Cranberry Inhibits Neurodegenerative Diseases in Vitro

By Kyle J. Norton


Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neuron due to aging, leading to the problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.

Dementia is a general term of neurodegenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life.

About 5-8% of all people over the age of 65 have some forms of dementia, and this number doubles every five years above that age.

Most common types of dementia are
* Alzheimer's disease
Alzheimer's destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of degeneration of hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.

* Absence of acetylcholine
Absence of acetylcholine is a condition caused by damage of nerves located in front of the brain, that lead to language difficulty, memory loss, concentration problem, and reduced mobile skills due to lacking reaction in muscular activity and refection and anxiety- and depression-like behaviors.

3. Dementia due to long-term alcohol abuse
 Most classic form of the condition is the Korsakoff's dementia results in extremely poor short term memory often associated with the memory losses of confabulations due to diminished processing resources and/or an encoding or retrieval deficit.

* Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.

Besides aging, geographical, hereditary and viral and toxicological exposure may also correlate to the development of the diseases on the elderly.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of neurodegenerative diseases, researchers examined the effect of purified cranberry proanthocyanidins (PAC-1A) on neuroblastoma (NB) cell lines.

On SMS-KCNR cells, PAC-1A caused a loss of proton motive force associated with the increase of generation of reactive oxygen species (ROS) that induce cytotoxicity in the tested cell line.

Furthermore, PAC-1A inhibited neuroblastoma (NB) cells proliferation by reducing the expression of the proteins associated with pro-survivals (Bcl-2, MCL-1, Bcl-xL) and increased levels of proteins associated with pro-apoptosis (Bax, Bad, Bid).

Moreover, pathways involved in apoptosis was also increased by the injection of PAC-1A compared to the inhibition of the expression of pathways involved in the promotion of cell cycle division.

More importantly, cyclophosphamide (CP), the chemo drugs used to suppress the immune system function also exhibited by the injection of PAC-1A.

In other words, PAC-1A and CP worked synergistically to increase cytotoxicity and expression of pro-apoptotic markers, reduced cellular antioxidants enzymes (glutathione (GSH) and superoxide dismutase (SOD)) levels.

Additional analysis of the anti-cancer activity of PAC-1A, researchers found that Additional features of PAC-1A also slow down the cancer cell cycle progression and induced cell death via TNF-family death receptor activity.

Based on the findings, researchers said, "PAC-1A has demonstrated the chemotherapeutic potential to treat a broad spectrum of NBs including highly malignant tumors that show resistance to standard chemotherapeutics and apoptotic stimuli".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of neurodegenerative disease, pending to the confirmation of the larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cells by Singh AP1, Lange TS, Kim KK, Brard L, Horan T, Moore RG, Vorsa N, Singh RK. (PubMed)
(1) Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vacciniummyrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin by Cásedas G1, González-Burgos E2, Smith C3, López V4, Gómez-Serranillos MP. (PubMed)
(2) Most common diseases of 50 plus - Diseases of Central Nervous system - Dementia: The Types by Kyle J. Norton

Turmeric Protects the arterial Stiffness Against Onset of Cardiovascular Disease In Diabetes

By Kyle J. Norton

Diabetes is a condition characterized by insufficient insulin entering the bloodstream that regulates the glucose.

Type 1 diabetes is associated with the immune system that destroys the producing insulin beta cells in the pancreas.

Types 2 diabetes is characterized by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.

There are no specific causes of type II diabetes. However, obesity, family history, ethnicity, the increase in age, gestation diabetes, polycystic ovary syndrome, and high blood pressure are the most common prevalent factors found in patients with prediabetes and type II diabetes.

Most common symptoms of diabetes are frequent urination, increased thirst, tiredness. In severe cases, patients may also experience symptoms of blurry vision, slow healing of cuts and wounds, tingling, numbness, or pain in the hands or feet and patches of dark skin.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), more than 100 million U.S. adults are living with diabetes or prediabetes.

In 2015, 30.3 million Americans or 9.4 percent of the U.S.population have diabetes.

Conventionally, medications used for the treatment of type 2 diabetes focus on alleviating the symptoms and improving quality of life and slowing down the progression of the disease.

Untreated and unmanageable type 2 diabetes may induce complications of the onset of cardiovascular disease, nerve damage (neuropathy). kidney damage (nephropathy), eye damage (retinopathy). foot damage and kin conditions.

Believe it or not, over 80% of type 2 diabetes diagnosed worldwide are associated with obesity.

