Herbal Bilberry, the Anti-Obesity Functional Food in Animal and Human Study

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy that visceral fat accumulation in obesity, according to studies.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.

Obesity is a medical condition caused by excess body fat accumulated to an extent that impact personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.

Dr. Maximilian Tremmel, the lead scientist in the investigation of economic burden in obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision makers" and "there was great variety in the included obesity-related diseases and complications among the studies".

And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".

The findings strongly suggested the widespread obesity has caused a significant pressure in the public health care system and impact in the financial and economic burden.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.


The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.

During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but in a lesser extent compared to aronia phytochemicals.

Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.

Bilberry lowered the mesenteric adipose tissue mass.

Bilberry also exerted the equivalently inhibited the increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.

The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity through suppressing the visceral fat accumulation and hyperglycemia.

In order to reveal more information about bilberry anti-obesity property, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.

Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.

The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids.

According to the urinary assay, the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.

In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.

Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.

The findings suggested that flavonoid-rich supplement may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma and considered a measurement of obesity and health beyond BMI.

Taken altogether, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


 Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)

Herbal Ginger, The Anti Asthma Functional Food

By Kyle J. Norton


Asthma is a medical and chronic condition characterized by the long-term inflammation of the airways of the lungs.

Besides episodes of wheezing, coughing, chest tightness, and shortness of breath, patients with asthma also experience symptoms of reversible airflow obstruction and bronchospasm.

Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.

Asthma in some cases can interfere with daily activities and may lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episode and severity of the attacks.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.

Believe it or not, African-Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.

Some researchers suggested that people who follow the Western diet pattern are at a substantially higher risk of asthma.

Dr. Laurent Guilleminault, the lead scientist said, "Asthma is a chronic respiratory disorder which is associated with airway inflammation. Environmental factors, in association with genetic susceptibility, play a critical role in asthma pathophysiology" and "some dietary patterns, such as the Western diet, which includes a high intake of refined grains, processed and red meats, and desserts, have pro-inflammatory effects".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound or whole food for the treatment of asthma, researchers investigated the immunosuppressive activity of ginger by using the mouse model of ovalbumin-induced allergic asthma.

Selected mice were treated with ethanol extract (500 mg/kg) and aqueous extract (720 mg/kg) of rhizomes, and methylprednisolone (5 mg/kg) which was initiated 1 week after second sensitization with ovalbumin and continued for 7 days.

Treated mice showed a significant reduction in goblet cell hyperplasia, infiltration of inflammatory cells in airways, and edema with vascular congestion associated with asthma attacks.

Both ginger ethanol and aqueous extracts exerted a strong effect in modulating the immune response observed by a significant reduction of total and differential count of eosinophils and neutrophils.

Ginger efficacy in the modulation of immune over-response by inhibiting Th2 accompanied by the decrease of levels of proinflammatory cytokines and total serum IgE levels.

Dr. Khan AM, the lead scientist said, "Our study validated the traditional use of ginger in respiratory disorders and suggests that ginger reduces allergic airway inflammation, possibly by the suppression of Th2-mediated immune response".

In order to reveal more information about the ginger anti-asthmatic property, researchers evaluated ginger inflammatory properties in a mouse model.

In vivo, ginger can exert the functions in the inhibition of Th2-mediated pulmonary inflammation observed by reducing levels of proinflammatory and IL-4, IL-5 and IgE expressions.

Similar to the aforementioned study, intraperitoneal injections of the extract on ovalbumin (OVA)-sensitized mice resulted in a marked decrease in the recruitment of eosinophils to the lungs.

The efficacy of ginger extract that suppressed eosinophilia in a mouse model of inflammation was attributed to [6]-gingerol, a major constituent of ginger.

Dr. Ahui ML, the lead scientist, after taking other factors into account wrote in the final report, "This is the first evidence that ginger can suppress Th2-mediated immune responses and might thus provide a possible therapeutic application in allergic asthma".

