#Healthyfood #BeetRoot In the Inhibition of the Diseases Associated with Over Expression of #OxidativeStress, Scientists Say

By Kyle J. Norton

Beet may have a potential effect as antioxidants in reduced free radical and oxidative stress expression through its chemical constituents, some scientists suggested
Antioxidants are a set of substances with inhibited oxidative function

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the joint study led by the Istanbul Technical University, fresh red beetroot and beetroots products contain several major antioxidants with efficacy different, depending on total antioxidant capacities (TAC)(total phenolic (TP) and total flavonoid (TF) contents and individual).


In Lactobacillus paracasei 0920 (FBJ) on carcinogen induction of aberrant crypt foci (ACF), the abnormal tube-like glands in the lining of the colon and rectum in rat colon by 2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) administrated intragastrically at a dose of 10 μg/day, every day of the experiment, rats fed with beetroot juice showed a significant improvement of cytotoxic and genotoxic effects through increased the antioxidant status of serum from 40% to 66% depending on the fraction.

In other words, oxidative stress-induced production of toxins and toxic chemical agents which may alternate DNA transcript were inhibited by phytochemicals in beet juice.

2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) is a toxic chemical formed in condensation of creatinine found in muscle meats, with amino acids in high temperature,

Interestingly, the formation of pro-oxidative stress found in the blood of colorectal carcinoma patients. was associated with decreased concentration of antioxidant status together with a lower amount of uric acid in the expression of antioxidants which was found to have a potential effect
in the treatment of diseases associated with oxidative stress.


Furthermore, levels of oxidative stress are also found in the measurement of serum antioxidant status and the level of malondialdehyde, a marker of oxidative stress in the rat's kidneys and liver.

Additionally, in a male Wistar rat model of oxidative stress induced by N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl(4)), the group fed with beetroot juice per os, 8 mL/kg/day for 28 days, and a single i.p. the dose of the xenobiotics: 150 mg/kg NDEA or 2 mL/kg CCl(4) and xenobiotics the only group, the treatment group showed a partial recovery in the activity of glutathione peroxidase and glutathione reductase, by 35% and 66%, respectively.

Glutathione peroxidase (GPx) with peroxidase activity is an antioxidant with a function to protect the organism from oxidative damage.

The activity of glutathione reductase is a cellular antioxidant with a function to protect the organism against xenobiotics.

Particularly, the levels of Superoxide dismutase activity against the oxidative stress-induced formation of inflammation also increased by 3-fold compared to the non-juice treatment group.


Importantly, the treatment group also showed significant inhibition of oxidative stress in protected DNA damage caused by N-nitroso diethylamine (NDEA) and carbon tetrachloride (CCl(4)) by 20%.

These findings showed a remarkable efficacy of beet juice and products in ameliorating free radicals and pro-inflammatory expression through elevated antioxidant status which warrant a human trial for validity.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.




Sources
(1) Home-Processed Red Beetroot (Beta vulgaris L.) Products: Changes in Antioxidant Properties and Bioaccessibility by Guldiken B1, Toydemir G2, Nur Memis K3, Okur S4, Boyacioglu D5, Capanoglu E6.(PubMed)
(2) Protective effect of lactofermented red beetroot juice against aberrant crypt foci formation, genotoxicity of fecal water and oxidative stress induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in rats modelm by Klewicka E1, Nowak A, Zduńczyk Z, Juśkiewicz J, Cukrowska B.(PubMed)