Tocopherols Promote Cytotoxicity in the Sensitive and Drug-Resistant Cancer Cells

By Kyle J. Norton


Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Drug-resistant cancer is a type of cancer that process chemotherapy resistance ability.

In other words, rug-resistant cancer processes the ability to survive and grow despite anti-cancer therapies. In some cases, cancers can evolve resistance to multiple drugs, called multiple drug resistance.

Cancer that responds to treatment with anticancer drugs is called sensitive-drug cancer.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer, researchers examined the effect of the encapsulated tocopheryl succinate (PTX) loaded with PSST micelles (PTX/PSST-M) which are designed to display synergistic functions in anticancer activities.

According to the analysis,
* PTX/PSST-M showed significantly increased cytotoxicity against PTX-resistant human ovarian cancer A2780/PTX cells for 48 h,
* The efficacy was attributed to the equivalent IC50 value of PTX that was reduced from 61.51 to 0.49 μmol/L.

* Other contributors to the cytotoxic activity also included reducing the mitochondrial transmembrane potential, ATP depletion, ROS production, and activation of apoptotic pathways.

Additionally, researchers also found that the administration of PTX/PSST-M significantly increased cell apoptosis/necrosis and cell cycle arrest at the G2/M phase in A2780/PTX cells.

After talking about other factors into account, researchers said, " These results demonstrate that the redox-responsive PSST micelles inhibit P-gp activity and have a good potential to effectively reverse PTX resistance in human ovarian carcinoma cells by activating intrinsic apoptotic pathways".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of drug-resistant cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of α-tocopheryl succinate-based polyphosphoester copolymers by Chen FQ1, Zhang JM1,2, Fang XF3, Yu H1, Liu YL4, Li H4, Wang YT1, Chen MW. (PubMed)

Beta-Sitosterol, the Potential Anti-Metabolic Dysfunction Antioxidant

By Kyle J. Norton

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndromes, you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in a high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.


Most people with metabolic syndrome do not experience any symptoms, until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.

Other risk factors that increased the risk of metabolic syndrome include aging, race, family history, long-term hormone imbalance such as polycystic ovary syndrome (PCOS), gestational diabetes.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of cardiovascular diseases and diabetes, researchers investigated the potential protective effect of β-sitosterol against the development of metabolic dysfunction.
The study included 35 21-day-old female Sprague Dawley rat pups randomly allocated to and administered the following treatments: group 1-standard rat chow (SRC) + plain drinking water (PW) + plain gelatine cube (PC); group 2-SRC + 20% w/w fructose solution (FS) as drinking fluid + PC; group 3-SRC + FS + 100 mg/kg fenofibrate in gelatine cubes; group 4-SRC + FS + 20 mg/kg β-sitosterol gelatine cube (Bst); and group 5-SRC + PW + Bst.

According to the results after 12 weeks of feeding,
* The high-fructose diet group showed an increase of visceral adiposity and plasma triglyceride concentration but decreased (P < .05) plasma adiponectin concentration associated with return cholesterol in the blood.

* β-sitosterol treatment prevented the high-fructose diet-induced visceral obesity, hypertriglyceridemia, and hypoadiponectinemia.

* Furthermore, β-sitosterol alone increased plasma adiponectin concentration and reduced plasma insulin concentration and homeostatic model assessment index.

Based on the results, researchers concluded, "β-sitosterol could be potentially used to prevent high-fructose diet-induced metabolic dysfunction".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of diseases associated with metabolic dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) β-Sitosterol Shows Potential to Protect Against the Development of High-Fructose Diet-Induced Metabolic Dysfunction in Female Rats by Gumede NM1, Lembede BW1, Brooksbank RL1, Erlwanger KH1, Chivandi E. (PubMed)

Antioxidant Ursolic acid Shows a Strong Effect on Muscle Atrophy in Vivo, Researchers Find

By Kyle J. Norton

Muscle atrophy is a condition associated with a lack of physical activity, inducing loss of muscle mass due to the muscles weakening and shrinking.

A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role to process and transmit information.

The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses.

*The motor neurons transmit impulses from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.

* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.

The most common diseases associated with neuron dysfunction are amyotrophic lateral sclerosis (ALS). Lou Gehrig's disease or classical motor neuron disease disrupts signals to all voluntary muscles on both sides of the body.

The most common disease involved in muscle atrophy is amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Amyotrophic lateral sclerosis (ALS) is a type of dementia associated with neurodegeneration syndrome among elders, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment.

Over 47 million worldwide populations are affected by the disease, mostly in the West.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of neurodegenerative diseases, researchers examined the ursolic acid (UA) activity on the alleviation of the deleterious effect of skeletal muscle atrophy on bone health.

