Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulate the production of blood palette to cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.
However, the overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damaged to the nearby healthy cells, leading to the formation of scars.
In most cases in a healthy individual, depending on the size of the wound, the immune system can easily eradicate all foreign invaders, and the wound is recovered within days and weeks.
Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, diarrhea, short-term joint or muscle pain, fever, headache, skin rash, and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.
In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling, and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.
Unfortunately, in people with a weakened immune system such as the elderly, the immune system can not destroy all microbial pathogens in a set period of time, leading to low-grade inflammation, a major cause of several chronic illnesses, including cardiovascular disease, and diabetes.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
Liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural compound for the treatment of chronic infection, researchers examined the result of a chronic wound infection treated by the use of hydrogel loaded with an extract from manuka honey.
Bacteria isolated from patients with infected wounds at Alexandria Main University Hospital (Alexandria, Egypt) were exposed to hydrogel sheets composed of chitosan and gelatin and loaded with a new formula from manuka honey.
According to the tested assays, Manuka honey formula exerted a strong antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter baumannii, Pseudomonas aeruginosa, and Proteus mirabilis.
Based on the findings, researchers suggested, "A hydrogel sheet composed of chitosan and gelatin loaded with a new formula extracted from manuka honey can be used as a dressing for chronically infected wounds".
In order to reveal more information about Manuka honey for the treatment of chronic infection, investigated the effect of the honey incorporated into cryogel scaffolds, utilizing its properties in a sustained release fashion to assist in the overall healing process.
According to the tested assays, a 5% MH silk fibroin cryogel has the potential to inhibit bacterial growth while still maintaining adequate porosity, mechanical properties, and cell infiltration.
In other words, such a scaffold would have been used in a number of applications, including bone regeneration without interruption by bacterial infection.
Taken altogether, Manuka honey may be considered a functional remedy for the prevention and treatment of acute and chronic infection with no side effects, pending the confirmation of large sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hydrogel film loaded with new formula from manuka honey for the treatment of chronic wound infections by Abd El-Malek FF1, Yousef AS2, El-Assar SA. (PubMed)
(2) A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections by Hixon KR1, Lu T1, Carletta MN1, McBride-Gagyi SH2, Janowiak BE3, Sell SA. (PubMed)
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