WHO  in the differentiation of the genetics risk in diabetes, wrote, "The major environmental risk factors for T2D are obesity (> 120% ideal body weight or a body mass index > 30 k/m2 ) and a sedentary lifestyle (van Dam, 2003; Shaw and Chisholm, 2003). Thus, the tremendous increase in the rates of T2D in recent years has been attributed, primarily, to the dramatic rise in obesity worldwide (Zimmet et al., 2001). It has been estimated that approximately 80% of all new T2D cases are due to obesity (Lean, 2000)".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the complications of diabetes, researchers examined the effect of Curcuma longa on arterial stiffness and endothelial dysfunction in patients with type 2 diabetes mellitus.

A total of 136 patients of type 2 diabetes participated in the randomized controlled trial including 114 completed at least one follow-up visit and data analysis.

According to the tested assays that measure the arterial stiffness parameters and endothelial dysfunction markers at baseline and every month for 3 months, treatment with C. longa produced significant reduction from baseline in carotid-femoral pulse wave velocity and, left brachial-ankle pulse wave velocity associated with arterial stiffness.

Furthermore, aortic augmentation pressure, aortic augmentation index, and aortic augmentation index involved in the risk of cardiovascular disease were also decreased by the administration of C. longa, compared to placebo.

Moreover, after 3 months of C. longa treatment, C. longa significantly decreases arterial stiffness, compared to placebo in type 2 diabetes mellitus patients.

Taken altogether, turmeric may be considered supplements for the prevention and treatment of arterial stiffness in diabetes patients, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double-blind, parallel arm, placebo-controlled trial by Srinivasan A1, Selvarajan S2, Kamalanathan S3, Kadhiravan T4, Prasanna Lakshmi NC5, Adithan S. (PubMed)
(2) Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes by Lekshmi PC1, Arimboor R, Indulekha PS, Menon AN. (PubMed)
(3) Genetics and Diabetes by WHO

Indicaxanthin, the Free Radical-Scavenger

By Kyle J. Norton

Free radical scavengers are antioxidants which process a function to protect the body against the oxidative stress by inhibiting free radical oxidation before they can facilitate a chain reaction or by stopping the chain reaction before they can cause damage to the body.

Free radicals are highly reactive molecules. Internally, they are produced by our body cell metabolism. Externally, free radical can enter our body from the environment sources, such as the air we breathe, the food we eat and the water we drink.

More precisely, any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.

Believe it or not, free radicals in moderate amount has benefits the body functioning, such as NO for vascular-relaxation.

However, without interfering by the antioxidant, overexpression of free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA, leading to chronic diseases, including arthritis, cardiovascular disease, and diabetes.

Oxidative stress is a result of the imbalanced ratio of the levels of free radicals and antioxidants enzymes in the body.

Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radical has a strong implication in the pathogenesis of various disorders and diseases.

Dr. Kota V. Ramana, the lead scientist in the joint study led by the University of Texas Medical Branch, wrote, "Lipid peroxidation is a complex chain reaction process due to the oxygen-free radicals mediated attack of cell membrane lipids such as polyunsaturated fatty acids (PUFA) resulting in cell damage and dysfunction".

And, "Indeed, a number of preclinical and clinical studies suggest the involvement of lipid peroxidation products in numerous pathological conditions such as inflammation, atherosclerosis, diabetes, aging, neurodegenerative diseases, and cancer".

In other words, an antioxidant with free radical scavenging activity may protect the body against the damage of various cellular components, including proteins, lipids, and DNA in the initiation of diseases.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

With an aim to find a potential compound for the treatment of diseases involved in oxidative stress, researchers examined the free radical-scavenging activity of indicaxanthin.

According to the tested analysis on the reaction of the phytochemical indicaxanthin with lipoperoxyl radicals generated in methyl linoleate methanol solution by 2,2'-azobis(2,4-dimethylvaleronitrile), and in aqueous soybean phosphatidylcholine unilamellar liposomes by 2,2'-azobis(2-amidinopropane) hydrochloride,

* Indicaxanthin incorporated in liposomes prevented lipid oxidation.

* The free radical scavenging property was found to be concentration-dependent, but not linearly related to the phytochemical concentration.

* In liposome, indicaxanthin showed a significant delay against oxidation, particularly in that of the lower the concentration.

* However, in the corporation with alpha-tocopherol, Indicaxanthin exhibited cooperative antioxidant effects and reciprocal protective interactions.

* The increase of the ratio (indicaxanthin)/(alpha-tocopherol).showed a significant decrease in the extent of synergistic effects.

