Herbal Therapy: Green Tea and its Bioactive epigallocatechin 3-gallate (EGCG) in Attenuated Risk, progression of Fibromyalgia Caused by Inflammatory Rheumatic Disorders

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of inflammatory rheumatic disorders induced fibromyalgia, some scientists suggested.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in US alone.

Inflammatory rheumatic disorder is condition of autoimmune diseases caused inflammatory connective tissues, joint and vessels of the body, including rheumatoid arthritis, systemic lupus erythematosus and vasculitis.

According to the Cairo University, as many as 15-30% of patients with classic inflammatory rheumatic disorders also have a co-morbid fibromyalgia syndrome (FMS) incompared to the rate of only 2% of the prevalence of FMS in the general population (2%).

These results suggested that rheumatological syndromes has a strong implication in the development of fibromyalgia syndrome (FMS) in compared to other initiators such as stress.

Therefore, patients with chronic rheumatic diseases are capable of triggering condition of  fibromyalgia syndrome (FMS).

Due to the highly correlated rheumatologic disease and FMS component, researchers postulated "Considerations of the FMS component in the management of rheumatologic diseases increase the likelihood of the success of the treatment" and "(prevented) FMS in misdiagnosed as an autoimmune disorder"

In the study of the effect of green tea's active ingredient, epigallocatechin 3-gallate (EGCG) in risk of inflammatory rheumatic disorders in collagen-induced arthritis (CIA) in mice, researchers found that application of green tea demonstrates a substantially marked inhibition of the inflammatory mediators cyclooxygenase (COX) -2 in converting arachidonic acid in stimulated production of proinflammatory cytokine prostaglandin H2, in catalyzation of symptoms of inflammation in the muscles.

Furthermore, green tea EGCG oral ingestion also inhibited levels of interferon gamma in precipitated inflammation by modulating T-cells and natural killer cells activated by antigens, mitogens or alloantigens to the site of infection.

Tumor necrosis factor alpha (TNFα) involved in systemic inflammation, one of the cytokines that make up the acute phase reaction in mice was also inhibited by injection of green tea EGCG.

These result suggested that green tea ameliorated symptoms expression of inflammatory rheumatic disorders, through attenuating production pro inflammatory factors without reducing the healing progression of injure tissue.

The above differentiation were supported by the study of  green tea extract GTE in modestly ameliorated rat adjuvant-induced arthritis.

According to researchers, a daily per oral administration of GTE (200 mg/kg) reduced expression of RA through reduced levels of MCP-1/CCL2 in expression (which can also be treated by biological agents, such as antibodies and inhibitory peptides) of a variety of diseases characterized by mononuclear cell infiltration involved substantial biological and genetic evidence,  including RA.
 and GROα/CXCL1 in the recruitment of inflammatory cells in the wound healing process after injury in angiogenesis and in formation of granulation tissue of wounds.

Additionally, application of green tea beside attenuated the expression of proinflammatory factors, its also exhibited the production of chemokine receptors CCR-1, CCR-2, CCR-5 in reduced direct communication between the innate and adaptive immune responses in initiated the development of inflammatory responses. through inactivation of leukocytes in inflamed tissues in contribution to the pathogenesis of inflammatory and autoimmune diseases.

And CXCR1 receptor in binding to IL-8 in reduced expression some infallmatory cytokines in initiated inflammation such as epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α).

Some researchers suggested that application of green tea extract may also reduce the symptoms of arthritis through expression of  IL-6 levels, as increased levels of Il-6 was associated to the presence and progression of rheumatoid arthritis (RA) found in conventional clinical and laboratory indices and MMP-2 activity in activated immune inflammatory response through inducing production of pro inflammatory factors.

