researchers found that

* Spinal cord injury (SCI) group without treatment group displays a significant increase of malondialdehyde (MDA) content and a decrease of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels, compared to other groups.

Malondialdehyde (MDA) the final form of polyunsaturated fatty acids peroxidation is considered as a natural marker for oxidative stress.

* Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) are natural antioxidants produced the host body tissue with an aim to maintain the balance of ratio of reactive oxygen species and antioxidant in the body.

The expression of lower levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)  is a strong indication of overabundant free radicals, compared to levels of antioxidant in the body.

* Group treated with lycopene regardless to concentration exerted an overwhelming effect in blocking the change of mRNA of the mitochondrial membrane caused by spinal cord injury (SCI), including cytochrome b and mitochondrial transcription factor A (Tfam), with functions in the induction of mitochondrial dysfunction.

Cytochrome b, a protein in the mitochondria of eukaryotic cells functioned as a  part of the electron transport chain which was oxidated in this case.

Mitochondrial transcription factor A (mtTFA or Tfam), a protein with functions as a key regulator of mammalian mitochondrial (mt) DNA transcription and replication which was altered caused by the presence of MDA.

Further analysis also found that application of lycopene also reduces the risk of neurons cell apoptosis through decreased levels of pro-inflammatory and increased levels of anti-inflammatory expression in the tested rats.

These results suggested that lycopene found in vegetable including carrot significantly ameliorated oxidative damage, mitochondrial dysfunction, and cell apoptosis via some parameters indicated above.

Dr. Hu W, the lead authors said in the classification of doses application said, " lycopene significantly ameliorated the hind limb motor disturbances in the SCI+lyco10 group and the SCI+lyco20 group compared with the SCI group".

Taken together, carrot with a high amount of bioactive flavonoids, particularly lycopene may be considered a functional food in reducing risk and treatment of various forms of the neurodegenerative disorder, including Alzheimer and Parkinson diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway by Hu W1, Wang H2, Liu Z2, Liu Y2, Wang R2, Luo X2, Huang Y3(PubMed)
(2) Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases by Putteeraj M1, Lim WL2, Teoh SL3, Yahaya MF(PubMed)
(3) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PuibMed)

Green Coffee, The Beverage Which Processes Anti Obesity Activity in Vitro, Scientists Reveal

By Kyle J. Norton

Coffee may be considered as a function beverage in reducing obesity prevalence and management, some scientists suggested.

According to the information of the World Health Organization, in 2016, approximately, 650 million adults were obese and 39% of adults aged 18 years and over (39% of men and 40% of women) were overweight.

Believe or not, overall, about 13% of the world's adult population (11% of men and 15% of women) were obese in 2016. And the prevalence of obesity has increased at an alarming rate due to 30 years of economic prosperity in the Far East.

Sadly, the organization wrote, "The worldwide prevalence of obesity nearly tripled between 1975 and 2016".

Dr. Janssen I, in the study of "The public health burden of obesity in Canada" wrote, " At present, there are approximately 7 million obese adults and 600 000 obese school-aged children in Canada. Prevalence estimates based on waist circumference are even more troubling as they indicate that 37% of adults and 13% of youth are abdominally obese".

Truly, obesity in Canada not only is a major contributor to morbidity and mortality but also places a large economic burden on the country.

The doctor continued, " In 2006 obesity accounted for $3.9 billion in direct health care costs (e.g., hospitalizations, medications, physician and emergency room visits) and $3.2 billion in indirect costs (e.g., costs related to disability and lost productivity due to illness or premature death)".

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the joint study led by the Huanggang Normal University, the health benefits of coffee studies over last 10 years, expressed a significant improvement of risk and treatment of obesity in decreased lipid accumulation in cells through regulating the cell cycle during fat metabolism.

Additionally, coffee consumption induced changes in transcription factors in fat deposit decreased body weight and visceral fat form of animal and humans studies.

Furthermore, coffee influenced gut microbiota in obese animals and humans also played an important role in the use as a functional and integrated food in reducing risk and treatment of obesity.

The study of obesity-induced mice that fed with the following patterns only HFD or HFD with GCBE at 50, 100, and 200 mg/kg for four weeks, researchers found that
* Mice treated with green coffee injection show a significantly decreased body weight gain, liver weight, and white adipose tissue weights through the regulation of adipose tissue lipolysis hormones, such as adiponectin and leptin.

