Thursday 12 October 2017

Food Therapy: Coffee Intake for Longevity

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer in easing symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, second to tea consumption, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee may have a profound effect in strengthen the telomere length, a biomarker of living longer, a renowned study suggested.

In a cross-sectional association between coffee consumption and telomere length in 4780 women , using the data from the Nurses' Health Study (NHS) from a prospective cohort study of female nurses began in 1976 with relative telomere length measured in peripheral blood leukocytes by the quantitative real-time polymerase chain reaction, after adjusting to other risk factors, researchers found that
1. Higher total coffee use were significantly associated with longer telomeres in compared to non drinkers
2. Intake of 2 to <3 and ≥3 cups of coffee/d showed a relative ratio of 1.29 and 1.36, respectively
3. Telomere length was associated linearly to caffeine consumption from all dietary sources

The result of findings, showed a strong indication of correlation between coffee caffeine intake and the length of telomeres among female nurses.

Dr. Liu JJ, the led author said, " ... better understand the influence of coffee consumption on telomeres, which may uncover new knowledge of how coffeeconsumption affects health and longevity".

Other, in a study of total of 5826 adults from the National Health and Nutrition Examination Survey (NHANES) cross-sectionally, using the quantitative polymerase chain reaction method, telomere length compared to standard reference DNA, after adjusting to other risk factors, including age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use,.. researchers showed that
1. Caffeine consumption was inversely related to telomere length
2. For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter
3. For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter
4. Among non-coffee drinkers only, 40.0 base pairs shorter

In compared to non drinker(40.0 base pairs shorter), coffee caffeine( 36.7 base pairs shorter) and caffeine( 35.4 base pairs shorter) intake expressed a positive effect in increased genetic telomeres length.

Taking altogether, coffee (regardless caffeinated or not and numbers of cups intake per day) expressed a significant effect in increased telomeres length, the DNA implication of living longer in both gender.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee Consumption Is Positively Associated with Longer Leukocyte Telomere Length in the Nurses' Health Study by Liu JJ1, Crous-Bou M2, Giovannucci E3, De Vivo I4.(PubMed)
(2) Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES) by Tucker LA1.(PubMed)

Food Therapy: Coffee In Risk of Kidney Stone?

By Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes. In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.
Epidemiological studies linking coffee and caffeine intake in risk of kidney stone formation have been contradictory.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Kidney stone is a deposit of insoluble calcium compounds in the kidney, affecting over 10% of world population, according to statistic.

According to the Warsaw Agricultural University, coffee and tea consumed daily and regularly expressed an increased risk of kidney stone by more than 80% in compared to risk of other factors, probably due to presence of oxalates found in coffee.

In fact, in the analyzed nutritional habits of 22 stone formers with special regard to oxalate content as one of the main nutritional lithogenic factors associated with kidney stones, researchers found that  risk of kidney stone increased substantially for men and women if dietary oxalate intake was over 354 mg and 406 mg, respectively

Contrastively, a prospective study in investigated relation between intake of 21 different beverages and risk of symptomatic kidney stones in a cohort of 45,289 men, 40-75 years of age conducted by the Harvard School of Public Health, suggested that the risk of stone formation decreased by 10%. of the amount for each 240-ml (8-oz) serving consumed daily in caffeinated coffee.

Other, in the analyzed association between intake of caffeine and incidence of kidney stones in 3 large ongoing cohort studies, and the Nurses' Health Studies (NHS) I and II also found a contradictory result in related to coffee and other plant base caffeine products.

In a total of 217,883 participants; over a median follow-up of >8 y, 4982 incident cases of kidney stone occurred studies, researchers files the following results.
1. The highest quintile of caffeine intake (95% CI: 12%, 38%) showed a significant reduced risk of developing stones by 26%, according to the Health Professionals Follow-Up Study (HPFS).
2. Caffeine inkate showed a 29 % lower risk in the NHS I cohort, and
3. and 31% lower risk in the NHS II cohort

Dr. the lead author said. "Among 6033 participants with 24-h urine data, the intake of caffeine was associated with higher urine volume, calcium, and potassium and with lower urine oxalate and supersaturation for calcium oxalate and uric acid".

Taking altogether, the findings demonstrated a contradictory result between caffeine and caffeinated and decaffeinated coffee intake and risk of formation of kidney stones, therefore, a cohost with large sample size study are warranted.



Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Tea and coffee as the main sources of oxalate in diets of patients with kidney oxalate stones by Gasińska A1, Gajewska D.(PubMed)
(2) Caffeine intake and the risk of kidney stones by Ferraro PM1, Taylor EN1, Gambaro G1, Curhan GC1.(PubMed)
(3) Prospective study of beverage use and the risk of kidney stones by Curhan GC1, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ.(PubMed)

Food Therapy: Green Coffee, The Best to Against Risk and Treatment of Obesity


By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Green coffee intake may have a profound effect in reduced risk and treatment of obesity, a renowned institute study suggested.

According to the joint study led by the Huanggang Normal University, the health benefits of coffee studies over last 10 years, expressed a significant improvement of risk and treatment of obesity in decreased lipid accumulation in cells through regulating the cell cycle during fat metabolism.

Additionally, coffee consumption induced changes in transcription factors in fat deposit, decreased body weight and visceral fat form of animal and humans studies

Furthermore,  coffee influenced gut microbiota in obese animals and humans also played an important role for used as a functional and integrated food in reduced risk and treatment of obesity.


Other in the study of obesity induced in mice using a HFD for four weeks, fed only HFD or HFD with GCBE at 50, 100, and 200 mg/kg suggested that
1.Mice treated with green coffee intake showed a significantly decreased body weight gain, liver weight and white adipose tissue weights with regulation of adipose tissue lipolysis hormones, such as adiponectin and leptin.
2. Mice treated with green coffee intake also demonstrated a decreased mRNA expression levels of adipogenesis and adipocyte metabolis  related genes in adipose tissues and the liver, and decreased the corresponding protein expression.
3. GCBE treated mice had a lower fat mass with decreased relative body weight and fat mass in compared to HFD alone fed mice.

According to the information collected, Dr. Choi BK, the led author said, "GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver".

More importantly, in the study of male ddy mice fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 day, researchers at the Oryza Oil & Fat Chemical Co,, Ltd, indicated that
1. GCBE with  0.5% and 1% reduced visceral fat content and body weight
2. Caffeine and chlorogenic acid showed a tendency to reduce visceral fat and body weight
3. Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days showed a tendency to reduce hepatic TG in mice
4. Chlorogenic acid (60 mg/kg. day) reduced hepatic TG level

The findings displayed a strong effect of coffee and its phytochemicals in reduced weight gain and fat accumulation by inhibition of fat absorption and activation of fat metabolism in the liver may be considered as a functional and integrated food  against risk and treatment of obesity

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice by Shimoda H1, Seki E, Aitani M.(PubMed)

30 Explicit Health Benefits of Herbal Andrographis Paniculata

Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

Andrographis paniculata, the forgotten herbal medicine may have a potential effect in delay skin aging, however, its therapeutic properties have rarely been applied in the field of skin care.

30 Explicit Health Benefits of Herbal Andrographis Paniculata
1. Herbal Andrographis and Cancers
2. Herbal Andrographis Hepatoprotective effect
3. Herbal Andrographis and Rheumatoid arthritis
4. Herbal Andrographis and Immunity
5. Herbal Andrographis and Heart diseases
6. Herbal Andrographis and Common cold
7. Herbal Andrographis and Gastric Ulcer
8. Andrographis and Anti-inflammatory effects
9. Herbal Andrographis and Colitis
10. Herbal Andrographis and malaria
11. Herbal Andrographis and Renoprotective effects
12. Herbal Andrographis and Oral Cancer
13. Herbal Andrographis and Hepatitis
14. Herbal Andrographis and Anti-fertility
15. Herbal Therapy: Andrographis, The Male Contraceptive Whole Herb Medicine or Not?
16. Herbal Therapy: Andrographis paniculata In Reduced Risk and Early Onset of Alzheimer's disease
17. Herbal Therapy: Andrographis Paniculata, a Neuroprotective Whole Herb Medicine
18. Herbal Therapy:, Andrographis aniculata, The Best Whole Herb Medicine for Relieving Symptoms and Treatment of Upper Respiratory Tract Infection
19. Herbal Therapy:, Andrographis paniculata in Reduced Risk of Early Onset of Cognitive Impairment
20. Herbal Therapy: Andrographis, The Best Whole Herb for Reduced Risk andTreatment of Gastric/Stomach Cancer
21. Herbal Therapy: Andrographis Paniculata, The Best Gastroprotective Whole Herb Medicine
22. Herbal Therapy: Andrographis in Reduced Risk and Treatment of Leukemia
23. Herbal Therapy, Andrographis, The Anti Skin Cancer Whole Herb Medicine
24. Herbal Therapy: Andrographis, A Chemotherapeutic Agent for Treatment of Breast Cancer
25. Herbal Therapy: Andrographis in Accelerated Wound Healing with Lesser Scar
26. Herbal Therapy: Andrographis, The Best Anti Platelet Aggregation Herbal Medicine
27. Herbal Therapy: Andrographis, The Best Whole Herb Medicine for Treatment of Ulcerative Colitis
28. Herbal Therapy: Andrographis, The Anti Lung cancer Whole Herb Medicine
29. Herbal Therapy: Andrographis, The Immunomodulatory Whole Herb Medicine
30. Herbal Therapy: Andrographis Paniculata, the Best Anti Skin Aging Natural herbal Medicine