Taken together, green tea and its bioactive compound such as EGCG may have a profound and theurapeutic effect in reduced the onset, progression and treatment of fibromyalgia induced by inflammatory rheumatic disorders through modulating the production of pro and anti inflammatory proteins. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Fibromyalgia and Rheumatic Diseases by Gheita TA*, El-Rabbat SM and Mahmoud NK(Open Access)
(2) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Salahuddin Ahmed(PMC)

Herbal Therapy: Green Tea And Its Bioactive Polyphenols in Reduced Risk, Progression of Fibromyalgia Caused by Sleep Disturbance

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of  fibromyalgia caused by sleep disturbance, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in US alone.

In the study of sleep disturbance causable fibromyalgia Dr. Choy EH suggested that patients with fibromyalgia demonstrated a reduced short-wave sleep and abnormal α-rhythms, suggestive of wakefulness during non-REM (rapid eye movement) sleep in compared to the healthy individuals according observation of polysomnography.

Further more, in healthy participants, the study indicated that sleep deprivation can also cause fibromyalgia like symptoms such as myalgia, tenderness and fatigue and suggested that sleep dysfunction might be not only a consequence of pain.

These results showed a strong correlated conditions of sleep disturbance and initiation of chronic fibromyalgia if sleep disorders are left untreated for a prolonged period of time.

Moreover, according to the presentation, long time effect of sleep disturbance may influences alter the pathophysiology of the central nervous system in abnormal pain processing and central sensitization, according to observation of the neuroimaging of patients with fibromyalgia neural activation in compared to lower pressure-pain threshold in healthy age-matched and gender-matched individuals.

After taking into account to other con founders, researchers said, " improving sleep quality can reduce pain and fatigue, further supporting the hypothesis that sleep dysfunction is a pathogenic stimulus of fibromyalgia".

Green tea, bioactive polyphenols (-)-Epigallocatechin gallate (EGCG) in the evaluation of the the chick brain under an acute stressful condition in facilitated sleep disturbance, researchers found that EGCG attenuates stress behavior with special reference to gamma-aminobutyric acid (GABA), a neurotransmitter with function in sending chemical messages through the brain and the nervous system, and involving in regulating communication between brain cells in stress environment.

Deficiency of is associated to many nervous conditions, including depression, anxiety, and sleep disorders.

Application of EGCG of doses of 50, 100 and 200 microg, intracerebroventricularly exerted a profound effect in suppressed the vocalization which normally occurs during social separation stress.

This illustration truly suggested that EGCG reduced the time spent in active wakefulness and induced sleep-like behavior in a dose-dependent manner.

Further more, under influence and presence of the GABAA receptor antagonist picrotoxin but not by the GABAB receptor antagonist CGP 54626 (3-N-(1-(3,4-dichlorophenyl)ethylamino)-2-hydroxypropyl cyclohexylmethyl phosphinic acid hydrochloride), a antidote in poisoning by CNS depressants, the effect of green tea EGCG is significantly decrease in attenuated the production of hormone corticosterone release under social separation stress.

These interaction opinionated that EGCG inducted sedation and hypnosis in reduced stress hormone production in precipitated sleep distance probably though GABAA receptors in moderated an acute stress response.

Some researchers suggested that green tea improved symptoms of fibromyalgia by normalizing the levels of GABA (gamma-aminobutyric acid) when came under stress,  may have a therapeutic effect in reduced anxiety by relaxing the muscles and the brain. through increased production of dopamines, serotonin, and alpha waves within the brain in orchestrated the sleep pattern.

These improvements were associated to the interaction of the brain with chemical compounds found in green tea Caffeine and L-theanine, suggested by the author.

Taken together, the information findings suggested that green tea and its bioactive polyphenols EGCG and L-theanine may be considered as a functional food for reduced risk, progression and treatment of fibromyalgia caused by sleep disorder. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The role of sleep in pain and fibromyalgia by Choy EH(PubMed)
(2) (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain by Adachi N1, Tomonaga S, Tachibana T, Denbow DM, Furuse M.(research gate)
(3) Green Tea Health Benefits To Get You Drinking Healthy! by Abby Hannaford

Herbal Therapy: Green Tea in Ameliorated Onset, Progression and Treatment of Juvenile Arthritis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced prevalence, progression and treatment of juvenile arthritis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expessed a significant activity in reduced the protein and lipid damage in liver, brain and plasma, caused by ROS expression in induction of oxidation which have been found to associated to the progression of arthritis.

