Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 19 October 2017

Food Therapy: Black Bean In Attenuated Risk and Treatment of Hyperglyctemia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Hyperglyctemia is a condition of abnormal high blood glucose presented in the blood stream.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Black or common bean with abundant fiber may be considered as function foods in reduced risk of hyperglyctemia, the early onset of diabetes, a renowned institute postulated.

In high-fat diet-induced glucose-intolerant obese C57BL/6J mice, black adzuki bean (BAB) extract injection showed an improved function of pancreatic β cells in inhibiting tolerance of the high glucose-induced glucotoxicity at concentration of 0.2 mg/mL.

The dietary supplementation BAB extract also expressed significantly (P < .05) improved hyperglycemia and homeostasis model, using insulin resistance index (HOMA-IR).

Furthermore, mice fed with the extract also stimulated genes expression in regulated glucose metabolism and insulin response.

Dr. Kim M, the lead researcher said, "BAB extract ameliorates hyperglycemia and glucose intolerance, and lowers HOMA-IR (assessment) by regulating insulin secretion and response, and by maintaining the integrity of pancreatic β cells exposed to hyperglycemic conditions".

Additionally, in the investigated possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice, researchers at the Xuzhou Medical College, indicated that black bean fed mice showed a different degrees, in decreased blood glucose, increased insulin secretion, pancreas weight index, and antioxidative activity.

Dr. Wang JY, the lead author said, "PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage".

The results of these experiments not only displayed the positive and effects of black bean in reduced hyperglyctemia risk regardless types of preparation but also addressed the important issue in contribution of higher outcome in risk control.

Promisingly, in compared glycemic response of bean and rice in traditional meals and rice alone in adults with type 2 diabetes of 17 men and women, group injection of traditional meal showed lower a postprandial net glucose values in contrast to the rice control at 90, 120 and 150 minutes.

Collectively, black bean may be used as a functional food in ameliorated risk and treatment of hyperglyctemia, thus reducing risk of early onset of diabetes.

Sources
(1) Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet by Kim M1, Kim DK2, Cha YS1.(PubMed)
(2) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)
(3) Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study by Thompson SV1, Winham DM, Hutchins AM.(PubMed)

Food Therapy: Coffee and Coffee caffeine in Risk of Psoriasis?

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Epidemiological studies, linking intake of coffee in related to risk of psoriasis have been inconclusive and contradictory.
Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Psoriasis is a condition of skin disease caused by autoimmunity with symptoms of red, itchy, scaly patches.

According to the Tel-Aviv University, Tel-Aviv, eventhough coffee consumption have linked to reduced risk of skin disease, but coffee intake showed no significant association to risk of psoriasis.

In the study of 43 patients with various forms of psoriasis (excluding pustular and erythrodermic psoriasis)selected and answered a questionnaire about their eating habits in the first visit, with special attention to the consumption of several products, researchers found that intake of coffee accompanied with black tea, chocolate, yerba mate, pepper,... showed reduced scaling and erythema, milder outbreaks during the year and improved quality of life in 88% of patients.

Unfortunately, 11.63% (5 patients) did not notice any effects on the skin

These result demonstrated that beside receiving proper scientific advice, education of patients in chosen of better eating habits and suspended use of alcoholic drinks and tobacco.are necessary for improvement quality of life, in injunction with use of medicine therapy.

Dr. Festugato M said," Psoriasis is a chronic inflammatory systemic disease,....(and) As a systemic disease, which shares the same pathophysiological substrate with other comorbidities, diet also leads to worsening of comorbidities".

Other in the study of a total of 82 539 participants free of psoriasis in 1991 included from the Nurses' Health Study (NHS) II7 and observed until 2005, with incidence of psoriasis ascertained by self-report on questionnaires in inquired about the clinician-diagnosed psoriasis and the date of diagnosis, researchers after analyzed the returned questionnaires showed that

1. Risk of psoriasis are moderately elevated with increasing coffee consumption in the age-adjusted model.

2. Intake of decaffeinated coffee implied no insignificant risk of psoriasis

3. Risk of psoriasis increased linearly was also observed with higher caffeine intake in the age-adjusted model.

But after adjusting to smoking status, researchers indicated that The association became null after adjustment for smoking.

Dr. Wenqing Li, the led author said, "Smoking appears to be the major confounder underlying the observed significant association between coffee and caffeine intake and risk of psoriasis in age-adjusted models".

Taking altogether, there is no doubt, coffee and coffee caffeine do not have any implication in elevated risk of psoriasis excepted long term smokers.

