Beta-Sitosterol in the inhibition of Mammary Gland Cancer in Vivo

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

The mammary gland located in the breasts of females is responsible for lactation, or the production of milk.

Both males and females have glandular tissue within the breasts; however, in females, the glandular tissue begins to develop after puberty in response to estrogen release.
A mammary tumor is a medical and chronic condition originated from the milk-producing gland.

The mammary gland located in the breasts of females is responsible for lactation.

Most cases of the mammary cancer are first found in the cell on the surface of the inner lining of the milk-producing gland, before penetrating deeper into the layers.

At the advanced stage, the malignant cancer cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.

Epidemiologically, mammary cancer has been found to spread to the colon and the liver.

Most common risk factors of mammary cancer are similar to those of breast cancer, including, aging, physical inactivity, being obese or overweight, family and personal history, having a dense breast, radiation therapy, pregnancy history, genetic proposition, particularly in women who had used drug diethylstilbestrol (DES).

Conventionally, treatment of mammary gland cancer is totally dependent on the stage and grade of cancer, including surgery, radiation therapy, chemotherapy, or a combination.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the anti-cancer effects of beta-sitosterol (BS), a plant-derived sterol on mammary gland cancer in albino Wistar rats.

Selected rats induced by a single i.v. injection of MNU followed by β-sitosterol supplementation therapy for 115 days, were randomized and divided into four groups with 8 animals each. Group I (sham control 1 % CMC in normal saline p.o.); Group II (toxic control, MNU 47 mg/kg, i.v); Group III (MNU 47 mg/kg, i.v + β-sitosterol, 10 mg/kg, p.o); Group IV (MNU 47 mg/kg, i.v + β-sitosterol, 20 mg/kg, p.o).

According to the experimental analysis,
* Treatment with β-sitosterol inhibited the onset of mammary gland cancer evidenced by the decrease in the alveolar bud and lobule score in the whole mount of the mammary gland.

* Furthermore, β-sitosterol inhibited the overexpression of oxidative stress through synchronizing lipid and enzymatic antioxidant defense.

* Moreover, β-sitosterol demonstrated showed a significant decrease in the saturated and unsaturated fatty acid.

* Additionally, β-sitosterol treatment inhibited the protein gene product 9.5 (PGP9.5) overexpression, a marker for tumors in a dose-dependent manner, compared to the MNU treatment group.

Based on the evidence, researchers said, "β-sitosterol afforded significant protection against the deleterious effects of MNU".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of mammary gland cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of β-sitosterol against methyl nitrosourea-induced mammary glandcarcinoma in albino rats by Manral C1, Roy S1, Singh M1, Gautam S1, Yadav RK1, Rawat JK1, Devi U2, Ansari MN3, Saeedan AS3, Kaithwas G. (PubMed)

Healthy Food Common Fig or Fig (Ficus carica) Kills Colorectal Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a group of chronic and medical associated with abnormal cell growth in a specific tissue of an organ, due to the alternation of DNA.

A primary tumor or original tumor is a tumor first arose and progression to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance and alter the metabolic pathways, leading to disordered and violent cellular behavior.

At the early stage, due to the small size of the tumor, most patients are asymptomatic.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA in the colon or rectum.

Colorectal cancer is relatively very common and slowly growing and progressing cancer.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

In general, the 5-year survival rate for people with colorectal cancer is 65%. However, the 5-year survival rate of localized colorectal cancer is about 90%.

Rectal cancer is the slowest growing cancer. Therefore, most cases of colorectal cancer are diagnosed at the advanced stage in the older population.

Rectum formed part of the colon acts as a temporary storage site for feces, before eliminating them as feces.

Rectal cancer is a malignant tumor that starts from the cells on the surface of the inner lining of the tissues of the rectum.

The most common symptoms of rectum cancer are a change in your bowel habits, such as diarrhea, constipation or more frequent bowel movements, dark or red blood in the stool, mucus in stool, abdominal pain and painful bowel movements accompanied by the general symptoms found in other types of cancer.

Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The causes of colon cancer are unknown but certain risk factors, such as genetic preposition and chronic inflammation induced by colonic diseases are associated with the onset of the disease.

Fig is a species of F. carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding a whole food for the prevention and treatment of cancers, researchers investigated the antitumor activity of Ficus carica extracts and latex.

According to the tested differentiation, in vitro, the peel, pulp, leaves, whole fruit and latex extracts of Ficus carica exerted significant antiproliferative effects on HCT-116 (IC50 values 239, 343, 177, 299, 206 µg/ml) and HT-29 cells (IC50 values 207, 249, 230, 261, 182 µg/ml) after 48h of treatment.

Furthermore, treatment with different doses of extracts of Ficus carica results in apoptosis in both HT-29 and HCT-116 cancer cells.

Moreover, the leaves and latex extracts of Ficus carica demonstrated the strongest antiproliferative activities.

Based on the results, researchers wrote, "Overall, our results showed that these natural products are strong apoptosis inducers which suggest their use of for therapeutic purposes".