Injection of green tea extract also enhanced the over expression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) with important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reduced cellular oxidation through chelative and detoxified activities and improved the natural antioxidant enzymes, produced by the body.

Further more, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased  in the liver, one of major risk factor for the development of arthritis.

These results suggested that application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced over expression of oxidative stress in precipitated injury to lipids and proteins.

Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reduced the symptoms and progression of arthritis.

According to the study of University of Health System of green tea effect in patient with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patients synovial fibroblast
of the lining of the tissue which surround the capsule of the joint by inhibited the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Over expression of IL-1B is associated in contribution of joint damage.

Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.

Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.

Due to limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".

More importantly, in the examine some major factors in contributed to the juvenile arthritis, green tea rich in catechins (Healthya green tea) in animal study restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.

Taken together, green tea and its bioactive polyphenols may be considered as a functional food for reduced early onset, progression and combined with standard therapy for treatment of juvenile and adult arthritis. However, intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)

(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)

Herbal Therapy: Green Tea in Alleviated Symptoms, Onset, Recurrence and Treatment of Gout

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset and treatment of gout and recurrent gout, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Gout is a condition of  recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by over expression of purine in the body.

According to the study, green tea and its bioactive compoud Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reduced vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for formation of gout through expression of levels of uric acid.

The study also emphasized that green tea with high levels of antioxidant and function in stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in induced  production of inflammatory cytokines to facilitate symptoms of inflammation. 

The above differentiation were supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.

Truly, the application green tea EGCG decreased expression of gouty arthritis caused by injection of  MSU-induced neutrophil infiltration with function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.

The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in activated inflammatory response to optimize healing and reduce injury to the body but the proteins has been found to cause severed damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.

Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patient of chronic inflammatory disease.without limiting the function of the mediators in protect the infectious site against pathogens invasion.

More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.

Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."

Additionally to above study, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited antioxidant effect in reduced  pronounce of oxidative stress by their antioxidant properties.

Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reduced reactive oxygen species in initiated oxidative stress in induction of inflammatory symptoms.

Taken together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset, and combined with conventional medicine for treatment of gout without inducing any adverse effects.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2.(PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1.(PubMed)

16 Impressive Health Benefits of Eggplant

Kyle J. Norton 

Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Tryptophan
14. Manganese
15. Calcium
16. Copper
17. Iron
18. Magnesium
19. Phosphorus
20. Potassium
21. Zinc
22. Etc.

Chemical constituents
Sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin and other polyphenolic compounds.

1. Food Therapy - Eggplant and cancer
2. Herbal Eggplant and Cholesterol
3. Eggplant as antioxidants
4. Eggplant and cardiovascular diseases
5. Vegetable Eggplant and Type II diabetes
6. Food Therapy: Eggplant in Attenuated Risk and Treatment of Colon Cancer
7. Food Therapy: Eggplant In Attenuated Risk and Treatment of Melanoma
8. Food Therapy: The Hetapoprotective Activities of Eggplant and its Bioactive Total Phenolics and Flavonoids
9. Food Therapy: Eggplant In Reduced Risk of Acute Inflammation and Treatment of Chronic Inflammatory Diseases
10. Food Therapy: Eggplant in Ameliorated Risk and Treatment of Liver Cancer
11. Food Therapy: Eggplant In Reduced Risk and Treatment of High Blood Pressure
12. Food Therapy: Eggplant in Reduced Risk and Treatment of Prostate Cancer
13. Food Therapy: Eggplant in Reduced Risk and Treatment of Hyperlipidemia
14. Food Therapy: Eggplant and Its Bioactive Glycoalkaloids in Ameliorated Risk of Melanoma
15. Food Therapy: Eggplant in Ameliorated Risk and Treatment of Lung Cancer
16. Food Therapy: Eggplant and Its Glycoalkaloids in Reduced Risk and Treatment of Bone Cancer

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Top 10 Studied Proof Veggies in Prevention and Treatment of Prostate Cancer

Kyle J. Norton


The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian, because of its tendency to effect even younger age population.

