Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Tuesday, 3 March 2020

Cruciferous Vegetables Processes Anti Glioblastoma Progression in Vivo

By Kyle J. Norton

Glioblastoma is one of the most aggressive cancers that begins within the brain.

According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.

If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.

Most cases of GBM are diagnosed at an older age with a median age of 64.

Although the disease does not have some specific symptoms, it shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.

Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.

Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.

According to the statistics, in the US, the incidence affects mostly in the elderly with the diagnosed rate of 3.19 per 100,000 persons. The disease is rare in children.

GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods that process neuroprotective property, researchers investigated the protective effect of sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables against glioblastoma (GBM) progression.

According to the tested analysis, the application of SFN in GBM showed to induce apoptosis and to inhibit both growth and invasion of GBM cells [78].

Furthermore, SFN can overcome the chemoresistance of tumor cells.

The efficacy of SFN against the progression of glioblastoma (GBM) was attributed to the phytochemicals that can cross the blood-brain barrier (BBB) to reach the tumor mass by inhibiting the functions of MMP-9 in GBM in mediating the BBB alternation.

Furthermore, SFN also demonstrated a strong activity in the induction of cancer cell apoptosis and anti-cancer cell proliferation and the protection of healthy neurons.

Moreover, SFN also induces apoptosis of GBM cells by increasing ROS levels in the cancer cells and inhibiting cancer cell migration and/or invasion.

Combination with chemo drug, SFN improved the function of the drug and reduce the chemoresistance of GBM without conferring significant toxicity to normal cells.

Based on the findings, researchers said, " ...the results of these studies support further investigations using SFN in animal models of GBM.

Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the prevention and treatment of GBM, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment by Sita G1, Hrelia P2, Graziosi A3, Morroni F. (PubMed)

Cranberry, the Anti-Alzheimer's disease Functional Remedy

By Kyle J. Norton

Dementia is a neuropsychiatric disorder as a result of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, contributing to caregiver burden and premature institutionalization.

About 5-8% of all people over the age of 65 have some forms of dementia, and this number doubles every five years above that age.

Dementia is the loss of mental ability that is severe enough to interfere with people's every life.

Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.

Alzheimer's disease worsens over time and it is fatal.

American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetable which can lead to dementia and other kinds of diseases.

As the disease progression, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.

In the elderly, age-related to the changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulated of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.

In free radical theory, free radical overexpression causes the reduced levels of antioxidant enzymes produced by the elderly initiates the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cells damage and development of AD.

β-amyloid (Aβ) accumulated in the neurons, the main component of the amyloid plaques in the brains have been found in patients with Alzheimer's disease.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of dementia, researchers investigated the cranberry extract (CBE) rich in polyphenols that delay paralysis induced by alleviating β-amyloid (Aβ) toxicity Alzheimer's disease (AD) in C. elegans model.

According to the experimental results, researchers suggested that CBE showed a strong anti-AD activity by inhibiting the level of Aβ toxicity and promoting memory health, the two major pathological parameters in AD.

C. elegans AD model treated with CBE exerted significantly preventive and therapeutic protocols.

Based on the findings, researchers said, "CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals".

Taken altogether, cranberry may be considered a remedy for the management of AD, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease by Guo H1, Dong YQ2, Ye BP. (PubMed)

Antioxidant Lycopene Protects Kidney Cells Against Renal Damage

By Kyle J. Norton

The kidneys, a pair of bean-shaped organs on either side of your spine are the second detoxed organ after liver by removing wastes or toxins in the blood come from the normal breakdown of active muscle and from the food you eat.

Kidney damage is a condition caused by the build-up of waste products and excess fluid in the body.

Depending on the stage of kidney damage, patients may experience symptoms of weakness, shortness of breath, lethargy, swelling, and confusion.

If the kidney can not remove extra potassium from the bloodstream, the condition can lead to abnormal heart rhythms and sudden death.

Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.

* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.

Conventionally, most cases of the renal damage caused by toxins are treated with cisplatin often associated with an acute kidney injury.

On CKD, treatment is totally depending on the causes of the disease including high blood medications, lowering high blood cholesterol and pain relievers.

