Food Therapy: Lentil (Plant) Lectin in Attenuated Risk and Treatment of Breast Cancer

Kyle J. Norton

Lentils (Legume) lectin may consist a therapeutic and chemo effect in reduced risk and treatment of breast cancer, some researchers suggested.

Lentil, a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens the Fabaceae family, native to Middle East.

Breast cancer is a medical condition characterized by cell growth disorderly in the breast tissues. At the late stage, the cancerous cell can travel a distance way from the original site to infect other healthy tissues and organs.

Differentiation of lectin effect in risk of breast cancer are depending to several different mechanisms through various aspects.

Lectins from various sources are proteins or glycoproteins specifically and reversibly bind to different types glycoproteins, with anti tumor activity in inhibited altered glycosylation of cell surface glycoproteins in breast cancer subjects.

In breast cancer cell lines, application of lectin induced cytotoxicity against MCF- 7 cell line through induction of cancer cell apoptosis, observed by DNA ladder assay.

Additionally, lectin extract also exerted a significant effect in exhibited function of PARP cleavage in initiated breast cell death processes, in dose-depend manner.

Moreover, the anti proliferation and apoptosis of lectin also demonstrated the increase of P21 level in association to cell cycle arrest in MCF-7 cell line, through inhibited the activity of cyclin D, a member of the cyclin protein family involved in regulating cell cycle progression.

Additional study of H3, a lectin anti tumor effect in binding to tumor associated carbohydrates antigens and precipitated human breast cancer cell line MCF7 apoptosis indicated that H3 exhibited anti breast cancer in induction of a significant arrest in the G1 cell cycle phase, through increasing expression of caspase-9 (CASP 9), a cysteine-aspartic protease with function in implication of apoptosis through cytokine signalling.

Interestingly, injection of H3 not only impaired dramatically the adhesiveness of MCF7 cells, but also exhibited increase of organelle acidity in promotion of cancer cell death, through conversion of LC3-I, to its conjugate LC3-II, an indication of autophagy, observed by Western blot.

In depth study of the effect other plant lectin in risk of breast cancer, researchers also found that bauhinia forficata lectin (BfL) inhibited the viability of the MCF7 cell line through increased α5 subunit expression in exhibition of metastasis suppression, and induced cell death through activation of cell apoptotic Caspase-9, cysteine-aspartic protease.

Amazingly, the infection of bauhinia forficata lectin (BfL) also precipitated deoxyribonucleic acid (DNA) fragmentation, an indication of cell cycle arrest in 2 phase of cell division as well as decreasing expression of the proteins pRb and p21.in regulated cell cycle progression and survival.

Taken together, lectins from many sources, including lentils may be used as secondary and therapeutic therapy combination with standard treatment to ameliorate progression and  treatment of breast cancer.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through caspase-9 pathway and LC3-II protein expression
do Nascimento-Neto LG1,2, Cabral MG2, Carneiro RF3, Silva Z4, Arruda FVS2,5, Nagano CS3, Fernandes AR4, Sampaio AH3, Teixeira EH#1,3, Videira PA#4.
(2) Bauhinia forficata lectin (BfL) induces cell death and inhibits integrin-mediated adhesion on MCF7 human breast cancer cells by Silva MC1, de Paula CA1, Ferreira JG1, Paredes-Gamero EJ2, Vaz AM3, Sampaio MU1, Correia MT4, Oliva ML5.(PubMed)
(3) A novel L-fucose-binding lectin from Fenneropenaeus indicus induced cytotoxicity in breast cancer cells by Chatterjee B1, Ghosh K1, Yadav N1, Kanade SR2.(PubMed)

Herbal Therapy: Herbal Catnip In Blocking Entry Phase of Prostate Cancer Onset

Kyle J. Norton 

Catnip may have a potential and substantial effect in reduced risk of pre-malignant cells slowly change from the properties of normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia, used in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..

Prostate cancer is medical condition characterized by irregular cell growth in the issues of prostate.  At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, based on 2012-2014 data, approximately 11.6 percent of men will be diagnosed with prostate cancer at some points during their lifetime.

On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity found that application of ethyl acetate extract in compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area, where the cancer cell has lost some DNA structure, in a concentration dependent manner.

Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.

Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with lesser value of IC50 and greater effect than other tested compounds was attributed to the activity of  PC3 cells can change its negative androgen receptors profile to positive (PC3AR+)

The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also due  to different response of cells to sex hormones.

Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage which has been found to be an important marker and in associated to the cell’s entry point into the apoptotic signaling pathway and Poly(ADP-ribose) polymerase (PARP) which also plays an essential role in execution of the apoptotic event and an early indicator of apoptosis.

Moreover, researchers also found that the Catnip extract also increased level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.

After taking into account of other con founders, Dr. Emami SA, the lead author said, " the semi polar EtOAc extract of N. cataria induces apoptosis in pc3 cells compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".

Taking altogether, eggplant with plenty phytochemicals may be considered as a functional food in reduced risk of Prostate cancer through blocking the entry phase of  the onset of prostate cancer.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125

Alternative Therapy: Yoga In Relief of Severity, Duration & Frequency in Chronic Headache

Kyle J. Norton 

Yoga therapy may have an important role in regulated central versus peripheral mechanisms in expression of chronic headache, the study by the All India Institute of Medical Sciences suggested.

Yoga, the ancient practical technique  for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the study to investigate the role of muscle spasm over activity in chronic tension type headache (CTTH) with 15 patients of CTTH and 7 age matched controls, randomized assigned to either yoga intervention or control, yoga group demonstrated a significant improvement in reduced overactivity of temporalis muscle in CTTH patients at rest in compared with control.

Furthermore after examined the the EMG records, researchers found that yoga group displayed a substantial decrease in the mean electromyography (EMG) amplitude of temporalis muscle during rest and mental activity in compared to other applications such as non steroidal anti inflammatory drugs, botulinum toxin injections, and improved subjective pain scores.

EMG amplitude is medical technique in evaluation of details of the timing and magnitude of muscle activation for many muscles powering a variety of types of locomotion.

Truly, yoga breathing and relaxation reduced daily stress through calming the central nervous system by connecting the mind and body, restoring the endocrine system in hormone balancing, thus reduced production of stress hormone cortisol through bring back the present moment, while letting them go or dealing them in a profound way.

Further more, yoga postures and deep breathing ameliorated over expression of nerve neurons in transmitted information of sensation, stress, and suffering by creating a state of ease of the body and mind, and strengthening the flow of energy, thus enhancing relaxation response to pain through unraveling the mind-body samskaras.

Other, a study is conducted of 50 patients (aged 18-58 years) in a clinical diagnosis of CCTH, divided in 2 groups. with group 1 (n=30) received 8 lessons and practical demonstration of Brahmakumaris spiritual based meditation known as Rajyoga meditation for relaxation therapy, in addition to routine medical treatment (analgesics and muscle relaxants) and group 2 (n=20) patients received analgesics and muscle relaxants twice a day but no relaxation therapy in the form of meditation by the Dr. Kiran, and colleagues, to support of the effect of yoga therapy in reduced symptoms and pain in tension types of headache, after 8 weeks follow up period, scientists showed that both therapies showed a highly significant reduction in headache variables but yoga group expressed a highly significant relief of severity, duration & frequency of headache in Group 1 by 94%, 91% and 97% in compared to group 2 of 36%, 36% and 49% respectively.

The total headache relief according to headache index was 99% in yoga group  in compared to 51% in control group.

These results indicated that yoga intervention may have an acute effect in ameliorated pain in chronic tension headache.

More promisingly, in the study to provide preliminary data on the feasibility, acceptability, and safety of alignment-based yoga for youths with chronic headaches researchers at the joint study led by the Medical College of Wisconsin/Children's Hospital of Wisconsin found that yoga therapy may be considered pediatric headaches treatment indicated by positive parent and participant ratings of the yoga experience. 

In deed, some yoga instructors suggested that the alleviation of stress induced insomnia and swelling and constriction of the blood vessels of yoga exercise in initiation of deep sleep and in reduced tension of the blood vessels in the face and neck may also decreased pain through head muscles relaxation and revitalization and improved hypertension in blood circulation, particularly in people with chronic headache. 

