Body Cleansing With A Holistically and Scientifically Prudent Diet

Detoxification is a natural process in removal of toxic substances of human body,  mainly carried out by the liver and kidney.

However, prolonged period exposed to toxins may lead to organs failure, causing a disruption of hormone production, damage to other organs and weakening immune system.

1. Spinach
Besides being rich in vitamin A, E, C , minerals such as iron, potassium, magnesium, zinc and calcium that are vital for a healthy heart.  it also contains antioxidants, lutein and beta carotene with function in strengthen immune defense against the forming of free radicals.

People with kidney disease should not eat spinach, due to highly oxalate, without drinking a lot of water or juice intake of spinach may increase the risk of forming kidney stones.

According to the study by the University of Tuscia, spinach exerted detoxifying effect in Chlorosis develops in Spinacia oleracea L. plants against exposed to Cd in the basal leaves through phytochelatin production and the nitrogen and sulfur metabolic pathways as dead leaves detach from the plant, they carry away the sequestered Cd(1). .

Furthermore, in model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo, researchers found that application of chlorophyll isolated from spinach enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway in regulated aging progression through detoxification and antioxidant activities(2).

2. Broccoli
Broccoli is high in vitamin C, an antioxidant with property in reduced inflammation and inhbited forming of free radicals caused by toxins in our body. 

Study shows that some of the chemicals such as indole 3, selenium and diindolymethane exerted anti cancer properties through preventing and repairing DNA damaging cells.

According to study by the Research and Development Division, Kagome Co., Ltd., broccoli sprout extract (BSEx) expressed a significantly liver protective effect casued by various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.on liver gene expression and acute liver injury in the rat(3).

Additionally, 3-methylsuphinylpropyl and 4-methylsulphinylbutyl glucosinolates. ioslated from broccoli demonstrated strong activity in enhanced ability to induce phase 2 detoxification enzymes in mammalian cells(4).

3. Garlic
Garlic is a super natural food with proven record in preventing heart diseases, lower cholesterol level, elevate blood pressure as well as increasing the transportation of oxygen and simulate the production of insulin if needed.

Allicin, an antibody isolated from garlic reduced inflammation and fought off degeneration caused by virus, bacteria by strengthening our immune system.

 The sulfur element processed a rejuvenate property by increasing the function of liver in removing toxins.

According to the Kagoshima University, sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxificationenzymes in rat hepatoma H4IIE cells(5).

Moreover, in the rat model NDEA-induced hepatocarcinogenesis, researchers found that application of garlic oil (GO) inhibited the infectious cells through activated changes of hepatic phase Ⅰ detoxified enzymes (including cytochrome P450 enzyme (CYP) 2E1, CYP1A2 and CYP1A1) and phase Ⅱ detoxified enzymes (including glutathione S transferases (GSTs) and UDP- Glucuronosyltransferases (UGTs))(6).

4. Green tea
Green tea processes highest antioxidants in compared to other foods with the same volume.

In the study of 70 rats randomly assigned into 4 groups of 10 and satudied over 2 months. Group 1: Normal diet and tap water; Group 2: 10 mg/kg intraperitoneal lead acetate weekly over 8 weeks; Group 3: Lead acetate + 100 mg/kg green tea, Group 4: Extract green tea, researchers found that green tea treated group inhibited lead exposure observed by weight change and lowest sperm abnormalities in compared to lead group with no treatment(7).

In redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) aspects, application of green tea EGCG, exhibited chemoprevention and cytoprotection in modulated Nrf2-mediated cellular events through its abilbity in regulated the expression of antioxidant proteins to protect against oxidative damage triggered by injury and inflammation(8).

5. Tomato
alpha and beta carotene found abundantly in tomatoes strengthen immune system in fighting off inflammation from bacteria and virus in initiated chronic diseases. 

Lycopene, a powerful pigment phytochemical inhibited free radicals to facilitated cytotoxicity in induction of cell damage and apoptosis. 

According to the joint study lead by the Washington State University, lycopene isolated from tomato exerted its host protective effects in modulation of Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms(9),

Similar to garlic, lycopene also activated changes of hepatic phase Ⅰ detoxified enzymes and phase Ⅱ detoxified enzymes against PAH-induced toxicity.