According to the analysis of the immobilization (IM) method used on the left hindlimb of Sprague Dawley (SD) rats for 10 days to induce muscle atrophy, divided into two groups, SED (sedentary, n=6) and UA (n=6) to demonstrate the effect of UA on atrophic skeletal muscles.
* Before UA treatment, muscle atrophy was induced and bone mineral density (BMD) decreased significantly in experimental rats.

* The 8-week UA treatment significantly increased the gastrocnemius muscle mass compared to the SED group.

* UA treatment showed negative results of a decrease in BMD, trabecular bone volume fraction, and trabecular number, and an increase in trabecular separation in the SED group.

* No significant difference was observed in atrophic hindlimbs between SED and UA groups.

After talking about other factors into account, researchers said, "These results alone are insufficient to suggest that UA is a potential resistance exercise mimetic for atrophic skeletal muscle and weakened bone. However, this study will help determine the potential of UA as a resistance exercise mimetic".

Taken altogether, ursolic acid, may have an effect on muscle atrophy, pending the confirmation of the larger sample size and multicenter human study.

Intake of ursolic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of ursolic acid on muscle mass and bone microstructure in rats with casting-induced muscle atrophy by Kang YS, Noh EB, Kim SH. (PubMed)

Queen Herb Chaste Tree Berry Shows a Valuable Chemotherapeutic Property for the Treatment of Cancers in Vitros, Researchers Say

Kyle J. Norton.

Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable ways in our body. In the late stage, the cancer cells may travel away from the originated site
to infect other tissues and organs.


According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under a light microscope, flow cytometric analysis, and agarose gel electrophoresis, Vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria(in regulated cell metabolism)-controlled apoptotic pathway".


In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits exerted strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for the treatment of various types of cancer, depending on further evaluation.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF.(PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y.(PubMed)

Coffee and Coffee's Caffeine May Reduce The Risk of Colon Cancer, Researchers Say

By Kyle J. Norton

Good news for coffee drinkers, coffee consumption regularly is associated with reduced risk of colon cancer, a renowned institute study suggested.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

Colon Cancer is a disease characterized by irregular cell growth in the colon, with the tendency in spreading to distant parts of the body, depending on the stage.

According to the Federico II University of Naples, the efficacy of coffee consumption in attenuated risk of the colon may be attributed to its bioactive components, such as polyphenols, melanoidins, carbohydrates, diterpenes,...

Dr. Vitaglione P, the lead author said, " ...metabolism and composition, both coffee chlorogenic acids and dietary fiber, including melanoidins, may reduce CRC risk, increasing colon motility and antioxidant status".

However, phytochemicals found in coffee may be different that depends on the amount and type of compounds ingested with the beverage, the variety of coffee used, the roasting degree, the type of brewing method as well as the serving size.


Additionally, in the investigated the protective action of coffee against Caco-2 human colon carcinoma cells. researchers filed the following results
1. Even with low concentrations, coffee (<5%) inhibited the proliferation of Caco-2 cells without affecting normal cell viability.
2. . Increasing the duration of coffee bean roasting showed a significant in reduction the mutative risk of gene KRAS expression.

3 Coffee reduces risk colon cancer through suppressed miR-30c and miR-96, in promoted cell proliferation, migration and invasion, and enhanced tumor growth.

Interestingly, in the examine of the association between coffee consumption and CRC risk as well as a risk by anatomic subsite among Japanese, using data from the Hospital-based Epidemiological Research Program at Aichi CancerCenter I and II (HERPACC-I and II) with subjects enrolled in HERPACC-I between 1988 and 2000 and in HERPACC-II between 2001 and 2005, scientists found that returned self-administered questionnaire from participants, coffee consumption in reduced risk of colon cancer is associated to numbers of cup intake daily, in compared to non-drinker.

The relative odd ratio of less than 1 cup/day, 1-2 cups/day, and 3 or more cups/day for CRC were 0.88, 0.90, and 0.78 respectively.

Dr. Senda Nakagawa H, the lead author said, " Subsite-specific analysis revealed a significant inverse linear trend between coffee consumption and distal colon cancer (p-trend = 0.048), and a tendency toward a lower risk of rectal cancer (p-trend = 0.068)".

The finding evidence suggested that coffee and coffee caffeine may have a profound effect in reduced risk of cancer linearly.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee, colon function and colorectal cancer by Vitaglione P1, Fogliano V, Pellegrini N.(PubMed)
(2) Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs by Nakayama T1, Funakoshi-Tago M1, Tamura H1.(PubMed)

Healthyfood Eggplants Process Anti-Fibrosarcoma Activity, According to Studies

Kyle J.  Norton

Eggplant may have a potential and substantial effect in reduced risk and treatment of Fibrosarcoma some scientists suggested.

Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Fibrosarcoma is a medical condition characterized by irregular cell growth in the fibrous connective tissue. The tumor can be classified into low grade, intermediate malignancy, and high malignancy, depending on different degrees of differentiation:

In the investigation of eggplant (Solanum melongena var. marunasu) extract activity on human fibrosarcoma HT-1080 cell lines, researchers at the Gifu Pharmaceutical University found that delphinidin, a flavonoid pigment-containing in the peel, do not affect tumor cell cells interact and attach to a surface, substrate or another cell to the basement membrane matrix Matrigel (MG) to initiate the tumor cells proliferation or migration, but modulated the expression of matrix metalloproteinase(MMP)-2 and MMP-9 secreted by the tumor cell, thus reducing the risk of the matrices in stimulated cancer cell growth and tumor expansion.

Basement Membrane Matrix is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma.

The function of matrix metalloproteinase(MMP)-2 and MMP-9 are to degrade the extracellular matrix (ECM) which plays essential role in collection of extracellular molecules secreted by support cells to provide structural and biochemical support to the surrounding cells.

In vivo, the basement membrane matrix Matrigel (MG) has been used to measure the angiogenic inhibitors and stimulators, repair damaged tissues, and increase tumor growth in some cancer experiments.


Further differentiation of delphinidin in cancer risk insisted that the chemical constituents also restained cancer cell invasion through reduced expression of inhibited serum- and vascular endothelium growth factor(VEGF) in induction of making new blood vessel to provide nutrients and oxygen for proliferation and cancer progression.

Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis, associated with unfavorable clinical characteristics by promoting proliferation secreted by various human cancers.
Moreover, researchers also indicated that the efficacy of anti-cancer cell activity of delphinidin was attributed to the function of phytochemical in triggering extracellular signal-regulated kinases (ERKs) in regulated cancer cell cycle division, including meiosis, mitosis, and post mitosis.


In-depth analysis also discovered that delphinidin isolated from eggplant also activated the independence of nitric oxide pathway in suppression of cancer cell progression by initiated cell cycle arrest in the G(0)/G(1) phase.

Interestingly, gallic acid and anthocyanins, the bioactive chemical constituents isolated from eggplant and other fruits and vegetables in the study of human fibrosarcoma HT-1080 suggested that injection of gallic acid and anthocyanins derivative delphinidin-3-glucoside demonstrated significant activity in the induction of cell apoptosis through cytotoxicity.


According to the Zymographic analysis, gallic acid exerted the anti-cancer cell growth and tumor invasiveness through inhibited the secretion and activation of gelatinase proteases in breaking down protein into its building blocks, amino acids of MMP to activate cancer progression and metastasis by the tumor.

In humans, gelatinases are expressed by matrix metalloproteinases MMP2 and MMP9.
Importantly, gallic acid also ameliorated cancer progression through inhibition of the matrix metalloproteinase(MMP)-2 and MMP-9 same as the effectiveness as delphinidin involved in the anti-angiogenetic activity.


Taken together, eggplant with abundant bioactive chemical compounds such as gallic acid and anthocyanins may be used as a functional food for reduced risk and treatment of fibrosarcoma, depending to further investigation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcomaHT-1080 invasiveness in vitro by Nagase H1, Sasaki K, Kito H, Haga A, Sato T.(PubMed)
(2) Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2 by Martin S1, Favot L, Matz R, Lugnier C, Andriantsitohaina R.(PubMed)
(3) Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action by Filipiak K1, Hidalgo M, Silvan JM, Fabre B, Carbajo RJ, Pineda-Lucena A, Ramos A, de Pascual-Teresa B, de Pascual-Teresa S.(PubMed)

Beetroots Inhibit the Early Onset of Insulin Resistances and Type 2 Diabetes, Researchers Say

Beet juice containing phytochemicals may alter postprandial glucose and insulin responses in prediabetics, some scientists suggested.

Insulin resistance, a condition of not providing enough insulin to counter the rise of blood glucose is considered as the early progression of onset of diabetes.

According to The American Diabetes Association (ADA), people with insulin resistance and prediabetes are associated with the early onset of type 2 diabetes as a result of unhealthy diet and physical inactivity.


And, 150 million people worldwide and 43 million people in the US are currently suffered from type 2 diabetes mellitus or metabolic syndrome.

In broader terms, insulin resistance is considered a major factor that can lead to type 2 diabetes, gestational diabetes, and prediabetes.


The actual cause of insulin resistance is debatable, some researchers suggested genetic mutation, aging and ethnicity play important roles in the development of insulin sensitivity, And people such as obesity, excess body weight, high blood cholesterol, and pressure, too much belly fat, a lack of exercise, smoking are susceptible to increase risk of insulin resistance.

More importantly, untreated insulin resistance may also increase the risk of abnormal skin conditions, known as acanthosis nigricans with dark, velvety patches.