The finding evidences suggested that yoga intervention may be used as an integrated form of exercise in provided relief in severity of headache, duration & frequency of chronic headache, particularly in tension types of headache.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Role of temporalis muscle over activity in chronic tension type headache: effect of yoga based management by Bhatia R1, Dureja GP, Tripathi M, Bhattacharjee M, Bijlani RL, Mathur R.(PubMed)
(2) Effect of rajyoga meditation on chronic tension headache by Kiran, Girgla KK, Chalana H, Singh H.(PubMed)
(3) A pilot study of yoga for chronic headaches in youth: promise amidst challenges by Hainsworth KR1, Salamon KS2, Khan KA3, Mascarenhas B4, Davies WH2, Weisman SJ3.(PubMed)
(4) Interpreting muscle function from EMG: lessons learned from direct measurements of muscle force byThomas J. Roberts1,* and Annette M. Gabaldón(PMC)

Herbal Therapy: Green tea and Its Polyphenols in Reduced Risk, Progression, Complications and Treatment of Liver Cirrhosis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and treatment of liver cirrhosis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Liver cirrhosis is a condition of abnormal function of liver due to damage liver tissue replaced by scar tissue.

According to statistic, risk of liver cirrhosis is 1.6% in adult population.

Green tea polyphenols in reduced risk and treatment of patients with liver cirrhosis was found to associate to numbers of implication, involving various mechanisms.

In male SD rats model induced liver cirrhosis through carbon tetrachloride(CCL4), randomly assigned to 3 groups, including normal group, green tea extract (GTE) group and cirrhosis group, with GTE group and the cirrhosis group were injected subcutanuously 2 times/wk over 9 weeks with 40% Carbon tetrachloride (CCl4), researcher found that green tea treatment groups displayed a significant reduction of concentration of  hydroxyproline, an amino acid produced during the hydrolysis of collagen initiate scar accumulation in the liver damage tissue caused by CCl4) in  compared to cirrhosis group.

Further analysis, also indicated that green tea exhibited antioxidant activities in decreased expression of malondialdehyde (MDA), a highly toxic reactive species in precipitated liver damage induced by application of carbon tetrachloride(CCL4).

Additionally, the green tea extract ameliorated the liver damage cell in formation of cirrhosis through attenuating the expression of transforming growth factor beta 1 or TGF-β1 in initiated cell growth, cell proliferation.

In differentiation of 11 patients with hepatitis C and detectable viremia of 4 Child-Pugh (CP) class A cirrhosis, 4 Child-Pugh class B cirrhosis, and 3 noncirrhotic, researchers at the Thomas Jefferson University indicated that injection of a single oral dose of green tea extract 400 mg containing 94% pure EGCG demonstrated a strong effect in reduced cirrhosis over expression in induction of liver tumor growth by inhibiting the virus hepatitis in facilitate the production of ROS species through chronic liver inflammation, according to the blood sample withdrawn from the patients without inducing liver toxicity.

Dr. Halegoua-De Marzio D, after taking into account of other con founders said, "A single 400-mg oral dose of EGCG was safe and well tolerated by all of the patients in the study" and disposition of EGCG was not significantly altered in these patients with cirrhosis".

Interestingly, in the concern of abnormal angiogenesis in patients with liver cirrhosis in induction of severe complications such as variceal haemorrhage and encephalopathy, Dr. Hsu SJ and colleges conducted a study to investigate the effect of green tea extract in Spraqtue-Dawley rats liver induced in by common BDL (bile duct ligation) in compared to control given distill water for 28 days and found that group treated with green tea extract expressed a strong implication in ameliorated the severity of portosystemic shunting, a rare malformation of the vessels supplying blood to the liver caused by excessive shunting of blood from the liver portal vein to the lower and middle body into the right atrium of the heart due to liver cirrhosis in induction portal hypertension and one of complication of variceal haemorrhage in patient with chronic liver cirrhosis and mesenteric angiogenesis in development of new blood vessels to supply oxygen and nutrients to initiate liver cancer.

Moreover, the effect of green tea GTP extract in reduced progression of liver cirrhosis was attributed to the suppression of hypoxia-inducible factor 1-alpha (HIF-1α) in expression of liver disease of diverse etiologies, including chronic liver diseases caused by viral infection, excessive alcohol consumption and activation of protein kinase B (Akt) in regulated infectious liver cell survival, cell-cycle progression,... and levels of VEGF in reflection of increased portal hypertension or decreased hepatic regenerative activity or the combination of both.