Taken together, intake of above food daily and regularly may have profound and positive effect in promote optimal health through cleansing the body toxin. However, in take of supplement of above foods should be taken with exceptional care as acute liver toxicity were reported in some medical literature.

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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

 

Sources

(1) Does the different proteomic profile found in apical and basal leaves of spinachreveal a strategy of this plant toward cadmium pollution response? by Fagioni M1, Zolla L.(PubMed)

(2) Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan by Wang E1, Wink M1(PubMed)

(3) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1,  Nakai Y1.(PubMed)

(4) Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells by Mithen R1, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J.(PubMed)

(5) Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxificationenzymes in rat hepatoma H4IIE cells by Chang HS1, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O.(PubMed)

(6) Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes by Zhang CL1, Zeng T, Zhao XL, Xie KQ.(PubMed)

(7) Survey of the detoxification effect of green tea extract on the reproductive system in rats exposed to lead acetate by Sha'bani N1, Miraj S2, Rafieian-Kohpayei M3, Namjoo AR4(PubMed)

(8) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG by Na HK1, Surh YJ.(PubMed)

(9) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors byPall ML1, Levine S2.(PubMed)

How to Detoxify Your Liver, Holistically and Scientifically

Detoxification is a natural process in removal of toxic substances of human body, mainly carried out by the liver and kidney.

1. Milk thistle(Backed by studies)
Milk thistle, a flower plant of the daisy family have been traditionally claimed in treating chronic liver disease.

Silymarin, a major bioactive compound isolated from milk thistle exerted a significant liver protective effects through liver regeneration, healing liver damage rapidly and prevented accumulation of lipid in the liver via activation of detoxification system

2. Licorice(Backed by studies)
Licorice is a legume plant and and native to southern Europe and parts of Asia.
According to the study by the joint study lead by the Capital Medical University, licorice demnostrated liver protective effect by reducing the liver toxicity and accelerated healing of liver injury.

Glycyrrhizin, a major chemical constituents found in licorice procresses a strong activity against liver damage and injure through stimulation of fatty acid metabolism and influence detoxification of xenobiotics in liver, the Duksung Women's University suggested.

3. Tabebuia heptaphylla(Backed by studies)

Tabebuia heptaphylla is also known as pink trumpet tree used in traditional medicine for neutralized poisons in the liver and treatment of liver diseases.

Alkaloids, major chemical compound isolated from Tabebuia heptaphylla protected liver against injure and damage caused by abnormal lipid and carbohydrate metabolism and recovery processes of liver xenobiotic-metabolizing function through its member berberine.

4. St. John wort(Backed by studies)
St. John wort is also known as tipton weed or klamath weed.

According to the study by Uniwersytet Medyczny we Wrocławiu, St. John wort with abundant chemical compound hyperforin, procresses hetapoprotect effect through increased increase the activity of cytochrome P450 in the liver in accelerated elimination of toxin from the body.

The herb also activated nuclear pregnane X receptor with function in detoxified xenobiotic substances from the liver.

5. Fennel(Backed by studies)
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.  

Essential oils from fennel showed a marked hepatoprotective effect against hepatotoxicity induced by toxic substance through its antioxidants

Estragole (4-allyl-1-methoxybenzene) is a naturally occurring food flavoring agent found in basil, fennel exerted liver cleansing activity through glucuronidation of 1'-HE is a major detoxification pathway.


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Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Anise, A Potent Herb for Women Health in All Aspects( Milk Secretion, Promoted Menstruation, Facilitated Birth, Alleviated Symptoms of Climacteric, Increased Libido and More....)

Kyle J. Norton

Anise may have a potential and substantial effect in promoted women health in all aspects, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the study of Anise estrogenic activity at doses levels of 50 mg, 70 mg and 80 mg/kg po. in rats, researchers found that application of Anise at all dose exerted a strong estrogenic effect without affecting the levels of progestational, anti-progestational, androgenic or anti-androgenic activities and inducing any side effects even at the doses of more than 3000 mg/kg with LD50, an indication of 50% percent of a population of animals killed usually within a certain time due to some application in dose dependent manner.

Also, in the investigation of Anise estrogenic effect, researchers found that application of Anise displayed estrogenic activity through increased milk secretion, promote menstruation, facilitate birth, alleviate the symptoms of the male climacteric, and increase libido.

