Herbal Turmeric Inhibits Risk Factors Associated with Cardiovascular Disease (CVD)

By Kyle J. Norton

Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.

 Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or stroke caused by reducing oxygen supply to the brain cells.

Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.

Stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain functioning.

Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.

According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.

Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.


Although there are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes, some researchers suggested the promotion of a high-fat diet over the past few decades induced widespread obesity may be one major condition that causes the onset of CVD.

Dr. Kachur S wrote, " Obesity is increasingly more common in postindustrial societies, and the burden of childhood obesity is increasing. The major effects of obesity on cardiovascular (CV) health are mediated through the risk of metabolic syndrome (insulin resistance, dyslipidemia, and hypertension), such that an absence of these risk factors in obese individuals may not be associated with increased mortality risk".

And, "The negative effects of obesity on CV health manifest as the accelerated progression of atherosclerosis, higher rates of ventricular remodeling and a higher risk of associated diseases, including stroke, myocardial infarction, and heart failure".

In other words, if you are obese, your risk of CVD is substantially higher compared to a non-obese individual.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of cardiovascular disease (CVD), researchers examined the efficacy of curcumin in the inhibition of cardio-risk factors.

According to the results of the comprehensive literature searching the PubMed, Embase, Ovid, Medline and Cochrane Library databases identified 7 randomized controlled trials including 649 patients, administration of turmeric and curcumin significantly reduced the levels of serum low-density lipoprotein cholesterol (LDL-C), and TG and triglycerides (TG) compared to the control group without affecting the levels of high-density lipoprotein cholesterol (HDL-C).

Furthermore, turmeric and curcumin lower the levels of total cholesterol (TC) in patients with metabolic syndrome.

However, turmeric extract may process a greater effect on reducing serum TC levels compared to curcumin.

Most importantly, turmeric and curcumin showed no serious adverse events in all studies.

In other words, turmeric and curcumin inhibited the parameters associated with risk factors of cardiovascular disease with no side effects.

Based on the findings, researchers said, "turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(2) Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trial by Campbell MS1, Ouyang A1, I M K2, Charnigo RJ3, Westgate PM3, Fleenor BS. (PubMed)
(3) Obesity and cardiovascular diseases by Kachur S1, Lavie CJ2, de Schutter A3, Milani RV2, Ventura HO. (PubMed)

Phytochemical Alliin, The Best Natural Antioxidants

By Kyle J. Norton

Antioxidants are stable atoms that inhibit oxidation caused by free radicals.

Free radicals, on the other hand, are unstable atoms with an unpaired electron in the outermost ring.

Therefore, in order for them to achieve stable, free radicals are always ready to intercept or donate an electron to other stable atoms, leading to a cascade that cannot be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.

Overexpression of free radicals in the long-term can lead to oxidative stress, leading to proteins and lipids and cell damage in facilitating the onset of cardiovascular disease, diabetes, neuro diseases,... and caners.

Most cases of oxidative stress is a result of an imbalance of the ratio of the levels of free radicals and antioxidant.

Believe it or not, free radicals in a moderate amount and in the control of the presence of antioxidant are essential for the body in food and energy metabolism and blood circulation.

Dr. V. Lobo, the lead scientist in the evaluation of "Free radicals, antioxidants, and functional foods: Impact on human health". wrote, "Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function".

And, " Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".

The results suggested by maintaining an adequate amount of functional foods (not synthetic antioxidants) with plenty of antioxidant, oxidative stress may be preventable.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find the potential compound for the treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of bioactive compound alliin.

Compared to garlic compounds representing the four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that alliin showed a better-scavenged superoxide property, particularly in hydroxyl radicals compared to others compound.

Allicin, a derivative of alliin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol and allicin exchange mechanism in the prevention of formation of free radicals.

However, Alliin and allicin did not prevent induced microsomal lipid peroxidation.

In other words, alliin is antioxidants with the free radical scavenging property.

Dr. Chung LY said in the final report, "allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".

In bone resorption associated with osteoclast differentiation and fusion, alliin (S-allyl-l-cysteine sulfoxides, SACSO) displayed a significant antioxidant activity by inhibiting the osteoclastogenesis with a dose-dependent manner via blocking the (c-Fos-NFATc1) signaling pathway involved cell differentiation and fusion.

