Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Delay Diagnosis

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                              Delay diagnosis 

Delay diagnosis of fibromyalgia is frequent due to patients difficulties in communicating their symptoms to the physician, causing over one third (35%) delay diagnosis of chronic widespread pain.

According to the King's College London," Patients wait a significant period of time before presenting to a physician, adding to the prolonged time to diagnosis. Patients typically present with a multitude of symptoms, all resulting in a delay in diagnosis and eventual management"(73).
In a questionnaire survey of 1622 physicians in six European countries, Mexico and South Korea including Specialties of primary care physicians (PCPs; n=809) and equal numbers of rheumatologists, neurologists, psychiatrists and pain specialists, 53% of physicians reported difficulty with diagnosing FM, 54% reported their training in FM was inadequate, and 32% considered themselves not knowledgeable about FM(74). The high percentage  of difficult diagnosis and inadequate training may contributed the delay diagnosis and contributing to widespread unnecessary pain and significant impact on quality of life and function to patients with FM(75).

Dr. Clark P and colleagues at the Clinical Epidemiology Unit HIM-Federico Gómez Faculty of Medicine UNAM in the physician survey of fibromyalgia across Latin America and Europe,
said, "Patient and physician perspective concerning FM impact and disruption were often misaligned within the same region. Our observations may be representative of cultural differences in stoicism, expression, beliefs, and attitudes to pain perception and management. Better understanding of these complexities could help targeted educational/training programs incorporating cultural differences, to improve chronic care"(76).

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References

(73) A patient survey of the impact of fibromyalgia and the journey to diagnosis by Choy E1, Perrot S, Leon T, Kaplan J, Petersel D, Ginovker A, Kramer E.(PubMed)

(74) Survey of physician experiences and perceptions about the diagnosis and treatment of fibromyalgia by Perrot S1, Choy E, Petersel D, Ginovker A, Kramer E.(PubMed)

(75) A patient survey of the impact of fibromyalgia and the journey to diagnosis by Choy E1, Perrot S, Leon T, Kaplan J, Petersel D, Ginovker A, Kramer E.(PubMed)

(76) A patient and physician survey of fibromyalgia across Latin America and Europe by Clark P1, Paiva ES, Ginovker A, Salomón PA.(PubMed)

                               

                                 

                           

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Misdiagnosis

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                   The Misdiagnosis 

1. Inflammatory arthritis

Inflammatory arthritis is an auto immune diseases induced tender and swollen joints causing pain, stiffness and joint damage my be misdiagnosed as Fibromyalgia fue to FM have a marked impact on tender joint count scores, resulting in a disproportionately high tender joint count to swollen joint count ratio similar to those of inflammatory arthritis(67). Dr. Pöyhiä R and colleagues at the McGill University Health Center,, said,"Patients with FM report a high rate of varied pain and adverse experiences throughout life" and "Patients with FM reported significantly more irritable bowel syndrome, migraine headaches, severe menstrual pain, physical and psychological trauma affecting well being, family history of FM, and family pain environment than subjects with IA or controls"(68).

2. Spondyloarthropathies (SpA) and connective tissue disease (CTD)

Spondyloarthropathies (SpA) and connective tissue disease (CTD) are joint disease similar to those of FM. According to the Sapienza University of Rome, although is FM is a wellknown clinical entity, differentiation of SpA, CTD and inflammatory arthritis can still be diagnosed as FM(69). But incorrect diagnosis can be avoid if rheumatologists recognise and distinguish primary and secondary FM(70).

3. Serotonin syndrome

Serotonin syndrome is a over production of hormone serotonin due to serotonergic medications, causing wide spread pain may be misdiagnosed as fibromyalgia, accordin to a 42-year-old woman referred for physical therapy with a diagnosis of fibromyalgia(71). But careful evaluation by the physical therapist indicated that signs and symptoms may alter intitial diagnosed Dr. Alnwick GM said.

4. Others

Dr. Shapiro AP and Dr. Teasell RW in the study of Misdiagnosis of chronic pain said "
it is not surprising that chronic pain disorders are often misdiagnosed as hysterical or psychological in origin" and  "can significantly increase the likelihood of treatment failure"(72).

