#Kidneybeans Process Anti-Proliferative Effects on #Leukemia, Researchers Suggest

By Kyle J. Norton

Intake of cooked Dried red kidney beans regularly may reduce the risk and delay the progression risk of Leukemia, a renowned institute study proposed.

Kidney bean is a popular food, with a kidney shape, strong flavor, and color reddish-brown in nature used often as an excellent dietary selection because of its enormous health benefits with a good source of protein and minerals.

Leukemia is a condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chemical compound purified from dried kidney beans, namely, 7.3-kDa antifungal peptide, used mainly for the treatment of fungal overgrowth, showed to suppress the spread of leukemia L1210 cells with a half concentration of 5.2±0.4 µM and 7.6±0.6 µM, according to the China Agricultural University.

Dr. Ma DZ, the lead researcher said, "(the antifungal peptide isolated from dried Nepalese large red beans) exerted an antiproliferative action on L1210 leukemia cells with an an half concentration of high doses at 15 and 60 microM, respectively".

Other chemical compound, L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds also enhanced anti-proliferative effect on ALL cells according to the WST-8 cell viability assay kit.

Furthermore, treatment of L-asparaginase enzyme also involved significantly in induced early apoptosis in acute Lymphoblastic leukemia in test subjects in vivo.

According to the joint study led by King Abdulaziz University, the efficacy of a novel L-asparaginase enzyme, isolated from Phaseolus vulgaris seeds (P-Asp) in mice study showed that mice treated with P-Asp had less distinct allergenic responses by the immune system in expression of higher risk of carcinogens and reduced treatment effects.

There is no doubt that kidney beans may be a potential health benefit in targeting the risk of Leukemia in the early stage and prevent the progression of cancer through anti-proliferative and induced tumors cell death.


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Sources
(1) An antifungal peptide with antiproliferative activity toward tumor cells from red kidney beans by Li M1, Wang H, Ng TB.(PubMed)
(2) A peptide with potent antifungal and antiproliferative activities from Nepalese large red beans by Ma DZ1, Wang HX, Ng TB.(PubMed)
(3) Trypsin isoinhibitors with antiproliferative activity toward leukemia cells from Phaseolus vulgaris cv "White Cloud Bean" by Sun J1, Wang H, Ng TB.(PubMed)
(4) Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells by Li M1,2, Liu Q3, Cui Y4, Li D5, Wang H6, Ng TB7.(PubMed)