Dr. Ryoma, the lead scientist in the study "The association between changes in lifestyle behaviors and the incidence of chronic kidney disease (CKD) in middle-aged and older men", wrote, "with respect to habitual moderate exercise and late-night dinner, maintaining an unhealthy lifestyle resulted in a significantly higher odds ratio (OR) for the incidence of CKD".

And, "the lack of habitual moderate exercise, late-night dinner, and bedtime snacking may increase the risk of CKD".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a potent ingredient for the protection of the kidney function, researchers examined protective effects of lycopene against the toxic effects of Aflatoxin B1(AFB1) exposure in the kidney of experimental rats.

The study included 42 healthy three-month-old male Wistar-Albino rats that were randomly divided into six experimental groups including 7 rats in each, as follows: control group, lycopene (5 mg/kg/day, orally for 15 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) group, AFB1 (1.5 mg/kg/day, orally for 3 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) + lycopene (5 mg/kg/day, orally for 15 days) group and AFB1(1.5 mg/kg/day, orally for 3 days) + lycopene (5 mg/kg/day, orally for 15 days) group.

According to the tested analysis, injection of Aflatoxin B1(AFB1) showed a significant effect on the kidney oxidative stress marker observed by the significant increase of malondialdehyde (MDA) levels.

Levels of antioxidant enzymes produced by the host such as glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) were also decreased in AFB1-rats kidney and heart tissues.

Additonally levels urea, creatinine levels of sodium concentrations in plasma of AFB1 treated rats were also increased substantially.

More precisely, Aflatoxin B1(AFB1) resulted in a significant reduction in the activities of antioxidant enzymes and non-enzymatic antioxidant system in AF treated rats observed by the elevated levels of MDA, compared to the control group.

In other words, Aflatoxin B1(AFB1) exhibited some parameters associated with kidney damage and injury.

However, all these parameters were significantly inhibited or normalized by the administration of lycopene.

Based on the results, researchers said, " lycopene showed protection against AF induced nephrotoxicity...".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of renal damage, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene has reduced renal damage histopathologically and biochemically in experimental renal ischemia-reperfusion injury by Kaya C1, Karabulut R1, Turkyilmaz Z1, Sonmez K1, Kulduk G2, Gülbahar Ö3, Köse F1, Basaklar AC. (PubMed)
(2) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(3) The association between changes in lifestyle behaviors and the incidence of chronic kidney disease (CKD) in middle-aged and older men by Ryoma Michishitaa, TakuroMatsuda, Shotaro Kawakamid Satoshi Tanaka, Akira Kiyonaga, Hiroaki Tanaka, Natsumi Moritoe, and Yasuki Higaki by (Science Direct)

Monday, 2 March 2020

Moronic acid, the Antihyperglycemic Antioxidant

By Kyle J. Norton

Antihyperglycemic activity is the process that promotes a hypoglycemic effect against the progression of hyperglycemia.

Oral antihyperglycemic agents are the medications used to lower glucose levels in the blood in the treatment of diabetes mellitus.

Hyperglycemia, a medical condition of abnormally high blood glucose and a hallmark of diabetes, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body's inability to make enough insulin.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.

The most common diseases associated with untreated hyperglycemia are cardiovascular diseases,

nerve damage (neuropathy) and kidney damage (diabetic nephropathy) or kidney failure and damage to the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness.

Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.

On finding a potential phytochemical for the treatment of high blood glucose, researchers examined the effects of Morolic (1) and moronic (2) acids, the main constituents of acetonic extract from Phoradendron reichenbachianum (Loranthaceae), a medicinal plant on hyperglycemia.

On mice induced diabetic model,

* Daily-administered morolic (1) and moronic (2) acids (50 mg/kg) significantly lowered the blood glucose levels at 60% since the first day until the tenth day after treatment than the untreated group (p<0.05).

* Both compounds diminished plasmatic concentration of cholesterol (CHO) and triglycerides (TG), returning them to normal levels (p<0.05).

* Pretreatment with 50 mg/kg of each compound induced significant antihyperglycemic effect after glucose and sucrose loading (2 g/kg) compared with the control group (p<0.05).

* Moreover, in vitro studies showed that compounds 1 and 2 induced inhibition of 11β-HSD 1 associated with hepatic glucose output activity at 10 μM.

