Bilberry, the Potent Antioxidants, Researchers Reveal

By Kyle J. Norton

Researchers may have found a natural whole food for the treatment of oxidative stress-related diseases with no side effects, according to the studies.

Oxidative stress is a result of long-term overexpression of free radical compared to the levels of antioxidants.

In other words, depletion of antioxidant enzymes produced by the body is no longer can perform the function of neutralizing the free radical expression.

Free radicals are unstable atoms which have an unpaired electron on the outer ring. Therefore, in order to maintain stable, free radicals must donate or intercept an electron from other atoms, causing the domino's reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.

Antioxidants are stable atoms which inhibit oxidation.

Oxidative stress has been found to induced protein, lipid and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.

Futhermore, although free radicals are a normal byproduct of oxygen metabolism, certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.

Some researchers suggested, maintaining a balanced ratio free radicals and antioxidants are the best way for good health.

Dr. V. Lobo, the lead scientist in the evaluation of the free radicals and antioxidants wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases".

And, "Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists with an aim to find a natural remedy for the treatment of diseases associated with oxidative stress investigated the bilberry antioxidant activity in an animal model.

Selected rats were divided into 4 groups: control, rats treated with only gentamicin, with only bilberry, and treated with both gentamicin and bilberry.

By analyzing the oxidative stress markers and levels of antioxidant produced by the host, bilberry (100 mg/kg daily) showed a strong nephroprotective effect by improving the antioxidant status against gentamicin toxicity in rats.

These results clearly suggested that bilberry exerted a significant effect was attributed to the expression of the levels of the polyphenolic content, particularly anthocyanin. 

Dr. after taking into account so and confounders said, " the demonstrated protective activity of bilberry extract matched well with the assessed in vivo and in vitro antioxidant activity as well as with its polyphenolic content, particularly with high anthocyanin levels".

In order to determine the antioxidant activity in bilberry, researchers examined the hepatoprotective effects of anthocyanins from bilberry extract in rats exposed to carbon tetrachloride (CCl4).

Rats selected to the study also were assigned randomly into four groups: Group I (0.9% NaCl-10days), Group II (bilberry extract, 75mg/kg-10days), Group III (0,9% NaCl-9days, and on the tenth day CCl4-2ml/kg), Group IV (bilberry extract, 75mg/kg-10days and on the tenth day CCl4-2ml/kg).

Compared to nontreatment group, bilberry extract group showed a significant decrease in the activity of biochemical parameters in serum associated with liver damage, including the levels of free radicals and lipid peroxidation in the liver.

Furthermore, bilberry extract treatment group IV displayed a strong improvement of antioxidant enzymes produced by the host compared to Group III.

Injection of bilberry extract also showed an increase in the number of apoptotic hepatocytes and the activity of caspase-3 in the liver tissue which has been damaged by the injection of CCl4.

The findings suggested that the anthocyanins from bilberry extract have strong antioxidant properties against the CCl4 induced liver toxicity and oxidative stress.

Taken altogether, bilberry may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress, pending to the reconfirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry: Chemical Profiling, in Vitro and in Vivo Antioxidant Activity and Nephroprotective Effect against Gentamicin Toxicity in Rats by Veljković M1, Pavlović DR2, Stojiljković N1, Ilić S1, Jovanović I3, Poklar Ulrih N4, Rakić V5, Veličković L6, Sokolović D. (PubMed)
(2) Antioxidant and proapoptotic effects of anthocyanins from bilberry extract in rats exposed to hepatotoxic effects of carbon tetrachloride by Popović D1, Đukić D2, Katić V3, Jović Z4, Jović M5, Lalić J6, Golubović I7, Stojanović S8, Ulrih NP9, Stanković M10, Sokolović D. (PubMed)
(3) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PubMed)

Excessive Green Tea Drinking May Increase Risk of Infertility

By Kyle J. Norton

Green tea is a popular beverage processed many health benefits, including a reduction in the risks of heart disease, diabetes, and cancer. However, excessive green tea drinking or overused of supplement over the long term can induce serious side effects.

Contrast to general belief, overdoses of green tea and green tea supplements may affect the function of male reproductive organs, according to studies.

In other words, excessive consumption of green tea a day may increase the risk of infertility, regardless of genders.

According to 2008 reports by the US Pharmacopeia, there are a number of cases of cytolytic and cholestatic liver damage associated with long term use or high usage of green tea products.

