By Kyle J. Norton
Platelet aggregation refers to the platelet-to-platelet adhesion in the blood that forms a clot.
Platelet aggregation plays a critical role in the protection of the body against blood loss due to injury or tissue damage.
However, activated platelets that stimulate blood clot formation have also been found to induce atherothrombotic disease.
Antiplatelet aggregation medicines, also known as a platelet agglutination inhibitor are the types of medicine that process blood thinning property.
In other words, antiplatelet aggregation medicines reduce the risk of blood clotting used in patients who have a high risk of cardiovascular disease such as aspirin.
Coagulation disorders or bleeding disorders are medical conditions that affect blood clotting activities. The most common diseases associated with coagulation disorders are Hemophilia, Von Willebrand disease, clotting factor deficiencies, hypercoagulable states, and deep venous thrombosis.
Most common causes of the bleeding disorder are found in patients with a lower red blood cell count
and vitamin K deficiency.
However, long-term use of certain medication has also been found to side effects of bleeding disorder.
Most common symptoms of blessing disorder are unexplained and easy bruising, heavy menstrual bleeding in women, frequent nose bleeding, excessive bleeding from small cuts or an injury
and bleeding into joints.
Dr. Copplestone JA in investigating the bleeding and coagulation disorders in the elderly wrote, "Ageing does not bring with it any major changes in the coagulation or fibrinolytic proteins or platelets. It does bring a greater burden of disease, with fewer reserves, and so when hemorrhage occurs in the elderly it has more serious consequences".
And, " Drugs are a significant and potentially preventable cause of bleeding in the elderly. The most frequent problems arise with anticoagulants. The risk of interactions increases with the number of other medications that are prescribed".
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.
In finding the natural compound which processes anti-thrombosis, researchers examined the antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables.
The study compared the effect of extracts prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction.at a final concentration of 1 mg/ml from samples of 19 fruits and 26 vegetables, including green beans representative of the local diet.
Extracts of green beans showed an inhibited platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner, compared to other extracts.
Compared to methanolic extracts of grapes prolonged activated partial thromboplastin time (APTT) and diluted prothrombin time (dPT) and raspberry prolonged APTT are higher compared to those of green beans.
Taken altogether, green beans may be used as an adjunct therapy for the prevention and treatment of platelet aggregation, pending the confirmation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Bleeding and coagulation disorders in the elderly by Copplestone JA. (PubMed)
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