Take all together, ginger processed bioactive compound 6-gingerol may be considered a functional alternative for the treatment of asthma and asthmatic attacks, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response by Khan AM1, Shahzad M, Raza Asim MB, Imran M, Shabbir A. (PubMed)
(2) Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation by Ahui ML1, Champy P, Ramadan A, Pham Van L, Araujo L, Brou André K, Diem S, Damotte D, Kati-Coulibaly S, Offoumou MA, Dy M, Thieblemont N, Herbelin A. (PubMed)
(3) Diet and Asthma: Is It Time to Adapt Our Message? by Laurent Guilleminault,1 Evan J. Williams,1 Hayley A. Scott,1 Bronwyn S. Berthon,1Megan Jensen,2 and Lisa G. Wood. (PMC)

Herbal Turmeric, the Potential and Natural Neuroprotective Remedy

By Kyle J. Norton

Scientists may have found a herbal spice which processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.

Neuroprotection an action involved the use of a natural substance to protect the integrity and viability of neurons against damage or death.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neuron in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neuro-degenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease.

The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function. 

There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer or a stroke in the brain.

A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.

Out of many factors, some researchers suggested that the prevalence of obesity may process some negative implication in stimulating the rise of neurodegenerative disease in older adults in the Western world.

Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".

And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".

The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural compound which processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.

The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.

Compared to ECAs as the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase of the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.

In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted a better neuron-protective and antioxidant activity than of ECAs.

Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.

The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.

Based on the finding, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".

In order to reveal more information about turmeric neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.

This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, group 2 received 6 mg/kg nicotine. Groups 3, 4, 5 and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40 and 60 mg/kg i.p. respectively) for 21 days.

According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced the nicotine-induced motor activity disturbances.

Before injection of curcumin nicotine treatment showed the increase of lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron-apoptosis in the hippocampus.

Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.

Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress and inflammation; and elevating the levels P-CREB and BDNF associated with the improvement of cognitive function,

Taken altogether, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neurons integrity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)

Cucurbitacins (CuB) Isolated from Cucumber Processes Both Antioxidant and Cytotoxic Activity

By Kyle J. Norton

Antioxidants are atoms that inhibit oxidation.

Cytotoxicity is an action that kills cancer cells by inducing toxin to the cells.

Antioxidant activity is an action in which the stable atoms inhibit the expression of free radicals including antioxidants with free radical scavenging properties.

In other words, an antioxidant produced by the host or from dietary source balances the levels of free radicals produced by the cellular metabolism and from outside of our body.

In a healthy individual, antioxidant enzymes produced by the body are good enough to counter the expression of free radicals. However, in people with a weakened immune system such as elderly, intake of antioxidant supplements may be necessary.

Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.

Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.

Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cells and lipid damage, leading to alteration of cell DNA.

Diseases associated with oxidative stress include atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation,... and stroke.

Risk of oxidative stress can be reduced by lifestyle change and moderate exercise.

Dr. Tameko Kihira, the lead scientist in the correlation of lifestyle and oxidative stress in patients with amyotrophic lateral sclerosis (ALS) wrote, "Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles was associated with high contents of transition metals, such as Mn, Al, and V, in the scalp hair".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural and potential ingredient for the treatment of disease associated with oxidative stress, researchers investigated the effect of Cucurbitacins (CuB), a major bioactive compound found in cucumber.

According to the antioxidative analysis, Cucurbitacins (CuB), not only showed significant scavenging free-radicals activity such as hydroxyl radical, superoxide anions and singlet oxygen but also inhibited the lipid peroxidation and oxidation.

In other words, CuB protected cells integrity by inhibiting the free radical expression before they can induce a chain of reaction to cause oxidative stress to the tissues and organs. 

Furthermore, Cub also processes anti-inflammatory and analgesic properties by modulating the immune response against the production of proinflammatory cytokines in facilitating the cellular and lipid damage and DNA alternation.

In the growth of four NSCLC cells (H1299, A549, HCC-827, and H661) Cucurbitacin B (CuB) inhibited cancer cell proliferation by altered the actin cytoskeletal assembly in the cell by cell cycle arrest and mitochondrial apoptosis.

Cucurbitacin B (CuB) inhibited the antioxidant activity produced by the cancer cells by significantly decreasing levels of protein thiols and GSH/GSSG ratio.

