Omega 3 Fatty Acid Promotes Myocardial Ischemia-Reperfusion in Vivo

By Kyle J. Norton

Compared to acute brain infarction that is the medical condition characterized by the obstruction of the blood supply to the brain, causing local death of the brain tissue. The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

Myocardial ischemia injury is a medical condition caused by severe impairment of coronary blood supply induced damage or dysfunction of the cardiac tissue.

Myocardial reperfusion is the process to restore the coronary blood flow after a period of coronary blockage that leads to severely reduced or no oxygen .blood flow to the heart.

The condition severity is totally dependent on the intensity and duration of the coronary occlusion.

According to the statistics from the WHO, in 2008, 12% of all death or approximately 7,254,000 deaths worldwide have directly or indirectly caused by myocardial ischemia injury.

Atherosclerosis, one of the major causes of cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing the arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.

Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.

Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.

Coronary heart disease causes 1/4 total death in the worldwide population and 50% of the death associated with other forms of heart disease.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of post-stroke, researchers examined the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury.

The study included 60 Sprague-Dawley rats that were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model.

* The sham group received continuous perfusion of 150 min.

* The remaining three I/R-treated groups sequentially received 30-min perfusion, a 30-min cardioplegia, and 90-min reperfusion.

* The I/R-ischemic preconditioning (IP) group additionally received three cycles of 20-s reperfusion and 20-s coronary re-occlusion preceded the 90 min of reperfusion.
* The I/R-ω group were perfused with ω-3 PUFAs for 15 min before the 90 min of reperfusion.

According to the results of the study,
* Compared with the I/R group, the I/R-ω group had significantly reduced myocardial infarct size, reduced levels of lactate dehydrogenase and malondialdehyde associated with cardio-stress markers.

* Furthermore, Omega 3 fatty acids elevated superoxide dismutase level involved in antioxidant production and elevated rising (+dp/dtmax) and descending (-dp/dtmax) rate of left ventricular pressure against myocardial ischemia-injury. 

* Moreover, The I/R-ω group had a significantly lower rate of mitochondrial damage in myocardial tissue compared with the I/R and I/R-IP groups.

In other words, Omega-3 fatty acids protect the heart tissues and muscles against damage after stroke.

Moreover, researchers said, " ω-3 PUFA postconditioning possesses good cardioprotective effects and may be developed into a therapeutic strategy for myocardial I/R injury".

Taken altogether, Omega-3 fatty acids may be considered a remedy for the treatment of myocardial ischemia injury, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury by Zhang FW1, Tong J1, Yan YS1, Chen QQ1, Zhao XP. (PubMed)

Fermented Soy Processes Anti Inflammatory Cytokines Release

By Kyle J. Norton

Inflammation is a natural immune response involving the stimulated production of pro-inflammatory activity with a target to protect our body against foreign invasions such as virus and bacteria after injury and damage.

In the acute phase of infection, the immune white blood cells in the first line of defense stimulating the blood vessel constriction and palette accumulated to the injury area to cover the wound and the proteins associated with the production of the pro-inflammatory cytokines to kill off the invasive microorganisms.

In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.

However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.

Chronic inflammation is a medical disease caused by the immune inability to destroy the invaders in the acute phase of infection, leading to the immune system in the adaption of the change.

Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.

In other words, pro-inflammatory cytokines are activated through systematic immune response to the damage cells which release chemicals including histamine, bradykinin, and prostaglandins to protect the injure area or location against infection, leading to blood vessels to leak fluid into the tissues, causing swelling and other symptoms such as pain, swelling, and redness.

However, in most cases, over-response of the immune system can lead to over expressions of certain pro-inflammatory cytokines, depending on the injured location such as Interleukin (IL)-1 and tumor necrosis factor (TNF) which can lead shock and death of healthy cells in the infectious location.

In most cases, long-term overexpression of pro-inflammatory cytokines can lead to chronic inflammatory disease as the immune system no longer can kill the invasive agents and heal the damage caused by acute infection.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant that processes anti-inflammatory activity researchers examined the effect of health benefits of QCAN® Plus-an easily available fermented soy drink.