Taken altogether, indicaxanthin processes strong free radical scavenging activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
(2) Lipid Peroxidation Products in Human Health and Disease 2014 by Kota V. Ramana, 1 ,* Sanjay Srivastava, 2 and Sharad S. Singhal. (PMC)

Bromelain Kills Gastrointestinal Cancer Cells in Vitro

By Kyle J. Norton

Gastrointestinal cancer is a medical and chronic condition caused by the alternation of cell DNA in the gastrointestinal tract including esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus.

Most cases of gastrointestinal cancer begin in the cell on the surface of the inner lining of the gastrointestinal tissue, before penetrating into the deeper layers.

Most common gastrointestinal cancer is gastric cancer, which is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women.

According to worldwide statistics, over 1 million new cases were diagnosed in 2018 with the South Korean leading the map, second to Mongolia.

In other words, if you are Asain, you are at an increased risk of gastric cancer.

At the advanced stage, the cancer cell of the affected tissues can travel a distance away to infect the other tissues and organ, leading to secondary metastasis.

Epidemiologically, primary gastrointestinal cancer is more likely to spread to the stomach, esophageal cancer, breast cancer, renal cell carcinoma, and ovarian cancer.

Most common symptoms of gastrointestinal cancer include 

* Throw up blood with the color of coffee grounds. if the bleeding cancer is located in the esophagus or stomach

* Black stool if the bleeding cancer is located in the stomach and small intestine.

*  Stool red with visible blood if the bleeding cancer is located in the large intestines.

Persistent bleeding to lead anemia due to a large amount of blood loss.

If you have some of the aforementioned symptoms that do heal in a short period of time, you may have gastrointestinal cancer. Please check with your doctor to rule out the possibility.

If the bleeding is slow, it often doesn’t cause the person to throw up blood or have a change in their stool. Over time, though, slow bleeding can lead to a low red blood cell count, and make a person feel tired and weak.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient against gastrointestinal cancer, researchers examined the effects of bromelain and N-acetylcysteine, the two natural agents anti-cancer effects.

In gastrointestinal cancer models to cisplatin, paclitaxel, 5-fluorouracil, and vincristine, a combination of bromelain and N-acetylcysteine with chemotherapeutic agents could give rise to an improved chemotherapeutic index.

In other words, chemo drugs used combined with bromelain and N-acetylcysteine are more effective in the inhibition of gastrointestinal cancer with lesser toxicity.

Furthermore, combined with bromelain and N-acetylcysteine also reduced the doses of chemo drugs used with the same efficacy.

Based on the findings, researchers said, "This represents a potentially efficacious strategy for the enhancement of microscopic cytoreduction".

Moreover, in the examination of the effects of bromelain (BR) and N-acetylcysteine (NAC) on MUC2 and MUC5AC which have been found to significantly contribute to the biology and pathogenesis of mucin-secreting gastrointestinal tumors, researchers found that in vitro (MKN45, KATOIII and LS174T cell lines) and in vivo (female nude mice bearing intraperitoneal MKN45 and LS174T), a combination of BR and NAC with dual effects on growth and mucin products of mucin-expressing tumor cells.

More precisely, the treatment of the combination of BR and NAC protected the gastric cells against the malignancies with the involvement of mucin pathology.

Taken altogether, bromelain may be considered supplements for the prevention and treatment of gastrointestinal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
(2) Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)

Antioxidants Betaxanthins Block the Gene Associated with Colon Cancer Developing

By Kyle J. Norton

Primary cancer is a class of chronic disease caused by cells growth disorderly and irregularly in the tissue of a specific organ as a result of the alternation of DNA.

Colon formed part of the digestive system including large intestine that connects to the small intestines and rectum plays a critical role to reabsorb fluids and process waste products from the body and prepare for its elimination through the rectum.

Colon cancer is a medical condition characterized by cell growth irregularly due to the alternation of DNA in the colon tissue.

Most cases of colon cancer start in the cell on the surface of the inner lining of the colon before penetrating into deeper layers to form a tumor through proliferating.

However, at the advanced stage, the cancerous colon cells in the colon can travel a distance far away to infect other healthy tissue and organ.

Furthermore, at this stage, the overgrowth can cause localized severe pain and bleeding as the proliferation of cancer have suppressed the nearby nerve cells and blood vessels, accompanied by the general symptoms shared by other types of cancer.

Researchers do not know the exact causes of the disease. A history of polyps, ethnicity, high-fat diet and low fiber, aging, the long-term infection of colon diseases are some of the prevalent risk factors associated with the onset and progression of colon cancer.

Believe it or not, colon cancer is the most slowing cancer and proliferates in a  predictable way. In some patients, cancer cells can present in the colon more than 20 years before being diagnosed.