Based on the findings, researchers said, "moronlic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol, and triglycerides, in part mediated by inhibition of 11β-HSD 1".

Taken altogether, moronic acids may be considered supplements for the treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD by Ramírez-Espinosa JJ1, García-Jiménez S, Rios MY, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ibarra-Barajas M, Ortiz-Andrade R, Estrada-Soto S. (PubMed)

Beta-Sitosterol Reduces Cholesterol Levels in Patients with cystic fibrosis

By Kyle J. Norton

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.

The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).

Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help to digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.

Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.

Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.

Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in children and young adults, leading to difficulty breathing and coughing up mucus due to frequent lung infections.

However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.

Believe it or not, most cases of CF are diagnosed by age 2.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of diseases associated with hyper cholesterol, researchers elucidated the β-sitosterol effects in the plasma of patients with cystic fibrosis (CF).

The study included the plasma of 26 patients with CF and 33 unaffected controls that are treated by β-sitosterol and campesterol, using gas chromatography (GC-FID and GC-MS) assays.

Before the administration of β-sitosterol, the plasma level of cholesterol is higher in patients with CF compared to control subjects.

* Furthermore, plasma cholesterol treated by β-sitosterol was significantly lower in CF patients, compared to control.

* Moreover, β-sitosterol prevent the impaired intestinal absorption of exogenous sterols in patients with CF that stimulates the endogenous synthesis of cholesterol, without affecting the total cholesterol in plasma.

In other words, cystic fibrosis induced transmembrane conductance regulator (CFTR) dysfunction reduces cholesterol blood excretion causing the accumulation of cholesterol in liver cells and in other tissues that CF chronic inflammation.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of hyper cholesterol in patients with CF, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reduced absorption and enhanced synthesis of cholesterol in patients with cystic fibrosis: a preliminary study of plasma sterols by Gelzo M, Sica C, Elce A, Dello Russo A, Iacotucci P, Carnovale V, Raia V, Salvatore D, Corso G, Castaldo G. (PubMed)

Sunday, 1 March 2020

Omega-3 Fatty Acids, the Promising Remedy for the Treatment of Advanced Esophagogastric Cancer

By Kyle J. Norton

Cancer is a class of diseases characterized by cell growth and multiplied disorderly and uncontrollably. In advance stage, cancerous cells from the originated site can travel a distance away to infect other healthy tissue via lymph or blood circulation.

Most cancers process a high survival rate if they are diagnosed early. According to the Mayo Clinic, over 56 percent of people diagnosed with early-stage lung cancer live for at least five years after diagnosis. However, the five-year survival rate for people diagnosed with late-stage of invasive lung cancer is 5 %.

According to the statistic of Canadian cancer provided by the government, in 2017, there were over 200,000 newly diagnosed cancer and 80,000 Canadian died from cancer. 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease, during their lifetime.

The exact cause of cancers is unknown. Researchers do not know why some people without gene mutation are susceptible to early onset of cancer while others do not

However, researchers do know that certain risk factors such as aging, tobacco, sun exposure, radiation exposure, chemicals, and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, physical inactivity are associated to gene change in the initiation of cancer development.

Most cancers share the common symptoms of tiredness, unexplained weight loss, loss of appetite, fatigue. In advance stage, cancer patients may also experience additional common symptoms of dehydration, nausea and vomiting, constipation and persistent pain.

Gastroesophageal adenocarcinoma is a rare type of cancer of the esophagus, the tube that connects your mouth and stomach.

Most common risk factors associated with the onset of esophagogastric adenocarcinoma are
* Having gastroesophageal reflux disease (GERD)
* Smoking.
* Having precancerous changes in the cells of the esophagus (Barrett's esophagus)
* Being obese.
* Excessive alcohol drinking
* Frequent bile reflux.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effects of omega 3 fatty acids in patients with advanced esophagogastric adenocarcinoma.
The study included 20 participants with advanced esophagogastric adenocarcinoma enrolled in phase II single-arm clinical trial of palliative chemotherapy (epirubicin, oxaliplatin, and capecitabine; EOX) coupled with the weekly infusion of Omegaven®.
According to the results of radiological responses,
* Partial response (EOX plus omega-3 group 73% vs. EOX alone 39%, p=0.03).