Further analysis, also suggested that the implication of fennel estrogenic activity was associated to the major bioactive compound anethole found at high levels in the fennel essential oil.

However, even with lesser amount in fennel essential oil, polymers of anethole, the derivative of dianethole and photoanethole are considered as actual pharmacological values in testing for drug in treatment of extrogenic deficiency related diseases, including menstrual disorder, libido, menopause symptoms, male climacteric,.....

The above differentiation was supported by the evaluation of estrogenic activity of essential oils of eleven Pimpinella species and the compounds isolated from these species, conducted by the Anadolu University.

According to yeast estrogen screen (YES) assay in the study, Anise essential oils containing (E)-anethole as major compound showed estrogenic activity, in compared to insignificant expression in aerial parts without fruits of P. anisetum and P. flabellifolia.

At the presence of anethole-containing oils from 30-50%, Anise exerted the maximal response in expression estrogenic activity.

Interestingly, Fruits of P. isaurica and P. peucedanifolia were estrogenic in spite of the absence or trace amount of anethole.

These result suggested that the estrogenic activity of Pimpinella oils may also contributed by other components other than anethole.

In other words, anethole, a major bioactive compound may not be solely responsible for contributing towards estrogenic activity and essential oil isolated from different parts of the plant and species expressed a varied in estrogenic potencies in compared to 17 beta-estradiol.

In herbal Anise the fruit oils were most estrogenic followed by the aerial parts without fruits and the root oils and their EC50 values varied from 45 micrograms/mL to 650 micrograms/mL.

Taken together, Anise and its major bioactive compound anethole may be considered as a functional food for reduced risk, progression and treatment of estrogenic deficiency syndrome and diseases, such as menopause symptoms and women reproductive diseases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Fennel and anise as estrogenic agents BY MichaelAlbert-Puleo(Science Direct)
(2) Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen by Tabanca N1, Khan SI, Bedir E, Annavarapu S, Willett K, Khan IA, Kirimer N, Baser KH.(PubMed)
(3) Anti-fertility activity and hormonal profile of trans-anethole in rats by Dhar SK1(PubMed)

Added This Queen Herb for ANTI: Ageing, Menstrual Disorders and Menopause Symptoms and More.......

Chaste tree berry processes both estrogenic and anti extrogenic properties may be considered as functional food for women in delayed aging progression, restored hormone balance in ameliorated menstrual disorders, and alleviated menopausal symptoms and more........

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Estrogenic Property
Chaste-tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.

According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.

Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that beside linoleic acid, flavones derivative vitexin and penduletin. isolated from vitex agnus-castus (VAC) also expressed estrogenic effect as most active ERss-selective phytoestrogens.


Anti estrogen Property
Chaste tree berry(Vitex agnus-castus), also processes anti estrogenic property in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.

Anti estrogenic effects is an action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulation in the body.

According to the University of Alabama in Huntsville, in the study of potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.

Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed anti estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti estrogenic effect.

In a hyperprolactinemia (MIHP) induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, application of casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.

More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti estrogenic activity in decrease excessive levels of 17β-Estradiol (E2) significantly

Summary

Chaste tree berry(Vitex agnus-castus) exerts estrogenic components of plant extracts may constitute a potential use for some dietary supplements in human for treatment of various estrogen related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration and anti estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.

In other words, chaste tree berry stimulated estrogen receptors in release estrogen into the blood in case of deficiency or inhibited extra levels of estrogen in case of excess in maintenance hormone balancing with other sexual hormones.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources

(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(5) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(6) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)

Herbal Therapy: Anise In Ameliorated Risk, Progression and Treatment of Oxidative Stress Related Chronic Diseases

Kyle J. Norton

Herbal Anise may have positive and potential effect in inhibited over expression of oxidative stress in initiated diseases expression, some scientists postulated.

Oxidative stress is a condition characterized by over expression of ROS in compared to low levels of antioxidants in the body.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.