Furthermore, alliin protected the bone density by decreasing the generation of reactive oxygen species (ROS) and inhibiting the expression of (NADPH oxidase 1 (Nox1)) protein associated with elevated ROS reactive oxygen.

Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases involved in oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)
(2) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(3) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PubMed)

Healthy Food Turmeric, a Natural Prevention and Treatment of Ulcerative Colitis (UC)<, Researchers Say

By Kyle J. Norton

Ulcerative colitis is a type of inflammatory bowel disease induced chronic inflammation and ulcers (sores) in the digestive tract.

The disease affects the colon and the rectum, leading to bloody diarrhea accompanied by symptoms of belly pain, not feeling hungry, fatigue, weight loss, dehydration.

Some patients may also experience symptoms of joint pain or soreness and sudden urges to empty the colon right away.

The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.

According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.

More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.

Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.

The are many prevalent factors associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.

Dr. Mitsuro Chiba, the lead scientist wrote, " Diets rich in animal protein (risk factor) and deficient in dietary fiber (preventive factor) are characteristic of westernized diets in affluent societies. Recent research shows that westernized diets are associated with reduced gut microbial diversity (dysbiosis), which may result in increased susceptibility to IBD and other common chronic diseases".

And, "Plant-based diets rich in dietary fiber are associated with increased microbial diversity. Recent reports on IBD therapy that replaced westernized diets with plant-based diets achieved far better outcomes than those previously reported in the literature. We believe that westernized diet-associated gut dysbiosis is the most ubiquitous environmental factor in IBD".

 The results strongly link the risk of IBD in people who follow the Western diet.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of ulcerative colitis, researchers conducted a systematical review and meta-analyze on the efficacy of oral curcumin administration as adjuvant therapy of UC. MEDLINE, Cochrane/CENTRAL, ClinicalTrials.gov, WHO-ICT.

According to the findings, With the M-H method, treatment with curcumin was significantly superior to placebo but not in the intention-to-treat (ITT) analysis.

However, with the more accurate B-B method, both analyses were found to be insignificant.

In other words, oral curcumin administration was not superior to placebo in attaining remission in patients with UC.

In other to clarify the effect of curcumin on UC, a joint study led by the Bassett Medical Center was conducted by searching the databases of medical literature in the MEDLINE, Pubmed, and Embase through December 2017.

According to the results of 3 randomized controlled trials including 142 patients included in the study, clinical improvement, endoscopic remission, and improvement rate also trended higher in the curcumin group compared to placebo.

In other words, higher clinical remission rates when curcumin was used in combination with mesalamine to achieve remission in patients with UC.

Dr. Iqb al U, the lead scientist wrote, "Curcumin, due to its cost effectiveness and safer side effect profile, can decrease the healthcare burden and morbidity associated with this relapsing and remitting disease".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of ulcerative colitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Grammatikopoulou MG1,2,3, Gkiouras K4,5, Theodoridis X6,7, Asteriou E8, Forbes A9, Bogdanos DP. (PubMed)
(2) Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis by Iqbal U1, Anwar H2, Quadri AA. (PubMed)
(3) Westernized Diet is the Most Ubiquitous Environmental Factor in Inflammatory Bowel Disease by Mitsuro Chiba, MD, PhD1; Kunio Nakane, MD, PhD1; Masafumi Komatsu, MD, Ph.D. (the Permanente Journal)

Herbal Ashwagandha Improved Muscle Mass and Strength In Exercise

By Kyle J. Norton

The Muscle is a soft tissue in the body containing protein filaments of actin and myosin that slide past one another, with a function to produce force and motion.

In other words, muscle contraction and expansion that changes both the length and the shape allow us to move and lift.

Muscle mass is the calculation of the weight of the muscles in the body in kilograms or pounds. However, other factors may also interfere with the above calculation including height, ethnicity, and fitness level.

Increased muscle mass is associated with lower fat accumulation and the ability to burn calories/energy.

Some researchers suggested, by boosting your muscle mass, you will also improve your health, including

* Boosts your metabolism. Dr. Alexandra C. McPherron, the lead scientist said, "increasing skeletal muscle mass by inhibiting signaling of myostatin, a transforming growth factor β (TGFβ) family member that negatively regulates muscle growth, prevents the development of diabetes in a mouse model of lipodystrophy. Muscle-specific myostatin inhibition also prevented hyperphagia suggesting muscle may regulate food intake".