Dr.Hsu SJ,  the lead author said after the conclusion, "GTP appears to be an appropriate agent in controlling portal hypertension-related complications via anti-angiogenesis.

Taken together, Green tea extract containing major polyphenols such as EGCG may be considered as a functional food in reduced risk, progression, complications and treatment of liver cirrhosis. Intake of green tea supplement should be taken with special care to prevent acute toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis by Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, Lee WS, Lin HC, Lee SD.(PubMed)
(2) [Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].[Article in Chinese] by Xiao J1, Lu R, Shen X, Wu M.(PubMed)
(3) Limited sampling estimates of epigallocatechin gallate exposures in cirrhotic and noncirrhotic patients with hepatitis C after single oral doses of green tea extract by Halegoua-De Marzio D1, Kraft WK, Daskalakis C, Ying X, Hawke RL, Navarro VJ.(PubMed)

Food Therapy: Eggplant in Ameliorated Risk and Treatment of Liver Cancer

Kyle J. Norton (Scholar, All right reserved)

Eggplant may have a therapeutic and positive effect in reduced risk and treatment of liver cancer, some scientists suggested.

Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Liver cancer is medical condition characterized by irregular cell growth in the issues of liver. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissue and organs.

According to statistic, approximately 40,710 new cases (29,200 in men and 11,510 in women) of liver cancer and and intrahepatic bile duct cancer will be diagnosed in US 2017.

Glycoalkaloids (α-solamargine and α-solasonine), nitrogen-containing secondary plant metabolites found in eggplants and numerous Solanaceous plants including potatoes, and tomatoes expressed a strong inhibition of the growth of the liver tumor cells in culture and tumor growth in vivo.

More specifically, α-solamargine and α-solasonine induced apoptosis in cancer cells but not normal cells through functions in eliminated  old cells, unnecessary cells, unhealthy cells and cancer cells without causing  harm to healthy cells in the surrounding area. 

Further differentiation, also suggested that α-solamargine also suppressed liver cancer cell proliferation and induced apoptosis through cell cycle arrest.

Additionally, in HCT-116 cell line, anthocyanins isolated from eggplant displayed  a substantial antioxidant effect in inhibited reactive oxygen species(ROS) expression in promoting oxidative stress and cytotoxicity in induction of healthy cellular DNA damage in initiated early onset of liver cancer.

In compared to anthocyanins, administration of nasunin with glycosylation on C3 and C5 and an acyl group (p-coumaric acid) derivatives demonstrated the least effect on ROS reduction but exhibited ROS over expression in induction of cytotoxicity in colon cell lines, thus ameliorating tumor proliferation and site expansion, according to microculture tetrazolium (MTT) assay.

Further differentiation, also indicated that nasunin and its deacylated derivatives protected healthy  cells from DNA damage through antioxidant capacity in a dose-dependent manner.

Importantly, in the valuations carried out with four concentrations each (0.1, 1, 10, and 100 microg/mL) of the the potato trisaccharide glycoalkaloids alpha-chaconine and alpha-solanine; the disaccharides beta(1)-chaconine, beta(2)-chaconine, and beta(2)-solanine; the monosaccharide gamma-chaconine and their common aglycon solanidine; the tetrasaccharide potato glycoalkaloid dehydrocommersonine; the potato aglycon demissidine; the tetrasaccharide tomato glycoalkaloid alpha-tomatine, the trisaccharide beta(1)-tomatine, the disaccharide gamma-tomatine, the monosaccharide delta-tomtine, and their common aglycon tomatidine, and the eggplant glycoalkaloids solamargine and solasonine and their common aglycon solasodine; and the nonsteroidal alkaloid jervine, researchers found that the glycoalkaloids isolated from all vegetables demonstrated as the most active compound in inhibited liver cancer in compared to colon cells.

In compared to anticancer drugs doxorubicin and camptothecin, all isolated compounds also exerted significant activity in decreased cancer cell proliferation and induced apoptosis in concentration dependent manner.