In other words, CuB causes the cancer cell apoptosis by inducing cytotoxicity through disrupting the cancer cellular redox balance.

The results strongly suggested that on one hand, CuB killed cancer cells through its cytotoxic by inducing overexpression of free radicals and on the other hand CuB protected the healthy cells against cytotoxic damage through its antioxidant property.

Taken altogether, cucumber processed abundantly bioactive compound CuB may be used for the treatment of diseases associated with oxidative stress and cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Search for a novel antioxidant, anti- inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba, and Olayinka Oridupa. (Research Gate)
(2) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(3) Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan by Tameko Kihira,1 Kazushi Okamoto,2 Iori Sakurai,1 Yuya Arakawa,1 Ikuro Wakayama,1Koichi Takamiya,3 Ryo Okumura,3 Yuhto Iinuma,3 Keiko Iwai,4 Yasumasa Kokubo,5 andSohei Yoshida. (PMC)

3,3'-Diindolylmethane Eradicates Ovarian Cancer in Vitro

By Kyle J. Norton


Ovarian cancer is the medical and chronic condition characterized by irregular cells growth in the tissues found either in at the tail ends of the fallopian tubes or the ovaries.

According to the statistics provided by the American Cancer Society, ovarian cancer is one of the dealy reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.

The lifetime risk of a woman getting ovarian cancer is 1/78 compared to the lifetime dying risk of 1/108.

The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, acquired genetic mutation such as TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.

Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvis area, changes in bowel habits, such as constipation. and a frequent need to urinate.

In seeking a natural product which processes anti-ovarian cancer property, researchers examined the effects of 3,3'-diindolylmethane (DIM) on ovarian cancer cell viability, invasion, and sensitivity to chemotherapy.

According to the final results obtained by the ovarian cancer SKOV3 and A2780 cell lines treated by the 3,3'-diindolylmethane (DIM), DIM treatment not only potently suppressed the viabilities of ovarian cancer cells but also inhibited xenograft growth in nude mice.

Furthermore, according to the gene analysis, DIM inhibited phosphorylation of STAT3 and AKT proteins and proteins activated by STAT3 and AKT involved in cell growth and division and cell movement in the ovarian cancer SKOV3 and A2780 cell lines 

Moreover, DIM inhibited the production of protein and genes associated with the production of a new blood vessel for the cancer cells to growth, promotion of cancer cell survival and anti-apoptosis.

Additionally, in order to obtain more information about DIM anti-ovarian cancer effects, researchers examined the phytochemical activity on Interleukin (IL6) which has been found to be a major contributor to the initiation and progression of ovarian cancer.

During the experiment, human ovarian carcinoma-derived cell lines SKOV3 and A2780 treated with IL6 and/or DIM and subjected to in vitro proliferation, DIM inhibited the increase of ovarian cancer cell adhesion, migration, and invasion caused by the administration of IL-6 through deactivated the expression of protein STAT3  similar to that of the aforementioned study.

Importantly, DIM induced ovarian cancer cells apoptosis associated with the inhibition of the expression matrix metalloproteinases MMP-2 and MMP-9 associated with the pathologic relationship to cancer.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo by Zou M1, Xu C2, Li H3, Zhang X4, Fan W. (PubMed)
(2) IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells by Zou M1, Zhang X2, Xu C. (PubMed)

Herbal Bilberry Reduces Risk of Macular Degeneration

By Kyle J. Norton


Macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macula.

Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.

The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.

There are 2 forms of macular degeneration
1. The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.

2. The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.

Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.

Although aging is one the prevalent risk of the macular degeneration onset, smoking, family history, gender, ethnicity and long-term exposure to the sun and genetic preposition are also some factors may facilitate the early onset of the condition.

Some researchers suggested that macular degeneration may also be caused by an unhealthy diet.

Dr. Chung-Jung Chiu, the lead scientist in the analysis of the relationship of major American dietary patterns to age-related macular degeneration wrote, " (In the comparison of the 2 diets pattern) The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".

