Whole Food Tomatoes, Protects the Aging Vision Against Age-related Macular Degeneration (AMD)

By Kyle J. Norton

Macular degeneration is a condition caused by the blurring of the center of the vision without affecting the side or peripheral vision.

Age-related macular degeneration (AMD) is an aging process found in older adults is the leading cause of blindness in adults over the age of 55.

Most adults with age-related macular degeneration (AMD) are asymptomatic. However, it can be detected by professions during annual eye check-up.

Untreated AMD, over time, can lead the increased size of blur-area and interfere with the vision, including reading.

AMD can be classified into 2 types
* The dry form is a milder form found in most patients with AMD with gradual degeneration of the central retinal tissues that make up the macula.

* The wet form is the serious form of AMD account for only 10% in all patients

However, the dry form can develop into the wet form over time.

Conventionally, as of today, there is no effective treatment for AMD. Most treatments such as from low vision aids and lifestyle control are to delay the progression and improve quality of life.

In some cases, wet AMD may be treated with medications injected into the eye to stop leaking blood vessels, depending on the disease severity.

Besides aging and exposure to UVB, smoking has been found to increased risk AMD by 2-5 fold.

Dr. Sara Velilla, the lead scientist said, "Age-related macular degeneration (AMD) is one of the main socioeconomic health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression".

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a natural treatment of eye disease, researchers examined the combinations of antioxidants including lutein+zeaxanthin (1 μM; 0.2 μM), zinc (10 µM), carnosic acid (2 µM), beta-carotene (2 µM), and standardized tomato extract containing lycopene and other tomato phytonutrients added to the culture media.against age-related macular degeneration (AMD).

Injection of the combination protected the eye against age-related macular degeneration (AMD) by yielding an antioxidative, anti-inflammatory, and antiangiogenic effect in M1 and M2 macrophages.

The results of the effects were attributed to the upregulation of antioxidative genes (HMOX1, SOD1) expression and the inhibition of pro-angiogenic genes and pro-inflammatory genes (SDF-1, TNF-alpha, IL-6, MCP-1).

Compared to the combination, lutein monotherapy or a combination of lutein and zinc had less effect on the expression of these genes.

Dr.Rinsky B, the lead scientist said, "Combinations of supplements can modify the expression of genes and proteins that may be relevant for the involvement of macrophages in the pathogenesis of AMD".

Futhermore, in oxidative stress-induced damage to the retinal pigment epithelial (RPE) on age-related macular degeneration and neovascular retinopathies (e.g., retinopathy of prematurity, diabetic retinopathy, researchers investigated xanthophyll carotenoids, lutein, and zeaxanthin, isolated from toma in damage of retinal pigment epithelial (RPE) cells.

Also, administration of carotenoids, lutein, and zeaxanthin showed to protect the macula (and the broader retina) via their antioxidant and photoprotective activities.

In undifferentiated ARPE-19 cells, lutein and lycopene, but not β-carotene, protected the cell integrity and viability by inhibiting the overexpression of retinal cell growth.

Moreover, pre-incubation of ARPE-19 cells with lutein or lycopene protected against tBHP-induced cell loss and cell co-exposure of lutein or lycopene with tBHP essentially neutralized tBHP-dependent cell death at tBHP concentrations up to 500 μM.

Where tert-Butyl hydroperoxide (tBHP) is an organic peroxide used to induce oxidation processes.

In other words, lutein and lycopene protected the RPE against oxidative stress-induced cell loss

Taken altogether, tomatoes may be considered a natural remedy for the prevention and treatment of age-related macular degeneration (AMD), pending to the confirmation of the larger sample size and multicenter human study.