Taking altogether, eggplant with abundant bioactive phytochemicals may be considered as a functional food used as secondary therapy to reduce risk and in combination of with standard chemo medicine for treatment of liver cancer.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells by Lee KR1, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS, Friedman M.(PubMed)
(2) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1.(PubMed)
(3) Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies Bill E. Cham by International Journal of Clinical Medicine, 2017, 8, 692-713

Herbal Therapy: Green Tea and Lower Dose of Its Bioactive Polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in Reduced Cardiac Fibrosis in Induction of Heart Failure

Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Green tea may have a therapeutic and positive effect in reduced risk and treatment of cardiac fibroids some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Cardiac fibrosis is a uncommon condition of abnormal thickening of the heart valves caused by inappropriate proliferation of cardiac fibroblasts but commonly, it is the excess deposition of molecules outside a cell or cells with structural and biochemical support to the surrounding cells in the cardiac muscle, leading to cardiac dysfunction and eventually heart failure.

The study of rat cardiac fibroblasts caused by injected by angiotensinII (AngII) also revealed that green tea inhibited the abnormal increase in level of connective tissue growth factor CTGF by decreased expression of the nuclear translocation of NF-κB p65 subunit and degradation of IκB-α in induced promotion of fibroblast proliferation and extracellular matrix (ECM) accumulation, thereby exacerbating cardiac hypertrophy and subsequent failure were attributed to bioactive polyphenol EGCG expression in significantly reduced collagen synthesis, fibronectin (FN) expression and cell proliferation.

In deed, due to the activity of CTGF as a matricellular protein modulating the fibrotic process in cardiac remodelling, some researchers suggested that the gowth factor may be considered as a biomarker for cardiac fibrosis for therapeutic intervention to mitigate fibrosis in the heart.

Interestingly, in the evaluated the effect of GABA tea, containing a high level of gamma-aminobutyric acid (GABA) in cardiac function with male Wistar rats injected with 55 mg/kg streptozotocin (STZ) to induce diabetes for 2 weeks and then orally given dosages of 4.55 and 45.5 mg/kg/day GABA tea extract for 6 weeks, researchers revealed that rats treated with injection of GABA tea not only induces fasting blood glucose levels returned to normal levels but also inhibits cardiac fibrosis in compared to untreated group.

Further experiments also showed that GABA tea in ameliorated cardiac deposit risk was attributed to inhibited the protein levels of tumor necrosis factor-alpha (TNF-alpha), Fas and activated caspase-8 and caspase-3 induced in STZ rats in mediated cardiomyocyte apoptosis which has been found in elevation in patient with cardiac dysfunction such as cardiac fibrosis and an indication of chronic hemodynamic overloading and early cardiac decompensation.

Dr. Cherng SH, the lead authors suggested," (GABA tea reduced)cardiac fibrosis (expression) in diabetic rats may be mediated by reducing blood glucose and further attenuating TNF-alpha expression and/or Fas/Fas ligand (FasL)-mediated apoptosis".

Unfortunately, injection of  bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in high dose was found to induce the oppositely effect by increasing cardiac fibroids.

According to the study of green tea bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in  risk of cardiac fibroids induction of myocardiotoxicity in animal model, at the the joint study lead by the Guangzhou Medical University, injection of EGCG 500 and 1000 mg/kg demonstrated a significant effect in initiated cardiac collagen synthesis involved in the formation of filtration systems, through cells differentiation in connective tissue growth factor (CTGF) mRNA expression and protein produced by fibroblasts.

Further more, the application of green tea extract also displayed an exhibited fibrosis-related protein expression in induction of cardiac fibroids deposit through stimulating function of fibronectin (FN), a ubiquitous extracellular matrix (ECM) glycoprotein circulated in the blood to initiated heart muscle repair.

After taking into account of other con confounders, Dr. Cai Y, the lead scientist said, "high oral doses of EGCG could induce cardiac fibrosis, and shed new light on the understanding of EGCG-mediated myocardiotoxicity".