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The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References

(67) Joint counts in inflammatory arthritis by Scott IC1, Scott DL.(PubMed)

(68) Previous pain experience in women with fibromyalgia and inflammatory arthritis and nonpainful controls by Pöyhiä R1, Da Costa D, Fitzcharles MA.(PubMed)

(69) Misdiagnosis in fibromyalgia: a multicentre study by Di Franco M1, Iannuccelli C, Bazzichi L, Atzeni F, Consensi A, Salaffi F, Pietropaolo M, Alessandri C, Basili S, Olivieri M, Bombardieri S, Valesini G, Sarzi-Puttini P.(PubMed)

(70) Chronic widespread pain in the spectrum of rheumatological diseases by Atzeni F1, Cazzola M, Benucci M, Di Franco M, Salaffi F, Sarzi-Puttini P.(PubMed)

(71) Misdiagnosis of serotonin syndrome as fibromyalgia and the role of physical therapists by Alnwick GM1.(PubMed)

(72) Misdiagnosis of chronic pain as hysterical by Shapiro AP1, Teasell RW2.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Diagnosis

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                                               The  Diagnosis

The American College of Rheumatology (ACR), evidence-based interdisciplinary German guidelines on the diagnosis and management of FMS by Klinikum Saarbrücken Internal Medicine 1 Winterberg 1 D-66119 Saarbrücken,  recommended  a step wise diagnostic work-up of patients with chronic widespread pain (CWP), including Fibromyalgia
1.  Complete medical history including medication, complete medical examination, as wide spread pain with no medical condition may constitute the disease development.
2. Basic laboratory tests to screen for inflammatory or endocrinology diseases to rule out other condition with similar symptoms.
3. Referring to specialists only in case of suspected somatic diseases. As psychological problems are found to associate to patients with Fibromyalgia(38)(39).
Dr. Tavel ME said, " Depending upon the type of physician/specialist consulted, those individuals may receive disease labels that range from an implied psychological origin such as somatoform or psychosomatic disease, or to a presumed physical disease such as fibromyalgia"(64)
4.  Referring to mental health specialists in case of mental disorder(63). Psycological treatment of patients with continual and widespread musculoskeletal pain, including multimodal therapy, hypnosis, cognitive-behavioral therapy for insomnia, behavioral therapies, mind-body-based techniques, and biofeedback component showed to reduce symptoms of FM(65).


[Here we quote the text and copy from the study of The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity by FREDERICK WOLFE,1 DANIEL J. CLAUW,2 MARY-ANN FITZCHARLES,3 DON L. GOLDENBERG,4
ROBERT S. KATZ,5 PHILIP MEASE,6 ANTHONY S. RUSSELL,7 I. JON RUSSELL,8 JOHN B. WINFIELD,9 AND MUHAMMAD B. YUNUS10
Objective. To develop simple, practical criteria for clinical diagnosis of fibromyalgia that are suitable for use in primary and specialty care and that do not require a tender point examination, and to provide a severity scale for characteristic fibromyalgia symptoms.
Methods. We performed a multicenter study of 829 previously diagnosed fibromyalgia patients and controls using physician physical and interview examinations, including a widespread pain index (WPI), a measure of the number of painful body regions. Random forest and recursive partitioning analyses were used to guide the development of a case definition of fibromyalgia, to develop criteria, and to construct a symptom severity (SS) scale.
Results. Approximately 25% of fibromyalgia patients did not satisfy the American College of Rheumatology (ACR) 1990 classification criteria at the time of the study. The most important diagnostic variables were WPI and categorical scales for cognitive symptoms, unrefreshed sleep, fatigue, and number of somatic symptoms. The categorical scales were summed to create an SS scale. We combined the SS scale and the WPI to recommend a new case definition of fibromyalgia: (WPI >7 AND SS >5) OR (WPI 3–6 AND SS >9).
Conclusion. This simple clinical case definition of fibromyalgia correctly classifies88.1% of cases classified by the ACR classification criteria, and does not require a physical or tender point examination. The SS scale enables assessment of fibromyalgia symptom severity in persons with current or previous fibromyalgia, and in those to whom the criteria have not been applied. It will be especially useful in the longitudinal evaluation of patients with marked symptom variability.
Please note:
This criteria set has been approved by the American College of Rheumatology (ACR) Board of Directors as Provisional.This signifies that the criteria set has been quantitatively validated using patient data, but it has not undergone validationbased on an external data set. All ACR-approved criteria sets are expected to undergo intermittent updates.As disclosed in the manuscript, these criteria were developed with support from the study sponsor, Lilly Research Laboratories.The study sponsor placed no restrictions, offered no input or guidance on the conduct of the study, did not participatein the design of the study, see the results of the study, or review the manuscript or submitted abstracts prior to thesubmission of the paper. The recipient of the grant was Arthritis Research Center Foundation, Inc. The authors receivedno compensation. The ACR found the criteria to be methodologically rigorous and clinically meaningful.ACR is an independent professional, medical and scientific society which does not guarantee, warrant or endorse anycommercial product or service. The ACR received no compensation for its approval of these criteria](66).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(63) Classification and clinical diagnosis of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines by Fitzcharles MA1, Shir Y2, Ablin JN3, Buskila D4, Amital H5, Henningsen P6, Häuser W7.(PubMed)