Suggestions emerged of over consuming bad fats in any time in history accompanied with unhealthy diet and life style may be the possible causes of the disease, linking to the economic prosperity over 2 decades.

Foods for diseases' management have been prescribed in folk medicine over thousands of year as one of best medicine of nature in preventing and treating diseases, including prostate cancer.

Prostate cancer is medical condition caused by irregular cell growth in the prostate tissue. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli....

Indole-3-carbinol, a major chemical compound in Crucifers, is effective in inhibited prostate cancer through inducing phases I and II detoxification pathways and suppressing prostate cancer progression, through down-regulated cell signaling pathways(1).

Its derivative 3,3'-Diindolylmethane (DIM), activated the AMPK(regulator of cellular energy homeostasis) signaling pathway in induction of apoptosis in both androgen-sensitive prostate cancer cells(2).

Erucin (ER), derived from Isothiocyanates (ITCs) in crucifers, displayed a strong  anti progressive prostate cancer  through increased significantly p21 protein expression (regulator of cell cycle progression at G1 and S phase) and ERK1/2 phosphorylation(cell regulation) in a dose-dependent manner(3).

Sulforaphane (SFN) in crucifers also inhibited prostate cancer cell line through impacting epigenetic pathways(4).

2. Tomato
Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America, grown world wide for commercial purpose and often in green house.

Studies linking tomato in reduced risk of prostate caner have produced inconsistent results.(5)(6)(7)(8)(9).

Regardless to these mixed results, intake of lycopene and specific tomato products acknowledged by many researchers is associated in reduced risk prostate cancer.

Lycopene, a lipid soluble carotenoid molecule  and Alpha (α)-tomatine, a saponin presented in tomato, exerted potential tumor suppressing effects by increased apoptosis and lower proliferation of tumor cells.(10)(11).

According to the Northwestern University Medical School, in a recent prospective dietary analysis,  lycopene was found to have clearest inverse relation to the development of prostate cancer(12)(13).

In Androgen-independent DU145 prostate cancer cells, Apo-lycopenals or other lycopene metabolites, significantly reduced cell proliferation through alteration of the normal cell cycle(14).

In BALB/c nude mice, lycopene caused DU145 cells to accumulate in the G(0)/G(1) (Cell cycle)phase and undergo apoptosis in a dose-dependent manner(15).

3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties.

Garlics intake, are related to decreased risk of prostate cancer(17).

In a reviewed study with evidence from 132,192 subjects(18). S-allylcysteine (SAC) derived from garlic, suppressed the proliferation of PC-3 cells and induced cell cycle arrest at the G0/G1 Cell cycle)phases, accompanied by the decreased expression of Bcl-2 and increased expression of Bax and caspase 8(19).

Diallyl disulfide (DADS) another compound in garlic, at 25 and 40 microM concentrations induced cell cycle arrest and apoptosis in PC-3 cells through increased expression of caspases(extent of apoptosis)(20) (3, 9, and 10), proapoptotic protein Bax(Apoptosis regulator)(21).

4. Sweet potato
Sweet potato is a large, starchy, sweet tasting tuberous roots vegetable, genus Ipomoea, belongings to the family Convolvulaceae. I

ts young leaves can be made into a delicious dish in Chinese foods but some species of batatas are actually poisonous.

Sweet potato (Ipomoea batatas) leaves, a favor vegetable consumed extensively in Africa and Asia, containing rich sources of dietary polyphenols (anthocyanins and phenolic acids) exerted a significant antiproliferative activity in some prostate cancer cell lines without damaging to normal prostate epithelial cells.

 SPGE (Sweet potato extract) altered cell cycle progression, reduced clonogenic survival, modulated cell cycle and apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo(22).

 In nude mice testing, the extract inhibited growth and progression of prostate tumor xenografts by ~75%(23).

5. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Ginger extract (GE) and 6-gingerol. a chemical constituent found in ginger root, synergistically inhibited proliferation of PC-3 cells(24).

Daily oral feeding of 100 mg/kg body weight of GE, inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice and reduced proliferation index and widespread apoptosis compared with controls(25).

In the comparison of GE and an artificial quasi-mixture (Mix) formulated by combining four most-active ginger constituents at concentrations equivalent, GE showed 2.4-fold higher tumor growth-inhibitory efficacy than Mix in human prostate tumor xenografts(26).

6. Spinach
Suggestion of intake of typical green and yellowvegetable and spinach were associated to reduce risk factors for prostate cancer(27) and risk of aggressive prostate cancer decreased with increasing spinach consumption(28).

Spinach extract (NAO) expressed anti profileration of the human PCA cell line PC3 by NAO-induced G1 delay and prolonged cell cycle prolongation as a result of downregulation of the protein expression of ppRb(tumour suppressor pathway)(29)and E2F transcription factors(30).

 In human prostatic cancer (PCA) cell lines DU145 and PC3, the extract attenuated  cellular proliferation occurred in a dose-dependent manner, through increasing numbers of G1 cells (Cell cycle)and reducing ROS(reactive oxygen species) levels(31).

7. Chili pepper
Chili pepper is the fruit of plants from the genus Capsicum, belongings to the nightshade family, Solanaceae, used in human history for spices and cultivated for commercial profits.


Capsaicin, a chemical constituent of chili pepper demonstrated a antiproliferative activity correlated to oxidative stress in induction of apoptosis thorough suppressef the growth of human prostatecarcinoma cells in vitro and in vivo(32) and induced apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax(33)(34).

Capsaicin in other study induced apoptosis in PC-3 cells(Prostate cancer) via ROS(reactive oxygen species) generation, JNK(tumorigenetic regulator) activation, ceramide accumulation, and second, extracellular signal-regulated protein kinase (ERK) activation(35).

8. Carrot
Studies of dietary intake of the carotenoids beta-carotene and lycopene found in carrot for its reduced risk of prostate cancer has produced some inconsistent results.

Some studies suggested that dietary intake of beta-carotene was largely unassociated with prostate cancer risk, whereas intake of lycopene and tomato-based foods was weakly associated with a reduced risk(36).

 In antioxidant study, some researchers suggested that beta-carotene supplementation in men with low dietary beta-carotene intakes were associated with reduced risk of prostate cancer(37) and vegetable and carotene intake was associated with lower risk of prostate cancer among Japanese(38).

Unfortunately, there is a report of intake of beta-carotene supplement may increase prostate cancer incidence, 23% higher in mortality, 15% higher in comparison with those not receiving(39).

9. Mushroom
Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,  belongings to the family Amanitaceae, cultivated in many cultures all over the world for foods and health benefits.

Mushroom Inonotus obliquus (I. obliquus) petroleum ether and ethyl acetate fractions was effectively against human prostate cancer cell line PC3 by inhibition effects on NO production and NF-κB luciferase activity in cells produced by the differentiation of white blood cells in RAW 264.7 cells and cytotoxicity(40).

Also in human androgen-independent cancer PC-3 cells, water-soluble extract (POE) of the fresh oyster mushroom exerted most significant cytotoxicity on PC-3 cells in comparison to 2 other mushroom species with cytotoxicity and induced apoptosis mediated in dose-dependent manner(41).

Polysaccharide-K® (PSK), an extract of the mushroom, induced significantly tumor suppression through reduction of tumor proliferation and enhanced apoptosis by lowering the decrease in number of white blood cells, accompanied by increased numbers of tumor-infiltrating CD4+ and CD8+ T cells.(42).

10. Bean sprouts
Eaten raw or cooked, bean sprouts are common ingredient in Asian cuisine, made from sprouting beans.
Isoliquiritigenin isolated from bean sprout, inhibited the migration, invasion and adhesion characteristics of DU145 human prostate cancer through decreased basal and EGF-induced cell(proliferation)migration, invasion in doses dependent manner(43).