Sources
(1) Coffee and autoimmunity: More than a mere hot beverage! by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(2) Pilot study on which foods should be avoided by patients with psoriasis.[Article in English, Portuguese]by Festugato M1.(PubMed)
(3) No Association Between Coffee and Caffeine Intake and Risk of Psoriasis in US Women by Wenqing Li, PhD; Jiali Han, PhD; Abrar A. Qureshi, MD, MPH(JAMA Dermatology)

Food Therapy: Black Bean reduced Risk and Treatment of Hypercholesterol

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy sometimes takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Included a portion of black bean in your diet may have a potential impact in reduced levels of high blood cholesterol, a renowned institute study proposed.

Hypercholesterol is a medical syndrome of abnormal high blood cholesterol in the blood stream. In most cases, it is a result of prolong period intake of saturated and trans fat.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to joint study lead by the University of Illinois at Urbana-Champaign, black bean peptides (-7.2 to -7.0kcal/mol) after injection showed a significant disrupt interactions between NPC1L1,(essential for intestinal sterol absorption) and membrane proteins (regulate.Cholesterol contains) in cholesterol absorption.

The efficacy of black bean peptides in reduced levels of cholesterol in the blood stream may be attributed to the binding cholesterol receptor Niemann-Pick C1 Like- ability in cholesterol transport, found on the gastrointestinal tract epithelial cells.

In compared primary rat hepatocytes and C57BL/6 mice study, methanol extract of black bean seed coats, exhibited anti hypercholesterol activity, by significantly reduced the expression of SREBP1c, involved glucose metabolism and fatty acid and lipid production, and FAS and HMGCR, involved inflammation and stimulated the expression of the reverse cholesterol transporters.

The result in reduced hypercholeterol level also was observed in the decrease in hepatic lipid depots and significant increase in bile acid secretion with some portion of lipids used for energy generation.

Dr. Chavez-Santoscoy RA, the lead author said, "the extract of black bean seed coats may decrease hepatic lipogenesis and stimulate cholesterol excretion, in part, via bile acid synthesis".

Additionally, other researchers also in the study of black bean (Phaseolus vulgaris L.) seed coats extracts, expressed the similar effect in reduced risk of high blood cholesterol but with phytochemicals mechanism.

Dr. the lead author said, "Contrary to the flavonoid content, saponins were correlated to the inhibitory effect of cholesterol micelle(lipid molecules) solubility as an approach to a potential reduction of cholesterol absorption".

Indeed, the high concentration of saponin in the extract showed a significant activity against cholesterol expression in fed mice,

Taking together, black bean with an effect in interrupt cholesterol absorption through peptides in the intestinal tract and anti hypercholesterol chemical constituents may be used as potential and therapeutic food in reduced early onset and treatment of hyperlipidemia.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Bean peptides have higher in silico binding affinities than ezetimibe for the N-terminal domain of cholesterol receptor Niemann-Pick C1 Like-1 by Real Hernandez LM1, Gonzalez de Mejia E2.(PubMed)
(2) Flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats modulate lipid metabolism and biliary cholesterol secretion in C57BL/6 mice by Chavez-Santoscoy RA1, Gutierrez-Uribe JA1, Granados O2, Torre-Villalvazo I2, Serna-Saldivar SO1, Torres N2, Palacios-González B2, Tovar AR2.(PubMed)
(3) Effect of flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats as cholesterol micelle disruptors by Chávez-Santoscoy RA1, Gutiérrez-Uribe JA, Serna-Saldívar SO.(PubMed)

Wednesday, 18 October 2017

Food Therapy: Roasted Coffee in Enhanced Neuroprotective Effects

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Intake of coffee daily may have a strong impact in reduced risk and treatment of neurodegenerative diseases, a renowned institute study suggested

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In rat study to investigate the effect of eicosanoyl-5-hydroxytryptamide(EHT) isolated from coffee against MPTP model of PD with rats fed a diet containing EHT for four weeks exhibited dose-dependent preservation in compared to animals given control feed, researcher found that
1. Mice fed with EHT exhibited a decreased protein aggregation and phosphorylation and improved neuronal integrity and reduced neuroinflammation.
2. The levels of degeneration of dopaminergic neurons(striatal dopamine (DA)) and tyrosine hydroxylase depletion, in the biosynthesis of DA also lower in fed rats in compared to control.
3. Fed rats also displayed a lower indice of oxidative stress and JNK activation in reduced neuro cell apoptosis.

Dr. V, the led author said, " neuroprotective effect of EHT against MPTP(induced PD) is through several mechanisms including its anti-inflammatory and antioxidant activities as well as its ability to modulate the methylation and hence activity of (phosphoprotein phosphatase 2A) PP2A(related to AD development)".

Other study suggested that coffee with its chemical compound cytoprotective transcription factor Nrf2 in activated the expression of antioxidant proteins, is the ingredient in induced neuroprotective in fly PD models as shown in Drosophila models of Alzheimer's disease and polyglutamine disease, through coffee (regardless to caffeinated or decaffeinated)

Dr. Trinh K, the led author said, "coffee......contain Nrf2-activating compounds that may account for the reduced risk of PD among coffee ....users. These compounds represent attractive candidates for therapeutic intervention in PD and perhaps other neurodegenerative diseases".

