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Sunday, 2 February 2014

Cruciferous vegetables as antioxidants

Cruciferous vegetables are the group of  vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc..
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include  glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..

The benefits
Isothiocyanates, the major phytochemical found in cruciferous vegetables, including broccoli and watercress, have been studied extensively for its chemopreventive properties, as it enhances the detoxification processes in  preventing the initial activation of abnormal cell growth, including human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, human ovarian cancer cells. More evidences emerged to suggest that ITCs may not only prevent cancer initiation by altering carcinogen metabolism but also inhibit post-initiation cancer development by suppressing the process of tumor progression. Isothiocyanates, the may be chemopreventive agent also interacted with glutathione S-transferases (GSTs) to the process of cell detoxification. These results suggested that Isothiocyanates, may be the potential; agent in preventing and treating cancers.

The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.



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(1) Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research by Singh SV, Singh K.(PubMed)
(2) Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention by Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.(PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)