Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday 21 March 2019

Curcumin, the Bioactive Compound of Turmeric Protects the Blood Vessels Against Cardiovascular Disease

By Kyle J. Norton

Cardiovascular disease (CVD) refers to any conditions caused by the underlying damage of blood vessels and the heart.

In other words, depending on the location of the blockage or disruption, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke.

According to the statistics provided by the American Heart Association, approximately 84 million people in this US suffer from some form of cardiovascular disease, leading to the death of about 2,200 people a day.

The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.

Epidemiological studies suggested that most people with CVD are also associated with atherosclerosis, a condition caused by long-term plaque buildup on artery walls, which can narrow the arteries and reduce blood flow through your arteries to the heart.

Some researchers suggested the promotion of the Western diet over the past few decades may have a strong implication on the rise of CVD.

Dr. Mirmiran P, the lead scientist, in the examination of the diet pattern and the risk of CVD in Iran, said, "During a mean 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events. In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)".

And "the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".

The results strongly indicated the increased risk of CVD in people who follow the Western diet pattern.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a potential compound for the treatment of cardiovascular disease (CVD) associated with the largest mortality worldwide, scientists examined the cardiovascular protective properties of curcumin in CVDs.

According to the review, curcumin showed significant activity against the onset of CVDs, including cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke, and diabetic cardiovascular complications.

In dyslipidemia, an important and common cardiovascular risk factor in the general population, researchers assessed the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD), through searching the database of medical literature.

The comprehensive literature search conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases were to identify randomized controlled trials (published as of November 2016).

Based on the results of 7 eligible studies (649 patients) satisfied the guideline and criteria, researchers found that
* Turmeric and curcumin significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels as compared to those in the control group.

* Turmeric and curcumin also were effective in lowering serum total cholesterol (TC), levels in patients with metabolic syndrome.

* Turmeric extract have a greater effect on reducing serum TC levels compared to curcumin.

* Both turmeric and curcumin did not improve the serum high-density lipoprotein cholesterol (HDL-C).

* More importantly, turmeric and curcumin are safe, and no serious adverse events were reported in any of the included studies.

Dr. Qin S, the lead researcher wrote, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".

Taken altogether, turmeric and its bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, the golden spice in treating cardiovascular diseases by Li H1, Sureda A2, Devkota HP3, Pittalà V4, Barreca D5, Silva AS6, Tewari D7, Xu S8, Nabavi SM. (PubMed)
(2) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(3) Western dietary pattern increases risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)

Herbal Artichoke, the Best Hepatoprotecitve Functional Remedy, According to Studies

By Kyle J. Norton

The hepatoprotective or liver protective effect is an action that maintains the liver healthy functioning against any harmful toxins.

The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood come from the digestive tract, before passing it to the rest of the body.

Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.

Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and tendency to bruise easily.

If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver diseases.

Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".

And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".

The results clearly and strongly suggested that reducing intake alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including the ALD.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural ingredient which processes liver protective effect evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.

Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.

Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.

Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.

According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.

The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.

In order to reveal more information about the liver protective effect of artichoke, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis and its complications are the major cause of death in infected cases.

Mice selected to the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ) and PZQ respectively. The 4th was a positive control and the 5th was the negative control group.and were compared to PZQ.

Injection of ALE and ALE + praziquantel (PZQ) caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.

Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.

Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.

Unfortunately, although, the herbal extract exerted a strong liver protective activity, it but failed to treat S. mansoni infection.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending to the confirmation of large sample size and multicenter human study.

Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)

Honey Protects the Bone Mass with No Side Effect, According to Studies

By Kyle J. Norton

Bone is a hard whitish tissue making up the skeleton in humans which provides a framework for the attachment of muscles and other tissues.

Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.

Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.

Risk factors of losing bone density include gender, (women are more likely to develop osteoporosis compared to men) the increase in age, race, (African Americans have both lower rates of bone density loss and osteoporosis), family history.

People with low bone mass accompanied by progressive bone density loss over time are associated with an increased risk of developing osteoporosis.

Low bone mass is a risk factor of osteoporosis, The condition may also increase the incidence of bone fracture if it is accompanied by other risk factors.

Some researchers suggested that people who follow a healthy diet pattern are less likely to develop osteoporosis.

Dr. Małgorzata Kostecka in the examination of the role of a healthy diet in the prevention of osteoporosis in perimenopausal period, wrote, "Diet of a large part of society is not properly balanced which can cause abnormalities in achieving proper bone mineralization. Long-term deficiencies in calcium and vitamin D in daily diet are the cause of taking dietary supplements".