According to Dr. Wallace IR, the lead author in the study of "Dose-response effect of fruit and vegetables on insulin resistance in people at high risk of cardiovascular disease: a randomized controlled trial", of 105 participants (mean age 56 years) followed a 4-week washout diet, some class of vegetables and fruits may have particular antidiabetic properties.

Therefore, the selection of such classes and types of vegetables and fruits may be good interventions in prevented diabetes in patients with insulin resistance or higher risk of diabetes.


Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belongings to the amaranth family,

Investigation of the efficacy of beet in ameliorated risk of insulin resistance may be associated different aspects involved numbers of mechanisms.

In a total of sixteen healthy individuals recruited, with consumed test meals in a controlled single-blind cross-over design including beet juice, researchers found that such meals exert a remarkable in countering the glucose uptake.

Additionally, the tested subject also showed a significant lowering of the postprandial insulin response in the early phase and a significantly lower glucose response in the 0–30 min phase, in compared to control fed with control beverage matched for macronutrient content (MCON).

Further analysis indicated that beet juice attenuated the rise of glucose in the bloodstream may be attributed to constituents of
* Betacyanin betalain pigments which process anti glucose uptake and insulin resistance in patients with diabetes and other metabolic diseases

* Phytochemical polyphenols in stimulated insulin secretion and reduced hepatic glucose output by inhibited α-amylase, α-glucosidase, and glucose absorption in the intestine.

α-Amylase is a protein enzyme having a function to convert hydrolysis of starch into sugars.

α-glucosidase is glucosidase in the small intestine with the function to break down starch and disaccharides to sugars.

Moreover, in the homeostasis model assessment-insulin resistance index, dietary nitrate from beet juice also demonstrated a strong effect in lowering insulin resistance in test subjects. compared to control through regulation of glucose homeostasis and insulin signaling pathway.

Dietary nitrate from beet juice also improved lipid homeostasis, inflammation, and endothelial function.

Dr. Peter C, the lead researcher said, "Betalains, polyphenols and dietary nitrate found in the beetroot juice may each contribute to the observed differences in the postprandial insulin concentration".

Interestingly, in comparison the effect of ingredients of combined 100 ml black tea, beetroot juice or control (water) in 16 obese, insulin-resistant males, researchers revealed that beetroot juice plus black tea treated groups exhibited a decreased postprandial peripheral vascular resistance (VR) in resistance vessels, but lesser than black tea, in compared to other groups.

According to further examination, the efficacy of beet juice and black tea in attenuated insulin resistance was attributed to increased postprandial blood flow in induced glucose disposal and decreased postprandial insulin response by 29 %...

Truly, standardized breakfasts with or without beet-fiber given, in random order, to non-insulin-dependent diabetics study, found that beet fiber intake individuals expressed a strong effect in rate of glucose decrease after the meal. with the blood glucose levels monitored continuously and hormonal responses determined at regular intervals for 3 hr.

Both tested subjects did not exert notable differences with regard to the plasma levels of insulin, C-peptide or glucagon in regulated levels of blood glucose,

C-peptide is a substance involved in proinsulin molecules produced by the beta cells in the pancreas.

The collective findings may provide footage of using beet juice as a functional food in ameliorated the risk of insulin resistance and prevented the early onset of type 2 diabetes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteer by Peter C. Wootton-Beard,1 Kirsten Brandt,2 David Fell,3 Sarah Warner,1,2 and Lisa Ryan1,4,*(PMC)
(2) Impact of flavonoid-rich black tea and beetroot juice on postprandial peripheral vascular resistance and glucose homeostasis in obese, insulin-resistant men: a randomized controlled trial by Fuchs D1, Nyakayiru J2, Draijer R1, Mulder TP1, Hopman MT2, Eijsvogels TM2, Thijssen DH3.(PubMed)
(3) Reduced glycemic response to beet-fibre meal in non-insulin-dependent diabetics and its relation to plasma levels of pancreatic and gastrointestinal hormones by Hagander B, Asp NG, Efendić S, Nilsson-Ehle P, Lungquist I, Scherstén B.(PubMed)
(4) Purified Betacyanins from Hylocereus undatus Peel Ameliorate Obesity and Insulin Resistance in High-Fat-Diet-Fed Mice by Song H1, Chu Q1, Xu D1, Xu Y1, Zheng X1.(PubMed)
(5) Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications by Bahadoran Z1, Ghasemi A2, Mirmiran P3, Azizi F4, Hadaegh F5.(PubMed)
(6) Dose-response effect of fruit and vegetables on insulin resistance in people at high risk of cardiovascular disease: a randomized controlled trial by Wallace IR1, McEvoy CT, Hunter SJ, Hamill LL, Ennis CN, Bell PM, Patterson CC, Woodside JV, Young IS, McKinley MC(PubMed)