Phytochemical 3,3'-Diindolylmethane, the Bioactive Compound Which Kills Gastric Cancer Cells

By Kyle J. Norton


Gastric cancer is a chronic condition characterized by irregular cells growth in the tissues of the stomach.

Most cases of gastric cancer start in the cells on the surface of the inner lining of stomach tissue.
Due to the small size at the early stage, gastric cancer is asymptomatic.

However, at the later stage, after penetrating into the deeper layers of the stomach, the cancer cell may travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

At this stage, most patients with gastric cancer may experience symptoms of severe abdominal pain caused by the suppressing of the oversize tumor on the nerve cells, or vague discomfort in the abdomen, usually above the navel, particularly heartburn and indigestion, accompanied by general symptoms shared with other types of cancer.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

Out of many risk factors associated with the onset of cancer, aging may be one of the major risk factors that cause the disease onset as cancer has been found to have a peak incidence between 50 and 70 years of age.

Dr. Saif MW said, "(In) a cross-sectional study was carried out on 1341 individuals (GC = 578, healthy = 763), who were stratified into two age groups: 35-59 years (middle-aged, n = 830) and ≥ 60 years (60 years-plus, n = 511)",...Age was clearly identified as a modifying factor on the risk projection of the combined states of Hp serology and sPG levels in gastric cancer screening, reflected by the augmented (~10.5 fold) risk of GC in the triple positive (Hppositive/sPGIlow/sPGI/IIlow) 60 year-plus subjects, which was not evident in the middle-aged group".

In the seeking a bioactive ingredient for the treatment of gastric cancer, researchers analyzed the role of 3,3'-diindolylmethane (DIM) on Forkhead box M1 (FOXM1) which is overexpressed in gastric cancer.

Used combined with paclitaxel, DIM significantly and dose-dependently inhibited the proliferation of SNU638 cells, compared to treatment with DIM or paclitaxel alone.

Furthermore, the combination also attenuated significantly the colony formation of SNU638 cells.

The combined treatment substantially increased apoptosis, indicated by increasing the level of proteins associated with the pro-apoptotic function.

Moreover, DIM dose-dependently sensitized gastric cancer cells by inhibiting the FOXM1 and potentiating the effects of paclitaxel.

Additionally, DIM significantly and dose-dependently inhibited protein kinase which plays a critical role in inducing proliferation in multiple cellular processes.

Dr. Jin H, the lead scientist said, "our results indicate that DIM effectively potentiates the efficacy of chemotherapeutic agents such as paclitaxel by downregulation of the Akt/FOXM1 signaling cascade in gastric cancer cells".

In order to reveal more information about DIM anti-gastric caner property, researchers gains investigated the cytotoxic effects of DIM in human gastric cancer cells. 

In human gastric cancer cell lines (SNU-1 and SNU-484), DIM significantly inhibited the proliferation in a dose-dependent manner.

DIM reduced the levels of proteins associated with cancer cell division and proliferation by increasing the expression of a gene associated with cancer suppression.

Interestingly, injection of DIM also increased the expression of enzymes in the induction of cell apoptosis while decreasing the expression of the anti-apoptotic protein.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade by Jin H1, Park MH2, Kim SM. (PubMed)
(2) 3,3'-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway by Li XJ1, Park ES, Park MH, Kim SM. (PubMed)
(3) Age-Specific Gastric Cancer Risk Indicated by the Combination of Helicobacter pylori Sero-Status and Serum Pepsinogen Levels by Sana Eybpoosh,1,2 Yeganeh Talebkhan,1 Samaneh Saberi,1 Maryam Esmaeili,1Akbar Oghalaie,1 Fatemeh Ebrahimzadeh,1 Toktam Karimi,1 Afshin Abdirad,3 Azin Nahvijou,4Mohammad Ali Mohagheghi,4 Mahmoud Eshagh Hosseini,5 and Marjan Mohammadi. (PMC)

Herbal Artichoke, the Anti Hyperglycemia Natural Remedy, According to Scientists

By Kyle J. Norton

Artichoke may process a substantial and profound effect in managing the levels of post-prandial glycemia in diabetics, according to studies.

Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.


Postprandial blood glucose is the levels taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.

Management of postprandial blood glucose has become an important feature for diabetics against the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).

Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate the glucose as a result of the cells in pancreas died off or receptor sites clogged up by fat and cholesterol. 

Insulin resistance is a hallmark of diabetes. The exact causes of insulin resistance are unknown. Researchers do not know why people with the same health conditions in the same family, some are susceptible to the onset of diabetes while others do not.

However, some researchers suggested that unhealthy diet with high saturated and trans fat, red meat and processed foods is one of the major risk factors associated with the onset of the disease in the Western world compared to a traditional diet.

In other words, if you follow the Western diet, you are at an increased risk of diabetes development.

Dr. David Hefner in the concern of the risk of diabetes in patients who are fans of the Western diet wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes" and  "That's what researchers at the Harvard School of Public Health have found and reported in the Annals of Internal Medicine."

The doctor continued, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".

The finding argued the risk of diabetes is reduced if you change your Western diet pattern to traditional diet with high fruits and vegetables and whole grain with a limited intake of saturated and trans fat, processed foods and red meat.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

With an aim to find a natural ingredient doe the treatment of hyperglycemia with no side effect, researchers examined the traditional use of artichoke (Cynara scolymus L., Asteraceae family) preparations for lowering post-prandial glycemia.

The study included non-selected Wistar and genetically obese Zucker rats treated acutely with a purified extract of Cynara scolymus flowering heads (500-1500 mg/kg by gavage) immediately prior to 1 h access to a fixed amount of food.

Any parts of Cynara scolymus flowering head extract with lack of any fiber content have excluded.

According to the results taking at 60, 120 and 360 min after food presentation, intake of Cynara scolymus flowering head extract showed a significant decrease of post-prandial glycemia in both rat groups.

The exclusion of the parts of Cynara scolymus flowering head extract with lack of any fiber content have excluded in the study suggested that the preparation induced hyperglycemic effect without involving the fiber which has been found to process a strong impact in the inhibitory activity.

Dr. Fantini N, the lead scientist wrote in the final report, "The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans".

In order to reveal more information of artichoke inhibited the hyperglycemic property, researchers evaluated the extract from Phaseolus vulgaris and Cynara scolymus and their combination on food intake and glycemia in rats.

The combination produced comparable reductions in intake of regular food and chocolate-flavored beverage, compared to low and ineffective to the single use of either extract.

Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on the glycemic rise.

These results of the mixture of P. vulgaris and C. scolymus extracts was attributed to the efficacy of the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts.

The findings strongly suggested that artichoke may play an important role in stimulating the mixture antihyperglycemic activity.

Based on the results, researchers wrote, after taking into account co and confounders, "These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field".

Taken altogether, artichoke used alone or combined with other herbal medicine may be considered a functional remedy for the prevention and treatment of hyperglycemia, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats by Fantini N1, Colombo G, Giori A, Riva A, Morazzoni P, Bombardelli E, Carai MA. (PubMed)
(2) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)

Whole Food Honey, the Natural Free Radicals Scavenger

By Kyle J. Norton


Free radicals are highly reactive molecules. Internally, they are produced by our body cell metabolism. Externally, free radical can enter our body from the environment sources, such as the air we breathe, the food we eat and the water we drink.

In other words, free radicals are everywhere. Any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.

Free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA.

Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radical has a strong implication in the pathogenesis of various disorders and diseases.

Free radicals cause lipid peroxidation by oxidizing the free and ester forms of unsaturated fatty acids and cholesterol through three distinct mechanisms, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, nonenzymatic oxidation. All of these chemical reactions cannot be stopped until the electrons on the outermost ring of free radical are paired or inhibited by antioxidants.

Free radical scavengers are atoms that process the function to prevent the free radicals from being formed or remove them before they can damage vital components of the cell. 

Dr. Slemmer JE, the lead scientist in the examination of free radical scavengers for the treatment of stroke wrote, "The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a common underlying mechanism of many neuropathologies, as they have been shown to damage various cellular components, including proteins, lipids, and DNA".