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Food Therapy: Coffee Intake > 2 cups/day In Increased Risk Type ! Diabetes

By Kyle J. Norton


Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.
Coffee, has become a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee in adulthood may increase risk of autoimmune diabetes or type 1 diabetes, a study of Institute of Environmental Medicine, Karolinska Institutet suggested.

In a population-based case-control study with incident cases of adult onset (≥ 35 years) diabetes, including 245 cases of latent autoimmune diabetes in adults (glutamic acid decarboxylase antibody positive), 759 cases of Type 2 diabetes (glutamic acid decarboxylase antibody negative), together with 990 control subjects without diabetes, randomly selected from the population, after inspection of the returned questionnaire, researchers found that coffee intake may be associated with an increased risk of high glutamic acid decarboxylase antibody latent autoimmune diabetes in adults.

The relative odd ratio of these population was 1.11 in compared to non drinkers.
The risk of disease development increased by 15.2% (P = 0.0268) for every additional cup intake.

Dr. Löfvenborg JE, the lead author said, " coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults".

More importantly, in the review of the association between coffee intake, its influence on the immune system and the insurgence of the most relevant autoimmune diseases conducted by the joint study lead by the Tel-Aviv University coffee intake showed a selectively both in increased(rheumatoid arthritis (RA) and type 1 diabetes mellitus (T1DM)) and decreased(multiple sclerosis, primary sclerosing cholangitis, and ulcerative colitis) risk of some auto immune diseases.

Particularly in type 1 diabetes, Dr. Sharif K, the lead author said, "Coffee intake led to a decrease in insulin sensitivity in T1DM" and " coffee consumption was shown to influence disease course and management options".

Remarkably, in the study of some diabetic children younger than 15 years, and diagnosed from September 1986 to the end of April 1989, with 600 newly diagnosed diabetic children and 536 randomly selected population-based children, researchers postulated that risk for type 1 diabetes were increased in the children who consumed at least 2 cups of coffee daily in compared to other groups.even after adjusting to other odd factors.

The finding evidences suggested that coffee intake daily and regular may have significant impact in increased development of type 1 diabetes in children and adults population regardless amount of cups intake. therefore, people with family history of type 1 diabetes should reduced intake of less than 2 cups of coffee per day.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study by Löfvenborg JE1, Andersson T, Carlsson PO, Dorkhan M, Groop L, Martinell M, Rasouli B, Storm P, Tuomi T, Carlsson S.(PubMed)
(2) Coffee and autoimmunity: More than a mere hot beverage! by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(3) Is children's or parents' coffee or tea consumption associated with the risk for type 1 diabetes mellitus in children? Childhood Diabetes in Finland Study Group by Virtanen SM1, Räsänen L, Aro A, Ylönen K, Lounamaa R, Akerblom HK, Tuomilehto J.(PubMed)

Wednesday 11 October 2017

Food Therapy: Coffee Increases Risk of GERD in Geographical or Racial Differences?

By Kyle J. Norton


Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.

Epidemiological studies linking coffee intake in risk of Gastro-esophageal reflux disease have been inconsistent and contradictory.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Gastro-esophageal reflux disease is a digestive disorder, affected ring of muscle between the esophagus and stomach, inducing symptoms of heartburn or acid indigestion.

Pathophysiological changes in esophageal functions that occur with aging may, at least in part is responsible for the high prevalence of Gastro-esophageal reflux disease (GERD).

In the review of online literature published database from Med, EMBASE, and Cochrane Library up to December 2012, researchers at the Seoul National University Hospital filed the following results
1. A meta-analysis showed that intake of coffee exerted no significantly associated risk of GERD.
2. Only the endoscopy group showed a significantly higher odds ratio risk induced by coffee in compared to other subgroups.