And, "Changes in the nutritional regimen are required already during childhood because nutritional mistakes are the main cause of diet-related diseases in adulthood".

The results indicated a link to an unhealthy diet in the risk of osteoporosis.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural remedy for the protection of bone structure investigated the honey effects on the cessation of exercise on bone properties in young female rats.

The experiment included a total of eighty four 12-week-old Sprague-Dawley female rats randomly divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks, 16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and J = jumping exercise).

Jumping exercise consisted of 40 jumps/day for 5 days/week and honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week.

After 8 weeks of cessation of exercise, honey supplementation groups (8JH) showed higher tibial energy, proximal total bone density, a midshaft cortical moment of inertia, and cortical area, compared to 16S.

Continuous sixteen weeks of combined jumping and honey group (16JH) exerted a significant greater tibial maximum force, energy, proximal total bone density, proximal trabecular bone density, midshaft cortical bone density, cortical area, and midshaft cortical moment of inertia, compared to 16S.

Dr. Tavafzadeh SS, the lead scientist said, "the beneficial effects of 8 weeks of combined exercise and honey supplementation still can be observed after 8 weeks of the cessation and exercise and supplementation".

In other words, these comparative results suggested that long term combined exercise and honey supplementation may have a long term effect on the bone structure, even after the cessation of exercise and honey supplementation.

In order to reveal more information about honey effects on bone structure, researchers examined the jumping exercise intensities combined with honey on bone and gonadotrophins in an animal model.

The experimental groups selected to the study were required to exercise 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20, and J80), Oher groups selected to the study also included honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.

HJ80 showed the greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations, compared to the lower levels of serum follicle stimulating hormone concentrations in H, J20, J80, particularly in the C group.

Furthermore, the serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.

The surprising result indicated moderate jumping exercise combined with honey supplementation may have a better effect compared to high-intensity exercise + honey supplement on bone mass and density.

Moreover, honey may have protection against the adverse effects induced by jumping exercise on gonadotropins in female rats.

Taken altogether, honey may be considered a functional remedy for the protection of bone mass regardless of the types of exercise, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bone Mechanical Properties and Mineral Density in Response to Cessation of Jumping Exercise and Honey Supplementation in Young Female Rats by Tavafzadeh SS1, Ooi FK1, Chen CK1, Sulaiman SA2, Hung LK. (PubMed)
(2) Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats by Mosavat M, Ooi FK1, Mohamed M. (PubMed)
(3) The role of healthy diet in the prevention of osteoporosis in perimenopausal period by Małgorzata Kostecka. (PMC)

Bilberry Stimulates the Cytotoxic Effects Against Cancer, Scientists Say

By Kyle J. Norton

Cytotoxicity is a process or action that destroys the living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.

Free radical cytotoxicity is the ability of ROS in exerting the oxidative stress in the cancer cells, leading to apoptosis.

Cancer is a class of diseases characterized by irregular cells growth due to DNA alternation.

Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.

Most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness and gastrointestinal discomforts and symptoms depending on the location of cancer.

If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.

The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, family history in the same family, some are susceptible to cancer, while others do not.

In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.

Most cases of natural remedy in initiating the cytotoxic effects against cancer without causing nearby healthy cells death probably are associated with the stimulation of the production of antioxidant produced by the host and the presence of antioxidants of the remedy.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.

GroES self-assemble into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cells toxicity.

Before application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.

Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.

The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.

Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.

Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound the bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].

Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.

The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.

And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.

At 48 h incubation, the highest percentage of inhibition was only 27%,.

The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.

Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)

Wednesday 20 March 2019

Ginger, May Detox Your Liver Against Toxicity, According to Studies

By Kyle J. Norton

Hepatotoxicity is a condition caused by the accumulation of toxin in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long term use of certain medicines.

The liver is a large internal organ of the human body that protects us by filtering the blood come from the digestive system before passing to other parts of the body.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linked to the increased mortality, extending to those with chronic liver disease.

There are many causes associated with liver toxicity including chemicals toxins, which normally induces acute liver toxicity, such as those used in laboratories and industries, natural chemicals and long-term use of certain medication.

In the Western world, acute and chronic liver toxicity mostly are caused by long-term excessive alcohol drinking and long-term use of medication in the elderly.

Most common signs and symptoms of liver toxicity may include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

If you are experiencing some of the above signs and symptoms, please check with your doctor to rule the possibility of liver toxicity.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists in finding a natural compound for the treatment of liver dysfunction investigated the ginger effect against Aflatoxin B1 (AFB1) induced liver toxicity.