And "several acute and chronic pharmacological therapies that have been extensively studied in order to reduce ROS/RNS loads in cells and the subsequent oxidative stress, so-called "free-radical scavengers".

In other words, an antioxidant with free radical scavenging activity may protect the body against the damage of various cellular components, including proteins, lipids, and DNA in the initiation of diseases.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

In the urgency to find a natural compound or therapy for the treatment of acute and chronic free radical-mediated diseases, including atherosclerosis, diabetes, and cancer, researchers examined the honey of multi-floral origin, standardized for total antioxidant power and analytically profiled (HPLC-MS) in antioxidants, in a cultured endothelial cell line (EA.hy926) subjected to oxidative stress.

Native honey (1% w/v pH 7.4, 10(6) cells) showed strong activity against lipophilic cumoxyl and cumoperoxyl radicals through several mechanisms, including suppression/prevention of cell damage, complete inhibition of cell membrane oxidation, of intracellular ROS production and recovery of intracellular GSH.

According to the observation of the results from the experiments with the endothelial cell, native honey showed strongest antioxidant activity against peroxyl radicals from 1,1-diphenyl-2-picrylhydrazyl (AAPH, 10 mM) and to hydrogen peroxide (H2O2, 50-100 microM) through its phenolic acids and flavonoids.

Dr. Beretta G, the lead scientist said, "These results provide unequivocal evidence that, through the synergistic action of its antioxidants, honey by reducing and removing ROS, may lower the risks and effects of acute and chronic free radical-induced pathologies in vivo."

In order to reveal more information of honey free radical scavenging activity, researchers evaluated the protective effect of several monofloral Cuban honey against lipid peroxidation in an in vitro model of rat liver.

All tested honey showed potent antioxidant activity with Linen vine displaying the highest scavenging capacity towards the DPPH, hydroxyl, and superoxide radicals, while the least efficient was Christmas vine honey.

Linen vine is the best in the inhibition of lipid peroxidation in rat liver homogenates in a concentration-dependent mode, compared to others.

Based on the findings, researchers suggested, "The ability to scavenge free radicals and protect against lipid peroxidation may contribute to the ability of certain Cuban honey to help in preventing/reducing some inflammatory diseases in which oxidative stress is involved".

Taken altogether, honey, particular native and Cuban honey may be considered functional remedies for the treatment of acute and chronic free radical-mediated diseases with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Radical-scavenging activity, protective effect against lipid peroxidation and mineral contents of monofloral Cuban honeys by Alvarez-Suarez JM1, Giampieri F, Damiani E, Astolfi P, Fattorini D, Regoli F, Quiles JL, Battino M. (PubMed)
(2) Antioxidant and radical scavenging activity of honey in endothelial cell cultures (EA.hy926) by Beretta G1, Orioli M, Facino RM. (PubMed)
(3) Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging by Slemmer JE1, Shacka JJ, Sweeney MI, Weber JT. (PubMed)

Whole Food Tomatoes Protect Your Stomach Against Gastric Cancer in Human Studies

By Kyle J. Norton

Gastric or stomach cancer is a chronic condition characterized by irregular cell growth in the tissues of the stomach caused by the alternation of cell DNA.

Most cases of gastric cancer start in the cell on the surface of the stomach inner lining before penetrating into the deeper layers.

At the early stage, patients with gastric cancer are asymptomatic. However, at the advanced stage, gastric cancer can induce symptoms of indigestion or heartburn,  stomach pain, discomfort in the abdomen particularly vomiting up solid food shortly after eating, change of bowel movement accompanied by the general symptoms shared by other types of cancer.

According to the statistic provided by the American Cancer Society, in 2019 approximately 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Believe it or not, most cases of gastric cancer in the US are found in older adults. The average age of people when they are diagnosed is 68.  

In other words, 6 of every 10 people diagnosed with stomach cancer each year are 65 or older.

Although there are many risk factors associated with gastric cancer including aging gender, ethnicity, medical condition such as lymphoma, smoking,... some researchers suggested that certain diet that has large amounts of smoked foods, salted fish and meat, and pickled vegetables may have a strong effect in gastric cancer developing.

