Elder (Sambucus) Processes the Natural Immunomodulatory Property

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In normal immunity, active immunity may also be artificially acquired caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of immune system against infection through the production of antigen.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

Depending on the substances that affect the immunomodulatory process, some may improve the immune function by modulating the genes involved immune responses and protect the immune system against toxins or immunotoxic effects such as abnormal allergic reactions, other such as heavy metals can induce opposite effects.

For example, curcumin (diferuloylmethane), found in the spice turmeric and processed anti-inflammatory, antioxidant, and chemopreventive activities may improve the immune system in the inhibition of cancer cell proliferation and overproduction of proinflammatory cytokines by target the genes associated with programming cell death and anti-inflammatory action and involved in the induction of these immune parameters.

On the other hand, toxic chemicals such as cadmium and lead accumulated in the body can have a negative impact on the immune defense by reducing the viability of both lymphocytes and macrophages was affected by heavy metals in a dose- and time-dependent manner.

On finding a natural ingredient for the improvement of immune functioning, scientists examined the immunomodulatory effects of bioactive compounds of Sambucus.

Elder or Common Elder, is a shrub or small tree of the genus Sambucus of 30 species, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere.

The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

According to tested analysis from orally administrated with 2.8 mg.kg-1 BW of DMBA for ten times within a month with 7,12-dimethylbenz[a] anthracene (DMBA)-treated BALB/c mouse, followed by S. javanica berries and leaves extracts for 2 weeks.

* The expression of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-ɣ) associated with the induction of inflammation were increased however after treated by S. javanica berries compared to that of leaves extracts that were significantly decreased.

* Furthermore, the DMBA-treated group showed an increase of necrosis incidence.

* Moreover, These increased was totally diminished with S. javanica extracts treatment.

Based on the results, researchers suggest, " these results suggested that S. javanica extracts have immunomodulatory activities to suppress inflammation and reduce necrosis incidence in experimental mice".

Taken altogether, Dandelion may be considered a remedy for the treatment of acute liver injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory Activities of Sambucus javanica Extracts in DMBA-Exposed BALB/c Mouse by Putra WE1, Rifa'i M. (PubMed)

Topical Elecampane Inhibits the Onset of Atopic Dermatitis

By Kyle J. Norton

Dermatitis or eczema is a group of diseases characterized by the inflammation of the skin.

There is no single cause of eczema, anything that we face every day can trigger a dermatitis flare, including stress, irritants, climate change, and sweating. However, infection and allergens.are considered the most common causes of the disease.
Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.

The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environment conditions may be involved in the development of the disease.

Epidemiological studies suggested that most patients with chronic atopic dermatitis also have asthma and hay fever, particularly in allergies.

Children are at a higher risk of atopic dermatitis compared to adults.

Most cases of atopic dermatitis are healed by itself or by rehydrating the skin with topical forms of petroleum jelly, such as Vaseline.

However, in serious cases, topical steroids to reduce inflammation and control itching may be prescribed. In patients with itching scratch, oral antihistamines may be recommended.

Besides red patches and itching on the affected area, patients may also experience symptoms of dry skin, small bumps containing fluids, cracked and scaly, sensitive, swollen skin due to scratching.

On finding a natural ingredient for the prevention and treatment of skin diseases, scientists examined the total sesquiterpene lactones isolated from Inula helenium L. (TSL-IHL) effect on atopic dermatitis (AD).
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* TSL-IHL, as well as AL and IAL, inhibited the proteins TNF-α-induced activation of pro-inflammatory cytokines NF-κB and the expression of TNF-α, IL-1, and IL-4 in HaCat cells in a dose-dependent manner in the range of 0.6-2.4 µg/ml.

* The topical application of TSL-IHL (1% W/W in emollient cream) attenuated DNCB-induced dermatitis severity and right ear swelling.

* Additionally, the serum levels of IgE produced by the immune system, TNF-α, and IFN-γ involved in the inflammatory phase in TSL-IHL-treated mice were reduced by 81.39%, 89.69%, and 87.85%, respectively.

* Moreover, the mRNA levels of IL-4, IL-5, and IL-13 associated with the inflammatory response in the back-skin lesions of TSL-IHL-treated mice were reduced by 39.21%, 40.62%, and 48.12%, respectively, compared to the untreated controls.