Male Wistar rats induced liver toxicity by Aflatoxin B1 (AFB1) were orally treated with GE (100 and 250mg/kg) daily, accompanied by the administration of AFB 1 (200μg/kg) every alternative day for 28days.

In vitro and in vivo, pretreatment of HepG2 cells with GE significantly inhibited the production of intracellular reactive oxygen species (ROS), DNA strand break associated with the cytotoxic activity and cytotoxicity induced by AFB1.

In the study of male Wistar rats were orally treated with GE (100 and 250mg/kg) daily, with the administration of AFB 1 (200μg/kg) every alternative day for 28days, application of GE showed a significantly reduced AFB1 induced toxicity observed by the reduced serum markers associated with liver damage.

Furthermore, injection of GE showed the significant hepatoprotective effect by reducing not only the lipid peroxidation but also by enhancing the antioxidant enzymes produced by the host of tested animals.

Moreover, the administration of GE also protected the liver against toxicity through exhibiting the Nrf2/HO-1 pathway associated with the inhibition of inflammation and oxidative stress.

Additionally, in order to reveal more information about ginger hepatoprotective activity, researchers examined ginger activity in preventing antituberculosis drug-induced hepatotoxicity in patients with tuberculosis.

Patients selected to the study were divided into the ginger and placebo groups (30 patients in each group). Patient in each group was given either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks.

During the study period, 26.7% of patients experienced antituberculosis drug-induced hepatotoxicity.

Treatment of ginger group experienced less liver toxicity in percentage, compared to the placebo group.

The results of the study strongly supported the use of ginger as a potential treatment of liver toxicity caused by adverse effects of some conventional medicine.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of liver toxicity, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity by A V V1, K RR1, Kurrey NK2, K A AA1, G V3. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)

Honey May Be Better Than Prednisolone for Acute and Chronic Pain Relief, According to Scientists

By Kyle J. Norton

Antinociception is the process which blocks sensory neurons respond to potentially damaging stimuli associated with pain.

Pain is a natural reaction with an aim to protect our body against danger or damage.

Acute pain is the pain that lasts less few weeks.

Chronic pain is pain that lasts more 6 months.

Chronic pain has been found to be the most common reason for someone to see his/her physician.

Chronic pain in some cases was a major symptom of a medical condition that can only be treated physically and mentally through pain management.

However, most cases of chronic pain are associated with injury, such as a back sprain, or there may be an ongoing cause, such as illness.

Chronic pain can interfere with a person's quality of life and general functioning.

According to statistics provided by Dr. Donald Schopflocher, lead scientists in the evaluation of the prevalence of chronic pain in Canada, researchers wrote, "The prevalence of chronic pain for adults older than 18 years of age was 18.9%".

And, "Chronic pain prevalence was greater in older adults, and females had a higher prevalence at older ages compared with males. Approximately one-half of those with chronic pain reported suffering for more than 10 years. Approximately one-third of those reporting chronic pain rated the intensity in the very severe range".

Chronic pain according to the study is very common, affecting approximately 19% of Canadian over 18 years of age, mostly in older adults.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a potential natural whole food for pain relief examined the Tualang honey (Fēng Mì) and prednisolone on the nociceptive response in male Sprague-Dawley rats.

35 male Sprague-Dawley rats selected to the study were divided into 5 groups. Each group was given either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days.

Where prednisolone is a steroid medication used for pain relief.

According to the response to a noxious thermal stimulus using tail flick test on Day 10, the tail flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group.

Compared to the groups treated with prednisolone or distilled water, Tualuang honey treatments showed no effects on other parameters.

In other words, Tualang honey treatment group showed signs of abnormal behavior, such as total food pellet intake or weight loss.

Dr. Aziz CB, the lead scientist at the Universiti Sains Malaysia, said, "preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses".

Based on these results, Tualang honey processes a strong antinociceptive better than those of corticosteroids (prednisolone).

In order to reveal more information about honey antinociceptive activity, researchers compared several kinds of honey pain relief efficacy.

Acacia honey showed most effective dose-dependent antinociceptive activity compared to the untreated group in tail-flick and paw-withdrawal tests, respectively.

Most tested honey exerted antinociceptive activity of reaching the maximum at 60 min post-treatment then gradually decreased, whereas the activity of indomethacin was persistent at 120 min post-treatment.

Interestingly, the major constituents found in honey such as fructose, glucose, maltose, and sucrose used alone do not demonstrate any effect compared to the whole food.

The results strongly suggested that there must be other compounds in the honey that process a significant antinociceptive property or all active ingredients in honey work together to stimulate the pain relief activity.