* Mice treated with green coffee injection also demonstrate a decreased mRNA expression levels of adipogenesis and adipocyte metabolis related genes in adipose tissues and the liver and decrease the corresponding protein expression.

* GCBE treated mice had a lower fat mass with decreased relative body weight and fat mass, compared to HFD alone fed mice.

These results suggested that green coffee intake exerted a strong activity in the regulation of adipogenesis and lipid metabolism which are found to associate to enhance weight gain.

According to the information collected, Dr. Choi BK, the lead author said, "GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver".

. Where HFD is a high-fat diet and GCBE is green coffee extracts

More importantly, in the study of male day mice fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 days, researchers at the Oryza Oil & Fat Chemical Co,, Ltd, indicated that
* GCBE with 0.5% and 1% reduce visceral fat content and body weight.

* Caffeine and chlorogenic acid show a tendency to reduce visceral fat and body weight.

* Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days shows a tendency to reduce hepatic TG in mice.

* Chlorogenic acid (60 mg/kg. day) reduces hepatic TG level.

The findings displayed a strong effect of coffee and its phytochemicals in reducing weight gain and fat accumulation by inhibition of fat absorption and activation of fat metabolism in the liver, therefore the beverage may be considered a functional and integrated food against risk and treatment of obesity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice by Shimoda H1, Seki E, Aitani M.(PubMed)
(4) The public health burden of obesity in Canada by Janssen I1.(PubMed)

Black Bean, The Potent Anti Liver Cancer Legume

By Kyle J. Norton(Scholar, Master of Nutrients), all right reserved


People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient.

Compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending on the stage of the treatment which directly addresses the cause of disease.

Intake of black bean regularly may have a profound effect in reducing risk and treatment of liver cancer, a renowned institute study proposed.

Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue.

According to statistics approximated 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.

The exact causes of liver cancer. However, researchers believed that age, gender, excessive use of alcohol, obesity, are ethnicity are associated with the increased risk of liver cancer.

Furthermore, gene mutation such as inherited metabolic diseases is also considered as the major prevalent risk factor of liver cancer onset.

More importantly, certain chronic diseases, such as diabetes, infection by hepatitis virus, liver diseases, including cirrhosis, and non-alcoholic fatty liver disease chemical toxins and long-term use of certain medication such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, also have the potential to increased risk of liver cancer.

Besides sharing the general symptoms of cancers, patients with liver cancer also experience symptoms of upper abdominal pain and swelling, yellow discoloration of the skin, jaundice,.... and chalky stool.

If you have some of the above symptoms, please check with your doctor to rule out the possibility.

Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.

The legume can be bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was first domesticated growth in South America.

According to the Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.

The efficacy of black bean on the ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.

Additionally, consumption of bean not only played a prominent role of gene expression involved the regulation of gene Hspa8 on reduced risk of liver disease but also addressed the important issue of attenuating hepatic stress or toxicity in the rat model.

In fact, increased beans consumption in rats exhibits changes of the hepatic damage caused by liver toxicity. Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.

More interestingly, dietary bean concentrations.is found to associate to the cholesterol 7α hydroxylase and UDP-glucuronosyltransferase genes increased with a connection to the development of liver cancer, in a dose-dependent manner.

These findings suggested that dietary black(dried) bean may have a potential effect in reducing risk and treatment of liver cancer through antioxidant activity and regulated genes involved early onset of the disease.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ. (PubMed)

Chaste Tree Berry, The Valuable Chemotherapeutic Remedy Which Targets and Kills Cancer Cells, Researchers Suggest

Kyle J. Norton, Master of Nutrition

Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable way in our body.

In the late stage, the cancer cell may travel away from the originated site to infect other healthy tissue and organs.

As to today, researchers do not what cause cancers. Neither they understand why? people who have similar health conditions, one group is susceptible to cancer onset, while other does not.

However, researchers do not know that certain prevalent risk factors such as aging, excessive alcohol consumption, chemical carcinogenic substances, an unhealthy diet with high amount saturated and trans fats, sugars,... and salts are associated to the onset of the disease.

Some researchers also suggested that people who have chronic inflammation, using hormone replacement and immunosuppression medicine are also at a higher risk of cancers development.

