Ginger, the Pungent Spice Which inhibits the Onset and Progression of Arthritis

By Kyle J. Norton

Scientists may have found a whole food which processes a significant effect in reducing and treatment of arthritis with no side effects, some studies found.

Arthritis is a class of inflammatory diseases that affect the joints.

Most common symptoms of arthritis are joint pain and stiffness.

However, some patients with arthritis may also experience symptoms of redness, warmth, swelling, and decreased the range of motion of the affected joints.

The most common causes of arthritis are the improper healthy of the joint injury in the younger age and infections that affect the integrity of the cartilage.

RA, an autoimmune disorder is a type of arthritis caused by immune system mistakenly attacks the joints tissues of the body.

The prevalent risk factors associated with the onset of the disease include the increase in age, family history, gender, ethnicity, and obesity.

Some researchers suggested that people who follow the Western diet with high saturated and trans fat, red meat and processed foods and fewer fruits and vegetables and whole grains are also at the increased risk of arthritis.

According to the study published in the journal JCI Insight on April 19, by the University of Rochester Medical Center in New York, after 3 months of feeding mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen, the mice became obese and diabetic and fat percentage was double compared to mice fed with a healthy, low-fat diet.

The contribution of overweight of obesity caused by long-term intake of the Western diet may contribute to the link of obesity in risk of arthritis.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reconfirm the tradition medicine use of ginger for the treatment of chronic inflammatory diseases, the research team at the examine the turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes effect in patients with arthritis rat adjuvant-induced arthritis (AIA) both plants at the dose 200 mg/kg body weight were orally administrated.

Turmeric and ginger exerted a significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing the production of anti-inflammatory and decreasing pro-inflammatory cytokines.

Both turmeric and ginger also restored the antioxidant enzymes in the rats.

In the anti-arthritic activity, turmeric was more effective compared to those of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.

Interestingly, The percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin, respectively.

Dr. the lead author said, after taking into account of co and confounders, "the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model".

The findings indicated a potential effect of ginger against arthritis although to the lesser extent than those of turmeric.

Furthermore, the investigation of the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat collagen-induced arthritis, also found that

* Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally significantly enhanced the immune function against the progression of arthritis.

* Continued administration of the said volume for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.

* The anti-arthritis effects were associated with reduced production of proinflammatory cytokines and antibody.

Most importantly, Z. officinale extract at the dose of 200 mg/kg/day was more superior than those of 2 mg/kg/day of indomethacin compared by most of the measured parameters.

Taken altogether, ginger may be used as a functional food for the prevention and combined with primary medicine for the treatment of arthritis

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(2) Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis by Fouda AM1, Berika MY. (PubMed)
(3) Western Diet, With Its High-Fat Content, Linked To ArthritisApr 19, 2018 09:00 AM By Sadhana Bharanidharan, (Medical Daily)

Honey, the Natural Whole Food for Prevention and Treatment of Dandruff

By Kyle J. Norton

Honey may have a potential effect in the prevention and treatment of dandruff, a common skin problem of many adults, some scientists suggested

Dandruff is a condition of the scalp most commonly caused by the dry skin resulting from dry air.

However, in many instances, the condition also is associated with seborrheic dermatitis. leading to rough, scaly skin on the scalp.

In other words, patients with oily skin accompanied by seborrheic dermatitis can lead to overexpression of yeast that causes the development of the large white flakes or yellow scales due to uneven shedding and clumping of dead skin cells.

Belief or not dandruff affects over 50% of the general population.

There are many causes of dandruff. Researchers suggested that dry skin, use of wrong kinds of hair products and skin conditions such as seborrheic dermatitis or eczema are associated with the onset of dandruff.

In some people, an overgrowth of a yeast-like fungus can also cause dandruff.

The increase of age hormone imbalance and prolonged periods of stress are the most common prevalent risk factors associated with the condition.

Most case of dandruff can be treated with daily shampoo to reduce the oil on the scalp. In severe cases, due to overexpression of fungi, pyrithione zinc shampoos may be recommended.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Dandruff, if left untreated can cause itchy and inflamed scalp that it lead to temporary hair loss.

On finding a natural ingredient for the prevention and treatment of dandruff with no side effects, researchers examine the anti-dandruff effects from honey, a bee-derived, supersaturated solution composed mainly of fructose and glucose, and contains proteins and amino acids, vitamins, enzymes, minerals, and other minor components.

Application of honey exerted a significant effect in reducing dandruff, through its moisturizing and antimicrobial property.