(64) Somatic symptom disorders without known physical causes: one disease with many names? by Tavel ME1.(PubMed)

(65) Systematic review of psychological treatment in fibromyalgia by Lami MJ1, Martínez MP, Sánchez AI.(PubMed)

(66) The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity by the Arthritis Care & Research

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - Diseases(Comorbidity) & mortality associated to Fibromyalgia

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

Diseases(Comorbidity) & mortality associated to Fibromyalgia

1. Infections
There is a association between FM and HIV and hepatitis C virus infections in patients with Fibromyalgia(51).
Dr. Adak B and colleagues at the University of Yüzüncü Yil insisted that there is a correlated relationship of chronic hepatitis B carriage and the risk of FM probably due to altered liver function, viral infection, concerns associated with chronic disease(52). Other infectious diseases including hepatitis C, Lyme disease, coxsackie B, HIV, and parvovirus infection, may also cause or trigger fibromyalgia(53).

2. Tumors
Patients with chronic generalized pain may have an increased risk of developing cancer, including patients with Fibromyalgia(51). According to the University of Pamo patients with  FM is found higher correlated to operated breast cancer patients than the report in normal populations in the literature(54). Others cancers may also be associated to FM include lymphatic and hematological cancers(55).

3. Cardiovascular disease
Patients with are at increased risk of early onset of cardiovascular disease(51). According to the joint study led by the China Medical University Hospital, fibromyalgia patients have an independent risk for CHD development(56)(57) and Fibromyalgia patients with concomitant comorbidities have markedly increased CHD risk relative to those with primary fibromyalgia(56).

4. Mortality
Risk of of accidental death and death from cancer is higher in patients with Fibromyalgia(51). In the study of a total of 8,186 fibromyalgia patients seen between 1974 and 2009 , mortality does not appear to be increased in patients diagnosed with fibromyalgia, but the risk of death from suicide and accidents was increased(58).
Dr. Dreyer L and colleagues at the Copenhagen University, Copenhagen University Hospital said, "The causes of a markedly increased rate of suicide among female patients with FM are at present unknown but may be related to increased rates of lifetime depression, anxiety, and psychiatric disorders. Risk factors for suicide should be sought at the time of the diagnosis of FM and at followup"(59).

5. Other related morbidities may include
5. 1. Psychological morbidity

Substantial lifetime psychiatric disorder in individuals with fibromyalgia(60).

5.2. Medical and unexplained disorders

Such as migraine, irritable bowel syndrome, chronic fatigue syndrome, major depression, and panic disorder are frequently associated to patients with Fibromyalgia(61)(62).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(51) [Is there an association between fibromyalgia and an increase in comorbidity: neoplastic and cardiovascular diseases, infections and mortality?] [Article in Spanish] by Chamizo-Carmona E1.(PubMed)

(52) Fibromyalgia frequency in hepatitis B carriers by Adak B1, Tekeoğlu I, Ediz L, Budancamanak M, Yazgan T, Karahocagil K, Demirel A.(PubMed)

(53) Rheumatic mimics and selected triggers of fibromyalgia by Daoud KF1, Barkhuizen A.(PubMed)