The Sapienza University of Rome, in the statement of hepatotoxicity of green tea, suggested, although there are many cases of green tea was found to cause liver toxicity, due to reactions induced by GT had a generally long latency (179.1 ± 58.95 days), but most patents were recovered within 2 - 3 months.

The University continued "Present data confirm a certain safety concern with GT, even if the number of hepatic reactions reported is low considering the great extent of use of this supplement".

The results suggested that our drinking green tea habit should not be altered due to the low incidence of liver toxicity.

If you are taking a green tea supplement, please follow the direction of the product carefully.

The University of California liver health team in the concern of green tea may increase the risk of male infertility, examined On finding a natural ingredient for the improvement of reproductive health with no side effects, researchers examined the green tea reproductive activity in Drosophila melanogaster.

The study included Drosophila melanogaster embryos and larvae exposed to various doses of green tea polyphenols (GTP).

According to the tested assay, larvae exposed to 10 mg/mL GTP were slower to develop, emerged smaller, and exhibited a dramatic decline in the number of emerged offspring. 

 Female offspring produced by GTP larvae group exhibited a decline in reproductive output and decreased survival while males were unaffected.

According to the observation of atrophic testes in males, mature eggs in females,  GTP had a negative impact on reproductive organs in both males and females.

The results suggested that high dose of GTP may have an adverse effect in the reproductive development and reproduction.

In the investigation of the gender-specific effects of green tea on the lifespan of fruit flies, researchers surprisingly found an inverse correlation between lifespan and reproduction, particularly in male reproductive fitness.

Truly, green tea negatively impacted male fertility as shown by a reduced number of offspring produced and increased mating latency. 

After taking into account co and confounders, researchers suggested that green tea extends the lifespan of male flies by inhibiting reproductive potential, possibly by limiting iron uptake.

Dr. the lead scientist in the comparison of the previous human study said, " ...(The) results also support previous studies that suggest that green tea might have a negative effect on reproductive fitness in humans".

Taken all together, overdoses green tea and green tea supplements may have a negative impact in reproductive organs, regardless of gender, pending to the validation of larger sample and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The impact of green tea polyphenols on development and reproduction in Drosophila melanogaster. (PMC)
(2) Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness by Lopez T1, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M.(PubMed)
(3) Hepatotoxicity of green tea: an update by Mazzanti G1, Di Sotto A, Vitalone A.(PubMed)

Honey Promotes Drainage of Bile and Pancreatic Duct Against Obstructive Jaundice

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.

Obstructive jaundice is a condition caused by the obstruction of bile or pancreatic duct, that interferes with the drainage of bile from the bloodstream into the intestines.

On the other hand, jaundice is a result of overexpression of bilirubin, a yellowish pigment found in hemoglobin in the blood.

Increased expression of bilirubin in the blood in some cases is caused by liver injury.

Some researchers suggested that gallstones, pancreatic disease, including cancer and cysts, developed on or nearby the tube connecting the pancreas to the intestines.

In other words, any diseases associated with the narrowing and blocking of the normal function of the drainage of bile from the blood may be considered the causes of obstruction jaundice. 

According to the statistics, obstructive jaundice is a very common symptom found in approximately 10-15% of patients with Gallstones. Sadly, most cases of obstructive jaundice were a result of cancers with a 2-year mortality rate of 95%.

Dr. D. PHILIP MACGUIRE, M.D. in the article of obstructive jaundice suggested that in the differentiation of obstructive jaundice, physicians should also take into consideration the biochemical analyses of icterus index, bile acids, blood sedimentation test, cholesterol, nonprotein nitrogen, urea and amino nitrogen, uric acid of the blood, and urobilin excretion in the urine.

The doctor continued, " there is also a distinctive change in the chemical composition of the blood in obstructive jaundice as shown by an increase of cholesterol which is present in two forms: (a) free alcohol and (b) combined with acid as esters".

The statement is clearly suggested that a surgeon should also know the extent of liver impairment in patients with obstructive jaundice before the surgery.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural and therapeutic compound for the treatment of obstructive jaundice (OJ), a serious, life-threatening condition that can lead to death, researchers examined the anti-obstruction jaundice of honey and immunonutrients.

The study included forty 24-week-old male Sprague Dawley rats, randomly placed into five groups, each group consisted of eight rats. The sham group underwent only common bile duct (CBD) dissection and no ligation was performed. CBD ligation was applied to the other groups and after the operation, one CBD group was fed with rat chow only, the others were fed with rat chow supplemented with honey, or immunonutrients, or honey plus immunonutrients.