The information findings suggested that green tea with bioactive poluphenols EGCG at lower dose may be used as function food in reduced risk of cardiovascular diseases caused by cardiac fibroids. In take of green tea supplement EGCG mus be taken with care as overdoses-toxicity has been reported in some cases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats by Cherng SH1, Huang CY2, Kuo WW3, Lai SE4, Tseng CY5, Lin YM6, Tsai FJ7, Wang HF8.(PubMed)
(2) High doses of (-)-epigallocatechin-3-gallate from green tea induces cardiac fibrosis in mice by Cai Y1, He SQ2, Hong HQ3, Cai YP4, Zhao L5, Zhang M2.(PubMed)
(3) EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast by Cai Y1, Yu SS, Chen TT, Gao S, Geng B, Yu Y, Ye JT, Liu PQ.(PubMed)

Herbal Therapy: Green tea and Its Bioactive Polyphenols in Ameliorated Risk Human Immunodeficiency Virus -1 (HIV-1) Infection

Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Green and black tea may have a therapeutic and positive effect in reduced risk of HIV 1 infection, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Human immunodeficiency virus -1 (HIV-1) is one of  2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,....

According to statistic, approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million of children less than 15 years of age.

According to the investigation of Theaflavins, the major components of tea polyphenols extracted from brewed black tea and green tea inhibited inhibited HIV-1 entry by targeting gp41 which is a transmembrane protein with function in embedded with outer coat of HIV to enter and infected host cells.

However, due to the unstable and purified of the individual theaflavins, natural preparation containing 90% of theaflavins (TFmix) in most study was used to experiment of its effect against HIV-1 microbide for preventing HIV sexual transmission.

In vitro using p24 production and luciferase assays, TFmix exhibited potent anti-HIV-1 activity on lab-adapted and primary HIV-1 strains with IC(50), the concentration of an application that gives half-maximal response in dose of less than 1.20 μM, through targeting the gp41 in inhibited virus-host membrane fusion during infection mediated by the formation of six helix bundle (6HB). 

In other words, theaflavins administration was found to initiate potent anti-HIV-1 activity by targeting the viral entry step through the disruption of gp41 6-HB core structure,

Further more, application of  theaflavins (TFmix) also inhibited reverse transcriptase (RT) activity, an RNA-dependent DNA, which is the process in replication of RNA from a DNA template through polymerase (DNAP) enzyme in forming new copies of DNA, in the form of nucleic acid molecules, with the IC(50) about 8-fold higher of theaflavins (TFmix) concentration than that for inhibiting gp41 6-HB formation.

In peptide fragments, derived from prostatic acidic phosphatase secreted in large amounts into human semen to form amyloid fibrils plaques with function to induced viral infection (SEVI), through capturing the HIV virions and direct them to target cells into liver cell to initiated entry step, during sexual activity, injection of green tea epigallocatechin-3-gallate (EGCG) inhibited the expression of SEVI and revoked semen in mediated enhancement of HIV-1 infection through precipitated viral degradation without induced healthy cell toxicity.

Further analysis of green tea EGCG activity using HIV-1 infectivity on human CD4+ T cells, at a physiologic concentration of 6μM, EGCG significantly inhibited HIV-1 p24 antigen production in expression of acute infection in both HIV-1 clinical isolates and laboratory-adapted subtypes B C, D, and G.

Particularly, EGCG-induced inhibition of HV-1 infectivity was not due to cytotoxicity, cell growth inhibition, nor apoptosis but blocking the HIV activity in attachment of HIV-1-gp120, a glycoprotein exposed on the surface of the HIV envelope to the CD4 molecule in the entry point in initiated infectivity.

Dr. Christina L., the lead author concluded, "(by) preventing the attachment of HIV-1-gp120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. As this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent, EGCG, is a candidate as an alternative therapy in HIV-1 therapy".

The information findings suggested that green tea with abundant bioactive polyphenols Theaflavins including epigallocatechin-3-gallate (EGCG) may be considered as a function food to ameliorated risk of HIV 1 infection by blocking the complex process in initiation.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection by Hauber I1, Hohenberg H, Holstermann B, Hunstein W, Hauber J.(PubMed)
(2) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(3) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41 by Liu S1, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S.(PubMed)
(4) Preclinical Development of the Green Tea Catechin, Epigallocatechin Gallate, as an HIV-1 Therapy by Christina L. Nance, Ph.D.,a Edward B. Siwak, Ph.D.,b and William T. Shearer, MD, Ph.Da(PMC)
(5) The HIV-1 gp41 N-terminal heptad repeat plays an essential role in membrane fusion by Sackett K1, Shai Y.(PubMed)