Application of the chemical compound also reduced cell proliferation and induced apoptosis in DU145 human prostate cancer cells and MAT-LyLu (MLL) rat prostate cancer cells, through inhibition of ErbB3 signaling and the PI3K/Akt ((anti-apoptosis and increased cell proliferation)pathway(44).

 Other researchers also suggested that these inhibition are associated with an evident disruption of the mitochondrial membrane potential, and the release of cytochrome c and Smac/Diablo(a mitochondrial protein), and the activation of caspase-9(apoptosis)(45).

Taken together,  the findings suggested thatvegetables or their chemical compounds may process a huge effect in reduced risk, progression and treatment of the prostate cancer  through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention by W Watson G, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)
(2) Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo by Chen D, Banerjee S, Cui QC, Kong D, Sarkar FH, Dou QP.(PubMed)
(3) Antiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells by Melchini A, Traka MH, Catania S, Miceli N, Taviano MF, Maimone P, Francisco M, Mithen RF, Costa C.(PubMed)
(4) Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells by Hsu A, Wong CP, Yu Z, Williams DE, Dashwood RH, Ho E.(PubMed)
(5) Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia by Mariani S1, Lionetto L2, Cavallari M3, Tubaro A4, Rasio D5, De Nunzio C6, Hong GM7, Borro M8, Simmaco M9.(PubMed)
(6) A prospective study of tomato products, lycopene, and prostate cancerrisk by Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC.(PubMed)
(7) A prospective study of lycopene and tomato product intake and risk of prostate cancer by Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, Urban DA, Crawford ED, Hayes RB(PubMed)
(8) Lycopene/Tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies by Chen J, Song Y, Zhang L.(PubMed)
(9) The role of tomato products and lycopene in the prev29ntion of prostate cancer: a meta-analysis of observational studies by Etminan M, Takkouche B, Caamaño-Isorna F.(PubMed)
(10) Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling by Lee ST, Wong PF, He H, Hooper JD, Mustafa MR.(PubMed)
(11) Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells by Lee ST, Wong PF, Cheah SC, Mustafa MR.(PubMed)
(12) Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis by Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ.(PubMed)
(13) Inverse associations between plasma lycopene and other carotenoids and prostate cancer by Lu QY, Hung JC, Heber D, Go VL, Reuter VE, Cordon-Cardo C, Scher HI, Marshall JR, Zhang ZF.(PubMed)
(14) Lycopene and apo-12'-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells by Ford NA, Elsen AC, Zuniga K, Lindshield BL, Erdman JW Jr.(PubMed)
(15) Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice by Tang L, Jin T, Zeng X, Wang JS.(PubMed)
(16) Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects by Zhou XF, Ding ZS, Liu NB.(PubMed)
(17) Allium vegetables and risk of prostate cancer: a population-based study by Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF Jr.(PubMed)
(18) Allium vegetables and risk of prostate cancer: a population-based study by Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF Jr.(PubMed))
(19) S-allylcysteine induces cell cycle arrest and apoptosis in androgen-independent human prostate cancer cells by Liu Z, Li M, Chen K, Yang J, Chen R, Wang T, Liu J, Yang W, Ye Z(PubMed).
(20) Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion by Vakkala M, Pääkkö P, Soini Y.(PubMed)
(21) Effects of diallyl disulfide (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3) by Gayathri R, Gunadharini DN, Arunkumar A, Senthilkumar K, Krishnamoorthy G, Banudevi S, Vignesh RC, Arunakaran J.(PubMed)
(22) Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo by Karna P, Gundala SR, Gupta MV, Shamsi SA, Pace RD, Yates C, Narayan S, Aneja R.(PubMed)