The study included lean (n = 10) and obese (n = 10) subjects, during pre-soy (weeks -2, -1, and 0), on-soy (weeks 1, 2, 3, and 4), and post-soy (weeks 6, 8, 10, and 12) periods.

According to the results of the analysis,
* The lipid peroxidation associated with total cholesterol and low-density lipoprotein (LDL) cholesterol levels were significantly reduced in both lean and obese individuals during on-fermented soy treatment.

* Cytokines associated with inflammation such as platelet-derived growth factor (PDGF) AA and AB/BB were significantly lowered on-soy compared with pre-soy (P ≤ .05) in lean subjects.

* PDGF AA, IL-1RA, and GMCSF associated with insulin resistance, lipoperoxidation and inflammation were significantly reduced on-soy (P ≤ .05) in obese subjects, respectively.

* Q-CAN Plus was safe.

Collectively, researchers said, "Q-CAN Plus ensures its safety for consumption and highlights its hypolipidemic and suppressive effect on certain cytokines".

Taken altogether,  QCAN®  may be considered a functional food for the prevention of the initiation of cytokines, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermented Soy Beverage Q-CAN Plus Consumption Improves Serum Cholesterol and Cytokines by Arumugam S1, Dioletis E1, Paiva R1, Fields MR2, Weiss TR2, Secor ER3, Ali A, (PubMed)

Dandelion(Taraxacum officinale), the Potential Antimicrobial Remedy

By Kyle J. Norton

Microbial organisms refer to microscopic organisms that exist as unicellular, multicellular, or cell clusters.

Microorganisms are widespread in nature and are beneficial to life, and most of them are unharmful to humans.

Antimicrobial activity is an action that kills microorganisms or stops their growth. In humans, these actions are carried out daily by the immune system.

Infection is a processive condition caused by the battle of the invasion of microorganisms and the host immune white blood cells. Microorganism during the battle might produce toxins which can lead to the initiation of infection-related transmissible disease or communicable disease.

In acute infections, the systematic immune system responds properly to the invasive pathogen, leading to a brief battle after which the immune system is always victorious.

However, chronic infections occur when the immune cannot kill off the invasive stimuli in the acute phase of infection, leading to chronic infectious diseases.

The most common diseases associated with microbial infection include

* Diseases caused by bacteria are totally dependent on the types of bacterias, such as pneumonia, caused by Streptococcus and Pseudomonas, and foodborne illnesses caused by bacteria such as Shigella, Campylobacter, and Salmonella.

* Diseases caused by the virus include smallpox. the common cold and different types of flu. measles, mumps, rubella, chicken pox, and shingles. hepatitis. herpes and cold sores. polio. rabies, Ebola and Hanta fever.

* Diseases caused by parasites are malaria, trichomoniasis, giardiasis, cryptosporidiosis, and toxoplasmosis.

* Diseases caused by fungi aspergillosis usually occurs in patients with lung diseases or weakened immune systems and Candidiasis is caused by the yeast Candida.

Depending on the types of microbial infection, most common symptoms are fever, diarrhea, fatigue, muscle aches, and coughing 

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the Taraxacum officinale, for the synthesis of silver nanoparticles (TOL-AgNPs) anti-microbial activity, ranging between 5 and 30 nm, with an average particle size of about 15 nm.

According to the tested differentiation, the TOL-AgNPs (at 20 μg/mL concentration) showed significant antibacterial activity with significant growth inhibition of phytopathogens X. axonopodis (22.0 ± 0.84 mm) and P. syringae (19.5 ± 0.66 mm).

Furthermore, the synthesized AgNPs had higher antibacterial activity in comparison with commercial AgNPs.

Moreover, nanoformulations with tetracycline showed better broad-spectrum efficiency to control phytopathogens.

Most importantly, AgNPs also possessed significant antioxidant potential and The TOL-AgNPs showed a high cytotoxic effect against human liver cancer cells (HepG2).