Intake of lutein and lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Characterizing the effect of supplements on the phenotype of cultured macrophages from patients with age-related macular degeneration by Rinsky B1, Hagbi-Levi S1, Elbaz-Hayoun S1, Grunin M1, Chowers. (PubMed)
(2) Effects of the Macular Carotenoid Lutein in Human Retinal Pigment Epithelial Cells by Gong X1, Draper CS2, Allison GS3, Marisiddaiah R4, Rubin LP. (PubMed)
(3) Smoking and Age-Related Macular Degeneration: Review and Update by Sara Velilla, 1 , 2 José Javier García-Medina, 3 , 4 , 5 Alfredo García-Layana, 2 , 6Rosa Dolz-Marco, 5 , 7 Sheila Pons-Vázquez, 5 M. Dolores Pinazo-Durán, 2 , 5 , 8Francisco Gómez-Ulla, 2 , 9 , 10 J. Fernando Arévalo, 11 , 12 Manuel Díaz-Llopis, 2 , 7 , 8 and Roberto Gallego-Pinazo. (PMC)

Herbal Ginger, the Natural Anti Male Infertility Functional Remedy

By Kyle J. Norton

 Fertility is a natural capacity for producing offspring.

According to traditional Chinese medicine, all women with no reproductive structure problems in the childbearing year are once fertile. However, due to many reasons such as the use of contraceptive, and workplace stress, some women and men have developed unexplained causes of infertility.

Unexplained causes of infertility is a condition of not getting pregnant in a couple without knowing causes.

Infertility is a condition that a female of a couple cannot get pregnant after 12 months of unprotected sexual intercourse, including those cannot carry the pregnancy to term.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), approximately 10 percent of women (6.1 million) in the United States ages 15-44 have difficulty getting pregnant or staying pregnant compared to 5-6% of males are infertile,

In males, although the sperm in the male reproductive organ does not change much, the quality and quantity of sperm may be reduced by low levels of testosterone due to aging. 

These explained why a couple in their late 20's is easier to conceive than a couple with a wife in her 20's and a husband at the age of 40 and more. 

According to the study of the European Society of Human Reproduction and Embryology, the rate of miscarriage also increases substantially when the father was over the age of 35.
1. Nearly 17 percent if the father was over 34 years old.

2. Around 20 percent if the father was between the ages of 35 and 39.

3. Over 32 percent if the father was older than 44.

In fact,  the odds of male fertility rate decreases at an alarming rate of 11% every year and the chance for his partner to conceive declines even further over the past few decades.

The results strongly suggested that if you follow a healthy diet with nutrients diet by focusing on calories, macronutrients, you may delay the process of biological aging, including the reproductive organs.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural ingredient for the treatment of male infertility examined the effects of ginger (Zingiber officinale) on sperm DNA fragmentation (SDF) in infertile men.

This randomized double-blind, placebo-controlled trial with a 1:1 allocation included 100 selected infertility candidates who were admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.

Patients were randomly assigned to receive either ginger given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger or placebo.

By analyzing the sperm concentration, motility, and SDF from the standardized semen samples before and after treatment, according to the World Health Organization, researchers found that

according to the multivariate analysis, patients receiving ginger (17.77, 95%CI: 6.16-29.39) was found to have a lower average positive percentage of SDF in compared with placebo, after three months of treatment without affecting the semen parameters.

In other words, ginger improves male fertility by decreasing SDF in infertile men.

Where SDF assay is a better diagnostic potential in evaluating the male infertilities, particularly in those with unexplained cause of infertility.

Researchers in the differentiation of the role of sperm DNA fragmentation in male factor infertility
wrote, "The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in the selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with the highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed".

Taken altogether, ginger may be considered a functional remedy for the improvement of male fertility, pending to the confirmation of larger sample sized and multicenter human study.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Jalil Hosseini, M.D.,1,2 Azar Mardi Mamaghani, M.Sc.,2 Hani Hosseinifar, Ph.D.,2Mohammad Ali Sadighi Gilani, M.D.,2,3 Farid Dadkhah, M.D.,2 and Mahdi Sepidarkish, Ph.D. (PMC)
(2) Role of sperm DNA fragmentation in male factor infertility: A systematic review by Chak-Lam Choa,1 and Ashok Agarwalb. (PMC)

Phytochemical Sinigrin, The Antibacterial Functional Supplement

By Kyle J. Norton


Bacterias are a class of microorganism consisted of a single cell with a simple internal structure with a number of different shapes.

Not all bacterias are harmful to human. Some are essential to human life, with benefits related to improve the digestive function, prevent overexpression of harmful disease-causing bacteria, and the synthesis of essential nutrients and vitamins.

Believe or not, human gut contains over 10 trillions of bacterias including at least 1000 different species of known bacteria with more than 3 million genes.