(23) Polar biophenolics in sweet potato greens extract synergize to inhibit prostate cancer cell proliferation and in vivo tumor growth by Gundala SR, Yang C, Lakshminarayana N, Asif G, Gupta MV, Shamsi S, Aneja R.(PubMed)
(24) Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation by Brahmbhatt M, Gundala SR, Asif G, Shamsi SA, Aneja R.(PubMed)
(25) Benefits of whole ginger extract in prostate cancer by Karna P, Chagani S, Gundala SR, Rida PC, Asif G, Sharma V, Gupta MV, Aneja R.(PubMed)
(26) Enterohepatic re-circulation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract by Gundala SR, Mukkavilli R, Yang C, Yadav P, Tandon V, Vangala S, Prakash S, Aneja R.(PubMed)
(27) A case-control study of prostatic cancer with reference to dietary habits by Oishi K, Okada K, Yoshida O, Yamabe H, Ohno Y, Hayes RB, Schroeder FH.(PubMed)
(28) Prospective study of fruit and vegetable intake and risk of prostate cancer by Kirsh VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC, Hayes RB; Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.(PubMed)
(29) Enterohepatic re-circulation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract by Gundala SR, Mukkavilli R, Yang C, Yadav P, Tandon V, Vangala S, Prakash S, Aneja R.(PubMed)
(30) Unique natural antioxidants (NAOs) and derived purified components inhibit cell cycle progression by downregulation of ppRb and E2F in human PC3 prostate cancer cells by Bakshi S, Bergman M, Dovrat S, Grossman S.(PubMed)
(31) Slowing tumorigenic progression in TRAMP mice and prostaticcarcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants by Nyska A, Suttie A, Bakshi S, Lomnitski L, Grossman S, Bergman M, Ben-Shaul V, Crocket P, Haseman JK, Moser G, Goldsworthy TL, Maronpot RR.(PubMed)
(32) Effect of capsaicin on prostate cancer cells by Díaz-Laviada I.(PubMed)
(33) Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells by Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M, McBride WH, Kizaki M, Koeffler HP.(PubMed)
(34) Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells by Malagarie-Cazenave S, Olea-Herrero N, Vara D, Díaz-Laviada I.(PubMed)
(35) Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation by Sánchez AM, Malagarie-Cazenave S, Olea N, Vara D, Chiloeches A, Díaz-Laviada I.(PubMed)
(36) Prostate cancer and dietary carotenoids by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM.(PubMed)
(37) Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk by Kirsh VA, Hayes RB, Mayne ST, Chatterjee N, Subar AF, Dixon LB, Albanes D, Andriole GL, Urban DA, Peters U; PLCO Trial.(PubMed)
(38) Relationship between vegetable and carotene intake and risk of prostate cancer: the JACC study by Umesawa M, Iso H, Mikami K, Kubo T, Suzuki K, Watanabe Y, Mori M, Miki T, Tamakoshi A; JACC Study Group(PubMed)
(39) Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial by Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, Haapakoski J, Malila N, Rautalahti M, Ripatti S, Mäenpää H, Teerenhovi L, Koss L, Virolainen M, Edwards BK.(PubMed)
(40)Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus by Ma L, Chen H, Dong P, Lu X.(PubMed)
(41)Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells by Gu YH, Sivam G.(PubMed)
(42) Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer by Wenner CA, Martzen MR, Lu H, Verneris MR, Wang H, Slaton JW.(PubMed)
(43) Isoliquiritigenin inhibits migration and invasion of prostate cancercells: possible mediation by decreased JNK/AP-1 signaling by Kwon GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH.(PubMed)
(44) Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells by Jung JI, Chung E, Seon MR, Shin HK, Kim EJ, Lim SS, Chung WY, Park KK, Park JH.(PubMed)
(45) Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells by Jung JI, Lim SS, Choi HJ, Cho HJ, Shin HK, Kim EJ, Chung WY, Park KK, Park JH.(PubMed)

The Science of Root Vegetables: Carrot and its Bioactive Compounds in Prevention and Treatment of Breast cancer

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression and treatment of breast cancer, some scientists suggested.

