By Kyle J. Norton
Cancers are a class of chronic and medical conditions characterized by cells growing irregularly and disorderly in the tissue of a specific organ.
Most cases of cancer start in the cell on the surface of the inner lining of organ tissue caused by the alternation of the cell DNA.
At the early stage, due to the very small size of the tumor, patients may not experience any symptoms. However, as the cancer progresses, cancer cells may penetrate into deeper layers, before colonizing entire organs. At this stage, the primary cancer cells can travel a distance away from the original site to infect other healthy tissue and organ via fluid and blood circulation.
According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, based on the 2013–2015 data.
In 2017, about 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer. Cancer in the same year also causes the death 1,790 of children and adolescent Americans.
As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.
There are many prevalent factors associated with cancer onset, including an increase in age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.
The most common factors that cause the rise of cancer, including colorectal cancer in the Western world according to Dr. Omran S, the led author in the study of "Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals" are dietary patterns, sedentary lifestyle, and other practices.
In CRC risk, the doctor continued, aging with the mean age of 57.0 ± 8.56 years, male gender with less than secondary school formal education.
And, the commonest risk factors for CRC among the participants were overweight or obesity (76.1 %), lack of exercise (71.6 %), limited consumption of vegetables (70.8 %), smoking (60.6 %), over-consumption of red meat (56.3 %), and diabetes mellitus (24.1 %)".
However, most people with some of the aforementioned risk factors have never developed cancer.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound that processes chemopreventive activity, researchers assessed the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines.
According to the results of AW13516 (poorly to moderately differentiated squamous cell carcinoma of the tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assays, the CHX efficacy of 80.15% & 95.7% of growth inhibition against AW13516 & KB cell line respectively.
* Administration of CE (80µg/ml) showed no anti-cancer properties against the AW13516 cell line.
*However, CE inhibited 70.6% growth against the KB cell line.
Furthermore, both CHX and CE were less potent than the positive control drug Adriamycin, at the values of GI50, TGI, and LC50.
Based on the findings, researchers said, "CHX exhibited better anti-cancer properties than CE for both the oral cancer cell lines".
In other words, CE exerted anti-cancer activity depending on the types of primary cancer cells.
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cancer, depending on the types of primary cancer cells, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study by Khairnar MR1, Wadgave U1, Jadhav H2, Naik R. (PubMed)
(2) Cranberry and its phytochemicals: a review of in vitro anticancer studies by Neto CC. (PubMed)
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