Healthy Food Onion Inhibits Invasive Osteosarcoma in Vitro

By Kyle J. Norton

Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.

Dr. James J. Morrow wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life".

And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)".

The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.

According to the statistic, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are diagnosed each year. Children and teens are younger than 20 accounts for half of the numbers.

The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% comapred to localized cancer between 60% to 80%.

Conventionally, Most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.

In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient for the treatment of osteosarcoma researchers examined the effects of quercetin on proliferation, migration, and invasion in U2OS and Saos-2 cells.

According to the tested analysis, quercetin (20, 40, 60, 80, or 100 μM) for 48 h, incubation with U2OS and Saos-2 cells showed a significant reduction of cancer cell viability, in a dose-dependent manner.

Cell adhesion, invasion, and migration of the tested cell lines were also significantly inhibited by the application of quercetin only at higher concentration.

Furthermore, the expressions of pro-apoptotic matrixes were increased accompanied by the decrease of anti-apoptotic proteins.

Moreover, gene PTHR1 associated with tumor proliferation was also decreased by quercetin.

More precisely, PTHR1 expression in U2OS cells was reduced by 0.18-, and 0.41-fold at 80, and 100 μM, respectively, whereas 0.15 and 0.38 folds in Saos-2 cells. 

In other words, by inhibiting the expression of PTHR, quercetin inhibited proliferation and invasion of the tested cell lines.

Based on the results, researchers said, "quercetin reduced human metastatic osteosarcoma cell invasion, adhesion, proliferation, and migration by inhibiting PTHR1."

Taken altogether, onion may be considered a remedy for the prevention and treatment of metastatic osteosarcoma, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1 by Li S1, Pei Y1, Wang W1, Liu F1, Zheng K2, Zhang X.
(PubMed)
(2) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)

Healthy Food Broccoli, Processes Depressant-Like Property

By Kyle J. Norton

Depression is a common and serious psychological illness, affecting physical and mental functions of patients, including the patients feeling, thinking and acting.

Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.

There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.

Most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.

In severe case, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming his or herself.

According to the statistics provided by the Anxiety and Depression of Association of American, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.

Conventionally, selective serotonin reuptake inhibitors (SSRIs) is the primary medication for the treatment of depression due to its relatively lower side effects comapred to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants and monoamine oxidase inhibitors (MAOIs).

Dr. Steven S. Clevenger and colleagues in examining the role of selective serotonin reuptake inhibitors in the relapse risk of major depressive disorder wrote, "According to the included studies, the relapse risk in adults was lower when SSRIs were combined with psychotherapy".

And, " the combination of SSRIs and cognitive behavioral therapy may effectively reduce relapse. Escitalopram appeared to yield better results and fewer side effects than did other SSRIs or SNRIs".
On finding a potent compound which process depressant-like activity, researchers examined the effects of Sulforaphane (SFN), an isothiocyanate compound derived from broccoli on inflammation-related depressive symptoms.

On lipopolysaccharide (LPS, 0.5 mg/kg) induced depression-like behavior in mice, pretreatment SFN showed a significant effect in the blockage of the increase in the production of pro-inflammatory cytokine (tumor necrosis factor-α (TNF-α)) level and an increase in microglial activation of the brain associated with the inflammatory response by increasing the expression anti-inflammatory cytokine IL-10.

Activation of microglia is a hallmark of brain diseases.

In the tail suspension test and forced swimming test, immotility caused by LPS of the tested mice was also attenuated by the injection of SFN.

Degeneration of the cognition in the brain caused by the alternation of the density of the proteins associated with the brain functioning due to the LPS was also restored by the SFN.

More importantly, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food in the juvenile and adolescence has been found to prevent the risk of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions at adulthood.

In other words, SFN isolated from the rich broccoli sprout exhibited depressant-like activity was attributed to the anti-inflammatory property.

Based on the findings, researchers said, "supplementation of SFN-rich broccoli sprout could be a prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients".

Taken altogether, broccoli sprout with rich of SFN may be considered a functional food for the treatment of depression, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation by Zhang JC1, Yao W1, Dong C1, Yang C1, Ren Q1, Ma M1, Han M1, Wu J1, Ushida Y2, Suganuma H2, Hashimoto K. (PubMed)
(2) The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder by Steven S. Clevenger, Devvrat Malhotra, Jonathan Dang, Brigitte Vanle, andWaguih William IsHak. (PMC)

Herbal Turmeric and Supplemental Copper Suppress the Oral Cancer Progression

By Kyle J. Norton

Oral cancer is a medical condition caused by any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Oral cancer can be classified depending on the types of cells that cause the onset including

* Squamous cell carcinoma

Squamous cell carcinoma is one of the most common types of oral cancer, accounting for over 90% of all cases and arise from the squamous cell layer in the lining of the oral cavity and oropharynx.

* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is uncommon cancer, accounting only to an approximate 5% of all cases, but it can spread deeply into the surrounding tissue.

* Minor salivary gland cancers
The cancer is originated from the salivary gland accounting for less than 1% of all cases.

The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

Most prevalent factors associated with a higher risk of oral cancer are tobacco use including cigarettes, cigars, pipes, chewing tobacco, and snuff, among others. 

Some researchers suggested that heavy alcohol use also in one of the most common risks of oral cancer. 

Dr. Binh Y. Goldstein the lead scientist wrote, "The evidence for the human carcinogenic effects of alcohol drinking on the risk of cancers of the oral cavity and pharynx has been considered sufficient in the IARC Monograph 44 on alcohol and cancer in 1988".

And, "Generally, the dominant type of alcohol consumption in each population is associated with the greatest increases in risk. A large number of studies on joint exposure of alcohol and tobacco consumption demonstrate a more than multiplicative synergistic effect".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of cancer, researchers examined the effect of curcumin found abundantly in turmeric on intracellular copper levels that affect the sensitivity of oral cancer cells.

According to the differentiation of intracellular copper levels and response to curcumin treatment in a panel of OSCC cell lines derived from oral cancer patients, the concentrations that inhibited 50% OSCC cell viability (IC50) of curcumin was reduced up to 5 times in the presence of 250 µM copper.

Furthermore, increased copper level in curcumin-treated OSCC cells exerted a significant effect in increased levels of intracellular ROS and Nrf2 which regulates oxidative stress responses in the cancer cells.

Moreover, supplemental copper also inhibited migration of curcumin-treated cells by suppressing epithelial-mesenchymal transition in the promotion of cancer cells metastasis.

Interestingly, early apoptosis in combined treatment is not found in treatment with curcumin or copper alone.

In other words, copper and curcumin work synergistically to induce cancer cell death, compared to no effect in either alone treatment.

Based on the findings, researchers wrote, "Supplement of copper significantly enhanced the inhibitory effect of curcumin treatment on migration and viability of oral cancer cells".

Taken altogether, curcumin found abundantly turmeric may be combined with the copper supplement for the prevention and treatment of oral cancer pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Usage of Curcumin as Chemopreventive Agent for Oral Squamous Cell Carcinoma: An Experimental Study on Sprague-Dawley Rat by Maulina T1, Widayanti R1, Hardianto A1, Sjamsudin E1, Pontjo B2, Yusuf HY. (PubMed)
(2) Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells by Lee HM1, Patel V1, Shyur LF2, Lee WL. (PubMed)
(3) Alcohol Consumption and Cancer of the Oral Cavity and Pharynx from 1988 to 2009: An Update by Binh Y. Goldstein,1 Shen-Chih Chang,1 Mia Hashibe,2 Carlo La Vecchia,3,4 andZuo-Feng Zhang. (PMC)

Herbal Ashwagandha Destroys Liver Cancer Cells In Vitro

By Kyle J. Norton

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood coming from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, steroid hormones, and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some forms of liver disease.  95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

Compared to cancer caused by irregular cell growth in specific tissues of an organ, liver cancer precisely is caused by uncontrolled cell growth in the liver tissue that starts in the cells on the surface of the inner lining tissue of the liver.

At the advanced stage, the cancerous cell in the primary liver cancer can travel a distance away to infect other nearby healthy tissue or organ, via blood and fluid circulation, leading to secondary metastasis.

Liver cancer is caused by the alternation of liver cell DNA. Because of lower nerve tissue, most patients in the very early stage of liver cancer are assymptomatic. However, at the advanced stage, patients may experience symptoms upper abdominal pain, general weakness, abdominal swelling, jaundice and white, chalky stools accompanied by general symptoms shared by other types of cancer.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The 5-year survival rate of 44% of people diagnosed in the early stage of liver cancer only is 31%., comapred to 90% and 100% of colon and breast cancer, respectively.

Some researchers suggested long-term excessive alcohol use has been linked to an increased risk of liver cancer and worse prognosis comapred to other forms of liver cancer

"Liver cancer is the second leading cause of cancer-related deaths worldwide, with hepatitis B and C infections being the main causes".

"Alcohol abuse and non-alcoholic fatty liver disease are other dominant risk factors. Due to improvements in the treatment of hepatitis infections and increased alcohol consumption in some regions, it is likely that alcohol will become a leading cause of liver cancer".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On the finding a potent ingredient for the treatment of liver cancer, researchers investigated the antioxidant and apoptotic inductive effects of Withania somnifera (Ashwagandha) leaf extract ((ASH-WX; 6.25 mg/ml-100 mg/ml)) against a hepatocellular carcinoma cell line (HepG2cells).