The effective doses range between 1 and 10%, but concentrations up to 70% can be reached by mixing with oils, gel, and emulsifiers, or polymer entrapment.

With an aim to reaffirming the honey anti-dandruff activity, a researcher at the Dubai Specialised Medical Centre and Medical Research Labs, investigated the potential use of topical application of crude honey in the management of seborrheic dermatitis and dandruff.

The study included 30 patients (20 patients were males and 10 were females, their ages ranged between 15 and 60 years) with chronic seborrheic dermatitis of scalp, face, and front of the chest.

Before applying honey to treat the condition, participants showed conditions of scaling, itching and hair loss. The lesions were scaling macules, papules and dry white plaques with crust and fissures.

All patients were asked to apply diluted crude honey (90% honey diluted in warm water) every other day on the lesions with gentle rubbing for 2-3 mins. And, honey was left for 3 hr before gentle rinsing with warm water.

After 4 weeks of treatment, honey showed a significant effect on prophylactic phase, which lasted for six months. 

Furthermore, in half of the patients treated with the topical honey once weekly and the other half served as control.

Treatment group demonstrated a reduction of Itching and disappeared scaling within one week. Skin lesions were healed and disappeared completely within 2 weeks.

Moreover, honey administration also improved in hair loss.

None of the patients treated with honey application once weekly experienced a relapse for six months

Dr. Al-Waili NS, after taking into account co and confounders, said, "crude honey could markedly improve seborrheic dermatitis and associated hair loss and prevent relapse when applied weekly".

The findings clearly suggested that honey may be considered a replacement of chemical ingredients for the prevention and treatment of dandruff associated with seborrheic dermatitis, with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L.(PubMed)
(2) Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff by Al-Waili NS1. (PubMed)

Herbal Burdock, the Best Anti Diabetes and Diabetic Complications Functional Remedy, Scientists Find

By Kyle J. Norton

Scientists may have found a herbal medicine for the prevention and treatment of diabetes with no side effects, according to studies.

Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

The disease is either caused by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.

Some researchers suggested that high blood cholesterol is one major risk factor not only contributed to the risk of obesity but also facilitates the onset of diabetes.

How to calculate your blood cholesterol, If the ratio your blood cholesterol is higher than 4, you have high blood cholesterol.

The normal ratio of blood cholesterol is 4 (low-density lipoprotein or bad cholesterol)/ 1 ( high-density lipoprotein or good cholesterol). Any number which is higher than 4 is considered high blood cholesterol.

How high blood cholesterol associated with diabetes
* Most patients with diabetes also have a syndrome oh high blood cholesterol.

* According to Dr. Michael Greger M.D long-term intake of a high-fat diet is associated with diabetes. According to the study of young, healthy people and split them up into two groups, high fat intake within 2 days demonstrated, a significant rise of glucose intolerance. During the course of study, the high-fat diet group ended up with twice the blood sugar compared to the carbohydrate-rich diet group.

* Also the spike of blood sugar in the high-fat diet group may also increase the onset of insulin resistance due to insulin no longer performs its function in activating the function of the insulin receptors site which now clogged up by cholesterol to stimulating the enzymes associated with glucose transport.

In other words, the pancreas beta cells will continue to produce insulin but can not lower the blood glucose due to the disruption of glucose metabolism, leading to insulin resistance, the major cause of diabetes.

Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal medicine has been using thousands of year in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.

It contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

With an aim to find a natural medicine for the treatment of diabetes and reduced the diabetic retinopathy is one of the most common and severe complications of diabetes mellitus, researchers at the Third Military Medical University examined Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L.(Burdock), antidiabetic activity.

Male Sprague-Dawley rats induced diabetes are randomly divided into five groups (n = 20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na and 20 nondiabetic sham-treated rats were treated with 0.5 % CMC-Na.

In the beginning, there was no significantly different occurrence of diabetic retinopathy among the groups.

However, at the week 16, the glycosylated hemoglobin (HBA1c) level was significantly decreased in all of the arctiin-treated groups when compared with the control group, and the serum glucose level was also decreased in the rats treated with the highest dose of arctiin

The normal levels of HbA1c of 6.5% and HbA1c are used as an objective measure of glycaemic control. 

The highest dose of the arctiin group showed a decrease in the serum glucose level which was elevated by the induction of diabetes.

Arctiin treatment group displayed a reduced inflammatory in the expression of retinal edema, detachment of the retina, and levels of pro-inflammatory cytokines observed by the histological and immunochemical examinations.

Furthermore, arctiin also increased the viability of retinal microvascular endothelial cells which reduced in diabetic rats, in vitro. 