(54) Frequency of fibromyalgia syndrome in breast cancer patients by Akkaya N1, Atalay NS, Selcuk ST, Alkan H, Catalbas N, Sahin F.(PubMed)

(55) Increased cancer risk in patients referred to hospital with suspected fibromyalgia by Dreyer L1, Mellemkjaer L, Kendall S, Jensen B, Danneskiold-Samsøe B, Bliddal H.(PubMed)

(56) Increased Risk of Coronary Heart Disease in Patients with Primary Fibromyalgia and Those with Concomitant Comorbidity-A Taiwanese Population-Based Cohort Study by Su CH1, Chen JH2, Lan JL2, Wang YC3, Tseng CH4, Hsu CY5, Huang L6.(PubMed)

(57) Fibromyalgia is associated with coronary heart disease: a population-based cohort study by Tsai PS1, Fan YC, Huang CJ.(PubMed)

(58) Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years by Wolfe F1, Hassett AL, Walitt B, Michaud K.(PubMed)

(59) Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide by Dreyer L1, Kendall S, Danneskiold-Samsøe B, Bartels EM, Bliddal H.(PubMed)

(60) Comorbidity of fibromyalgia and psychiatric disorders by Arnold LM1, Hudson JI, Keck PE, Auchenbach MB, Javaras KN, Hess EV.(PubMed)

(61) Comorbidity of fibromyalgia with medical and psychiatric disorders by Hudson JI1, Goldenberg DL, Pope HG Jr, Keck PE Jr, Schlesinger L.(PubMed)

(62) Fibromyalgia and other unexplained clinical conditions by Aaron LA1, Buchwald D.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Complications

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                              The  Complications

1. Negative impact in relationships
Fibromyalgia can result in a substantial negative impact on important relationships with family and close friends(36), according to the survey of 6,126 adults, lts diagnosed with fibromyalgia, including mildly to moderately damaged relationship(s) with their spouse(s)/partner(s) or contributed to a break-up with a spouse or partner.(35).

Dr. Yener M and colleagues at the joint study led by the Suleyman Demirel University, said, "FM can cause deterioration of emotional status and lead to sexual dysfunction. Also, psychological status could be affected in spouses of women with FM at reproductive age, and the severity of depression of their spouses was significantly correlated to that of women with FM"(36). further more, fibromyalgia also found to induce sexual dysfunction and quality of life of the spouse as well, according to the Harran University Medical School study(37)

2. Psychological problem
According to the study by Monash University and Monash Medical Centre in comparison between FM patients and healthy individuals found significant difeferences in control (Perceived Control of Internal States Scale and Mastery S.cale), patients with fibromyalgia also are associated to both high and low levels of stress, mood, pain, and fatigue(38).
Dr. Malin K Dr. Littlejohn GO said, "Stress in females with fibromyalgia associates with both key symptoms and a range of relevant psychological variables. Stress appears to have a major role in modulating several key 'up-stream' processes in fibromyalgia"(39). Spouse of reproductive age women are also experience to enormous amount of psychological problem, including anxiety and depression(40).
3. Pain disability
Fibromyalgia syndrome (FMS) has found to exhibited pain disability but  differences in genders
(41). Women with fibromyalgia reported higher intensity of pain, tender point count, and depression than men(41). According to the, manual therapy protocol was effective to improve pain intensity, reduce pressure pain sensitivity, with significant impact of FMS symptoms, sleep quality, and depressive symptoms, particular in women(42).
In fact, the joint study led by the McGill University Health Centre suggested, the risk of disability of patients with fibromyalgia is substantial high in Western World(one out of three)(43).

4. Impaired functionality, and impact on the quality of life
Women with Fibromyalgia also showed a positive correlation of  impaired functionality(46), and impact on the quality of life in comparison to women without(44). According to the Pamukkale University Medical School, in the survey of 51 patients with FMS and 41 control subjects, patients with fibromyalgia reported higher in impaired functional status(46) and diminished quality of life than control(45).