Out of that group of risk factors, the increase in age has been under intensified studies by many scientists.

According to the statistic, colorectal cancer is the third common cancer in the US. The median age at diagnosis for colon cancer is 68 in men and 72 in women.

In other words, most cases of colon cancer are found in the aging population in the US.

Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly, in the 39% of colon cancer diagnosed at the localized-stage disease, the five and ten years survival rate are 90%.

Dr. and colleagues wrote, "Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. As society ages, the number of elderly patients with CRC will increase. The percentage of patients with right-sided colon cancer and the incidence of microsatellite instability is higher in elderly than in younger patients with CRC.".

And, "Moreover, the higher incidence of comorbid diseases in elderly patients indicates the need for less invasive treatment strategies".

These results furtherly confirm the prognosis of colon cancer in the aging population. However, most aging population do not develop colon cancer.

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

With an aim to find a potent compound for the promotion of colon health, researchers examined the effects of indicaxanthin, a constituent of betaxanthins on the human colon cancer cell line CACO2.

In colon cancer lines induced demethylation, the chemical process that causes the removal of a methyl group (CH3) to initiate some methylation-silenced onco-suppressor genes involved in colorectal carcinogenesis, indicaxanthin exhibited anti-proliferative activity in all cell lines but HT29 and cancer cell line involved in hypermethylated tumor-suppressor genes(SFRP1 and HPP1).

Furthermore, although DNMT gene expression that provides instructions for making an enzyme called DNA methyltransferase 1 were increased by the injection of indicaxanthin, observed by the increased the expression of genes involved in DNA demethylation, its activity associated with gene suppression was inhibited by the phytochemical.

The results strongly suggested that indicaxanthin exerts a stable binding of the DNMT1 undergoing a chemical reaction against the initiation of colon cancer cell proliferation.

Taken altogether, Betaxanthins processed the abundantly indicaxanthin may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity by Naselli F1, Belshaw NJ, Gentile C, Tutone M, Tesoriere L, Livrea MA, Caradonna F. (PubMed)
(2) Treatment of Elderly Patients with Colorectal Cancer by Yoshiro Itatani, Kenji Kawada, and Yoshiharu Sakai. (PMC)

Lycopene Protects the Arteries Against Atherosclerosis

By Kyle J. Norton


Atherosclerosis is a condition caused by long-term plaques built-up on the wall of the arteries. Over time, continued plaques accumulation can lead to cardiovascular disease.

In other words, narrowing the arteries due to plaques accumulation is a major cause of heart disease and stroke.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Epidemiologically, the most common risk factors of atherosclerosis are unhealthy blood cholesterol levels associated with high levels of bad and low levels of good cholesterol, high blood pressure, smoking, insulin resistance, diabetes, overweight or obesity, physical inactivity.

Most common symptoms found in patients with antiatherosclerosis are involved in the reduce blood flow to the body including, chest pain or angina, pain in the leg, and arm, shortness of breath and fatigue and confusion.

Some researchers suggested that the promotion of a high-fat diet that induces widespread obesity in the Western world may be one of the major culprits that cause atherosclerosis.

Dr. Lovren F and colleagues wrote, "Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases".

And, " A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis.".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potent compound for the protection of arterial functions, researchers investigated the effects of lycopene on the diet-induced increase in serum lipid levels and the initiation of atherosclerosis in an animal model.

New Zealand White (NZW) rabbits.enrolled in the study were divided into four groups of 9 animals each, fed either a standard diet, a high-cholesterol diet containing 0.5% cholesterol, a high-cholesterol diet containing placebo beadlets, or a high-cholesterol diet plus 5 mg/kg body weight/day of lycopene (in the form of lycopene beadlets), for 4 weeks.

According to the chemical analysis of phytochemicals, the animal group treated with lycopene beadlets showed a significantly elevated lycopene plasma levels compared to other groups.

The lycopene group demonstrated a significant reduction of 50% in total cholesterol and LDL cholesterol serum levels compared to the high-cholesterol and placebo group.

Levels of cholesteryl ester accumulated in the aorta were significantly decreased in lycopene treated group without a significant decrease in the extent of aortic surface lipid accumulation.

In other words, lycopene inhibited some parameters associated with the increased risk of atherosclerosis, particularly in the cholesterol levels.

Based on the findings, researchers concluded, "Lycopene supplementation for 4 weeks increased lycopene plasma levels in the animals. Although we found strongly reduced total and LDL cholesterol serum levels as well as significantly lower amounts of cholesteryl ester in the aortae in the lycopene-treated group".

