Omega -3 Fatty Acids DO NOT Exert Anti-Inflammatory Activity on Colon Cancer Surgery

By Kyle J. Norton

The colon formed part of the digestive system also is known as the large bowel or large intestine with a function to reabsorb fluids and process and secret waste products from the body.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

Colon cancer is one most slow-growing cancer compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered. Therefore, only 39% of colon cancer is diagnosed in the early stage, which orchestrates more incidences of death compared to other cancers.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerve cells causing localized symptoms and severe pain.

Most common colon cancer metastasis are the lungs, liver.

According to the epidemiological studies, the most common risk factors of colon cancer are older
age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.

According to the statistic provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.

The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effects of perioperative intravenous n-3 PUFAs on inflammatory cytokines in colon cancer surgery.

A randomized, double-blind, placebo-controlled clinical trial included 44 patients undergoing elective colon resection for nonmetastasized cancer that were randomly assigned to 2 intravenous n-3 PUFA (n=21)or saline (n=23) control infusions the night before and the morning after surgery. 

Patient and operation characteristics were equal between groups, except for open resection (saline n = 5 compared with n-3 PUFA n = 0, P = 0.056)
Based on the evidence from the experiment,
* Ex-vivo, pro-inflammatory cytokine IL-6 after LPS stimulation was significantly higher in the n-3 PUFA group on the first day after surgery (P = 0.014), but not different at the second day after surgery (P = 0.467).

* White blood cell count was higher in the n-3 PUFA group on the fourth day after surgery (P = 0.029).

* There were more patients with infectious complications in the n-3 PUFA group (8 compared with 3, P = 0.036).

* There were no overall differences in serum IL-6, IL-10, C-reactive protein, and length of stay.

* The administration of n-3 PUFAs resulted in rapid increases in leukocyte membrane n-3 PUFA content.

Based on the findings, researchers said, " In the n-3 PUFA group a clear relation with serum and LPS-stimulated cytokines was not found but, unexpectedly, more infectious complications occurred ".

Taken altogether, Omega-3 fatty acids doe not show anti-inflammatory activity on patients undergoing elective colon resection for nonmetastasized cancer,  pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of perioperative intravenous ω-3 fatty acids in colon cancer patients: a randomized, double-blind, placebo-controlled clinical trial by Bakker N1,2, van den Helder RS1, Stoutjesdijk E3, van Pelt J1, Houdijk APJ. (PubMed)

Herbal Ashwagandha Processes immune-Modulatory Activity

By Kyle J. Norton

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.

In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

Most common symptoms of acute inflammation occurred with a short period of time such as hours is a pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound which modulatory immune response, researchers examined the ashwagandha WS immunomodulatory effect.

According to the searching of the related studies and trials on Databases- DPED, UNPD, PubChem, Binding DB, ChEMBL, KEGG, and STRING, WS immune showed an immunomodulatory capability of regulating 15 immune system pathways.

Additionally, WS also exerted the immunomodulatory effect by targeting16 proteins and protein-protein interactions.

Chemical analysis also suggested that the efficacy WS in immunomodulation was also attributed to
the potential of withanolide-phytosterol combination and seven novel bioactive-immune target combinations.

Based on the findings, researchers said, "The study elucidated an in silico molecular mechanism of immunomodulation of WS. It unveils the potential of withanolide-phytosterol combination to achieve better immunomodulation. Experimental validation of the network findings would aid in understanding the rationale behind WS immunomodulation as well as aid in bioactive formulation based drug discovery.".

Taken altogether, Ashwagandha may be considered a functional herb for immune-modulation, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Network ethnopharmacological evaluation of the immunomodulatory activity of Withania somnifera by Chandran U1, Patwardhan B. (PubMed)

Broccoli Kills Primary Effusion Lymphoma (PEL) Cells in Vitro

By Kyle J. Norton

Lymphoma is a medical and chronic condition associated with abnormal growth of lymphocytes, a type of white blood cells of the immune system that fights infection.

Lymphocytes included natural killer cells T cells and B cells are found in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body.

According to the statistics, in the US, this year, approximately, 8,000 people will be diagnosed with Hodgkin lymphoma, leading to the death of 1,000 patients with the disease.

Non-Hodgkin's lymphomas are the most common types of lymphoma

According to statistics provided by the Leukemia and Lymphoma Society, in the US, approximately over 1,30,000 people are either living with or are in remission from, leukemia, lymphoma or myeloma, causing the death of over 9% of all cancer death in 2018.

60 years of age and over, weakened immune system, previous exposure to toxic chemicals, previous chemotherapy or radiation therapy are some of the most common prevalent factors of lymphoma.

Interestingly, most people with some of the above risk factors have never developed lymphoma.
Believe it or not, Hodgkin's lymphoma is treatable, especially in its early stages. The 5-year survival rate for all patients diagnosed with Hodgkin's lymphoma is 92%.

Primary effusion lymphoma (PEL) is a rare subtype of non-Hodgkin's B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV) in immunosuppressed patients.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticancer activity, researchers examined the effects sulforaphane (SF), on primary effusion lymphoma (PEL).