5. Fall risk and Postural control deficits
There were significant relationships between fall risk  in patients with Fibromyalgia. Worse postural performance and fall risk found in the fibromyalgia patients may be resulted of the sleep quality in the last 24 h and level of fatigue(47). According to the Oregon Health & Science University, objective sensory deficits on dynamic posturography(48) and impaired balance(49)
 is also found consistently to associate to middle-aged FM patients inducing fall rates.
The reduced fall risk and postural control deficits probably can be achieved through  combine balance training with exercise and cognitive training(50).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(35) Chronic widespread pain and fibromyalgia: could there be some relationships with infections and vaccinations? by Cassisi G1, Sarzi-Puttini P, Cazzola M.(PubMed)

(36) The evaluation of anxiety and depression status in spouses of sexually active reproductive women withfibromyalgia by Yener M1, Askin A1, Soyupek F1, Akpinar A2, Demirdas A2, Sonmez S3, Soyupek S3.(PubMed)

(37) Quality of life, depression, and sexual dysfunction in spouses of female patients with fibromyalgia by Tutoglu A1, Boyaci A, Koca I, Celen E, Korkmaz N.(PubMed)

(38)  Psychological control is a key modulator of fibromyalgia symptoms and comorbidities. by Malin K1, Littlejohn GO.(PubMed)

(39) Stress perception and depressive symptoms: functionality and impact on the quality of life of women withfibromyalgia.[Article in English, Portuguese] by Homann D1, Stefanello JM, Góes SM, Breda CA, Paiva Edos S, Leite N.(PubMed)

(40) The evaluation of anxiety and depression status in spouses of sexually active reproductive women withfibromyalgia by Yener M1, Askin A1, Soyupek F1, Akpinar A2, Demirdas A2, Sonmez S3, Soyupek S3.(PubMed)

(41) Gender differences in pain severity, disability, depression, and widespread pressure pain sensitivity in patients with fibromyalgia syndrome without comorbid conditions by Castro-Sánchez AM1, Matarán-Peñarrocha GA, López-Rodríguez MM, Lara-Palomo IC, Arendt-Nielsen L, Fernández-de-las-Peñas C.(PubMed)

(42) Short-term effects of a manual therapy protocol on pain, physical function, quality of sleep, depressive symptoms, and pressure sensitivity in women and men with fibromyalgia syndrome: a randomized controlled trial by Castro-Sánchez AM1, Aguilar-Ferrándiz ME, Matarán-Peñarr, the ocha GA, Sánchez-Joya Mdel M, Arroyo-Morales M, Fernández-de-las-Peñas C.(PubMed). 

(43) Disability in Fibromyalgia Associates with Symptom Severity and Occupation Characteristics by Fitzcharles MA1, Ste-Marie PA1, Rampakakis E1, Sampalis JS1, Shir Y1.(PubMed)

(44) Stress perception and depressive symptoms: functionality and impact on the quality of life of women withfibromyalgia.[Article in English, Portuguese] by Homann D1, Stefanello JM, Góes SM, Breda CA, Paiva Edos S, Leite N.(PubMed)

(45) Relationship between the body image and level of pain, functional status, severity of depression, and quality of life in patients with fibromyalgia syndrome by Akkaya N1, Akkaya S, Atalay NS, Balci CS, Sahin F.(PubMed)

(46) Measuring health status in Israeli patients with fibromyalgia syndrome and widespread pain and healthy individuals: utility of the short form 36-item health survey (SF-36) by Neumann L1, Berzak A, Buskila D.(PubMed)

(47) Assessment of the relationship between postural stability and sleep quality in patients with fibromyalgia by Akkaya N1, Akkaya S, Atalay NS, Acar M, Catalbas N, Sahin F.(PubMed)

(48) Postural control deficits in people with fibromyalgia: a pilot study by Jones KD1, King LA, Mist SD, Bennett RM, Horak FB.(PubMed)

(49) Fibromyalgia is associated with impaired balance and falls by Jones KD1, Horak FB, Winters-Stone K, Irvine JM, Bennett RM.(PubMed)

(50) Postural control deficits in people with fibromyalgia: a pilot study by Jones KD1, King LA, Mist SD, Bennett RM, Horak FB.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Risk factors

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                            The Risk factors

B. Risk factors
1. Gender
If you are women, you are at higher risk than men to develop Fibromyalgia. According to the Katedra Propedeutyki Pediatrii i Klinika Immunologii Wieku Rozwojowego Akademii Medycznej we Wrocławiu, fibromyalgia may occur at any age, even in childhood, is much more common in women than in men(23).