In the study to evaluated Anise essential oil effect in metabolic disease favism, an acute hemolytic anemia caused by G6PD deficiency of a total of 48 male albino rats divided into six groups: group 1 orally administrated 1 mL distilled water, group 2 orally received 300 mg/kg anise oil, group 3 orally administrated 100 mg/kg anethole over a seven-day period, group 4 favism-induced rats, group 5 orally administrated 300 mg/kg anise oil and group 6 orally administrated 100 mg/kg anethole once a day over a seven-day period prior to favism induction, researchers found that groups treated with Anise anethole showed a significantly inhibited the reduced-levels of hemoglobin, hematocrit, red and white blood cell counts, serum glucose, blood glutathione, glucose-6-phosphate dehydrogenase, in compared to group 4 favism-induced rats.

Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues and returns carbon dioxide from the tissues back to the lungs and low levels of hemoglobin is a biomaker of anemia.

Hematocrit is a ratio of the volume of red blood cells to the total volume of blood. Low levels of hematocrit is an indication of anemia with destruction of red blood cells and risk of bleeding.

Blood glutathione is antioxidants produced by our body. Low levels of glutathione is associated to patient with chronic diseases caused by over expression of ROS.

 Glucose-6-phosphate dehydrogenase chronic deficiency is associated to development of  favism.

Truly, by inhibited reduced levels of glutathione (GSH), a tripeptide with a free sulfhydryl group, Anise improved the antioxidant status through its antioxidant expressors and improved natural antioxidant in the tissue by increased glucose-6-phosphate dehydrogenase expression.

These results suggested that Anise exerted significant antioxidant activity in inhibited oxidative stress in induction of glucose-6-phosphate dehydrogenase deficiency in facilated the development of favism.

Further analysis of the anti oxidative effect of different extracts and essential oil from Pimpinella anisum L. seeds in carbon tetrachloride (CCl4)-induced toxic models including human liver cancer cell line HepG2 and male Sprague-Dawley rats, researchers found that application of the n-hexane extract found in Anise essential oil, effectively attenuated CCl4-induced toxicity through improved the expression of cell viability, cellular reduced and oxidized glutathione and lipid peroxidation in HepG2 cells.

The final assessment suggested that although Anise exerted strong anti ROS production, some extracts and essential oil do not have a profound effect in reduced oxidative stress expression by initiated antioxidant production of both in the herb and the host.

Dr. Jamshidzadeh A, after taking into account of futher analysis, the lead author said, "As the oxidative stress markers were ameliorated, it might be concluded that anise seed possesses protective effects probably due to its antioxidant constituents".

The above differentiation were supported by the study conducted by Dr. Conforti F and colleagues in the assessment of chemical profile of Anise.

According to the results, Anise extract containing most abundant major components of monoterpenes trans-anethole (54.5%), limonene (13.5%), and sabinene (4.4%) displayed a significant antioxidant activity (50% inhibitory concentration [IC(50)], 3.02 mg/mL) observed by the 2,2-diphenyl-1-picrylhydrazyl assay.

Moreover, the administration of the extract also inhibited over production of nitric oxide (NO)  in precipitated oxidative stress in induction of cardiac and pulmonary dysfunction.

Finally, researchers postulated that Anise extract with abundant petrochemicals have a significant anti oxidative stress effect through its antioxidant and antioxidants produced by the host body without inducing  toxicity to nearby healthy cells.

Taken together, Anise may be considered as a functional herb in ameliorated risk, progression and treatment of oxidative stress in induction of chronic diseases such as atherosclerosis, cancer, diabetics, rheumatoid arthritis,....

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The Protective Role of Anise Oil in Oxidative Stress and Genotoxicity Produced in Favism. by Koriem KM1, Arbid MS2, El-Gendy NF(PubMed)
(2) Protective effect of Pimpinella anisoides ethanolic extract and its constituents on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages by Conforti F1, Tundis R, Marrelli M, Menichini F, Statti GA, De Cindio B, Menichini F, Houghton PJ.(PubMed)
(3) An in vivo and in vitro investigation on hepatoprotective effects of Pimpinellaanisum seed essential oil and extracts against carbon tetrachloride-induced toxicity by Jamshidzadeh A1, Heidari R2, Razmjou M3, Karimi F3, Moein MR4, Farshad O5, Akbarizadeh AR6, Shayesteh MR3.(PubMed)

Herbal Therapy: Fennel In Reduced Symptoms and Treatment of Estrogenic Deficiency Related Diseases

Kyle J. Norton

Fennel may have a potential effect in increased plantbase estrogenic levels in reduced risk of estrogen-related diseases, some scientists suggested.