According to the analysis, SFN decreased the viability of KSHV-infected PEL cells compared to KSHV-uninfected B-lymphoma cells.

SFN demonstrated the anti-proliferative effects on PEL cells by activating caspases involved in cancer cell apoptosis.

Furthermore, SFN also inhibited the activated p38MAPK and AKT signaling to induce apoptosis against cancer cell survival and proliferation.

Collectively, researchers said, "the anti-proliferative effects of SFN indicate its potential as a new substance for the treatment of PEL".

Taken altogether, broccoli processed a high amount of SFN, may be considered a functional food for the treatment of Primary effusion lymphoma (PEL),  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion LymphomaCells by Suppressing p38MAPK and AKT Phosphorylation by Ishiura Y1, Ishimaru H1, Watanabe T1, Fujimuro M. (PubMed)

Beta-Sitosterol Reduces the Risk and Onset of Tuberculosis

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Chronic respiratory diseases are the medical conditions related to abnormal function of the airways and other parts of the lung.

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Commonly, the bacterium attacked the lung tissue but in some cases, it also can cause major damage to other parts of the body.

The disease is very contagious, as types of bacteria that cause TB can spread from person to person through microscopic droplets released into the air.

In other words, people can be infected by TB if they can to close contact with TB patients through tuberculosis coughs, speaks, sneezes, spits,.... and laughs.

The disease is rare in the Western world, however, according to the report of WHO of the region including 36 countries in the Western Pacific Region, approximately 1.4 million notified cases of all forms of TB in 2011 (75 per 100 000 population), corresponding to 23% of the total cases notified globally.

There were 0.6 million new smear-positive cases notified in 2011 (32 per 100 000 population), corresponding to 22% of the total smear-positive cases notified globally.

Most common TB complication has been recorded are spinal pain, back pain, and stiffness, joint damage. 

Furthermore, depending on the diseases associated with the complication induced by tuberculous, patients may also experience the hips and knees malformation, swelling of the membranes that cover your brain, liver or kidney problems, and heart disorders.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers examined the adjuvant effect of beta-sitosterol and its glucoside in the treatment of culture-proven pulmonary tuberculosis (PTB).

The blinded randomized placebo-controlled trial was conducted by using the culture-proven drug-sensitive PTBs from patients hospitalized for the duration of treatment.

According to the chemical analysis,
* Weight gain was significantly greater in the sitosterol group (mean weight gain 8.9 kg) compared to placebo.

* However, the speed of achieving culture negativity, radiological improvement and induration on Mantoux testing was similar in the two groups.

* Most importantly, the sitosterol treatment group demonstrated a significant increase of lymphocyte counts and eosinophil counts from baseline compared to placebo.

Collectively, scientists suggested, "The study has shown significantly improved weight gain and higher lymphocyte and eosinophil counts in PTB patients receiving sitosterols in addition to an efficacious antituberculosis regimen".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of tuberculosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis by Donald PR1, Lamprecht JH, Freestone M, Albrecht CF, Bouic PJ, Kotze D, van Jaarsveld PP. (PubMed)

Dandelion(Taraxacum officinale), the Antimicrobial Herbal Remedy

By Kyle J. Norton

Microorganisms, or microbes, are a class of microscopic organisms, including the single-celled form.

Microbial infection is a disease caused by microorganisms, including viruses, bacteria, fungi, or parasites.

Antimicrobial activity is an action that kills microorganisms or stops their growth. In humans, these actions are carried out daily by the immune system.

Infection is a processive condition caused by the battle of the invasion of microorganisms and the host immune white blood cells. Microorganism during the battle might produce toxins which can lead to the initiation of infection-related transmissible disease or communicable disease.

In acute infections, the systematic immune system responds properly to the invasive pathogen, leading to a brief battle after which the immune system is always victorious.

However, chronic infections occur when the immune cannot kill off the invasive stimuli in the acute phase of infection, leading to chronic infectious diseases.

Microbial infection includes 4 different stages
* Stage 1 or incubation stage
In stage 1, harmful microorganisms after successfully entering the host start to incubate on the specific site by the multiplying organism to reach a population, leading to an early stage of symptoms.

* Stage 2 or prodromal stage
After successfully multiplying, the organisms start to show symptoms of illness, depending on the location of the infection.

* Stage 3 or acute stage
The numbers of microorganisms have grown exponentially, leading to very pronounced symptoms, also depending on the location and organ being infected.

* Stage 4 or convalescence stage is the recovery stage. The microorganism starts to decrease or are wiped out from the host.

Most cases of recovery infection are the result of the use of antibiotics. The length of the 4 stages of microbial infection can be vary depending on the host immune system.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the antimicrobial effects of crude and dialyzed extracts from the dandelion root (Taraxacum officinale) on Gram-positive and Gram-negative bacterial strains.