Dr. Reiffenberger DH and Amundson LH said, "Fibromyalgia syndrome includes symptoms of widespread, chronic musculoskeletal aching and stiffness and soft tissue tender points. It is frequently accompanied by fatigue and sleep disturbance. Fibromyalgia is more common in women than in men, and it occurs at a mean age of 49 years"(24).
2. Family history
 It appears that there are factors in this personality trait that are hereditary and that may contribute to the development of FM(25), including psychological distress(26), familial history of depression(27),.... According to Dr. Hudson JI and colleagues, said,  "the familial prevalence of major affective disorder were significantly higher in the fibromyalgia patients than the rheumatoid arthritis patients":(28).

3. Environment factors
Environmental susceptibility may be the possible causes of Fibromyalgia(29) such as chronic stress(30)

4. Chronic illness
There is a believe that certain illness are associated to the increased risk of Fibromyalgia(35) such as diseases of infection(33)(34),  and Chronic fatigue syndrome (CFS)(32), affecting the quality of work and social life, according to Dr. Asbring P.(31).

5. Etc.

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References

(23) [Fibromyalgia syndrome--pathogenesis, diagnosis, and treatment problems].[Article in Polish]
 by Polańska B1.(PubMed)

(24) Fibromyalgia syndrome: a review by Reiffenberger DH1, Amundson LH.(PubMed)

(25) Differences in the personality profile of fibromyalgia patients and their relatives with and without fibromyalgia by Glazer Y1, Buskila D, Cohen H, Ebstein RP, Neumann L.(PubMed)

(26) Are psychological distress symptoms different in fibromyalgia patients compared to relatives with and withoutfibromyalgia? by Glazer Y1, Cohen H, Buskila D, Ebstein RP, Glotser L, Neumann(PubMed) 

(27) Self-reported depression, familial history of depression and fibromyalgia (FM), and psychological distress in patients with FM by Offenbaecher M1, Glatzeder K, Ackenheil M.(PubMed)

(28) Fibromyalgia and major affective disorder: a controlled phenomenology and family history study by Hudson JI, Hudson MS, Pliner LF, Goldenberg DL, Pope HG Jr.(PubMed)

(29)  Sleep disorders and fibromyalgia. by Roizenblatt S1, Neto NS, Tufik S.(PubMed)

(30) Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great East Japan disaster by Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Okamura S, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K.(PubMed)

(31) Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome andfibromyalgia by Asbring P1.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Causes

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.


                                        The Causes 

1. Oxidative stress
There are some evidences demonstrating that oxidative stress is associated to clinical symptoms in chronic pain syndrome of fibromyalgia(8), particular in lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma(9).
According to the Universidad de Sevilla, mitochondrial dysfunction is found to associated to the increased risk of fibromyalgia, probably due to CoQ10 deficiency in blood mononuclear cells(10).
In a total of 60 female study conduced by the King George's Medical University study, oxidative stress is a major cause of FMS. Moreover, the increased oxidative stress parameters are more strongly associated with severity of FMS.(11).


2. Chronic stress and psychological symptoms
The relationship between stress, depression and functionality seems to be part of a complex mechanism, which might affect the quality of life of patients with FM(12). According to the study led by the Universidade Federal de São Paulo, Stress index (96%), trait anxiety (over 50) and clinically relevant depression (greater than 20) are found in the female patient with FMS(13).
In spouses of sexually active reproductive women with fibromyalgia, Dr. Yener M and colleagues at the said, "FM can cause deterioration of emotional status and lead to sexual dysfunction" and "Also, psychological status could be affected in spouses of women with FM at reproductive age, and the severity of depression of their spouses was significantly correlated to that of women with FM"(14).


3. Alpha1-Antitrypsin (AAT)
There is  a possible relationship between AAT deficiency (AAT-D) and fibromyalgia (FM) due to
inflammation(15). According to the Hospital Valle del Nalón, AAT replacement therapy has shown to induce a rapid, progressive, and constant control of their FM symptoms, in 2 Spanish sisters with alpha1-antitrypsin (AAT) deficiency and fibromyalgia (FM)(16).