On the final day of the experiment, researchers found that honey and immunonutrient reduced the markers of oxidative stress observed by the levels of alanine aminotransferase (ALT) compared to the other groups.

Bacterial translocation (BT) rates also significantly reduced in the honey and immunonutrient treatment group according to the liver and spleen samples.

Futhermore, the mean mucosal thickness of ileum samples also improved notably in the BDL+HI group compared to the other groups.

Dr. Oguz S after taking into account co and confounders wrote, "Immunonutrition applied with honey had immunostimulant effects, decreased BT due to an additive effect, and had positive effects on intestinal mucosa".

Additionally, in order to reveal more information about honey anti-OJ property, researchers once again investigated the possible effects of honey supplementation on anastomotic wound healing in obstructive jaundice (OJ) model.

The study included 80 Wistar-albino rats divided into four groups as control, OJ, O plus artificial honey and OJ plus honey.

Selected rats were fed with standard rat chow (SRC) in group-I&II, SRC plus 10 mg/kg/day honey in group-4 and SRC plus artificial honey including the same caloric amount with honey in group-3. Colon anastomoses were performed in all groups.

Also, common bile duct ligation was performed in group-1, group-2, and group-3.

Honey treatment significantly lowers the levels of jaundice in the animal by inhibiting the levels of hydroxyproline compared with the controls and those given honey or artificial honey.

According to the anastomotic bursting pressure assay, the use of honey significantly increased the bursting pressure compared with that of the bile duct ligated group.

Dr. Ergul E, the lead scientist said, based on these results, "The oral administration of honey can be considered when attempts at conventional internal drainage fail in obstructive jaundice".

Taken altogether, honey may be considered a functional remedy for the treatment of obstructive jaundice (OJ), pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Combined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Study by Oguz S1, Salt O2, Ibis AC3, Gurcan S4, Albayrak D1, Yalta T5, Sagiroglu T1, Erenoglu C. (PubMed)
(2) The effect of honey on the intestinal anastomotic wound healing in rats with obstructive jaundice by Ergul E1, Ergul S. (PubMed)
(3) OBSTRUCTIVE JAUNDICE by D. PHILIP MACGUIRE, M.D.

Herbal Artichoke Inhibits the Incidence of Metabolic Syndrome

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy for the prevention and treatment of metabolic syndrome, according to studies.

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type II diabetes, including excess body fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.

Individuals are considered to have metabolic syndrome if they process 3 or more of the aforementioned conditions.

Being overweight or obesity, lack of physical activity and Insulin resistance are some of the risk factors associated with the onset of metabolic syndrome.

Some researchers suggested that the promotion of the Western diet over the past few decades may be the major factors that cause widespread metabolic syndrome in the Western world.

Dr. Silvia Moreno-Fernández, the lead scientist in the cross-sectional study of diet pattern in risk of metabolic syndrome wrote, " At the end of the study, HFG animals showed lower expression of energy expenditure genes when compared to the other DIO groups. Oxidative stress biomarkers such as MDA and mitochondrial RT-qPCR analyses showed an increase of oxidative damage together with mitochondrial dysfunction in HFG group".

And, "This group also showed increased insulin and glucose plasma levels, though HFF animals showed the greatest increase on these parameters. All DIO groups showed increased plasma levels of triglycerides".

The finding strongly suggested the correlation between the Western diet and metabolic syndrome risk.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

With an aim to find a natural ingredient for the treatment of metabolic syndrome, researchers examined the Artichoke leaf extract (ALE) anti-metabolic syndrome activity through its antioxidant activity.

The double-blind placebo-controlled randomized clinical trial included 80 patients with MetS randomly allocated to either "ALE group" (received 1800 mg ALE as four tablets per day) or "Placebo group" (received placebo containing cornstarch, lactose, and avicel as four tablets per day) for 12 weeks.

According to the results of 68 patients completed the experiment, dietary intakes of energy, macronutrients, and micronutrients were not significantly different between the two groups throughout the trial, with the exception of zinc.

However, the concentration of oxidative of low-density lipoprotein is decreased significantly in ALE group, compared to placebo without affecting the oxidative stress marker and antioxidant enzymes.

The finding strongly suggested that Artichoke leaf extract (ALE) only reversed one of the conditions of the cluster in metabolic syndrome, namely, hyperlipidemia.

Furthermore, in order to reveal more information of artichoke anti-metabolic syndrome effects, researchers evaluated the activity of Boldocynara®, a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus.

Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) involved the breaking down of carbohydrates.

Artichoke alone displayed a moderate inhibitory activity of 31% at 100 µg/ml.