Dr. L T Ngoan, the lead scientist said, "During 139 390 person-year of follow-up of over 13 000 subjects, 116 died from stomach cancer. Using a Cox proportional hazards–regression analysis of relative risk (RR, 95% CI) controlling for age, sex, smoking, and other dietary factors, a significant decline was found with high consumption of green and yellow vegetables (RR=0.4, 95% CI=0.2–0.9)"

And, "The risk was significantly increased by the high consumption of processed meat (RR=2.7, 95% CI=1.0-7.4) and by the frequent use of cooking oil (RR=4.0, 95% CI=1.3-11.8). The high consumption of pickled food and traditional soups also increased risk, but not significantly. The findings suggest that a diet high in salt and low in vitamins may be associated with an increase in stomach cancer"

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding potential and natural compound for the treatment of gastric cancer, researchers examined the possible association between tomato products consumption and gastric cancer.

The review of MEDLINE and EMBASE and contacted authors to identify potential studies published from January 1966 to June 2012 was conducted by the Shanghai Tenth Peoples' Hospital, Tongji University included a total of 21 eligible studies satisfied the guideline and criteria.

According to the results, the consumption of large amounts of tomato products compared to the highest and lowest consumption groups showed a significantly reduced the risk for gastric cancer.

The OR ratio of lycopene consumption and serum lycopene was 0.88 and 0.79, respectively.

Based on the finding, researchers said, "Consumption of large amounts of tomato products is associated with a reduced risk of gastric cancer".

Furthermore, by examining the anticancer effect of Pectic-Oligosaccharide isolated from Sour Raw Tomato (SrTPOwith  its bioavailability and structure elucidated from purified fraction (SrTPO1), scientists at the CSIR-Central Food Technological Research Institute showed that administration of SrTPO1 inhibited galectin-3 activity with MIC of 0.25 ug/mL (100 fold better than standard galactose), inhibited the growth of AGS cells (IC50 3.4μg/mL) and induced apoptosis (70% inhibition at 30μg/mL concentration) without affecting the normal cells.

Where galectin-3 expression is associated with the promotion of tumor progression and metastasis.

Taken altogether, tomatoes processed a high amount of lycopene and Pectic-Oligosaccharide may be considered functional foods for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The role of tomato products and lycopene in the prevention of gastric cancer: a meta-analysis of epidemiologic studies by Yang T1, Yang X, Wang X, Wang Y, Song Z.(PubMed)
(2) Pectic Oligosaccharide from tomato exhibiting anticancer potential on a gastric cancer cell line: Structure-function relationship by Kapoor S1, Dharmesh SM. (PubMed)
(3) Dietary factors and stomach cancer mortality by L T Ngoan,1 T Mizoue,1 Y Fujino,1 N Tokui,1 and T Yoshimura. (PMC)

Whole Food Ginger Enhances the Chance of Conception in Vivo

By Kyle J. Norton

Fertility is a natural process to ensure the survival of human species. Through natural selection, we produce many offsprings when the reproductive system works at its peak in a suitable environment.

In other words, female fertility is the ability of women to conceive a biological child before menopause compared to male fertility which generally relies on the quantity and quality of the sperms.

But regardless of all factors, most women are capable of conceiving during their menstrual cycle before reaching the stage of menopause.

Infertility is a condition characterized by the inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term.

The condition affects over 5 million couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from a professional specialist.

Epidemiologically, the rate of pregnancy statistics shows that before:

* The age of 31, 73% of women will get pregnant within one year, and 90% within four years.

* The age of 36, 65% of women will get pregnant within one year, and 82% within four years.

* The age of 41, 40% of women will get pregnant within one year, and 60% within four years.

You can see the rate of pregnancy goes down with age.

Although women can get pregnant anytime during their menstrual cycle, the best days to get pregnant are 2 days before and after ovulation because the sperm can only survive 2-3 days(sperm may survive up to 6 days) in the uterus after ejaculating into the vagina.

In the Western world, most cases of infertility are associated with no explanation.

Unexplained causes of infertility may be the reasons which drive many couples to seek help from alternative medicine.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural ingredient for the treatment of female infertility examined the effects of ginger powder on ovarian folliculogenesis and implantation in an animal model.