Taken altogether, common fig or fig may be considered a remedy for the prevention and treatment of colorectal cancers, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antitumoral activity of Ficus carica L. on colorectal cancer cell lines by Soltana H1, Pinon A2, Limami Y3, Zaid Y3, Khalki L4, Zaid N5, Salah D5, Sabitaliyevich UY6, Simon A2, Liagre B2, Hammami M. (PubMed)

The Wild Cabbage (Brassica Oleracea) in the Prevention of Stroke

By Kyle J. Norton

Stroke is a condition in which the brain function is interrupted rapidly due to the loss of blood supply as a result of the blockage of blood such as thrombosis and arterial embolism, or leakage of blood causes of death of brain cells, according to the article of Mitochondria, oxidative metabolism and cell death in stroke by Sims NR, Muyderman H (September 2009).

Stroke is caused by cholesterol build up in the arteries and high blood pressure.

 In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, resulting in some cells in the brain to die off and are unable to reproduce.

Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or its complications.

According to the statistic of the Heart and Stroke Foundation, strokes kill 45% more women than men in Canada. 

In the study, published in the journal Neurology, researchers from the University of California at Los Angeles monitored 17,000 people over a period of six years. They found the incidence of stroke rising faster among women than men. 

When women reach the age of 45, the risk of stroke begins to rise rapidly, it may be due to levels of estrogen has dropped significantly at age 45 and onward.

Stroke can be classified into 4 types

* Ischemic stroke
This is the most common type of stroke accounting for almost 80% of all strokes

** If blood clots from the inside of the arteries of the brain, we have a thrombotic stroke

** If a blood clot in other parts of the body's arteries subsequently entering the brain, we have an embolic stroke.

* Hemorrhagic stroke 

Hemorrhagic stroke is associated with high blood pressure, which stresses the arterial walls until they break.

Cabbage is a species of Brassica oleracea belong to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

On finding a potent compound for the prevention of stroke, researchers compared  the effects of herbal preparations against the thrombolytic activity,

In a thrombolytic model in vitro, the clot lysis effect of the crude extracts and fractions of five Bangladeshi plant viz., Trema Orientalis L., Bacopa monnieri L., Capsicum frutescens L., Brassica oleracea L. and Urena sinuata, researchers found that B. oleracea and U. sinuata showed highest significant (P < 0.05 and P < 0.001) clot lysis activity viz., 46.44 ± 2.44%, 48.39 ± 10.12%, 36.87 ± .27%, 30.24 ± 0.95% and 47.89 ± 6.83% respectively, compared with positive control standard streptokinase (80.77 ± 1.12%) and negative control sterile distilled water (5.69 ± 3.09%).

The order of clot lysis activity was found to be: Streptokinase > Chloroform fractions > Methanol (crude) extract > Hydro-methanol fractions > Ethyl acetate fractions > n-hexane fractions > Water.

The Lower effects of other extracts might be associated with the lack of bio-active components and/or insufficient quantities in the extract.

Also, in vivo, T. Orientalis and B. monnieri also demonstrated clot dissolving property

Based on the findings, researchers concluded, " ..., active component(s) of T. orientalis and B. monnieri for clot lysis could lead the plants for their therapeutic uses" and ",,,. these plants could be incorporated as a thrombolytic agent for the improvement of the patients suffering from atherothrombotic diseases".

Taken altogether, wild cabbage may be considered a functional food for the prevention of stroke, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis by Emran TB1,2, Rahman MA3, Uddin MM4, Rahman MM5, Uddin MZ6, Dash R7, Layzu C. (PubMed)

Turmeric Modulates the macrophage Against the Risk of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with a high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.

Heart disease is a class of medical condition that affects your heart, including blood vessel diseases, such as coronary artery disease, heart rhythm problems such as arrhythmias, and congenital heart defects,

There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. Here are some early indication of heart disease symptoms:

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention and treatment of heart diseases, researchers examined the effects of curcumin, a bioactive compound isolated from turmeric on atherosclerosis.

In vitro and in vivo, the administration of curcumin exerted lipid-lowering effects and modulated the function of different macrophage subsets in various macrophage-involved diseases, including atherosclerosis.

Curcumin attenuated the atherosclerotic plaques induced by microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes.

Moreover, curcumin regulated two main phenotypes called proinflammatory M1 and anti-inflammatory M2 macrophages against unstable plaques and senescent erythrocytes against the onset of plagues accumulation.

Based on the findings, researchers said, "The current review aimed to present role of macrophage subtypes in atherosclerosis development and progression and to understand the effect of curcumin on macrophage polarization and foam cell formation in the atherosclerosis lesion".

Taken altogether, turmeric processed a high amount of bioactive compound furanodiene may be considered supplements for the prevention of tumor metastasis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy by Momtazi-Borojeni AA1,2, Abdollahi E3,4, Nikfar B5, Chaichian S6,7, Ekhlasi-Hundrieser M. (PubMed)

Herbal Angelica Improves the Mitochondrial Functioning

By Kyle J. Norton

Mitochondria are power generators of the cell found abundantly in the liver and play a critical role in converting oxygen and nutrients to energy for the cell's metabolisms.