*Stable disease (EOX plus omega-3 21% vs. EOX alone 39%, p=0.24), and

* Progressive disease (EOX plus omega-3 7% vs. EOX alone 18%, p=0.34).

Most importantly, grade 3 or 4 toxicity was less common (thromboembolism & gastrointestinal) and the concentrations of pro-inflammatory proteins such as IL-2 (p=0.009), TNF-α (p<0.0001) and VEGF (p=0.002) was reduced. in those who received EOX plus omega-3.

Based on the evidence, researchers said, "The treatment with supplementary omega-3 fatty acids reduced chemotherapy-related toxicity and resulted in better radiological responses".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered an adjunct therapy in the treatment of advanced esophagogastric adenocarcinoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Effect of Supplementary Omegaven® on the Clinical Outcome of Patients With Advanced Esophagogastric Adenocarcinoma Receiving Palliative Epirubicin, Oxaliplatin, and Capecitabine Chemotherapy: A Phase II clinical trial by Eltweri AM1, Thomas AL2, Chung WY3, Morgan B3, Thompson J4, Dennison AR3, Bowrey DJ. (PubMed)

Omega 3 Fatty Acids Ameliorates the Symptoms of Anxiety

By Kyle J. Norton

Anxiety is a psychological and physiological state triggered by feelings of fear, worry, uneasiness, and dread, etc.

The condition is a normal reaction to stress that allows a person to cope with the situation during an emotionally difficult time. But when anxiety symptoms escalate or become excessive, it can lead to anxiety disorder.

People experience anxiety differently. Some people feel a sudden moment of anxiety just a bad feeling, it comes and goes, only lasting a short time. Depending on how people cope with the moments of anxiety, the events can be brief or last a few days.

However, in some persons, if anxiety does not go away, they may require treatment from the related field specialists.

Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors and the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.

According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.

The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.

The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping, irritability, persistent stomachaches or diarrhea, sweaty palms, shaking and rapid heartbeat.

Other patients may also experience frequent nervousness, restlessness, or being tense feelings of danger, panic, or dread rapid heart rate rapid breathing, or hyperventilation,..... you may have developed an anxiety disorder.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of psychological disorders, researchers investigated the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) for anxiety symptoms compared with controls.

The study included the research of clinical trials involved in the anxiolytic effect of omega-3 PUFAs in humans, in either placebo-controlled or non-placebo-controlled designs found 104 selected articles with 19 entered the final data extraction stage.

Based on the differentiation of the selected articles including 1203 participants with omega-3 PUFA treatment (mean age, 43.7 years; mean female proportion, 55.0%; mean omega-3 PUFA dosage, 1605.7 mg/d) and 1037 participants without omega-3 PUFA treatment (mean age, 40.6 years; mean female proportion, 55.0%), the researchers found that
* The administration of omega 3 fatty acid showed an association between clinical anxiety symptoms among participants with omega-3 PUFA treatment compared with control arms (Hedges g, 0.374; 95% CI, 0.081-0.666; P = .01).

* Furthermore, in subgroup analysis, injection of Omega 3 fatty acid showed that the association of treatment with reduced anxiety symptoms was significantly greater in subgroups with specific clinical diagnoses than in subgroups without clinical conditions.

* Moreover, The anxiolytic effect of omega-3 PUFAs was significantly better than that of controls only in subgroups with a higher dosage (at least 2000 mg/d) and not in subgroups with a lower dosage (<2000 mg/d).

In other words, omega 3 fatty acid has a strong implication in reducing anxiety symptoms in a dose-dependent manner.

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of anxiety, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis by Su KP1,2,3, Tseng PT4, Lin PY5,6,7, Okubo R8, Chen TY9,10,11, Chen YW12, Matsuoka YJ. (PubMed)
(2) A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16 week randomized placebo-controlled trial for participants concurrently treated with risperidone by Robinson DG1, Gallego JA2, John M3, Hanna LA4, Zhang JP2, Birnbaum ML2, Greenberg J4, Naraine M4, Peters BD4, McNamara RK5, Malhotra AK2, Szeszko PR. (PubMed)