Selected rats for the study were divided into 2 groups. 7 rats included in each in 5 days (one estrous cycle) treatment was given 100 mg ginger powder, 200 mg ginger powder and or distilled water respectively.

In the 10 days treatment group, same doses were given for 10 days (two estrous cycles) to the three subgroups each also containing seven rats.

According to results from the tested assay at the end of the 5th day, the 5-day treatment group with 100 mg ginger subgroup exerted a significantly higher antral follicle count and ovarian stromal VEGF, an indication of increased blood in the ovaries, compared to other subgroups.

Observation at the end of the 10th days, the 10 days treatment groups with 100 mg ginger showed a significantly higher endometrial VEGF and ovarian stromal eNOS, compared to the other groups.

In other words, ginger at doses of 100mg improved the function of ovaries secretion of mature follicles and endometrial function in facilitating conception by increasing blood flow to the reproductive organs.

Interestingly, at 200 mg ginger dose produced no statistically significant difference in both 5-day and 10-day treatment groups.

The finding strongly suggested that ginger improved female fertility in doses dependent manner. The optimized doses to induce fertility are 100mg.

Researchers in the final report wrote, "The increases in the antral follicle count and ovarian stromal VEGF in the 100 mg/5-day treatment subgroup indicate that ginger has positive effects on folliculogenesis in short term with a low dose. Additionally, ginger may enhance implantation in rats in the long term with low dose".

Taken altogether, ginger may be considered a functional remedy for the improvement of female fertility, pending to the confirmation of larger sample sized and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ginger (zingiber officinale) might improve female fertility: A rat model by Nafiye Banu SevenaHakan,Timura Ayçağ,Yorgancıa Hasan, Ali İnalb Müberra, Namlı,Kalemc, Ziya Kalemd, ÖzgeHane, Banu Bilezikçie (Science Direct)

Manuka Honey improves the Cellular Antioxidant Defense Enzymes

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy for the treatment of diseases associated with oxidative stress, according to studies.

Free radical or reactive oxygen species are unstable atoms with unpaired electrons on the outermost ring that are ready to donate or intercept an electron from other atoms, leading to a chain reaction which can not be stopped until they all electrons on the outermost ring are paired or inhibited by antioxidants.

On the other hand, antioxidants are stable atoms which inhibit oxidation caused by free radicals.

In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.

However, in people with a weakened immune system such as infants, children and the elderly, dietary sources from supplements, fruits and vegetables may be needed.

Oxidative stress is a result of an imbalance of the ration of free radical and antioxidant in the body. A prolonged period of oxidative stress has been found to cause proteins and lipid damage and alteration of cell DNA inducing chronic diseases such as CVD, diabetes, and cancer.

Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.

In other words, Dr. says Håkan Westerblad said, ""Free radicals play an important role since they contribute to the heart being able to pump more blood in stress-filled situations."

And "On the other hand, persistent stress can lead to heart failure, and chronically increased levels of free radicals may be part of the problem here."

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient which enhances the cellular antioxidant defense system against diseases, researchers examined Manuka honey effects in the genotoxic and genoprotective properties in cells activity against free radicals in the ranging from 25-1000 μg/mL.

In a modest decrease of H2O2-induced cellular DNA damage, Manuka honey displayed a stronger potential to attenuate damaged cells at all tested concentrations, particularly in the concentrations of 25 and 100 μg/mL.

More precisely, Manuka honey protected DNA of whole blood cells from oxidative damage induced by hydrogen peroxide in vitro.

Furthermore, Manuka honey exerted a similar activity against free radical overexpression, compared to buckwheat honey which has higher contents of sugars, proteins, and total phenols but a lower content of MGO.

Additionally, Manuka honey also exhibited a strong cellular antioxidant and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa,, compared to those of buckwheat honey.