In a healthy individual, the levels of microorganisms in the gut are balanced.

The gut microbiota plays a critical role in breaking down foods that stomach and small intestines cannot digest, stimulating the production of vitamin K and D, protecting the intestinal against damage caused by bad bacteria and increasing the immune functioning. 

Bacterias that cause disease are called pathogenic microorganisms.

Epidemiological studies suggested that Mycobacterium tuberculosis bacteria is one of the bacteria that causes tuberculosis, killing over 2 million people a year, mostly in sub-Saharan Africa.

Other pathogenic bacterias include Streptococcus and Pseudomonas, and Shigella, Campylobacter, and Salmonella.

According to the statistics, pathogenic bacterial infection is a leading cause of death of infants in developing countries.

On the finding a bioactive ingredient with antibacterial activity, researchers examined allyl isothiocyanate (AIT) is derived from the glucosinolate sinigrin in E. coli O157:H7 numbers in food products.

Injection of AIT showed a greater antimicrobial activity at low pH values. In other words, at pH 4.5 and 5.5 the MIC was 25 microL/L, while at pH 8.5, 500 microL/L was required to inhibit bacterial growth. 

Furthermore, bacterial decomposition was found at the highest rate in water at 37 degrees C.

Moreover, in bacterial enzymes (the thioredoxin reductase and acetate kinase), AIT at 10 to 100 microL/L was able to significantly inhibit both enzymes, but only 1 microL/L was needed to decrease the activity of thioredoxin reductase.

Interestingly, in a Nanocomposite carboxymethyl cellulose films tested on Escherichia coli O157:H7-containing sinigrin (SNG) prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG), researchers found that

* In beef pieces measuring 6 × 5 × 2 cm(3) (L × W × H) were dipped in an E. coli O157:H7 broth suspension containing >8 log10 CFU ml(-1) and were drained for 3 min over a sterile cloth, the CMC and NCMC films without SNG were not antimicrobial against E. coli O157:H7; however, NCMC and CMC films with SNG were highly antimicrobial.

* After 5 days at 8°C, E. coli O157:H7 was reduced more than 4 log10 by the NCMC•pSNG film.

* The reduction remained almost the same until 18 days at 8°C when E. coli O157:H7 was reduced >5 log10 CFU g(-1) meat.

The findings strongly support the use of sinigrin for food storage against bacteria.

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the treatment of bacterial infection, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Source
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)

3,3'-Diindolylmethane, the Natural Treatment for Arthritis

By Kyle J. Norton


Arthritis is a group of diseases associated with the inflammation of the joints. According to the epidemiological studies osteoarthritis (OA) and rheumatoid arthritis (RA) are 2 most common types of arthritis.

According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults of which diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.

Depending on types and the location affected,  arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.

* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. 

* Polymyalgia arthritis is a condition of inflammatory rheumatic disease induced pain, stiffness, and tenderness in large muscles, including muscles shoulders and pelvic girdle.

* Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve quality of life for patients to carry out daily activity.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.

The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.

According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.

Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.

Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.

Where Receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.

Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)

Herbal Turmeric, the Best Functional Herb Which Processes Anti Diseases Associated with Chronic Low Grade Inflammation Potential

By Kyle J. Norton

Inflammation is a natural response induced by the immune system in which the white blood cells in the first line of defense try to destroy the harmful pathogens before they can enter the body to multiply in the acute phase of infection

However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.

Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissues damage.

If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.

Long-term low-grade inflammation ultimately leads to tissues and organs damage, inducing a number of chronic illness, including diabetes and cardiovascular disease.

Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety and mood disorders due to pain. gastrointestinal complications like constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.

According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of diseases associated with chronic inflammation is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.

Turmeric is a perennial plant in the genus Curcuma,  belonging to the family Zingiberaceae, native in demagogical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural compound for the treatment of diseases associated with chronic inflammation, including cancers, researchers examined the effects of the turmeric through its bioactive components.

According to the review of previous studies, turmeric oil, present in turmeric, can enhance the bioavailability of curcumin.

In other words, essential oil isolated from turmeric in the form of curcumin-free turmeric (CFT) components is more effective for the treatment of chronic inflammatory disease compared to other extracts.

In the components analysis, turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrene were all contributed to the efficacy of the curcumin-free turmeric (CFT).