According to the tested differentiation, ASH-WX injection demonstrated increased cytotoxicity in HepG2 cells compared to untreated control with IC50 of 5% (approximately 5.0 mg/ml).

ASH-WX also exerted strong antioxidant activities by increasing the levels of Fas-ligand associated with cell death programming and matrixes involved regulating of cancer cell migration, invasion, and metastasis and decreasing the production of pro-inflammatory induced systemic inflammation.

Furthermore, the extracts were also found to interact with cyclin D1, an important regulator of cell cycle progression.

More precisely, ASH-WX induced cell death in HepG2cells was found to increase significant accumulation in the G0/G1 and G2/M phases compared to the control and untreated cells.

In other words, ASH-WX blocked the proliferation through cell cycle arrest.

Based on the results, researchers said, "Ashwagandha could be a powerful antioxidant and a promising anticancer agent against HCC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of liver cancer, pending to larger sample size and multicenter study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant activity and apoptotic induction as mechanisms of action of Withaniasomnifera (Ashwagandha) against a hepatocellular carcinoma cell line by Ahmed W1, Mofed D1, Zekri AR2, El-Sayed N3, Rahouma M4, Sabet S. (PubMed)
(2) Liver cancer caused by alcohol consumption may have a worse prognosis than other forms by Wiley. (Medical Express)

Lycopene Prevents the Onset of Metabolic Syndrome

By Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndrome you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

Most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Common complications of untreated metabolic syndrome epidemiologically have been found by experts to complicate chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Symptoms of signs of metabolic syndrome depending types of affected conditions and complications.

Some researchers suggested that in the US, metabolic syndrome may be correlated with the promotion of a high-fat diet over the past few decades.


Dr. Silvia Moreno-Fernández wrote, "The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast".

And, "High-fat/high-glucose fed rats showed an increased bodyweight, abdominal circumference, and fat deposition, combined with oxidative stress, impaired glucose tolerance, dyslipidemia, and mechanical allodynia. Altogether, our results showed an early-stage MetS which, in addition, could lead to T2DM and cardiovascular disease development over time in HFG animals. ".

The results strongly suggested that both metabolic syndrome and obesity in the US population are attributed to the Western diet pattern.

In other words, by changing to a healthy diet such as traditional diet, the risk of obesity and metabolic syndrome can be decreased substantially.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a potent compound for reducing risk cardiovascular disease and diabetes, researchers examined the effects of lycopene on metabolic syndrome.

In a total of 13 196 participants, aged 20 years and older, divided into three groups according to serum concentrations of lycopene, researchers found that prevalence of the metabolic syndrome associated with levels of antioxidant was significantly higher in the normal and overweight group compared to the obese group.

In other words, the risk of metabolic syndrome depending on the levels of lycopene in the body only affects people with normal weight or overweight.

Additionally, the study included A total of 2499 participants 20 years and older with metabolic syndrome that were divided into 3 groups based on their serum concentration of lycopene suggested that levels of lycopene also showed significant effects on HRs of mortality.

In other words, people with higher levels, compared to those of lower serum lycopene concentration.have a lower mortality rate and hazard ratios (HR).

Taken altogether, lycopene found in tomato may have a strong effect on the initiation of metabolic syndrome, particularly in normal weight and overweight individuals, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Higher levels of serum lycopene are associated with reduced mortality in individuals with metabolic syndrome by Han GM1, Meza JL2, Soliman GA3, Islam KM1, Watanabe-Galloway S. (PubMed)
(2) The influence of BMI on the association between serum lycopene and the metabolic syndrome by Han GM1, Soliman GA2, Meza JL3, Islam KM1, Watanabe-Galloway S. (PubMed)
(3) High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model by Silvia Moreno-Fernández,1,2 Marta Garcés-Rimón,3 Gema Vera,2,4 Julien Astier,5Jean François Landrier,5 and Marta Miguel. (PMC)

Healthy Food Kale Promotes Bile Acid Binding Naturally Against High Blood Cholesterol

By Kyle J. Norton

Bile acids synthesized from by oxidation from cholesterol in the liver, flowing to the gallbladder to aid digestion.

Bile acids binding is a process to interfere with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.

In other words, binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.

By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.

Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 gram/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% comapred to high doses of 24 gram/day of only 25%.

In other words, bile acid-binding medicine such as Cholestyramine, used alone are less effective, comapred to statins in lowering LDL cholesterol.

Most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.

Bile acid sequestrants such as lovastatin combined with niacin may be used to lower aggressively lower LDL cholesterol levels.

Dr. Gordon Schectman and colleagues in the study published at the American Journals of Cardiology wrote, " Niacin and lovastatin are effective drugs for hypercholesterolemia management in the Veterans Administration Medical Center setting. However, in elderly veterans, bile acid sequestrants were associated with a higher rate of adverse effects limiting compliance, and psyllium was ineffective".

Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe.

The Kale's leave is highly nutritious cultivated as foods in most part of Europe.

On finding a potent compound for the prevention and treatment of hypercholesterolemia, researchers examined the effects of kale bile acid-binding capacity.

The study included the testing of three different compositions of bile acids to establish the optimal dose for bile acid-binding.

Compared to other cruciferous vegetables such as red leaf lettuce, red cabbage, red kale, green kale, and Brussels sprouts, kale showed significantly higher bile acid-binding capacity at 1.5 g sample and remained constant up to 2.5 g.

In kale Comparision, minimally processed (microwaved 3 min or steamed 8 min) green kale showed significantly higher bile acid-binding capacity (91.1 ± 0.3 and 90.2 ± 0.7%, respectively) compared to lyophilized kale (85.5 ± 0.24%).

Furthermore, kale also prevented cholesterol reabsorption into the blood by binding to hydrophobic bile acids, chenodeoxycholic acid, and deoxycholic acid preferably.

These results suggested that kale processes the highest anti hypercholesterolemic activity by binding to bile acids compared to other veggies in the same family.

Based on the findings, researchers said, " regular consumption of kale, especially minimally processed kale, can help excrete more bile acids and, thus, may lower the risk of hypercholesterolemia".

Taken altogether, kale may be considered a functional food for the promotion of bile acid-binding, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In Vitro Bile Acid Binding Capacities of Red Leaf Lettuce and Cruciferous Vegetables by Yang IF1, Jayaprakasha GK1, Patil BS. (PubMed)
(2) Evaluation of the effectiveness of lipid-lowering therapy (bile acid sequestrants, niacin, psyllium and lovastatin) for treating hypercholesterolemia in veterans by Gordon Schectman, Schectmana, Jan Hiatt, Pharm D. Arthur Hartz, MD. (the American Journals of Cardiology)

Phytochemical Alliin Suppresses the Onset of Hyperlipidemia in Vivo

By Kyle J. Norton

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

High blood cholesterol is the most common causes of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL.  and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 millions of American and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, produces vitamin D and steroid hormones.

The healthy ratio of low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is ant numbers that are less than 4.

People with hyperlipidemia are asymptomatic. However, if untreated, the condition can cause cholesterol build-up on the arterial wall, leading to narrowing the arteries inducing blockage that causes heart disease and stroke.

Although there are many factors that can induce the expression of hyperlipidemia, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a significant implication on the onset of hyperlipidemia in the population in the US.

An article cited from the study by Tufts University wrote, "In two studies published online in the American Journal of Transplantation, researchers determined that hyperlipidemia accelerates heart-transplant rejection in mice. By using models that mimic the health conditions found in human transplant recipients, the researchers from Tufts determined that transplant rejection was accelerated whether the hyperlipidemia (high cholesterol and high triglycerides in the blood) was caused by genetics or solely by a high-fat diet".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a potential compound for the treatment of hyperlipidemia, researchers examined the bioactive compound alliin (S-allyl cysteine sulfoxide) derived from garlic in an animal model.

The study included C57BL/6J DIO mice randomly assigned to drinking water with or without alliin (0.1 mg/ml) for 8 weeks.

Based on the tested results, alliin exerted antihyperlipidemic activity with no significant effect on the body weight, adiposity or energy balance.

However, alliin treatment enhanced glucose homeostasis and increased insulin sensitivity.

The efficacy of alliin antihyperlipidemic effects was attributed to alliin induced balance of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.

Collectively, researchers concluded," alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders".

In other to find out more information about alliin hypolipidemic activity, researchers examined the effects of alliin on the lipid profile in a rabbit model. 

The study included 19 New Zealand White rabbits were fed a cholesterol-rich diet (0.25% cholesterol) for 18 weeks with 10 rabbits received freshly produced allicin (3 mg/kg orally) starting at 8 weeks, and nine received a placebo.

According to the results from tested assays, allicin produced by reacting alliin showed a significant effect on serum cholesterol and low-density lipoprotein concentrations compared to control in days dependent manner.

Additionally, levels of serum high-density lipoprotein levels were also improved between groups.

Dr. Eilat S, the lead scientist wrote, in the final report, "allicin has a beneficial effect on the serum lipid profile in hyperlipidemic rabbits, and should be further tested clinically".

Taken altogether, alliin may be considered supplements for the prevention and treatment of hyperlipidemia with no side effect, responding to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) (1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice.
Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)

(2) Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic by Eilat S1, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z.(PubMed)
(3) Hyperlipidemia, caused by a high-fat diet, aggressively accelerates organ rejection by Tufts University (Science News)