"For early AMD, multivariate-adjusted odds ratio (OR) from generalized estimating equation logistic analysis comparing the highest to lowest quintile of the Oriental pattern score was ORE5O=0.74 (95% confidence interval (CI): 0.59–0.91; Ptrend=0.01), and the OR comparing the highest to lowest quintile of the Western pattern score was ORE5W=1.56 (1.18–2.06; Ptrend=0.01). For advanced AMD, the ORA5O was 0.38 (0.27–0.54; Ptrend<0.0001), and the ORA5W was 3.70 (2.31–5.92; Ptrend<0.0001)".

These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.


The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Searching the list of natural compounds for the treatment of vision decline, scientists examined anthocyanins, bioactive compounds found in bilberry are known to have antioxidant, anti-inflammatory, on macular degeneration.

Bilberry anthocyanosides (Vaccinium myrtillus L.), according to the differentiation was found to promote rhodopsin synthesis and regeneration, thus increasing the retinal sensitivity to changes in light intensity and visual acuity and dark adaptation.

The bioactive compound also was found to the promoted blood supply of the retina in the prevention of macular degeneration due to aging-induced death of macula cells.

Where rhodopsin is the pigment-containing sensory protein that converts light into an electrical signal for vision in dim light 

The improvement of the visual function by bilberry may have a strong effect against age-related macular degeneration, Dr. Vorob'eva IV, the lead scientists suggested.

Additionally, with an aim to reveal more information of bilberry anti gradual loss of vision, researchers investigated the changes in clinical, functional, and morphological parameters of the retina in type 2 diabetes patients with diabetic retinopathy (DR) and those with combined fundus pathology (DR plus age-related macular degeneration). 

The study included 180 patients (180 eyes) with type 2 diabetes divided into 6 groups of 30 each randomly assigned into group 1 consisted of patients with DRO,; group 2--DR1 without DM, group 3--DR1 with DM, group 4--DRO and "dry" AMD (AREDS 1-3), group 5--DR1 with no DM but with AMD (AREDS 1-3), and group 6--DR1 with DM and AMD (AREDS 1-3). 

A drug containing lutein 6 mg, zeaxanthin 0.5 mg, vitamin C 60 mg, vitamin E 7 mg, vitamin A 1.5 mg, vitamin B2 1.2 mg, rutin 25 mg, zinc 5 mg, Selenium 25 mcg, and bilberry extract 60 mg was used for antioxidative therapy. Ginkgo biloba leaf extracts 60 mg was chosen as the radioprotector. 

At the end of the experiment, researchers found that
*  Macular thickness was statistically significant only in 3 and 6 (p<0.05)compared to only slight changes on other groups and light sensitivity of the macula showed a reduction, which was statistically significant in groups 4-6 before treatment.

* Injection of the supplements antioxidant and angioprotective activities displayed a strong improvement of all parameters related to visual decline, including increased visual acuity.

Dr. the lead scientist wrote in the final report, "a combined antioxidant and double-dose angioprotective (240 mg) therapy appeared to be the most effective and can be considered not only a preventive but also a therapeutic measure in type 2 diabetes patients with initial stages of DR (DRO, DR1) or those with DR and DM or combined DR and AMD (AREDS 1-3)".

Taken altogether, bilberry may be considered a herbal remedy for the improvement of visual decline, particularly,  in patients with macular degeneration, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(2) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(1) [Results of the use of antioxidant and angioprotective agents in type 2 diabetes patients with diabetic retinopathy and age-related macular degeneration].[Article in Russian; Abstract available in Russian from the publisher] by Moshetova LK1, Vorob'eva IV1, Alekseev IB1, Mikhaleva LG. (PubMed)
(3) The Relationship of Major American Dietary Patterns to Age-related Macular Degeneration by Chung-Jung Chiu, DDS, PhD, Min-Lee Chang, MS, Fang Fang Zhang, PhD, Tricia Li, MS, Gary Gensler, MS, Molly Schleicher, BS, and Allen Taylor, PhD. (PMC)

Cucumber Seed, the Potent Anti Hyperlipidemic Remedy Found In Vivo and Human Study

By Kyle J. Norton

Hyperlipidemia is a medical condition associated with the abnormally high levels of lipid, including cholesterol and fat in the bloodstream.