More precisely, TSL-IHL treatment reduced epidermis/dermis thickening and dermal inflammatory infiltration in both ear and back skins.

Based on the results, researchers suggest, "TSL-IHL inhibited the development of AD-like skin symptoms by regulating cytokine expression and may be an effective alternative therapy for AD".

Taken altogether, Dandelion may be considered a remedy for the treatment of atopic dermatitis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice by Wang Q1, Gao S2, Wu GZ2, Yang N2, Zu XP2, Li WC2, Xie N3, Zhang RR4, Li CW5, Hu ZL2, Zhang WD. (PubMed)

Low Levels of Omega-3 Fatty Acids Are Associated with Increased Risk of Atherosclerosis

By Kyle J. Norton

Cardiovascular disease refers to heart diseases, affecting millions of people in the world.

According to statistics, over 17.7 million people died from CVDs in 2015.

The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.

Most cases of heart diseases in the Western world are associated with atherosclerosis. 

In other words, atherosclerosis is a leading cause of coronary heart disease (CHD).

According to the 2016 Heart Disease and Stroke Statistics, 15.5 million people in the USA. have CHD. The lifetime risk of developing CHD with ≥2 major risk factors is 37.5% for men and 18.3% for women.

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.

In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of EPA and DHA on the early-onset of coronary atherosclerosis.

According to the results of 71 participant groups included 51 were below and 20 were above the 75th AS-percentile.

* A significantly lower value for EPA (0.77%[0.63; 0.97] vs. 0.93%[0.72; 1.21]; p = 0.045), DHA (4.90%[4.12; 5.57] vs. 5.50%[4.58; 6.52]; p = 0.038) and the Omega-3 Index (5.73%[4.75; 6.35] vs. 6.22%[5.46; 7.71]; p = 0.034) were seen in patients above the 75th AS-percentile was found to associated with the onset of coronary atherosclerosis.

* All other fatty acids showed no significant differences.

* In multivariable analysis, the Omega-3 Index showed a significant inverse association with early onset of CAC (OR: 0.533 (95%CI: 0.303-0.938; p = 0.029)), independent of age, gender, statin use, and creatinine level (all p > 0.05).

Collectively, researchers said, "Low levels of EPA and DHA (Omega-3 Index) are associated with early-onset coronary atherosclerosis. This finding needs to be validated in larger cohorts and might help understand the beneficial cardiovascular effects of omega-3 fatty acids".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Early-onset coronary atherosclerosis in patients with low levels of omega-3 fatty acids by Bittner DO1, Goeller M2, Zopf Y3, Achenbach S2, Marwan M. (PubMed)
(2) The Impact of Omega 3 Fatty Acids in Atherosclerosis and Arterial Stiffness: An Overview of their Actions by Verveniotis A1, Siasos G1,2, Oikonomou E1, Tsigkou V1, Papageorgiou N1, Zaromitidou M1,2, Psaltopoulou T1, Marinos G1, Deftereos S1, Vavuranakis M1, Stefanadis C3, Papavassiliou AG4, Tousoulis D. (PubMed)

Herbal Angelica Protects the Neurons Against the Onset of Parkinson's Disease in Vivo

By Kyle J. Norton

Neurological diseases are the medical conditions of brain disorder. Anything that involves the structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves, including brain damage are considered as neuro diseases.

The most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunction, dementia can be Parkinson's, Alzheimer's, and Huntington's disease.

Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant inherited cause of stroke and vascular dementia.

Dementia is a neurodegeneration syndrome among the elderly, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment over 47 million
of the worldwide population, mostly in the West.

Parkinson disease (PD) is a disabling, progressive condition induced symptoms of the olfactory deficit, sleep problems such as rapid eye movement behavior disorder, constipation and the more recently described male erectile dysfunction(456), due to the interruption of frontal-subcortical loops facilitated cognition and parallel the motor loop(457).

Contrary to common perception, many non-motor symptoms (NMS) also link to early onset of PD(459) and some may even predate the diagnosis of PD based on motor signs(458).

In the very early stage of PD, patients may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.

As of today, researchers do not know why the neurons in the brain in some people are susceptible to gradually break down or die while others do not even they have similar health conditions and from the same family.