According to the tested differentiation, 

* The methanol hydrophobic crude extract (DRE3) demonstrated the strongest inhibition of microbial growth against Staphylococcus aureus, methicillin-resistant S. aureus and Bacillus cereus strains.
* Normal phase (NP) fractionation of DRE3 (NPF4 and NPF5) enhanced antimicrobial activity.

* Furthermore, further NP fractionation of NPF4 resulted in two fractions (NPF403 and NPF406) with increased antimicrobial activity.

Based on the findings, researchers said, " the antimicrobial efficacy of dandelion root extracts demonstrated in this study support the use of the dandelion root as a source of natural antimicrobial compounds".

Taken altogether, Dandelion may be considered a remedy for the treatment of infectious diseases caused by bacteria, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR by Kenny O1, Brunton NP, Walsh D, Hewage CM, McLoughlin P, Smyth TJ. (PubMed)

Common Fig or Fig (Ficus carica) Inhibits the Cervical Cancer Risk in Vitro

By Kyle J. Norton

The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts as a transition area for vaginal lining (squamous epithelium) to the uterus type (columnar epithelium) which hosts the development of the fetus.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cell DNA.

Precervical cancer is the early stage of abnormal cell changes in the cervical tissues, if left untreated, it can develop into true invasive cervical cancer.

A vaccine, Gardasil used to prevent pre-cervical cancer from the infection of two types of HPV was approved by the U.S. Food and Drug Administration in 2006. It is for your benefit to take this vaccine if you are sexually active with several partners.

Researchers do not know what causes cervical cancer. Neither they can explain that women with the same health condition, family history, some are susceptible to the disease while others do not.

Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer were diagnosed with the death of 4,020 patients.

The 5-year survival rate for women with invasive cervical cancer is 92%. and approximately, 46% of women with cervical cancer are diagnosed at an early stage.

Epidemiological also suggested that HPV infection, sexual activity, smoking, giving birth many times. Infection with the human immunodeficiency virus (HIV, history of sexually transmitted infections (STIs) and long-term use of oral contraceptives are some prevalent risk factors of cervical cancer.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding natural compounds for the treatment of malignant tumors, researchers examined the latex of fig fruit (Ficus carica) on cervical cancer cell lines CaSki and HeLa positive for HPV type 16 and 18, caused by high-risk human papillomaviruses (HPVs).

Based on the experimental results, fig latex inhibits the rapid growth and invasion properties that cause HPV-positive cervical cancer bt alternating the cell DNA.

Furthermore, fig latex also inhibited the substantially downregulated the expression of p16, a tumors suppressor and HPV oncoproteins E6, E7 associated with the turnover of tumors suppressive genes in the tested cell line.

Based on the findings, researchers said, " Ficus carica latex has the potential to be used in the development of therapeutic modalities for the possible treatment, cure, and prevention of HPV related cervical cancer".

Taken altogether, common fig or fig (Ficus carica)  may be considered a remedy for the prevention and treatment of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(10) Biological activities of Ficus carica latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers by Ghanbari A1, Le Gresley A2, Naughton D2, Kuhnert N3, Sirbu D3, Ashrafi GH4. (Research Gate)

Tocopherols Kills Oral Cancer Cells in Vitro

By Kyle J. Norton

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissues of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that lines the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die because of these cancers in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

Stages
1. Stage O
Benign tumor
2. Stage I
The cancer is < 2 cm in size (about 1 inch), with no lymph nodes spreading found in the area.
3. Stage II
The cancer is ≥ 2 cm in size, but < 4 cm (less than 2 inches), with no lymph nodes spreading found in the area.4. Stage III

The cancer is ≥ cm in size or any size with only one lymph node on the same side of the neck as of cancer. The cancerous node is ≤ 3 cm (about one inch).
5. Stage IV
Cancer has spread to tissues around the lip and oral cavity with lymph nodes in the area may or may be infected. The cancer of any size and has spread to more than one lymph node on the same side of the neck or lymph nodes on one or both sides of the neck, or to any lymph node that measures ≥ 6 cm (over 2 inches) in size or to distant parts of the body.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases associated with inflammation, researchers examined the effects of α-tocopherol on the oral squamous carcinoma cells ORL-48.

According to the experimental results,

* In vitro study, α-tocopherol exhibited effective antitumor activity on ORL-48 at 2.5 ± 0.42 µg/mL.

* Although Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL, compared to α-tocopherol which exhibited cytotoxicity on normal human epidermal keratinocytes at very low concentration (<0.1 µg/mL).

* Despite the lower potency of α-tocopherol, signs of apoptosis such as the shrinkage of cells and appearance of apoptotic bodies were observed much earlier than cisplatin in time-lapse microscopy. 

* Both applications increased the number of cell accumulation in the G0/G1 phase with ultrastructural changes of the cellular structures verified the apoptotic mode of cell death by both agents.

Based on the findings, researchers said, " Both cisplatin and α-tocopherol displayed cell cycle arrest at the Sub G0 phase. α-tocopherol thus showed potential as an antitumor agent for the treatment of oral cancer and merits further research".

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48 by Zulkapli R1,2, Abdul Razak F1, Zain RB. (PubMed)