In examining the effect of ar-turmerone (ATM) and turmerones (TUR, a mixture of 5 sesquiterpenes including ATM) against disease associated with inflammation, researchers found that both CUR and ATM inhibited lipopolysaccharide (LPS)-induced expression of inducible forms of inflammation by exhibiting the production of free radicals and protein involved overexpression proinflammatory cytokines.

Furthermore, ATM prevented LPS-induced translocation of certain inflammatory genes.

In a colitis model, oral administration of TUR significantly protected the large bowel against 2% dextran sulfate sodium (DSS)-induced shortening of the large bowel by 52-58% and colon carcinogenesis.

Moreover, at a low dose, TUR markedly suppressed adenoma multiplicity by 73%, compared to the range of 63-69% of CUR.

Also, the combination of CUR and TUR at both low and high doses showed a complete abolish of tumor formation.

Based on the findings, Murakami A, the lead scientist in the chronic inflammatory disease team wrote, "we consider that its use in combination with CUR may become a powerful method for prevention of inflammation-associated colon carcinogenesis".

Taken altogether, turmeric in the form of essential oil, CUR, and TUR may be considered herbal remedies for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric by Aggarwal BB1, Yuan W, Li S, Gupta SC. (PubMed)
(2) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis by Murakami A1, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. (PubMed)

Herbal Artichoke, the Anti Inflammatory Bioactive Compound

By Kyle J. Norton


 Inflammation is a natural response of the immune system against the stimuli and foreign pathogens which try to enter the body through wound or injury.

In the acute phase of infection, after receiving the message transmitted by the central nervous system, the immune macrophages stimulating the blood palette to cover the affected site and production of pro-inflammatory cytokines to protect the body against microorganisms.

Some anti-inflammatory cytokines in this phase may also switch to proinflammatory activity, causing overproduction of proinflammatory cytokines.

In some cases, depending on the severity of the wound, overexpression of pro-inflammatory cytokines may cause damage and death of nearby cells, leading to the formation of scars.

Most common symptoms of the acute phase of infection area pain, swelling and redness in the affected areas.

If the immune macrophages kill off the foreign pathogens in the acute phase of infection, the inflammatory progress proceeds to other stages including the stage one of acute phase of infection followed by the repair and regeneration stage, where collagen fibers are formed then by the remodeling and maturation stage, where the new tissue continue to remodel, strengthen and improve.

Chronic inflammation occurs if the immune system can not kill off all invaders within a set period, it will adapt to the news change, leading to chronic low-grade inflammation, the major cause of various chronic illness, including cardiovascular disease and diabetes.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the treatment of Porphyromonas gingivalis, the disease has been found to induce the expression of inflammatory cytokines that promote inflammatory bone destruction, investigated the anti-inflammatory effects of an extract from Cynara scolymus L. and its pharmacologically effective compound cynaropicrin, a sesquiterpene lactone, on human gingival fibroblasts (HGFs).

Human gingival fibroblasts (HGFs)used in the study were induced inflammation by lipopolysaccharide (LPS).

Artichoke bioactive compound injection inhibited the production of pro-inflammatory cytokines in LPS-stimulated HGFs in a dose-dependent manner.

P. gingivalis LPS-induced expression of enzymes and proteins in the cellular response to inflammation were also suppressed by cynaropicrin.

The additional analysis also suggested that cynaropicrin's inhibition of P. gingivalis LPS-induced production pro-inflammatory expression may be due to the inhibition of the activation of the inflammatory pathways.

Dr. Hayata M, the lead scientist said, "These results suggest that cynaropicrin may be useful for preventing periodontal diseases and could prove valuable in the development of more effective preventative approaches for periodontal diseases".

In order to reaffirm the efficacy of artichoke anti-inflammatory activity, researchers at the University of Sfax examined the Artichoke Leaves Extracts (ALE) phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test. 

In the carrageenan (Carr) model induced paw edema, EtOH extract of ALE contained the highest phenolic, flavonoid, and tannin contents exerted the strongest antioxidants activities, according to the DDPH (94.23%), ABTS (538.75 mmol), FRAP assay (542.62 umol), and β-carotene bleaching (70.74%) compared to the other extracts of ALE.