More importantly, in the study of the effect of different types of coffee against risk neuro degenerative diseases, researchers at the Kraft Foods Research & Nutrition showed that

1. All regular and decaffeinated samples of both roasted and green coffee showed high hydrophilic antioxidant activity in vitro,
2. In neuronal cell cultures, pretreatment with green and roasted coffees (regular and decaffeinated) protected against expression of oxidative stress.
3. Roasted coffee regardless to caffeine content, exerted a much higher protection of cell survival of 203% in compared to 78% of green coffee.
4. Only roasted coffee expressed a significant activity in inhibited neuro cell apoptosis.

Further observation, also indicated that coffee phenolic compounds in roasted coffees demonstrated high levels of chlorogenic acid lactones (CGLs) which has been found to induce neuroprotective efficacy through other studies.

Taking altogether, there is no doubt that roasted coffee intake, regardless caffeineated content, displayed a significant effect in attenuated risk and treatment of neurodegenerative diseases.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease by Lee KW1, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM.(PubMed)
(2) Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism by Trinh K1, Andrews L, Krause J, Hanak T, Lee D, Gelb M, Pallanck L.(PubMed)
(3) Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees by Chu YF1, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, Lin YC, Hsu CW, Cheng IH.(PubMed)

Food Therapy: Caffeinated and Decaffeinated Coffee in Lower Risk of Mortality in Chronic illness Patients, excluding Cancers

By Kyle J. Norton

Regular consumption of caffeinated and decaffeinated coffee may prolong total mortality rate on chronic illness patients excluding cancers, a study by renowned institute suggested.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

The review of literature using the databases of PubMed and EMBASE databases to search all articles published through June 2013, produced twenty studies of coffee consumption and total mortality, including 129,538 cases of deaths among the 973,904 participants met the guidelines, researchers at the Kyung Hee University, filed the following reports
1. The Relative risk ratio(RR) of total mortality for the high v. low category of coffee consumption was 0.86 in compared to .95 of the base line
2. The relative risk ratio was similar to The pool of ≥ 2-4 cups/d and ≥ 5-9 cups/d
3. Coffee consumption showed a strongly inverse association to risk of total motility expression in Japanese and European studies in compared to studies in US.
4, Risk of motility showed no gender difference
5. Both moderated caffeine coffee and decaffeinated coffee expressed an inverse association in lower risk of death.

Regardless to types of chronic illness, coffee displayed a significant value in a reduced risk of total mortality.

Furthermore, in review of associations of consumption of total, caffeinated, and decaffeinated coffee with risk of subsequent total and cause-specific mortality among 74,890 women in the Nurses' Health Study (NHS), 93,054 women in the Nurses' Health Study II, and 40,557 men in the Health Professionals Follow-up Study, after reading the returned semiquantitative food frequency questionnaire, researchers suggested that
1. Consumption of total, caffeinated, and decaffeinated coffee were associated to reduced risk of mortality, nonlinearly.
2. Coffee intake of 1 to 5 cups per day expressed a strong effect in lower risk of mortality in compared to non coffee drinking group
3. Coffee consumption of more than 5 cups per day was associated with reduced risk of mortality.
4. Caffeinated coffee and decaffeinated coffee displayed a similarly significant inverse associations in risk of motility.
5. More importantly, coffee consumption exhibited a enormous effect in reduced deaths attributed to cardiovascular disease, neurologic diseases, and suicide but not in cancer patients.

Dr.Ding M , the lead author said, "when restricting to never smokers compared with nondrinkers, the hazard ratios of mortality were 0.94 for 1.0 or less cup per day, 0.92 for 1.1 to 3.0 cups per day, 0.85 for 3.1 to 5.0 cup per day, and 0.88 for more than 5.0 cup per day".

Interestingly, in this restriction, numbers of cup intake daily were associated linearly to lower risk of total motility in compared to non linearly in other group.

In support to the above differentiation, the Brigham and Women's Hospital study to assess of the association between coffee consumption and mortality from cardiovascular disease (CVD), cancer, and all causes during 18 years of follow-up in men and 24 years of follow-up in women, filed the the following results

1. After adjustment for age, smoking, and other CVD and cancer risk factors, coffee intake showed a moderated effect in lower on all-cause and CVD in both gender but no statistically significantly associated with risk for cancer death

2. Caffeine was not associated to risk of motility

Taking altogether, caffeinated and decaffeinated coffee showed a profound and positive effect in lower risk of motility linearly and nonlinearly in chronic illness other than cancers, depending to other risk factors and group selection.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies by Je Y1, Giovannucci E2.(PubMed)
(2) Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts by Ding M1, Satija A1, Bhupathiraju SN1, Hu Y1, Sun Q1, Han J1, Lopez-Garcia E1, Willett W1, van Dam RM1, Hu FB2.(PubMed)
(3) The relationship of coffee consumption with mortality by Lopez-Garcia E1, van Dam RM, Li TY, Rodriguez-Artalejo F, Hu FB.(PubMed)

Food Therapy: Dried Pea and Bean Fibers in Reduced Incidence of Hypertension

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Intake of dried pea and bean fibers daily and regularly may reduce risk and treatment of hypertension, a respectable medical service study suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

According to the Veterans' Affairs Medical Center, daily intake of fiber has emerged not only to prevent and treat various types of chronic diseases.but also reduced risk of hypertension.