But after accounting to other risk factors, such as amount of coffee intake, quality of study, and assessment of exposure researchers found that coffee intake do not associate to increased risk of GERD.

Other, in the study to investigate the association of habits and social conditions reported lead to reflux in the employees of hospital, researchers indicated that even with the the prevalence rate of 21.7% of GERD incidence in this group of participants, intake of coffee daily and regularly showed no effect in increased risk GERD, regardless to amount of coffee intake per day.

Contrast to the above studies,  the Korean prospective study of recruited subjects with GERD visited a health promotion center for upper gastrointestinal cancer surveillance at Hallym Medical Center (five institutions) between January 2008 and February 2009, researchers reported that
1. Coffee intake showed a significant correlation to independent risk of GERD in young and adults groups
2. and Coffee intake was considered as a major risk factor in elderly group.

Dr. Park CH, the lead author said, "The risk factors for RE according to age group were found to differ. In elderly group, Helicobacter pylori infection was not a significant protective factor contrary to young and adult groups.

Taking altogether, Coffee intake showed a conflict result in risk of GERD, probably due to geographic difference as Asian population are susceptible to risk of the diseases in compared to population in the West. Further studies are necessary.



Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Association between coffee intake and gastroesophageal reflux disease: a meta-analysis by Kim J1, Oh SW, Myung SK, Kwon H, Lee C, Yun JM, Lee HK; Korean Meta-analysis (KORMA) Study Group.(PubMed)
(2) The prevalence of gastroesophageal reflux disease among hospital employees by Ercelep OB1, Caglar E, Dobrucali A.(PubMed)
(3) Differences in the risk factors of reflux esophagitis according to age in Korea by Park CH1, Kim KO, Baek IH, Choi MH, Jang HJ, Kae SH, Kim JB, Baik GH, Shin WG, Kim KH, Kim HY.(PubMed)

Herbal Therapy: Andrographis Paniculata, the Best Anti Skin Aging Natural herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

Andrographis paniculata, the forgotten herbal medicine may have a potential effect in delay skin aging, however, its therapeutic properties have rarely been applied in the field of skin care.

Skin aging, a naturally biological process caused by thinning of layer  just underneath the skin can not be prevented but delayed


Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

According of the joint study lead by the Biospectrum Life Science Institute, in vitro, ex vivo, and in vivo, Andrographis paniculata extract (APE) exhibited a significant anti aging activity through ameliorate the process of loss of human epidermal stem cells (EpSCs).

Truly, the epidermal stem cells (EpSCs). treated with Andrographis paniculata extract (APE) exerted an anti aging effect by increased cells quantity significantly in the G2/M and S stages in cell division in a dose-dependent manner. 

The study also found that APE-treated EpSCs enhanced the Type 1 collagen production in normal human fibroblasts (NHFs).and improved skin hydration, dermal density, wrinkling, and sagging significantly.

In UV-Induced Skin Photoaging Andrographolide sodium bisulfate (ASB), a water-soluble form made from andrographolide increased the function of antioxidants in attenuated oxidative stress and inflammation responsible for ultraviolet (UV) irradiation causing skin damage and premature aging.
Dr. the lead anthor in the study of ultraviolet (UV) induced skin aging said, "topical administration of ASB suppressed the UV-induced skin thickness, elasticity, wrinkles, and water content, while ASB, especially at dose of 3.6 mg/mouse, increased the skin collagen content by about 53.17%, decreased the epidermal thickness by about 41.38%, and prevented the UV-induced disruption of collagen fibers and elastic fibers"

Furthermore, the study also proposed, the anti aging effect of the herbal Andrographis may be attributed  to anti enzymes in inhibited free radicals induced of oxidative stress and reduced the expression of pro inflammatory cytokins.

Taking together, Andrographis paniculata expressed significantly anti-skin aging effects through various mechanisms, but intake of large amount should be taken with care.



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The Antiaging Properties of Andrographis paniculata by Activation Epidermal Cell Stemness by You J1, Roh KB2, Li Z3, Liu G4, Tang J5, Shin S6, Park D7, Jung E8.(PubMed)
(2) Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation by Janis Ya-Xian Zhan,1 Xiu-Fen Wang,1 Yu-Hong Liu,1 Zhen-Biao Zhang,1 Lan Wang,2 Jian-Nan Chen,1 Song Huang,1 Hui-Fang Zeng,2 and Xiao-Ping Lai1(Hindawi)