Taken altogether, honey, particularly, Tualang and Acacia honey may be considered a functional remedy for acute and chronic pain relief, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The antinociceptive effects of tualang honey in male sprague-dawley rats: a preliminary study by Aziz CB1, Ismail CA1, Hussin CM2, Mohamed M. (PubMed)
(2) Antinociceptive activity of natural honey in thermal-nociception models in mice by Azim MK1, Perveen H, Mesaik MA, Simjee SU. (PubMed)
(3) The prevalence of chronic pain in Canada by Donald Schopflocher, PhD,1,2 Paul Taenzer, PhD,3 and Roman Jovey, MD. (PubMed)

Artichoke Inhibits Breast Cancer Cells Against Proliferation, Researchers Found

By Kyle J. Norton

Breast cancer is the medical condition caused by cell growth disorderly in the breast tissue due to the alternation of DNA.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

According to the statistics, in the US, 1 in 8 women (about 12.4%) will develop invasive breast cancer over the course of her lifetime. In 2018, over 260,000 new cases of invasive breast cancer were diagnosed.

The 5 years of the survival rate of early diagnosis of breast cancer is close to 100%. This result suggested that women should self examine their breasts every month, particularly during the day's menstruation for preventive measure.

By age analysis, according to epidemiological studies, rates of breast cancer are low in women under 40, accounting only 5% of all breast cancer cases.

However, the rates begin to increase after age 40 and women who are over the age of 70 are associated with the highest risk of the disease.

These results strongly suggested that declines hormones production in the older women may have a direct implication on the breast cancer onset.

Dr. Ruth C Travis, the lead scientist in the concern of estrogen exposure and breast cancer risk in menopausal women explained, "Although risk for breast cancer increases with age, there is a marked decline in the rate of increase in risk with age following the loss of ovarian function, either as a result of a bilateral oophorectomy or due to the menopause".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers with an aim to find a potential natural compound for the treatment of breast cancer investigated the polyphenolic extracts from the edible part of artichoke (Cynara scolymus L.)
chemopreventive and anticancer activity.

Administration at the high doses of polyphenolic extracts (AEs) induced apoptosis and decrease the invasive potential of the human breast cancer cell line, MDA-MB231.

Artichoke also displayed a significant increase of senescence-associated β-galactosidase (SA-β-gal) staining associated with a decreased cell proliferation, the G1/S cell cycle arrest cells, altered cell morphology, against the breast cancer cell line.

Furthermore, the herbal medicine also exhibited the tumor suppressor genes, p16(INK4a) and p21(Cip1/Waf1) in MDA-MB231 cells. In other words, artichoke caused cancer cell apoptosis by the increased expression of a series of tumor suppressive genes.

Cell growth arrest was found to be correlated with the increased reactive oxygen species (ROS) production in AEs treated breast cancer cells. In other words, AE exhibited the production of free radicals in the induction of cancer cells cytotoxicity.

The scientists after taking into account co and confounders, wrote in the final report, " Chronic AEs treatment inhibits breast cancer cell growth via the induction of premature senescence through epigenetic and ROS-mediated mechanisms".

Moreover, in order to reveal the polyphenolic extracts (AEs) of artichoke against breast cancer, researchers evaluated the antitumor effect of polyphenolic extracts from the edible part of artichokes (AEs).

Polyphenolic extracts (AEs) injection reduced cancer cell viability and inhibited cell growth in a dose-dependent manner.

Injection of AEs triggered apoptosis and cell death programming in the mitochondrial and death-receptor pathway.

The anti-cell proliferation also was observed by an increase of the Bax: Bcl2 ratio associated with the cancer apoptosis and proteins involved cell cycle division, tumor suppressive gene, and decreased the expression of the cellular proliferative enzyme.

These results strongly indicated the cancer cell motility and invasion capabilities of highly invasive MDA-MB231 cells were remarkably inhibited by AEs-treatment.

Dr. Mileo AM, said, "AEs reduced cell viability, inhibited cell growth, triggered apoptotic mechanisms, and showed inhibitory properties against the invasive behavior of MDA-MB231 cancer cell line".

Taken altogether, artichoke processed abundantly polyphenolic compounds may be considered a functional remedy for the prevention and treatment fo breast cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line by Mileo AM1, Di Venere D2, Abbruzzese C1, Miccadei S. (PubMed)
(2) Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231. by Mileo AM1, Di Venere D, Linsalata V, Fraioli R, Miccadei S. (PubMed)
(3) Oestrogen exposure and breast cancer risk by Ruth C Travis