Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc...
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Parkinson's disease is a type of dementia caused by nerve cell dysfunction that produces dopamine in the brain, affecting muscle rigidity, tremors, and changes in speech and gait.
Uncaria tomentosa may be one of the medicinal plants used for reduced symptoms and treatment of Parkinson's disease.
According to a recent study, AC11 (a standardized aqueous extract of Uncaria tomentosa) exhibited scavenging several types of free radicals, decreased lipid peroxidation level and reduced α-synuclein aggregation by 40%.
Dr. Cosentino C. the lead researcher at the Instituto de Ciencias Neurological, said, "Uncaria tomentosa (UT),,... reversed worsening of motor signs in a patient with Parkinson's disease after oral intake"
Further study of Cat's Claw (Uncaria tomentosa) also found that the medical plant enhanced DNA repair and immunity in model systems with the capability of generating neuroprotective effects in neurons.
Although the therapeutic intervention of Cat's claw may exhibit properties against Parkinson's disease, using the medicinal plant should be taken with care.
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Sources
(1) Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model byShi Z1, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B.(PubMed)
(2) Reversible worsening of Parkinson's disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw) by Cosentino C1, Torres L.(PubMed)
(3) Quinic acid could be a potential rejuvenating natural compound by improving the survival of Caenorhabditis elegans under deleterious conditions by Zhang L1, Zhang J, Zhao B, Zhao-Wilson X.(PubMed)
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