Certain infectious agents including hepatitis A, B, C and bacterium Helicobacter pylori infection also have the potential to induce a change of DNA of the healthy cells, a major cause of cancers,

Depending on the location of the cancer onset, patients may experience certain related symptoms such as heartburn or indigestion, and abdominal pain.in stomach cancer and swelling of all or part of a breast, nipple pain, and retraction in breast cancer.

However, most general symptoms that felt to almost all cancer patients include unintended weight loss, loss of appetite, lump and, swollen glands,

If you experience some general and localized symptoms of the above, please make sure that you check with your doctor to rule out the possibility.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under light microscope, flow cytometric analysis and agarose gel electrophoresis, vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria (in regulated cell metabolism)-controlled apoptotic pathway".

In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits also exerted a strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved in various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for treatment of various types of cancer, depending on further evaluation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF. (PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y. (PubMed)

Cruciferous Vegetables - The Best Whole Food Medicine That Process Anti Acute and Chronic Inflammatory Potency, Scientists Say

By Kyle J. Norton, Master of Nutrition


Intake of cruciferous vegetable may be inversely correlated with circulating of proinflammatory levels of in women, some scientists suggested.

Inflammation is a natural immune response involving the stimulated production of pro-inflammatory activity with a target to protect our body against foreign invasions such as virus and bacteria after injury and damage.

In other words, pro-inflammatory cytokines are activated through systematic immune response to the damage cells which release chemicals including histamine, bradykinin, and prostaglandins to protect the injure area or location against infection, leading to blood vessels to leak fluid into the tissues, causing swelling and other symptoms such as pain, swelling, and redness.

However, in most cases, over-response of the immune system can lead to over expressions of certain pro-inflammatory cytokines, depending to the injured location such as Interleukin (IL)-1 and tumor necrosis factor (TNF) which can lead shock and death of healthy cells in the infectious location. 

In most cases, long-term overexpression of pro-inflammatory cytokines can lead to chronic inflammatory disease as the immune system no longer can kill the invasive agents and heal the damage caused by acute infection.

Dr. Dinarello CA, the lead author in the study of pro and anti-inflammatory cytokines said, " Some cytokines act to make disease worse (proinflammatory), whereas others serve to reduce inflammation and promote healing (anti-inflammatory). Attention also has focused on blocking cytokines, which are harmful to the host, particularly during overwhelming infection".

This explanation showed that under normal conditions, some anti-inflammatory cytokines may have a strong effect in reducing inflammation in the body daily to speed up the healing, caused by various events.

Cruciferous vegetables are the group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

In the study to investigate whether higher intakes of cruciferous vegetables or their constituents can decrease the levels of inflammation in humans, researchers conducted an experiment to evaluate associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women.

After observation of the returned a food frequency questionnaire, researchers found that
* Multivariable-adjusted circulating concentrations of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 were lower among women with higher intakes of cruciferous vegetables.

* The differences in concentrations of inflammatory biomarkers between extreme quintiles of cruciferous vegetable intake were 12.66% for TNF-α (Ptrend=0.01), 18.18% for IL-1β (Ptrend=0.02), and 24.68% for IL-6 (Ptrend=0.02).

* Inverse association was found for intakes of all vegetables combined but not for noncruciferous vegetables

* Levels of the urinary oxidative stress markers F2-isoprostanes and their major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-IsoP, were not associated with intakes of cruciferous vegetables or all vegetables combined.

These results suggested that daily intake of cruciferous vegetables may have a profound effect in reducing the risk of overexpression of inflammation in inducing chronic inflammatory diseases.

Dr. Jiang Y, the lead author, after taking into account co and con-founders said, " he previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables".

 Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells, both in vivo and in vitro models exerted a significant effect in killing cancer cells through a change of tumor cells membrane blebbing, DNA condensation, and also by nuclear DNA fragmentation.

Additional differentiation suggested that apoptosis of cancer cells induced by Sulforaphane (SFN) and Diallyl disulfide(DAFDs) was attributed to the involvement of proinflammatory cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-12p40, and granulocyte-macrophage-colony-stimulating factor (GM-CSF).

Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through an induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.

Other phytochemical found the vegetables, such as 3,3'-diindolylmethane (DIM), a derivative of indole-3-carbinol, also expressed anti proinflammatory effect through interleukin (IL)-1beta, IL-6 and tumor necrosis factor.

In fact, chemical compounds found in the vegetable inhibited the pro-inflammatory cytokines in the expression of chronic diseases and cancers, involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.