Moreover, administration of EtOH extract at dose 400 mg/kg/bw exhibited a maximum inhibition of inflammation induced by Carr for 3 and 5 hours compared to reference group Indomethacin (Indo).


Based on the finding, Dr. Ben Salem M, the lead scientist wrote, "ALE displayed high potential as a natural source of minerals and phytochemicals compounds with antioxidant and anti-inflammatory properties".

Taken altogether, artichoke processed abundantly bioactive compound may be considered a functional remedy for the treatment of diseases associated with chronic inflammation, with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells by Hayata M1,2, Watanabe N2,3, Kamio N2, Tamura M2, Nodomi K2, Tanaka K4, Iddamalgoda A4, Tsuda H5, Ogata Y6, Sato S3, Ueda K1, Imai K. (PubMed)
(2) Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC by Ben Salem M1, Affes H1, Athmouni K2, Ksouda K1, Dhouibi R1, Sahnoun Z1, Hammami S1, Zeghal KM. (PubMed)

Turmeric, the Potential Spice that Detoxes Your Lung Against Toxicity

By Kyle J. Norton

Lung toxicity or pulmonary toxicity refers to the toxicity induced by the side effects of the lung in patients under chemotherapy or radiotherapy.

Most common drugs associated with lung toxicity used for the treatment of cancer include Arsenic trioxide (Trisenox®) Bleomycin (Blenoxane®)1 Idarubicin (Idamycin®).

However, lung toxicity is also caused by inhaling chemical compounds, the most famous (infamous) example is pulmonary toxicity due to asbestos. air pollution and airborne particulate matter produced by car traffic, overland traffic (trucks), industrial production facilities, and cigarette smoking.

Symptoms of lung damage or toxicity are a shortage of breath, breathlessness during exercise, fatigue dry cough Shortness of breath, particularly the symptoms that worsen when lying on your back breath.

Acute pulmonary toxicity, the damage to the lungs that resolves with a short period of time by addressing the cause.

Conventionally, most common treatments of lung toxicity are the use of
* Corticosteroids to decrease inflammation and relieve the cough and pain

*Narcotics to reduce pain medications and promote breathing center

* Oxygen therapy to increase oxygen in the blood and prevent shortness of breath.

In severe cases, patients may be sent to the hospital for Pulmonary (lung) rehabilitation.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of lung toxicity scientists evaluated the protective effects of curcumin on lipid peroxidation and antioxidants status in bronchoalveolar lavage fluid (BALF) and bronchoalveolar lavage (BAL) of a nicotine-treated animal model.

Wistar rats selected to the study were induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22 weeks) and following by administration of curcumin (80 mg/kg body weight) given simultaneously by intragastric intubation for 22 weeks. 

Before injecting of curcumin, injection of nicotine rats showed the increased biochemical marker enzymes, lipid peroxides in BALF and BAL of accompanied by a significant decrease in the levels of antioxidant in the lung.

Following the treatment of curcumin, infected rats showed a significantly lowered the biochemical marker enzymes, lipid peroxidation and enhanced the antioxidant status.

Based on the results, researchers said, "The results of the present study suggest that curcumin exert its protective effect against nicotine-induced lung toxicity by modulating the biochemical marker enzymes, lipid peroxidation and augmenting antioxidant defense system".

In order to reveal more information about turmeric detoxed activity, researchers examined the protective role of curcumin and a synthetic analog of curcumin (BDMC-A) on nicotine-induced oxidative stress.

Male albino rats of Wistar strain selected to the study induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (five days a week, for 22 weeks) and followed by the treatment of curcuminoids given simultaneously by intragastric intubation for 22 weeks.

Nicotine-treated groups before injection of curcumin showed increased oxidative stress, as evidenced by lipid peroxidation indices.

Injection of curcumin and BDMC-A not only restored the antioxidant status which was decreased in the nicotine-treated group.

Based on the findings, researchers said, "The present study suggests that BDMC-A exerts its protective effect by modulating the extent of lipid peroxidation and augmenting the antioxidant defense system".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of lung toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats by Kalpana C1, Menon VP. (PubMed)

(2) Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity by Kalpana C1, Sudheer AR, Rajasekharan KN, Menon VP. (PubMed)