Estrogen is a primary female sex hormone, responsible for the development and regulation of the female reproductive system and secondary sex characteristics.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In the evaluation of the fennel estrogenic effect in inhibited the increased ectopic uterine motility in facilitated symptoms including pain in primary dysmenorrhea, researchers found that in compared to non-steroidal anti-inflammatory drugs (NSAIDs) in induction of severe adverse effects used for treatment in long-term therapy, application of fennel essential oil (FEO) of LD(50, 1326 mg/kg) in rat model, exerted a therapeutic effect in reduced expression of prostaglandin E(2) (PGE(2)) in induced muscle contraction.

Further analysis suggested that fennel essential oil reduced the intensity of oxytocin and PGE(2) induced uterine muscle contractions significantly (25 and 50 microg/ml for oxytocin and 10 and 20 microg/ml PGE(2), respectively without inducing mortality in tested subjects.

Abnormal production of prostaglandins E2 was found to associate to the intensity of symptoms of primary  dysmenorrhea, including vomiting, fever, diarrhea, and excessive uterine contraction.

According to the P. G. Institute of Basic Medical Sciences, acetone extract isolated from Foeniculum vulgare Mill., seeds at different dose levels (50/ug, 150/ug and 250/ug/100gm body wt.) exerted a potential and positive estrogenic activity in increased nucleic acids and protein concentration and organ weights, particularly in the medium and high doses.

The above differentiation were supported by the study of "Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats" conducted by Dr. Malini T and colleagues.

According to the results, fennel extrogenic effect in oral administration of acetone extract of Foeniculum vulgare (fennel) seeds for 15 days in male rats, exerted a  significant malformation of the male reproductive tract including decreased in testes through inhibited Leydig cell production of testosterone and disrupted fluid reabsorption in the efferent ductules via the ERα and vas deferens in transported sperm from the testicle to the urethra.

Moreover, application of the extract also demonstrated an increased volume of seminal vesicles and prostate gland and decreased activities of acid and alkaline phosphatase in all these regions, including bones, intestines, pancreas, and kidneys.

In female rats, ingestion of acetone extract for 10 days showed a strong effect in expression of estrogenic effect through the observation by vaginal cornification, the test of appearance of cornified epithelial cells in a vaginal smear for confirmation of  the presence of high levels of estrogen.

The application also catalyzed the  the imbalanced production of sex hormone of female estrus cycle.

At moderate doses the seeds caused increase in weight of mammary glands by over expression of estrogen circulation in precipitated a negative effect in regulated systemic mammogenic factors (prolactin, growth hormone), and directed influence of the mammary tissue, such as stromal components and epithelial cells.

At higher doses fennel seeds increased the weight of oviduct, endometrium, myometrium, cervix and vagina.

Taken together, fennel may be considered as a function food for reduced symptoms of estrogen deficiency syndrome and combined with the standard medicine for treatment of estrogenic related diseases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats by Malini T, Vanithakumari G, Megala N, Anusya S, Devi K, Elango V.(PubMed)
(2) Primary dysmenorrhoea: the importance of both prostaglandins E2 and F2 alpha by Lumsden MA, Kelly RW, Baird DT.(PubMed)
(2) Effect of foeniculum vulgare seed extract on mammary glands and oviducts of ovariectomised rats by Devi K1, Vanithakumari G, Anusya S, Mekala N, Malini T, Elango V.(PubMed)
(3) Fennel and anise as estrogenic agents by Albert-Puleo M.(PubMed)
(4) The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study by Ostad SN1, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H.(PubMed)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

The Magic of Camellia Sinensis Leaves: Green Tea In Ameliorated Risk, Progression and Treatment of Pulmonary Fibrosis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of pulmonary fibrosis, some scientists suggested.