Epidemiologically aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the prevalent factors involved in the increased risk of the disease.

On finding a natural ingredient for the prevention and treatment of neurodegenerative diseases, scientists examined the investigated the neuroprotective effects of the triple herbal extract DA-9805 ((Moutan cortex, Angelica dahurica root, and Bupleurum root in a 1:1:1 mixture) in experimental models of Parkinson's disease (PD) by induced neurotoxic effects on dopaminergic neurons by inhibiting mitochondrial oxidative phosphorylation (OXPHOS) complex.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of the differentiation
In SH-SY5Y cells,
* DA-9805 ameliorated the suppression of tyrosine hydroxylase expression and mitochondrial damage on OXPHOS complex 1 activity,

* DA-9805 also inhibited the expression of mitochondrial membrane potential, reactive oxygen species (ROS) generation, and oxygen consumption rate.

In the MPTP-induced subacute PD model mice,

* Oral administration of DA-9805 recovered dopamine content as well as bradykinesia.

* DA-9805 protected against neuronal damage in the substantia nigra pars compacta (SNpc) and striatum.

In both vitro and vivo, DA-9805 normalized the phosphorylation of AKT that that promotes survival and growth of the neurons at S473 and T308 on the insulin signaling pathway and the expression of mitochondria-related genes.

Based on the results, researchers suggest, "triple herbal extract DA-9805 showed neuroprotective effects via alleviating mitochondria damage in experimental models of PD. We propose that DA-9805 may be a suitable candidate for disease-modifying therapeutics for PD".

Taken altogether, Dandelion may be considered an antioxidant remedy for the treatment of PD, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease by Jeong JS1,2, Piao Y3,4, Kang S3, So. (PubMed)
(2) The Conventional Treatment of Dementia associated with the motor symptoms of Parkinson's disease by Kyle J. Norton

Healthy Veggie Broccoli Inhibits the Onset of Oxidative Stress

By Kyle J. Norton

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anti-oxidative activity researchers examined the efficacy of sulforaphane found in broccoli in protecting alcohol-induced hepatic injury in vivo.

The study included selected male C57BL/6 mice which were orally administrated with broccoli sprout extract (BSE) containing sulforaphane [7.6, 25.2, and 50.4 mg/kg of body weight (bw)] once a day for 14 days.

On the 13th day, mice were challenged with alcohol (5 g/kg of bw) every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44 ± 1.24 nmol/mg of protein, p < 0.01) of oxidative stress in the liver.

According to the results of the experiment, the administration of low-, medium-, and high-dose BSE markedly reversed the decrease of antioxidant capacity.

More precisely, BSE increased the levels of antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione S-transferase (GST)  in the liver, compared to control.

The efficacy in protecting the liver oxidative stress was attributed to the activation of phase 2 enzymes via nuclear erythroid-2-related factor 2 (Nrf2).

Most importantly, BSE also significantly attenuated the levels of the endoplasmic reticulum (ER)-stress-specific proteins, a defense system which protects cells from ER stress such as glucose-regulated protein 78 (GRP78), activating transcription factor 6, and protein kinase RNA (PKR)-like ER kinase (PERK),

Collectively, researchers said, "These results indicate that BSE protects the liver against alcohol challenge via upregulating antioxidant capacity and downregulating ER stress".

Taken altogether, broccoli may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli Sprout Extract Alleviates Alcohol-Induced Oxidative Stress and Endoplasmic Reticulum Stress in C57BL/6 Mice by Lei P1, Zhao W1, Pang B1, Yang X1, Li BL2,3, Ren M4, Shan YJ. (PubMed)

Moronic Acid, A Promising Antidiabetic Antioxidant

By Kyle J. Norton

Diabetes is a chronic low-grade inflammatory condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Inflammation is a natural defense of the immune system that protects the body against the insult from the foreign invasion.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Sub-chronic diabetic treatment is a process associated with the treatment of diabetes that lasts only in a moderate or intermediate duration.

Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.

On finding a potential phytochemical for the treatment of diabetes, researchers examined the ix derivatives (1-6) of moronic acid that were semi-synthesized and their in vitro protein tyrosine phosphatase 1B (PTP-1B) inhibition activity in diabetes.