Based on the results, researchers suggest, "dandelion-mediated AgNPs synthesis can represent a novel approach to develop effective antimicrobial...drugs with a cheap and eco-friendly nature.".

Taken altogether, Dandelion may be considered a remedy for the protection against microbial infection, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens by Saratale RG1, Benelli G2,3, Kumar G4, Kim DS5, Saratale GD. (PubMed)

Broccoli' SFN Protects the Lung Against Lung Cancer in Vitro

By Kyle J. Norton


The lung formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.

Additionally, the lung also processes other ability in protecting our body against disease, including
* By balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.

* By removing small blood clots the lung protects the body against the forming air embolisms.

* The airflow produced by the lung also help us to speak.

* The lung also protects the infection through the secretion of immunoglobulin A.

Any part of the lung injury can reduce lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

Lung cancer is a chronic and medical condition characterized by abnormal growth of the cells in the lung's tissue.

A most common form of primary lung cancer is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

According to the statistics provided by the American cancer society, lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of cancer, researchers examined the chemopreventive role of SFN through the inhibition of histone deacetylase (HDAC) associated with regulation of DNA expression, in two different lung cancer cells by in vitro and in vivo mouse models.

According to the experimental results from A549 and H1299 lung cancer cells were treated with SFN for 48h,

* SFN inhibited HDAC activity and increased the levels of acetylated histones H3 and H4 involved in cell death in all two lung cancer cells.

* Furthermore, SFN induced cancer cells apoptosis, increased the accumulation of cells at G0/G1 and G2/M and arrest cells at S phase.

* Moreover, SFN also suppressed lung cancer growth in a xenograft mouse model in vivo.

Based on the results, researchers wrote, " the chemopreventive effect of SFN is associated with inhibition of HDAC activity, thereby attenuating lung cancer growth. Therefore, these findings suggest that SFN may be a therapeutic agent for lung cancer through the inhibition of HDAC".

Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity by Jiang LL1, Zhou SJ1, Zhang XM2, Chen HQ2, Liu W. (PubMed)

Angelica Sinensis Processes Anti-Apoptotic and Anti-Inflammatory Effects

By Kyle J. Norton


Apoptosis is a process to induce the death of cells formed part of human normal and controlled growth or development.

In other words, in normal cells, apoptosis is an orderly process that occurs during development and aging and as a homeostatic mechanism to maintain cell populations in tissues.

Cancer cells prevent the process of efficiently eliminate dysfunctional cells.

More precisely, defective apoptotic (programmed cell death) genes represent a major causative factor in the development and progression of cancer and enhanced apoptosis may cause degenerative diseases.

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, DNA damage.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

On finding a natural ingredient for the prevention and treatment of cancers, scientists examined the Chinese angelica polysaccharide (CAP), the main effective ingredient of angelica sinensis anti-inflammatory and anti-apoptotic effects.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the PC12 cells were pretreated by CAP and were subjected to LPS,
* LPS stimulation induced significant cell damage in PC12 cells.

* LPS stimulation also induced cell apoptosis and increased the expression of pro-inflammatory proteins such as IL-1β, IL-6, IL-8, and TNF-α.

* CAP pretreatment not only protected PC12 cells against LPS-induced cell damage but also reduced the expression of COX-1 even in LPS-stimulated PC12 cells.

* Interestingly, COX-1 overexpression abolished the protective effects of CAP on LPS-injured PC12 cells.

* Moreover, CAP activated PI3K/AKT pathway associated with the regulation of cell cycle in a COX-1-dependent manner.

Based on the results, researchers suggest, "CAP exerted anti-apoptotic and anti-inflammatory effects on LPS-injured PC12 cells via down-regulation of COX-1".