According to the tested enzymes, the combination had moderate to weak effects against the expression of the metabolic syndrome.

The results indicated a moderate potential of the dietary supplement Boldocynara® and artichoke for the treatment of metabolic disorders.

Taken altogether, artichoke used alone or combined with other herbal medicines may have a potential effect against the onset of metabolic syndrome, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial by Rezazadeh K1, Aliashrafi S2, Asghari-Jafarabadi M3, Ebrahimi-Mameghani M. (PubMed)
(2) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)
(3) High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model by Silvia Moreno-Fernández,1,2 Marta Garcés-Rimón,3 Gema Vera,2,4 Julien Astier,5Jean François Landrier,5 and Marta Miguel. (PMC)

Tomatoes, The Vegetables Which Normalize the Blood Pressure in Hypertensive Patients

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the prevention and treatment of hypertension with no side effects, according to studies.

Hypertension is a medical condition characterized by abnormally high blood pressure.

Blood pressure is a measurement of a force against the walls of blood vessels that the heart pumps blood around the body.

Chronic and untreated high blood pressure has been associated epidemiologically with an increased risk of heart disease and stroke.

According to the statistics provided by the American Heart Association, there are over 103 million Americans living with high blood pressure.

In other words, nearly half of all adults in the US have hypertension.

According to the new definition in the measurement of blood pressure, the percentage of U.S. adults with high blood pressure jumped from 32 percent under the old definition to nearly 46 percent.

Most people with mild hypertension can control the blood pressure by a change of lifestyles such as a change to diet and exercise.

There are many prevalent factors associated with the onset of hypertension, including age, ethnicity and gender, diet, physical inactivity, exercise, and smoking.

Some researchers suggested widespread hypertension in the obese subjects may be correlated to the promotion of a high-fat diet over the past few decades.

Dr. Lia Taylor, the lead scientist wrote, "Diets high in fat and cholesterol have been linked to weight gain and hypertension, and T cell activation has been suggested to mediate these diet-induced changes in male animal models".

And, "a 4wk-HF diet increased BP and decreased renal anti-inflammatory T cells in female DSS rats. The loss of renal anti-inflammatory T cells is expected to lead to a more pro-inflammatory immune cell profile that may sensitize female DSS rats to HF-diet induced increases in BP".

Tomato is red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, tomatoes are cultivated worldwide for commercial purpose and often in the greenhouse.

On finding a potential compound for the treatment of hypertension with no side effects, researchers assessed whether the addition of standardized tomato extract (STE) or acetylsalicylic acid (ASA) to standard antihypertensive therapy can improve BP control in patients with arterial hypertension (HT).

The study included 82 high-risk hypertensive patients with primary HT at high to a very high total CV risk were randomized in a blinded fashion to one of two groups, i.e. the ASA and STE group.

STE treated group showed a statistically significant reduction in 24-h systolic BP, diastolic BP, and mean arterial pressure values measured in ABPM after four weeks compared to ASA treated group.

Furthermore, after four weeks of treatment, the STE group exhibited a statistically significant reduction in pulse pressure (PP) during the daytime and during 24 h.

Moreover, STE treatment in obese patients also significantly decreased the day PP.

Based on the results, researchers said, "The results of this study show that the addition of STE to standard antihypertensive therapy improves BP control in hypertensive patients with high CV risk. This effect, together with the anti-aggregatory effect, may indicate the pleiotropic effect of tomato extract."

Additonally, in the study of 65 patients with arterial hypertension and high cardiovascular risk. researchers compared the influence of adding acetylsalicylic acid (ASA) or standardized tomato extract (STE) to standard hypotensive therapy on the values of arterial pressure and the daily blood pressure profiles of patients with hypertension and high cardiovascular risk.

All patients evaluated with high-risk of primary hypertension were randomly allocated in a blinded fashion to one of two groups (ASA or STE).

Similar to the aforementioned study, the blood pressure values during the day, during the night, and in 24-h BP profiles obtained with ABPM were significantly lower in the STE group in compared to the ASA group, after 4 weeks of treatment.

The addition of STE to standard hypotensive treatment resulted in a favorable increase in the nocturnal fall of diastolic blood pressure (DBP) (by 6.5%) and mean arterial pressure (MAP) (by 3.3%).

In other words, tomato normalized the blood pressure against the risk of CVD regardless of the levels of blood pressure.

Dr. Osińska AN, the lead scientist wrote in the final report, "The use of STE is significant in HT patients with high total cardiovascular risk; it is associated with better BP control and improvements in the daily BP profile.".