Dr. Anderson JW, the led author said, "Dried beans, oat products, and certain fruits and vegetables are good sources of soluble fiber" and "Current guidelines advise a doubling of dietary fiber intake for Americans. Inclusion of ample servings of fruits and vegetables, whole grains, and dried beans and peas will help individuals meet these guidelines".

Additionally, in the examined iineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation researcher found that high fiber diet not only modified the gut microbiota populations and also increased the abundance of acetate-producing bacteria independently of mineralocorticoid excess and reduced systolic and diastolic blood pressures.

Dr. Marques FZ, the led researcher said, "The favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the gut microbiota, the short-chain fatty acid acetate. Acetate effected several molecular changes associated with improved cardiovascular health and function."

These result demonstrated a significant effect of fibers intake in promoted health gut microbiota in regulating molecular changes associated with improved risk factor related to cardiovascular health and function, including blood pressure.

Other, in the examined cross-sectional studies of dietary intake as one of the major determinants in hypertension development and Dietary Approach to Stop Hypertension and the risk of incident hypertension in a large cohort study including incidence of hypertension among 80 426 French adults, researchers at the joint study led by the Paris-Descartes University found that
1. During a mean follow-up of 3.4±2.1 years, 2413 cases of incident hypertension were documented
2. Fiber intake displayed a strong effect in reduced risk of hypertension with relative odd risk of 0.81 in compared to the baseline.
3. Adopting a global healthy diet associated to several nutritional factors intake may be one of the best solution in reduced hypertensive incidence

Taking altogether, dried peas and beans fibers accompanied with adequate intake of marco nutrients and reduced intake red and processed meat may form a daily diet in reduced risk of hypertension

Sources
(1) Health benefits and practical aspects of high-fiber diets by Anderson JW1, Smith BM, Gustafson NJ.(PubMed)
(2) High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques FZ1, Nelson E2, Chu PY2, Horlock D2, Fiedler A2, Ziemann M2, Tan JK2, Kuruppu S2, Rajapakse NW2, El-Osta A2, Mackay CR2, Kaye DM1(PubMed)

(3) Individual and Combined Effects of Dietary Factors on Risk of Incident Hypertension: Prospective Analysis From the NutriNet-Santé Cohort by Lelong H1, Blacher J2, Baudry J1, Adriouch S1, Galan P1, Fezeu L1, Hercberg S1, Kesse-Guyot E1.(PubMed)

Food Therapy: Black Bean, Reduced Risk and Treatment of Colitis

Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black bean with abundant chemical constituents and fiber may be considered as function foods for prevention and treatment of colitis, a renowned institute indicated.

Colitis is medical condition of inflammation of the inner lining of the colon.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the joint study lead by the University of Guelph, in vivo, cooked whole-bean flours, with differing phenolic compound levels and profiles, showed a completed inhibition of colitis in a mouse model.

In C57BL/6 mice fed a 20 % navy bean or black bean flour-containing diet or an isoenergetic basal diet (BD) for 2 weeks before the induction of experimental colitis via 7 d dextran sodium sulphate (DSS, 2 % (w/v) in the drinking-water) exposure, coincidentally, both groups exerted similarly a beneficial and adverse effects in induced locally and systemically while aggravating colonic mucosal damage with unknown identity and systemic inflammation.

In bean treatment group, the efficacy in ameliorated colitis may be a result of the inhibition of pro inflammatory expression, such as colonic inflammatory cytokines (IL-6, IL-9, IFN-γ and IL-17A) and increased anti-inflammatory IL-10.

In mice with colon inflammation triggered by high-fat diet (HD)-induced obesity, injection of black bean expressed a significant decreased the concentrations of lipid and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mice with HD-induced obesity, in attenuated change associated to colon inflammation.

Furthermore, mice treated with black bean also improved antioxidant status in reduced progression
of reactive oxygen species (ROS) in induction of oxidative stress.

Dr. Yook JS, the lead researchers said, "BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".

Taken together, black bean may be considered as a functional diet in reduced risk of colitis in high risk healthy subjects and treatment of patients with colitis with little or no adverse effects.

Sources
(1) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1.(PubMed)