In other words, increasing muscle mass improve your body metabolism.

* Improves Bone Mass. Dr. Colletti LAand colleagues said, "additional evidence that muscle-building exercise is associated with increases in BMD at weight-bearing sites but not at on weight-bearing sites".

* Reduces fat accumulation. Dr. Silva TR, the lead scientist wrote, "Skeletal muscle mass index (SMI) was positively correlated with physical activity (r = 0.205, P = 0.038) and protein intake (r = 0.334, P = 0.001), and negatively correlated with waist circumference (r = -0.505, P < 0.001) and %body fat (r = 0.808, P < 0.001)".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent anti-aging compound, researchers examined the effects of ashwagandha root extract on muscle mass and strength in healthy young men engaged in resistance training.

The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance training randomized into treatment received 300 mg of ashwagandha root extract twice daily, (29 subjects) and placebo, consumed starch placebos (28 subjects) groups.

Besides baseline measurements, both groups also underwent resistance training for 8 weeks with measurements repeated at the end of week 8.

Based on the results of measurement of the participants in both groups, compared to placebo, the treatment group showed significantly greater increases i

* In muscle strength on the bench-press exercise (Placebo: 26.4 kg vs. Ashwagandha: 46.0 kg)

*  In the leg-extension exercise (Placebo: 9.8 kg) vs. Ashwagandha: 14.5 kg)

* In muscle size increase at the arms (Placebo: 5.3 cm(2) vs. Ashwagandha: 8.6 cm(2))

* In chest (Placebo: 1.4 cm vs. Ashwagandha: 3.3 cm). 

Furthermore, ashwagandha treated group also had a significantly greater reduction of exercise-induced muscle damage.

Moreover,  Ashwagandha treated group also showed a significantly greater increase in testosterone level (Placebo: 18.0 ng/dL Ashwagandha: 96.2 ng/dL)

More importantly, there was a significantly greater decrease in body fat percentage in treament group compared to placebo (Placebo: 1.5% vs. Ashwagandha: 3.5%).

Based on the finding, researchers wrote, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".

Taken altogether, Ashwagandha may be used as a supplement for the improvement of muscle mass and strength in the resistance training program, pending to the results from the large sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
(2) Increasing muscle mass to improve metabolism by Alexandra C. McPherron, Tingqing Guo, Nichole D. Bond, and Oksana Gavrilova. (PMC)
(3) The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men by Colletti LA1, Edwards J, Gordon L, Shary J, Bell NH. (PubMed)
(4) Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study by Silva TR1, Spritzer PM. (PubMed)

Betaxanthins, the Natural Free Radical Scavenger

By Kyle J. Norton


Free radical scavengers are types of antioxidants that inhibit free radicals before they can induce oxidation.

Antioxidants are stable atoms which inhibit oxidation caused by free radicals.

Oxidative stress associated with chronic disease is caused by long-term imbalanced ratio of free radicals and antioxidants. Over time, oxidative stress epidemiologically can cause proteins, lipid, and cellular damage, major causes of heart disease, stroke, and diabetes.

Antioxidants besides produced by the body, they can also come into the body from the dietary sources.

Not all free radicals are bad, in a moderate amount, free radicals are necessary for the body functioning, including the promotion of heart function in blood circulation.

Dr. Anu Rahal and colleagues in the examination of the interplay of oxidative stress, prooxidants, and antioxidants wrote, "Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme systems participating in the in vivo redox homeostasis".

And, "the importance of oxidative stress in the body growth and development as well as proteomic and genomic evidences of its relationship with disease development, incidence of malignancies and autoimmune disorders, increased susceptibility to bacterial, viral, and parasitic diseases, and an interplay with prooxidants and antioxidants for maintaining a sound health, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue".

Most common types of free radical scavengers produced by the human
* Catalases are antioxidants that protect the cell from oxidative damage by decomposed hydrogen peroxide to water and oxygen.

*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.

*Superoxide dismutase (SOD) dissolves superoxide radical into either ordinary molecular oxygen or hydrogen peroxide.

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effects of proline-betaxanthin generated by betalamic acid, the chromophore of betaxanthins.

According to the results of 24 betaxanthin species synthesized by the condensation reaction of purified betalamic acid and amino acids or amines, researchers found that all compound exerted a significant inhibition of free radicals.