However, due to the limitation of above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH. (PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)

Herbal Arnica and Its' Bioactive Sesquiterpene Lactones That Block Cancer Cells of Leukemia From Spreading, Scientists Reveal

By Kyle J. Norton

Arnica may have substantial and sustainable effect in reducing risk, progression, and treatment of leukemia, some scientists suggested.

The results of these report were conducted by numbers of respectable institutes, including the Chonnam National University and Westfälische Wilhelms-Universität and published online on the database of medical literature.

Leukemia is a medical condition characterized by cells growth uncontrollable and disorderly produced by the body's blood-forming tissues, including the bone marrow and the lymphatic system. In most cases, it is the result of abnormal white blood cells, which don't function properly.

According to the reliable statistic, approximately every 3 minutes one person in the United States (US) is diagnosed with leukemia. New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of 1,735,350 new cancer cases diagnosed in the US in 2018.

The exact causes of leukemia are unknown. However, certain risk factors including smoking, mutation gene inherited from parents such as Down syndrome. blood disorders such as myelodysplastic syndrome are associated with the increased risk of the disease.

Some researchers also suggested that people who have previous treatment for cancer with chemotherapy or radiation are at higher risk of cancer development.

Most common symptoms of leukemia include fever or chills,  persistent fatigue and weakness frequent or severe infections due to dysfunction of the immune system caused by immature white blood cells produced. 

Some patients may also experience symptoms of unattended weigh loss,  swelling lymph nodes,... and enlarged liver or spleen.

If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.

Leukemia is a chronic condition characterized by high numbers of abnormal white blood cells in the bone marrow.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the investigation of the effect of helenalin, a bioactive chemical compound isolated from Arnica on human promyelocytic leukemia HL-60 cell line, researchers found that application of the compound exerts a significant effect in induced HL-60 cell differentiation through the expression of granulocytes, white blood cells with secretory granules in its cytoplasm, at a concentration-dependent manner.

Further analysis, injection of helenalin inhibited HL-60 through activating the protein kinase C (PKC) inhibitor with a function to act as ruboxistaurin in signaling molecules that link to multiple cellular processes of cancer.

Moreover, researchers also found that helenalin also inhibits HL-60 proliferation through activating the extracellular signal-regulated kinase (ERK) inhibitors which are used in some cancer therapy in controlling diverse tumor cellular processes such as proliferation, survival, and motility.

Protein kinase C (PKC) is a family of protein kinase enzymes with function in controlling the expression of other proteins through certain mechanisms.

Additional differentiation also suggested that helenalin induced expression of protein kinase C (PKC) inhibitors without interfering with PKC activity and protein level of PKC beta I and PKC beta II isoforms activities which have been found to promote progression of human cancer.

Interestingly, helenalin also inhibited HL-60 through increasing levels of protein kinase R-like endoplasmic reticulum kinase (PERK) with function in triggering cancer cell death in a concentration-dependent manner.

Finally, researchers also indicated that the inhibition of HL-60 by helenalin are also carried out through ameliorating levels of NF-kappa, with aberrant activity in enabling leukemia cells to evade apoptosis and stimulate proliferation.

High levels of NF-κB has been detected in most of the patients with acute myeloid leukemia (AML).

These result postulated that helenalin isolated from Arnica inhibits the expression of human promyelocytic leukemia HL-60 cell line through many different pathways involved several aspects in tumor cellular differentiation.

More importantly, in the different aspect of the study, Dr. Dirsch VM and colleagues found that sesquiterpene lactones also exerted a significant cytotoxic effect in triggering leukemia cell apoptosis.

According to cell morphology, four compounds found in sesquiterpene lactones, including ambrosin, alantolactone, hymenin and helenalin induced apoptosis of Jurkat leukemia T cells, individually, through inducing apoptosis of nuclei and the outer surface of the cell membrane.

Taken together, Arnica and its bioactive sesquiterpene lactones, particularly helenalin may be used to ameliorate the risk, progression, and treatment of  Leukemia.

However, additional data collection on large example size and multi-centers studies performed with human consumption of herbal arnica or its' bioactive sesquiterpene lactones during the course of the disease will be necessary to complete the picture of garlic anti-leukemia possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone by Kim SH1, Oh SM, Kim TS. (PubMed)
(2) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis by Dirsch VM, Stuppner H, Vollmar AM. (PubMed)