Where buckwheat honey is considered to have great nutritional and commercial potentials

Taken altogether, Manuka honey may be considered anti hypertension functional remedy for the enhancement of the cellular antioxidant defense system with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Biochemical properties, antibacterial and cellular antioxidant activities of buckwheat honey in comparison to manuka honey by Deng J1, Liu R2, Lu Q3, Hao P1, Xu A1, Zhang J2, Tan J. (PubMed)
(2) Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro by Živković L1, Bajić V2, Dekanski D3, Čabarkapa-Pirković A4, Giampieri F5, Gasparrini M5, Mazzoni L6, Potparević BS. (PubMed)
(3)  Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes. by Daniel C Andersson, Jérémy Fauconnier, Takashi Yamada, Alain Lacampagne, Shi-Jin Zhang, Abram Katz & Håkan Westerblad (The Journal of Physiology)

Turmeric Protects Your Skin Against Photo-Damage

By Kyle J. Norton

Photodamage is a type of skin damage caused by long-term exposure to the sunlight or tanning bed.

Photodamage skin is one most common form of skin damage in the US, due to misunderstanding the benefits and adverse effects on light exposure.

Believe it or not, a quarter of lifetime sun exposure occurs before the end of the teenage years. Most cases of photo skin damage can also stimulate some unwanted skin conditions, including advanced aging or wrinkling, uneven skin, hyperpigmentation, telangiectasias, actinic keratoses liver, and age spots.

In severe cases, long-term photodamage skin can also lead to skin cancer. More people in the US are diagnosed with skin cancer each year than all other cancers combined.

According to the statistic, 1 in 5 Americans will develop skin cancer by the age of 70.

Conventionally, most cases of early-stage and mild damage of skin are treated by topical Levulan that remove scaly patches of actinic keratoses from your skin.

However, Laser surgery may be necessary, if the topical fails.

Dr. Jee SH, the lead scientist in the examination of the risk of photodamage skin in the risk of skin cancer wrote, "Some workers in paraquat manufacturing, exposed to bipyridines, have developed pigmentation and keratosis on sun-exposed skin".

And, "This pathologic study proves that all the lesions showed either photodamage or skin cancer. The strong trend in the correlation between the severity of photodamage and exposure to bipyridine leads to the speculation about the synergistic role of bipyridine exposure and the solar effect in causing these malignant and premalignant skin lesions".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the concerns of Ultraviolet B (UVB) irradiation in inducing skin photo-damage associated with the onset of a sunburn, erythema, photoaging, and photocarcinogenesis, researchers evaluated the protective effects of curcumin against acute photo-damage.

In hairless mice, topical application of curcumin exerted a kin protective effect by significantly inhibiting acute UVB (540 mJ cm-2 , for 3 successive days)-induced inflammatory cells, collagen accrementition derangement, and lipid peroxidation.

Additionally, the topical cream with curcumin also stimulated the NF-E2-related factor 2 (Nrf2) nuclear accumulation involved in skin defense on uncovered (Uncv) hairless mice skin.

In vitro, treatment of HaCaT cells with curcumin significantly attenuated acute UVB (300 mJ cm-2 ) tissue damage in releasing lactate dehydrogenase release (LDH) into the bloodstream.

Levels of intracellular reactive oxygen species production and DNA damage are also inhibited by the injection of curcumin by activating the expression of phase II detoxifying enzymes and promoting DNA repair activity. 

Additional analysis of the skin protective activity of curcumin, researchers found that The photoprotective effect provided by curcumin was potentially associated with modulation of Nrf2-factor associated with antioxidant defense.

In order to reveal more information about the effects of turmeric anti skin damage, researchers looked into the turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.

The prospective, double-blind, randomized pilot study included 33 healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017 receive one of three interventions (placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks.

According to the results, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline (P = 0.03) compared to that of placebo and turmeric groups with no statistically significant changes in image analysis-based facial redness.

Based on the findings, researchers said, "Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin used alone or combined with other phytochemical may be used for the prevention of skin photo-damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage by Li H1, Gao A1, Jiang N1, Liu Q1, Liang B1, Li R1, Zhang E1, Li Z1, Zhu H. (PubMed)
(2) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study by Vaughn AR1, Pourang A2, Clark AK2, Burney W2, Sivamani RK. (PubMed)
(3) Photodamage and skin cancer among paraquat workers by Jee SH1, Kuo HW, Su WP, Chang CH, Sun CC, Wang JD. (PubMed)