γ-aminobutyric acid (GABA)-betaxanthins, compared to Proline-, dopamine-, under large-scale conditions, and their 1,1-diphenyl-2-picrylhydrazyl showed comparatively low activity,

Furthermore, the free radical scavenging activity of dopamine-betaxanthin was similar to that of red pigment betanin and the anthocyanin cyanidin 3-glucoside.

Moreover, proline-betaxanthin demonstrated the highest antioxidant activity compared to those of dopamine-, 1,1-diphenyl-2-picrylhydrazyl, similar to those of flavonoid quercetin.

Taken altogether, betaxanthins may be considered a free radical scavenging antioxidant remedy,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro synthesis of betaxanthins using recombinant DOPA 4,5-dioxygenase and evaluation of their radical-scavenging activities by Sekiguchi H1, Ozeki Y, Sasaki N. (PubMed)
(2) Oxidative Stress, Prooxidants, and Antioxidants: The Interplay by Anu Rahal, Amit Kumar, Vivek Singh, and Brijesh Yadav. (Research Gate)

Antioxidants Betanin Protect the Digestive Tract Against the Onset of Inflammatory Bowel Disease

By Kyle J. Norton

Inflammatory bowel disease (IBD) is a class of chronic conditions associated with the inflammation of the gastrointestinal tract, including

* Ulcerative colitis is a chronic inflammation and ulcers found in the innermost lining of the colon and rectum. 

* Crohn's disease. is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.

Most common symptoms of IBD are severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.

If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.

The causes of IBD are unknown. However, some researchers suggested that the promotion of a high-fat diet over the past few decades that cause the alternation of the ration of gut microbiota may be the major culprit in facilitating the onset of IBD.

The research of Case Western Reserve University, wrote, "A high-fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation -- a major discovery for patients suffering from Crohn's disease, research indicates. Crohn's disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea".

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a treatment of inflammatory bowel disease (IBS), researchers examined the effect of beetroot (Beta vulgaris var. Rubra) products and their major component betanin on the reactive oxygen species (ROS) production and DNA damage in vitro.

In neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), injection of betanin at 100 μM for 24 h increased DNA damage, according to the comet assay.

However, in Caco-2 cells.injection of betanin at 100 μM for 24 h showed a lesser pronounced stimulation of DNA damage.

Treatment of Caco-2 cells with H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

In other words, betanin exerted a cytotoxic effect against the DNA alternated cells but inhibited the free radical expression in the induction of DNA damage of normal cells.

More precisely, betanin led to the release of ROS and apoptotic cell death.

Based on the findings, researchers wrote, " betanin may exert anti-inflammatory and potentially cancer preventive activity".

Taken altogether, betanin may be considered supplements for the prevention and treatment of inflammatory bowel disease, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High fat diet reduces gut bacteria, Crohn's disease symptoms by Case Western Reserve University. (Science Daily)

Healthy Food Cranberry Protects the Heart Against Cardiovascular Toxicity

By Kyle J. Norton


Cardiac toxicity is a condition in which the heart has been damage to some extents caused by harmful chemicals, including toxins induced by the treatment of chemotherapy, leading to reduced heart muscles function to pump blood and heart failure.

Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.

 Dr. Polonsky TS, the lead scientist wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".

And, "Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".

Additionally,  human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.

Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.

* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.

* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.

* Acute coronary syndromes that affect the blood flow due to blood vessel damage.

* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.

Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.

Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of cardiovascular diseases, researchers examined the protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in an animal model.

According to the results of rats were given CRAN orally (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) for 7 days, CRAN protected the heart function against DOX-induced increased mortality and ECG changes.

The reduced levels of antioxidants enzymes and increased oxidative stress in the cardiac tissues induced by DOX such as glutathione (GSH) depletion and oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls were significantly inhibited by the administration of CRAN.

Furthermore, the reduced cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) induced by DOX were also inhibited by CRAN.

Moreover, CRAN also improved the cardiac myeloperoxidase (MPO) activity against infection compared to untreated rats.

Most important, CRAN also normalized the levels of enzymes associated with cardio muscle damage and injury casued by DOX such as troponin I, creatine phosphokinase (CK), and creatine kinase-MB.

Based on the findings, researchers said, "CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats".

Taken altogether, cranberry may be considered a remedy for the protection of cardiovascular toxicity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats by Elberry AA1, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour OM. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)