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial by Krasińska B1, Osińska A, Krasińska A, Osiński M, Rzymski P, Tykarski A, Krasiński Z. (PubMed)
(2) The influence of adding tomato extract and acetylsalicylic acid to hypotensive therapy on the daily blood pressure profiles of patients with arterial hypertensionand high cardiovascular risk by Osińska AN1, Begier-Krasińska B1, Rzymski P2, Krasińska A3, Tykarski A1, Krasiński Z. (PubMed)
(3) A High Fat Diet Increases Blood Pressure and Leads to a Renal Proinflammatory Immune Cell Profile in Female Dahl Salt-Sensitive Rats by Lia Taylor, Jacqueline Musall, Babak Baban, Eric J Belin de Chantemele, and Jennifer Sullivan. (Faseb Journal)

Fermented Cucumbers (Cucumis sativus), the Natural Probiotics to Human Health

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the prevention and treatment of neurodegeneration with no side effects, according to studies.

Probiotics are live bacteria and yeasts that play an essential role in the improvement of digestive functioning.

In other words, probiotics balanced the ratio of the gut microbiota by improving the levels of healthy organisms in the gut, particularly in people who are taking antibiotics, leading to the optimization of the digestive system in the absorption nutrients for the body needs such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function.

Where gut microbiota is the complex community of microorganisms that live in our gastrointestinal tracts.

Microbial imbalance or dysbiosis induced intestinal inflammation as a result of overexpression of bad organisms in the gut has been found to utilize a complex arsenal of virulence factors to colonize and persist in the intestine, implicating the development of intestinal diseases. 

Some virulence factors such as the genotoxin colibactin, produced by overexpression of bad bacteria in the gut were found to promote colorectal cancer and chronic intestinal inflammatory diseases.

Dr, Yu-Jie Zhang, the lead scientists in the examined the importance of gut bacteria on Human Health wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells".

And, " they (imbalanced ratio of gut microbiota) can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".

Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find potential and natural compound for the improvement of digestive health, researchers investigation the probiotic activity of cucumber.

According to the novel strain of lactic acid bacterium isolated from fermented cucumber, the ferment carbohydrates such as sucrose, dextrose, and arabinose showed a significant gastroprotective effect against antibiotics, including ciprofloxacin, kanamycin, vancomycin.

Furthermore, the isolate displayed potential probiotic properties in the improvement of the digestive health observed by hydrophobicity, autoaggregation, coaggregation, and in vitro cell adhesion ability.

Moreover, the isolate also exhibited resistance against bad bacteria and simulated gastric juice at pH 3.0.

Based on the findings researchers suggested that novel strain of lactic acid bacterium isolated from fermented cucumber protected the digestive tract against the injection of antibiotics, inhibited the production of bad bacteria such as gram-positive bacterial and utilized the effects of prebiotics such as inulin and raffinose.

Dr. Shukla R, the lead scientist said, " These results indicate both probiotic property and the glucansucrase-producing ability of P. pentosaceus CRAG3".

In vitro, in the evaluation of the probiotic potentials of three Bacillus strains 437F, 1630F and 1020G obtained from the traditional pickle researchers found that

* All strains only showed high acid, bile tolerance but also exhibited antagonistic activity against various pathogens. 

* All strains exhibited antioxidant activity, auto- and co-aggregation ability and surface hydrophobicity and attachment capacity against the Caco-2 cells were similar to those of well-known probiotic strains.

* All strains are safe without causing harm to healthy colon cells.

Based on the findings, researchers said, "With respect to their characteristics and safety aspect, these Bacillus species may have potential to consider as probiotics for animal and/or human applications".

Taken altogether, cucumber may be considered supplements for the protection of digestive functioning, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Probiotic Potential of Pediococcus pentosaceus CRAG3: A New Isolate from Fermented Cucumber by Shukla R1, Goyal A. (PubMed)

(2) Three novel Bacillus strains from a traditional lacto-fermented pickle as potential probiotics by Talebi S1, Makhdoumi A1, Bahreini M1, Matin MM1,2, Moradi HS. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li1. (PubMed)

Herbal Artichoke, The Anti Hypertriglyceridemic Functional Remedy, According to Studies

By Kyle J. Norton

Artichoke may be the next generation of whole food or remedy for the treatment of hypertriglyceridemia with no side effects, according to studies.

Hypertriglyceridemia is a condition characterized by high levels of triglycerides in the blood.