Taken altogether, Dandelion may be considered an antioxidant remedy which processes anti-apoptotic and anti-inflammatory effects, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chinese Angelica Polysaccharide (CAP) Alleviates LPS-Induced Inflammation and Apoptosis by Down-Regulating COX-1 in PC12 Cells by Xie Y, Zhang H, Zhang Y, Wang C, Duan D, Wang Z. (PubMed)

Herbal Elder (Sambucus) Promotes Neuronal Survival and Neuritogenesis in Neurological Diseases

By Kyle J. Norton

A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role in the process and transmit information.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

Other risk factors associated with the disease prevalence are the increase in age, the most consistent risk factor for developing a neurodegenerative disease, especially AD or PD, as the disease has been found over 60% in the population aged 65 and beyond compared to another group.

Neuritogenesis, the process of new neurites were formed that develop into axons and dendrites, plays a critical role to influence neural functions and reduce the risk of neurodegenerative diseases.

On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of peptides mimicking α2,6-sialyllactose (6'-SL) on neural functions.

A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.

The progressive loss of neurons induced neurological and neuropsychological signs and symptoms have also been found in comparison to the stage of disease onset of patients.

Elder or Common Elder, is a shrub or small tree of the genus Sambucus of 30 species, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere.

The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

According to tested analysis,
* The mimetic peptide frequently inhibited the lectin binding to 6'-SL.
* The mimetic peptide, increased viability, and expression of neural cell adhesion molecule L1 in SK-N-SH human neuroblastoma cells.

* Additionally, the mimetic peptide also promoted survival and neurite outgrowth of cultured mouse cerebellar granule neurons challenged by H2O2-induced oxidative stress.

These results strongly suggested that 6'-SL mimetic peptide promotes neuronal survival and neuritogenesis.

Based on the results, researchers suggest, "(These results indicated) raising hopes for the treatment of neurodegenerative diseases. This study was approved by the Medical Ethics Committee of Shantou University Medical College, China (approval No. SUMC 2014-004) on February 20, 2014".

Taken altogether, Elder lectin, which specifically binds to 6'-SL may be considered a remedy for the treatment of neurological diseases, pending to the confirmation of the larger sample size and multicenter human study.Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A mimetic peptide of α2,6-sialyllactose promotes neuritogenesis by Chen SX1, He JH2, Mi YJ3, Shen HF2, Schachner M4, Zhao WJ. (PubMed)

Beta-Sitosterol Improves The Liver and Kidney Functioning in Hypertensive Rats in Vivo

By Kyle J. Norton

Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.

Hypertension or high blood pressure is a condition characterized by persistently or abnormally high blood pressure that leads to raising the pressure in your heart.

It also is a member of the cluster of metabolic syndrome associated with the risk of diabetes and cardiovascular disease.

High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.

If the pressure stays high over time it can cause hardening and stiffening arterial wall,, a major risk factor of heart diseases.

The ideal blood pressure is more than 120 over 80 and less than 140 over 90 (120/80-140/90), according to the consensus.

In the US approximately, one-third of the adults have high blood pressure, affecting over 77 million people in the country.

Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.

High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress or intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.

Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.

 If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of metabolic syndrome, researchers compared the effects of β-sitosterol (BSS) and lisinopril, antihypertension in rats.

According to the tested analysis of rat groups induced hypertension by cadmium chloride treated by BSS and lisinopril, 

* BSS showed a significant decrease (p<0.05) in the serum creatinine concentration, compared to hypertensive rats.

* Lisinopril treatment showed a significant increase (p<0.05) in the activity of oxidative stress markers AST and ALP, compared to normal rats.

* Treatment of with BSS and lisinopril showed slight variations in the concentration of serum electrolytes compared with normal and hypertensive rats.

* BSS significantly reduced calcium levels compared with the hypertensive group in the activation of oxidative stress.

Based on the findings, researchers said, "The study shows that BSS is effective in restoring basal liver and kidney functions in hypertensive rats.

Taken altogether, beta-Sitosterol may be considered a supplement for the protection of liver and kidney functioning, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ameliorative effects of β-sitosterol on some biochemical indices of hypertension in wistar albino rats by Olaiya CO1, Esan AM1, Alabi TD. (PubMed)