Breast cancer is a condition characterized by cell growth disorderly and uncontrollably in breast tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

Carrot, a root vegetable with orange color is  a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutritional Benefits 
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C

13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium

In the review of carrot fractions' anticancer activities in vitro and in vivo, researchers found that pentane/diethyl ether (50:50) isolated from carrot express a significant anti cancer activity against various tumors, including on lung, skin, breast and glioblastoma cancer cell.

Further analysis, application of the ether demonstrated a pronounced inhibition of mobility of above 4 cancer cell lines through an decrease cancer cell invasion and increased cell adhesion.

Also, pentane/diethyl ether (50:50) decreased activation of the Rho family of GTPases, a family of small GTP-binding proteins with function in initiated cancer mobility involved in cell migration, transcription, and proliferation and hyperactivation of Cdc42 with function in stimulated the development, progression, and metastasis of breast cancer.

Over expression of levels of Cdc42 is found in patients with breast cancer tissue in compared to healthy women.

Dr. Zgheib P, after taking into account of other con founder, said, " the treatment (of pentane/diethyl ether ) induced decrease in cell motility" and "(These results) demonstrates a crucial effect of the DC pentane/diethyl ether fraction on cancer cell motility and metastasis".

Additionally, in human breastadenocarcinoma cell lines MDA-MB-231 and MCF-7, administration of Daucus carota oil extract (DCOE) fractions, namely, the pentane fraction (F1) and 1:1 pentane:diethyl ether fraction (F2) exerted potential anti both cancer lines through induction of cytotoxicity.

According to the Flow cytometric assay, both factions of carrot induced cell cycle arrest in the sub-G1 phase and increased apoptotic cell death.

In Western blot, F1 and F2 also promoted the increase in apoptosis through increase in BAX in suppressed the tumor proliferation and decrease in Bcl-2 levels in promoted anti breast cancer apoptosis and caspase-3 nd poly ADP ribose polymerase in activated death protease through cell cycle arrest.

Also, both factions also increased chromatin condensation in facilitated cell apoptosis observed  by chromatin activity of cancer cells undergone of phase change from a heterogeneous, genetically active network to an inert, highly condensed form.

Interestingly, injection of F1 and F2 in MDA-MB-231 cells did not significantly reduce the level of phosphorylated Erk and phosphorylated Akt protein in induction of cancer cellular process involved cancer cell proliferation, differentiation, and survival.

In other words, F1 and F2 inhibited expression and proliferation of MDA-MB-231 cells through  mediating a variety of biological responses including cell growth, proliferation and survival through phosphorylated Erk pathway without alternated expression of phosphorylated Akt proteins.

Moreover, observation of combined treatment with wortmannin, a potent PI3K inhibitor and F1 or F2 fraction revealed that two drugs work on different pathways in the synergistically inhibitory effect on cell survival.

The above differentiation were supported by the National Institute of Environmental Health Sciences in estimate nutrients intake in nine questions on food and supplement in a population-based case-control study of breast cancer risk conducted in Maine, Massachusetts, New Hampshire, and Wisconsin in 1988-1991 with data for 3543 cases and 9406 controls.

According to the results, eating carrots or spinach more than twice weekly was associated with an relative odds ratio of 0.56 in compared with no intake.

However, these data did not distinguish among several potential explanations for the protective association observed between intake of carrots and spinach and risk of breast cancer but consistent with a diet rich in these foods having a modest protective effect.

The result findings strongly suggested that long term intake of carrot in moderate amounts may have substantial implication in prevention and treatment of breast cancer. But Intake of carrot supplement should be taken with care to prevent acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN


Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Daucus carota Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of CancerCells by Zgheib P1, Daher CF, Mroueh M, Nasrallah A, Taleb RI, El-Sibai M.(PubMed)
(2) Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells by Shebaby WN, Mroueh M, Bodman-Smith K, Mansour A, Taleb RI, Daher CF, El-Sibai M1.(PubMed)
(3)Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer by Longnecker MP1, Newcomb PA, Mittendorf R, Greenberg ER, Willett WC.(PubMed)