Pulmonary fibrosis (PF) is a chronic and progressive condition of lung disease characterized by reduced numbers and increased stiffness of air sac in the lungs (alveoli), affecting the lung breathing function to provide enough oxygen into the bloodstream

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the evaluation of green tea extract efficacy in pulmonary fibrosis caused by direct injury due to over expression of oxygen free radicals and inflammatory cells and fibroblasts in mice model with injection of Paraquat (0.3 mg/kg) into the right lungs of rats, after 2 weeks, then assigned the tested mice to group treated by green tea extract or non treatment groups and control group treated by saline, after assessment,  researchers found that

* Non treatment group exerted a significant expression of pulmonary fibrosis, observed by contents of light microscopic morphometry and hydroxyproline caused by over capacity of ROS observed by the lipid perioxidation assay.

Further examination also discovered that non treatment mice group displayed a pronoucely increased
levels of malondialdehyde (MDA), an indication of over expression of free radicals in induction of oxidative stress caused by ROS chain reaction and endothelin (ET)-1, and prepro-ET-1 mRNA expression, a strong indication of the endothelium signals of vasoconstriction and local cellular growth and survival of air sac cells in the lungs (alveoli).

*In compared to non treatment and saline groups, green tea administered 1% GTE mixed with feed group showed significant decreases in pulmonary fibrosis, along with decreases in MDA, ET-1, and prepro-ET-1 mRNA expression

The result suggested that green tea inhibitorily oxidative activity in reduced expression of pulmonary fibrosis through its antioxidants and promoted production of antioxidants from the host to restore the ratio of antioxidant and free radicals and decreased the facilitation of proinflammatory cytokines in precipitated damage and apoptosis of lung cells and fibroblasts. 

Dr. Kim HR, thelead author, after taking into account of other con founders said, "GTE inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and ET-1 expression".

Additional study of the neutrophils in the site of infection in initiation of host defense and inflammation in precipitation of pulmonary fibrosis development by the Medical School of Padova, revealed that application of green tea (-)epigallocatechin-3-gallate (EGCG) strongly inhibits neutrophil elastase by repressing the reactive oxygen species activity in induction of apoptosis of activated neutrophils.

In vitro, administration of EGCG dramatically inhibited chemokine expression, a secondary pro-inflammatory mediators induced by primary pro-inflammatory in activated neutrophil chemotaxis in migration of neutrophils of immune system to  the site of infection.

Importantly, injection of green tea EGCG also demonstrated a significant effect by blocking neutrophil-mediated angiogenesis in vivo  by initiated growth of new blood vessels to stimulate and fuel the ongoing lung cell damage and death of the cell in the alveoli.

These results constituted a substantial and protective effect in enhanced resolution in a pulmonary inflammation model and significantly reduced consequent fibrosis.

Dr. Donà M, at the end of the analysis said, "These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential".

The above differentiation of green tea effect in protect the lung against the development of pulmonary fibrosis caused by free radical chain reaction and over production of pro inflammatory factors were supported by the study of "the protective effect of green tea extract (GTE), curcumin, against N-acetyl cysteine (NAC) on experimentally induced pulmonary fibrosis" by Cairo University.

According to the study, application of curcumin (200 mg/kg b.w), GTE (150 mg/kg b.w), and NAC (490 mg/kg b.w) orally for 14 days with concomitant administration of cyclophosphamide (CP),  revealed a strong activity in inhibited oxidative stress and lung myelo-peroxidase activity observed in animals of the CP group.

Treatment group also decreased the levels of N-acetyl-β-d-glucosaminidase, leukotriene C₄, and protein in bronchoalveolar lavage fluid (BALF) in demonstration of over reaction of immune response in induction of inflammation through inhibited production of proinflammatory cytokines (growth factor-β, interleukin -1β, and histamine) in initiated lung injure and induced apoptosis of lung cells.

Taken together, green tea and its bioactive polyphenols may be considered as a function food for treatment of pulmonary fibrosis through reducing oxidative stress and inflammatory effect in elevated risk and progression of the disease.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/2018/03/the-magic-of-camellia-sinensis-leaves_4.html

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis by Donà M1, Dell'Aica I, Calabrese F, Benelli R, Morini M, Albini A, Garbisa S.(PubMed)
(2) Green tea extract inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and endothelin-l expression by Kim HR1, Park BK, Oh YM, Lee YS, Lee DS, Kim HK, Kim JY, Shim TS, Lee SD(PubMed)
(3) Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine by Hamdy MA1, El-Maraghy SA, Kortam MA(PubMed)