Triglycerides are accumulated in the blood for future use by converting any unused calories. Overexpression of hyperglyceridemia is found to patients with atherosclerosis even without the presence of high cholesterol levels, and predispose.

In other words, hypertriglyceridemia can also be accumulated to the arterial wall or combined with other substances to form plaque that narrows the arteries in transporting rich oxygenated blood to the heart and other parts of the body.

There are 2 main sources of plasma triglycerides
* Dietary fat which is carried in chylomicrons.

* Fat is produced by the liver carried in very-low-density lipoprotein (VLDL) particles.

Primary hypertriglyceridemia is found in 5% of patients associated with genetic preposition compared to 95% of secondary hypertriglyceridemia found in obese metabolic syndrome, diabetes,... patients.

Treating hypertriglyceridemia is difficult, as the condition is frequent coexistence with other conditions that affect cardiovascular disease risks, such as high levels of low-density lipoprotein, obesity, metabolic syndrome, and type 2 diabetes. 

In severe cases of hypertriglyceridemia, patients may also experience the complication of acute pancreatitis, independent to the risk of CVD.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

In the concern of the overexpression of hypertriglyceridemia in risk of cardiovascular diseases, researchers examined the potentially favorable effects of artichoke leaf extract (ALE) on anthropometric (the size, shape, and composition of the human body) and metabolic indices affected by fat mass and obesity-associated (FTO)-rs9939609 polymorphism.

The double-blind placebo-controlled randomized clinical trial, included 52 patients with hypertriglyceridemia randomly allocated to receive ALE (1800 mg/day as four tablets) or matching placebo (consisting of corn starch, lactose, and avicel) for 12 weeks.

Interestingly, in 48 patients completed the trial (intervention, n = 24, placebo = 24), ALE and placebo groups were similar in the baseline characteristics.

However, the ALE treatment group showed a strong interaction between FTO-rs9939609 polymorphism and the levels of TC, LDL-C, and TG.

These results suggested that ALE modulated the TG level in A allele carriers compared to subjects with TT genotype, compared to those without.

Based on the findings, scientists wrote in the final report, "No significant effect of ALE supplementation was shown on anthropometric and biochemical indices in Iranian hypertriglyceridemic patients. However, rs9939609 variant of FTO gene seems to affect lipid profile response to ALE supplementation".

In order to reveal more information about artichoke antihypertriglyceridemic activity, researchers investigated the anti-dyslipidemic properties of the combination of the artichoke leaves extract, turmeric extract, prickly pear dried leaves (PPL) and garlic extract versus each one alone in two different hyperlipidemic animal models.

The study included a two-week treatment of each of the natural extracts, combination 1 (artichoke, turmeric, and PPL) or combination 2 (artichoke, turmeric, PPL and garlic) prior to a single intraperitoneal injection of Pluronic F-127.

Single intraperitoneal injection of Pluronic F-127 showed a significant increase in levels of serum LDL before treatments.

In a 10-day high fat diet model, only the combination 1 and 2 lowered serum cholesterol, LDL by 8–12%, decreased significantly triglycerides, LDL/HDL ratio; and increased significantly HDL.

Additionally, in the long-term treatment of each natural product for 7 weeks observation, researchers found that only artichoke and PPL inhibited significantly the activity of HMG-CoA reductase, the metabolic pathway associated with the production of cholesterol.

The finding strongly suggested that the combination of artichoke, turmeric, PPL and garlic extract prevents dyslipidemia with a short and long-term use.

Taken altogether, artichoke use alone or combined with other herbal medicines may be considered a functional food for the prevention and treatment of hypertriglyceridemia, pending to the confirmation of larger sample size and multicenter human study.

A

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The interaction of FTO-rs9939609 polymorphism with artichoke leaf extract effects on cardiometabolic risk factors in hypertriglyceridemia: A randomized clinical trial by KhaterehRezazadehab, Mohammad Asghari-Jafarabadicd, Mehranghiz Ebrahimi-Mameghaniy. (ScienceDirect)
(2) Effects of Prickly Pear Dried Leaves, Artichoke Leaves, Turmeric and Garlic Extracts, and Their Combinations on Preventing Dyslipidemia in Rats by Nidal A. Qinna, 1 ,* Basma S. Kamona, 1 Tawfiq M. Alhussainy, 1 Hashem Taha, 2Adnan A. Badwan, 3 and Khalid Z. Matalka. (PMC)
(3) Hypertriglyceridemia: its etiology, effects, and treatment by George Yuan, Khalid Z. Al-Shali and Robert A. Hegele. (CMAJ)