People with hyperlipidemia are symptomatic. However, depending on the amount of lipid accumulated on the arterial wall, some people in the advanced stage may be at substantial risk to heart disease and stroke.

Hyperlipidemia is a condition of the cluster of metabolic syndrome. If untreated, it can lead to atherosclerosis, a condition of hardening and narrowing of the arteries that facilitates the onset of coronary artery disease.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

Conventionally, hyperlipidemia is treatable. Most patients with the condition are treated by prescribed high-cholesterol medicine statins, such as simvastatin, lovastatin, atorvastatin, and rosuvastatin. 

However, for people with a high risk of cardiovascular diseases, PCSK9 inhibitors, such as Redpath (evolocumab) may be prescribed.

If you are taking medicine to lower your blood cholesterol, please make sure that you know all the side effects for preventive measure.

Although there are many factors that cause the onset of hyperlipidemia, some researchers suggested the promotion of high-fat diet over the past few decades may have strong implication in inducing the rise of hyperlipidemia in the US.

Dr. Cole TG,, the lead scientist wrote, " In normals, dietary cholesterol increases LDL production and decreases LDL receptor-related LDL clearance, resulting in elevations in LDL cholesterol levels of approximately 30 mg/dL".

And, " the effects of high fat and high cholesterol diets on the lipoproteins of individuals with diminished LDL receptors, three kinds of diets, including ones high in cholesterol, were fed to four patients with familial hypercholesterolemia, in the expectation that diet effects on apoB- or apoE-containing lipoproteins would be exaggerated".

The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

In a concern of hyperlipidemia associated with increased risk of atherosclerosis, researchers examined the Cucumber (Cucumis sativus) seed effect on how to control this risk factor for the prevention of atherosclerosis.

The randomized double-blind placebo-controlled clinical trial included hyperlipidemic patients randomly assigned to either Cucumis (n=23) used one medicinal capsule or placebo groups (n=24)used one placebo capsule once daily with food for 6 wks.

According to the tested assays, at the end of the experiment, Cucumis seed extract showed a significant reduction of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), and body mass index (BMI) and a significant increase of high-density lipoprotein (HDL-C), compared to the placebo group.

More precisely, the consumption of C. sativus seed extract with a daily dose of 500 mg exerted a maximum effect on serum lipid profile in adult hyperlipidemic patients.

In other words, cucumber (Cucumis sativus) seed not only reduce the expression of hyperlipidemia but also inhibited the risk of atherosclerosis.

Furthermore, in vivo, researchers in the CVD team at the Sharadchandra Pawar College of Pharmacy evaluated the anti-hyperlipidemic activity of Cucumis melo fruit peel (CMFP) methanolic and aqueous extract in high cholesterol diet-induced hyperlipidemic rats.

Injection of CMFP methanolic and aqueous extract resulted in a significant (P<0.01) reduction in gaining body weight, serum lipid profile like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level.  

Compared to the hyperlipidemic control group, the treatment group showed a strong effect on the atherogenic index and increase of the serum high-density lipoprotein cholesterol (HDL-C) levels in 28 days.

Treatment groups also exerted anti-hyperlipidemic activity observed by the increased fecal excretion of bile acids and sterols similar to that of standard drug.

Once again, the administration of a methanolic extract of CMFP at a dose of 500 mg/kg showed higher antihyperlipidemic activity, compared to other extract doses.

Taken altogether, cucumber may be used for the treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of the Effects of Cucumis sativus Seed Extracts on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Soltani R1, Hashemi M2, Farazmand A1, Asghari G3, Heshmat-Ghahdarijani K2, Kharazmkia A4, Ghanadian SM. (PubMed)
(2) The anti-hyperlipidemic activity of Cucumis melo fruit peel extracts in high cholesterol diet induced hyperlipidemia in rats by Bidkar JS1, Ghanwat DD, Bhujbal MD, Dama GY. (PubMed)
(3) Effects of high cholesterol high fat diet on plasma lipoproteins in familial hypercholesterolemia by Cole TG, Pfleger B, Hitchins O, Schonfeld G. (PubMed)