4. Inflammatory rheumatic disorders
There is evidence to suggest that fibromyalgia occurs much more frequently than expected in
individuals with inflammatory rheumatic disorders(17). According to the cross-sectional study carried out in a hospital-based rheumatology unit. Standard clinical and laboratory data, FM patients with inflammatory and patients with non inflammatory rheumatic disorders, experience to fibromyalgic features dominate and become the main cause of morbidity(18).
Dr. Jiao J and colleagues at the joint study led by the China Academy of Chinese Medical Sciences, said, "FM patients with rheumatic diseases were found to have worse SF-36-assessed pain and physical health and less improvement in these measures following treatment from FTP than patients withoutrheumatic diseases. FM patients with rheumatic disease may require additional intervention to address underlying rheumatic disease-related limitations."(19).

5. Sleep disturbance
There is a reciprocal relationship exists between pain and sleep, and that intervention targeted primarily at insomnia may improve pain(20). According to the jopint study led by the Penn State College of Medicine, rates of CFS, FM or CFS + FM were high: 13% in SDB and 48% in insomnia. CFS occurred frequently in SDB and insomnia, but FM occurred frequently only in insomnia(21).
There is a report that low sleep quality has induced sexual dysfunction in female patients with fibromyalgia(22).
6. Etc.

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The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(8) Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement by Cordero MD1, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA(PubMed)

(9) Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma by Cordero MD1, Alcocer-Gómez E, Cano-García FJ, De Miguel M, Carrión AM, Navas P, Sánchez Alcázar JA.(PubMed)

(10) Oxidative stress and mitochondrial dysfunction in fibromyalgia by Cordero MD1, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM.(PubMed)

(11) Some oxidative and antioxidative parameters and their relationship with clinical symptoms in women withfibromyalgia syndrome by Fatima G1, Das SK2, Mahdi AA1.(PubMed)

(12) Stress perception and depressive symptoms: functionality and impact on the quality of life of women withfibromyalgia, [Article in English, Portuguese] by Homann D1, Stefanello JM, Góes SM, Breda CA, Paiva Edos S, Leite N.(PubMed)

(13) Investigation of stress, anxiety and depression in women with fibromyalgia: a comparative study.

[Article in English, Portuguese] by Ramiro Fde S1, Lombardi Júnior I2, da Silva RC3, Montesano FT1, de Oliveira NR2, Diniz RE4, Alambert PA4, Padovani Rda C5.(PubMed)

(14) The evaluation of anxiety and depression status in spouses of sexually active reproductive women with fibromyalgia by Yener M1, Askin A1, Soyupek F1, Akpinar A2, Demirdas A2, Sonmez S3, Soyupek S3.(PubMed)

(15) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC.(PubMed)

(16) Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency by Blanco I1, Canto H, de Serres FJ, Fernandez-Bustillo E, Rodríguez MC.(PubMed)

(17) The Overlap Between Fibromyalgia and Inflammatory Rheumatic Disease: When and Why Does it Occur? by Clauw DJ1, Katz P.(PubMed)

(18) The impact of concomitant fibromyalgia on visual analogue scales of pain, fatigue and function in patients with various rheumatic disorders by Levy O1, Segal R2, Maslakov I3, Markov A3, Tishler M3, Amit-Vazina M3.(PubMed)

(19) Association of rheumatic diseases with symptom severity, quality of life, and treatment outcome in patients withfibromyalgia by Jiao J1,2, Davis Iii JM3, Cha SS4, Luedtke CA5, Vincent A6, Oh TH2,5.(PubMed)

(20) Does effective management of sleep disorders improve pain symptoms? by Roehrs TA1; Workshop Participants.(PubMed)

(21) Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the 'unitary' hypothesis. by Pejovic S1, Natelson BH2, Basta M3, Fernandez-Mendoza J4, Mahr F5, Vgontzas AN6.(PubMed)
(22) Effects of low sleep quality on sexual function, in women with fibromyalgia by Amasyali AS1, Taştaban E2, Amasyali SY3, Turan Y2, Kazan E1, Sari E4, Erol B5, Cengiz M6, Erol H1.(PubMed)