* In rat induced diabetes, derivatives 2 (IC50=10.8 ± 0.5 μM) and 6 (IC50=7.5 ± 0.1 μM) displayed the most potent inhibitory activity.

* The derivatives decreased plasma glucose levels during all the experiments in vitro and vivo.

* Most importantly, The #2 had polar and Van der Waals interactions in both sites with Val49, Gln262, Met258, Phe182, Ala217, Ile219, and Gly259 and # 6 showed polar interaction with Gln262 and Van der Waals with Val49, Ile219, Gly259, Arg254, Ala27, Phe52, Met258, the proteins associated with the onset of diabetes.
Based on the findings, researchers said, "derivatives 2 and 6 have the potential for the development of antidiabetic agents".

Taken altogether, moronic acid may be considered a remedy for the treatment of diabetes in a short duration, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives by Cerón-Romero L1, Paoli P2, Camici G2, Flores-Morales V3, Rios MY4, Ramírez-Espinosa JJ1, Hidalgo-Figueroa S1, Navarrete-Vázquez G1, Estrada-Soto S. (PubMed)

Pinto Bean (Phaseolus) Suppresses the Onset of Nasopharyngeal Cancer in Vitro

By Kyle J. Norton

The nasopharynx is the upper part of the pharynx, connecting with the nasal cavity above the soft palate that allows a person to breathe through the nose.

Cancer is a group of diseases caused by cell growth irregularly in the affected tissue caused by DNA alternation.

Nasopharyngeal cancer is a medical condition characterized by cells growth irregularly and disorderly in the tissues of the nasopharynx.

Most cases of nasopharyngeal cancer start in the cells on the surface of the inner lining of the nasopharynx. The early stage of nasopharyngeal cancer is asymptomatic due to the very small size of the tumor.

However, at the advanced stage, the oversize may suppress the nearby nerves and blood vessels, leading to severe throat pain and symptoms of a lump in your neck blood in the saliva, bloody discharged from your nose, particularly, persistent nasal congestion or ringing in your ears, accompanied with the general symptoms shared with other cancers.

According to the statistics provided by the American cancer society, nasopharyngeal cancer (NPC) is quite rare in the United States). The risk of cancer is less than one case for every 100,000 people.
Epidemiologically, some patients at this stage may also experience symptoms of frequent ear infections, hearing loss and headaches.

Pharynx cancer is originated in the tissue of the pharynx and classified
* The nasopharynx (the upper part of the throat behind the nose)
Cancer of the pharyngeal most commonly begins with malignant cells that line the nasopharynx, including nasal passages and auditory tubes join the remainder of the upper respiratory tract.

* The oropharynx (the middle part of the pharynx)
Cancer of the oropharynx also begins with the malignant cells that line the oropharynx, including the base of the tongue, the tonsils, the soft palate.

* The hypopharynx (the bottom part of the pharynx)
Cancer of the hypopharynx most commonly begins with the malignant squamous cell that lines the hypopharynx where the area of the larynx and esophagus meet. 90% of oropharyngeal neoplasms are squamous cell carcinoma.

On finding a natural ingredient for the prevention and treatment of diseases associated with oxidative stress, scientists examined the effects of purification of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans on cancers.


Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to tested analysis,
* Lectin at 30 μM showed strong antioxidant activity against the infectious agents including fungal species such as Phyllosticta citriasiana, Magnaporthe grisea, Bipolans maydis, Valsa mali, Mycosphaerella arachidicola in the induction of oxidative stress associated with proteins lipids and DNA damage.

* The lectin did not exert any discernible antiproliferative effects on breast cancer MCF-7 cells but was able to suppress proliferation of nasopharyngeal carcinoma HONE-1 cells, with an IC50 of 17.3 μM.

In other words, purification of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans exerted a significantly apoptotic activity against the viral induction of nasopharyngeal carcinoma HONE-1 cells.

Taken altogether, Pinto beans may process antioxidant and cytotoxic properties against nasopharyngeal cancer cells, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Purification and characterization of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans with antiproliferative activity towards nasopharyngeal carcinoma cells by Ang AS1, Cheung RC, Dan X, Chan YS, Pan W, Ng TB. (PubMed)