Moreover, in the comparison of the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene in the animal model, lycopene exerted an anti-atherosclerotic property in high cholesterol diet-fed rats by decreasing TC, LDL-C, VLDL-C, and triglycerides and increased HDL-C level significantly compared to the control.

Lycopene used a combination with Astaxanthin also showed better hypolipidemic and anti-atherogenic potential compared to the individual application.

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of atherosclerosis pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of Antioxidant, Hypolipidemic, and Antiatherogenic Property of Lycopene and Astaxanthin in Atherosclerosis-induced Rats by Kumar R1, Salwe KJ2, Kumarappan M. (PubMed)
(2) Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits by Lorenz M1, Fechner M, Kalkowski J, Fröhlich K, Trautmann A, Böhm V, Liebisch G, Lehneis S, Schmitz G, Ludwig A, Baumann G, Stangl K, Stangl V. (PubMed)

Healthy Food Onion, the Anti-Hypertensive Remedy

By Kyle J. Norton

Hypertension, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and change constantly depending on activity. However, persistent hypertension due to poor management over time can lead to diabetes and cardiovascular disease.

According to the statistics provided by the American Heart Association.,  nearly half of all adults in the United States are living with high blood pressure or 1 in 3 American are hypertensive.

Hypertension is leading risk factors of heart disease and stroke that cause most death in the US

Most common prevalent factors associated with the condition onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet and medical condition such as chronic kidney disease.

Believe or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.

Depending on the levels of blood pressure, most people with mild hypertension are assymptomatic. However, unmanaged high blood pressure can induce complication of heart attack or stroke, heart failure, weakened and narrowed blood vessels, metabolic syndrome and trouble with memory or understanding,

In severe cases, chronic hypertension can lead to dementia.

Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications have caused many side effects such as damaging the kidney.

Some researchers suggested by making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.

Dr. Myung Hwa Yang wrote, "a healthy eating, weight management, and appropriate physical activity are essential for the management of high blood pressure in adults since these lifestyle managements have the potential to improve blood pressure control and even reduce the need for medication.23)"

And "Our findings indicate that to achieve better rates of blood pressure control, the clinician should advise lifestyle modifications such as adequate physical activity and low salt intake, in addition to prescribing medication and monitoring the patient for hypertension control".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient which processes cardioprotection researchers examined the effects of onion on blood pressure in N(G)-nitro-L-arginine methyl ester (L-NAME) induced-hypertensive rats and stroke-prone spontaneously hypertensive rats (SHRSP).

The vivo study included male 6-weeks-old Sprague-Dawley rats induced-hypertensive to receive tap water containing L-NAME of a concentration of 50 mg/kg BW/day and dried onion at 5%.

Onion application showed significant anti-hypertensive activity on the L-NAME induced-hypertensive rats and the SHRSP by decreasing the thiobarbituric acid reactive substances (TBARS) associated with lipid peroxidation in blood plasma.

Furthermore, nitrate/nitrite (products of nitric oxide (NO)) involved in blood vessel relaxation excreted in urine and the NO synthase (NOS) associated with vascular tone activity in the kidneys in SHRSP were also increased by the onion injection.

Interestingly, the efficacy of onion that inhibits the onset of high blood pressure was not found similar to those in the L-NAME induced hypertensive rats such as increasing the levels of NOS.

More precisely, onion promoted hypotension in  L-NAME treated rat without inhibiting of NOS activity by L-NAME, and decreased nitrate/nitrite excretion in urine may be associated with only the promotion of antioxidants activity

Dr. Sakai Y, the lead scientists said, "The mechanism of the antihypertensive effect of onion probably involves increased saving of NO by the antioxidative activity of onion in L-NAME induced-hypertensive rats".

Taken altogether, onion may be considered a remedy for the prevention and treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive effects of onion on NO synthase inhibitor-induced hypertensiverats and spontaneously hypertensive rats by Sakai Y1, Murakami T, Yamamoto Y. (PubMed)
(2) Effects of boiling on the antihypertensive and antioxidant activities of onion by Kawamoto E1, Sakai Y, Okamura Y, Yamamoto Y. (PubMed)
(3) The Effect of Lifestyle Changes on Blood Pressure Control among Hypertensive Patients by Myung Hwa Yang,1 Seo Young Kang,1 Jung Ah Lee,1 Young Sik Kim,1 Eun Ju Sung,2Ka-Young Lee,3 Jun-Su Kim,3 Han Jin Oh,4 Hee Chul Kang,5 and Sang Yeoup Lee. (PMC)