Mitochondrial permeability transition (MPT) and the mitochondrial generation of oxidative stress have been found to initiate hepatic mitochondrial dysfunction caused by hepatocellular necrosis and apoptosis.

Where, the protein mitochondrial permeability transition pore is formed in the inner membrane of the mitochondria under certain pathological conditions, including stroke, leading to symptoms of lethargy, hypotonia, vomiting, poor suck, and seizures.

Mitochondria bioenergetics play a critical for normal cell function and human health. The alternation of mitochondrion DNA has been found to induce a number of diseases.

More precisely, the genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people. Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer. including mitochondrial myopathy, diabetes mellitus, and deafness.

Most common symptoms of mitochondrial dysfunction include poor growth muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, mental retardation depending on the location of the infected cells.

According to the statistics, 1 in 5,000 individuals has a genetic mitochondrial disease. Each year, about 1,000 to 4,000 children in the United States are born with mitochondrial disease.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of diseases associated with mitochondrial dysfunction, the researchers examined the effects of Danggui Buxue Tang (DBT) on mitochondrial respiration of cultured H9C2 cardiomyoblasts.

According to the chemical analysis, DBT exerted a strong antioxidant and radical scavenging activity against oxidative stress, and protective effect in tert-butyl hydroperoxide (tBHP)-treated cultured cardiomyoblast.

Furthermore, the transcript expressions of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PCG-1α) and other genes, relating to mitochondria biogenesis were enhanced by the injection of the decoction.

Moreover, cultured cardiomyoblasts showed an improvement of total status under DBT treatment through a number of mechanisms, including an increase of basal respiration, proton leak, non-mitochondria, and adenosine triphosphate (ATP) production by stimulating the mitochondrial biogenesis and DNA replication

Taken altogether, Herbal Angelica may protect the mitochondrial functioning, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Modulates Mitochondrial Bioenergetics in Cultured Cardiomyoblasts by Kwan KKL1,2, Huang Y1,2, Leung KW1,2, Dong TTX1,2, Tsim KWK. (PubMed)

Dandelion(Taraxacum officinale), the Potential and Natural Anti-Inflammatory Remedy

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.


Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.

However, people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.

Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, DNA damage.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of diseases associated with inflammation, scientists examined the mechanisms responsible for the anti-inflammation effects of water extract of T. mongolicum Hand.-Mazz (WETMHM) on lipopolysaccharide (LPS)-induced inflammatory in acute lung injury.

Female BALB/c mice selected to the investigation were randomly divided into five groups with 10 mice in each group: (1) control group (saline), (2) LPS group, (3) LPS+dexamethasone (LPS+Dex, 2mg/kg, administered by gavage), (4) LPS+WETMHM (5 g/kg, administered by gavage), (5) LPS+WETMHM (10 g/kg, administered by gavage).

According to the results from the tested analysis, treatment with the WETMHM exhibited a number of mechanisms against LPS-induced inflammation, including the

* Attenuating inflammation cell numbers in the BALF

* Decreasing the protein levels of lung PI3K/Akt/mTOR, and 

* Improving the antioxidant activity of  SOD.

* Inhibiting MPO activity associated with inflammation

Furthermore, the histological studies also demonstrated that WETMHM substantially inhibited LPS-induced neutrophils in lung tissue.

Based on the results, researchers suggest, " The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice".

Taken altogether, dandelion may be considered a remedy for the treatment of diseases associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway by Ma C1, Zhu L1, Wang J1, He H1, Chang X1, Gao J1, Shumin W2, Yan T. (PubMed)

Turmeric Postpones the Onset of Age-Related Disease

By Kyle J. Norton

Age-related diseases are medical conditions associated with the increase of age.

Most recently age-related diseases in the elderly are cardiovascular diseases.

Cardiovascular diseases are a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.

*Cancer

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

*Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1).

* Cataracts

A cataract is a condition of clouding, developed in the crystalline lens of the eye. The condition mostly happens to the elder and in case of severity, it can be complete opacity and obstructing the passage of light.

* Osteoporosis

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries.

*Type 2 diabetes

Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

*Hypertension 

Hypertension is a condition characterized by persistently high blood pressure.

* Alzheimer's disease.

Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neurons due to aging, leading to the problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention of chronic inflammatory diseases, researchers examined the effects of curcumin on aging and age-related diseases.

According to the tested analysis, injection of curcumin showed a strong activity against low-grade inflammation driven by oxygen stress in the induction of the increased level of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α.

Furthermore, the anti-aging-related diseases involved in low-grade inflammation of curcumin were attributed to the inhibiting genes activated by the transcription factor NF-κB. 

In other words, curcumin slowed down the aging process and postponed the onset of age-related diseases by blocking the NF-κB-dependent inflammation

Based on the findings, researchers said, " We consider the possibility of the spice curcumin, a powerful antioxidant and anti-inflammatory agent possibly capable of improving the health status of the elderly".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of aging related-diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, inflammation, ageing and age-related diseases by E Sikora,1 Giovanni Scapagnini,2 and Mario Barbagallo. (PubMed)