Dr. Lu LC, the lead scientist wrote, "these findings demonstrate that arctiin decreases the severity of diabetic complications, demonstrating the importance of this compound as an inhibitor of diabetic retinopathy".

Additionally, in the review of anti-diabetes effects of the active compounds present in the different botanical parts of burdock, researchers examined the active ingredients in the roots and seed.

The results of chemical analysis suggested that the compounds isolated from root showed a strong effect in the inhibition of diabetes through its antioxidant activity.

In the seeds, some active compounds possess anti-inflammatory effects similar to that of arctiin treatment rats group.

These results suggested that herbal burdock exerted a strong anti-diabetes and diabetic complication through its glycaemic control and antioxidant and anti-inflammatory properties.

Taken altogether, herbal Burdock processed high numbers of the bioactive compound may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of diabetes and diabetic complication.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats by Lu LC, Zhou W, Li ZH, Yu CP, Li CW, Luo MH, Xie H.(PubMed)
(2) A review of the pharmacological effects of Arctium lappa (burdock) by Chan YS1, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW. (PubMed)
(3) Fat is the Cause of Type 2 Diabetes by Written By Michael Greger M.D. FACLM on November 17th, 2016. (Nutrition Facts)

Herbal Aloe Vera, the Potent Anti Colon Cancer Herbal Remedy

By Kyle J. Norton

Herbal Aloe vera may have a profound and positive effect on reducing risk and treatment of colon cancer, with no side effects, some scientists suggested.

Colon Cancer is a condition characterized by the abnormal proliferation of cells in the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. In the early, as the cancer cells are only found in the outmost layer of the localized linning, patients may not experience any symptoms.

However, in the advanced stage, the colon cancer cells can travel a distance away to infect other healthy tissue or organs, leading to secondary metastasis.

The most common sites of metastasis for colon or rectal cancer is the liver and lung.

According to the statistic provided by the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in the United States. Every year approximately, 90000 new cases of colon cancer. 43,000 new cases of rectal cancer are diagnosed, leading to the death of 50,000 patients.

The lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The 5-year survival rate for patients diagnosed with localized stage colorectal cancer is 90%. About 39% of patients are diagnosed at this early stage.

Although there are many risk factors associated with the onset of colon cancer such as age, family and personal history, genetic preposition, smoking, alcohol, being overweight or obese are, many researchers suggested that the most common cause of colon cancer in the Western world is due to the promotion of the Western diet.

Dr. Jessie A. Satia, the lead scientist in the examine the dietary patterns and colon cancer risk in Whites and African Americans in North Carolina strongly indicated "Compared to the Western-Southern pattern, the fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk, for example, lower BMI, higher education, and higher NSAID use".

And, "The fruit-vegetable pattern was significantly inversely associated with colon cancer risk in Whites (OR = 0.4, 95% CI = 0.3–0.6) and the metropolitan pattern with a nonsignificant 30% risk reduction in both Whites and African Americans after adjustment for education".

These results strongly suggested that people who follow the diet pattern of the Western diet are at a substantial risk of the disease. In other words, the risk of colon cancer is significantly reduced for people who follow the diet with high fruits and vegetable and low red meat and processed foods.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The medical plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

With an aim to find a natural ingredient or remedy for the treatment of colon cancer, researchers at the Sree Chitra Tirunal Institute for Medical Sciences and Technology examine the anti-colon cancer effects on Aloe-emodin (AE), a natural anthraquinone.

In colon cancer cell lines, AE inhibited cell proliferation by the cell cycle arrest at the G2/M phase and protein associated with cellular proliferation and division.

AE also induced cancer cell death through stimulating the function of proteins associated with pro apoptosis.

In order to obtain additional information related to the Aloe vera anti-colon cancer activity, researchers analyzed the molecular mechanisms involved in the antimigratory and antiangiogenic activity of this hydroxy anthraquinone.

AE suppressed the phorbol-12-myristyl-13-acetate (PMA), a diester of phorbol in the promotion of promotes tumor expression through migration and invasion.

AE also inhibited the mRNA expression of colon cancer cells and the matrixes involved malignant tumor growth, invasion, and metastasis and gene associated with the signaling in the formation and dissemination of a range of cancers.

Furthermore, EA inhibited the Vascular Endothelial Growth Factor (VEGF) expression in forming a new blood vessel in the promotion of endothelial cell migration/invasion.

Moreover, AE also suppressed the protein complex that controls the transcription of DNA, cytokine production and cell survival.

Researchers wrote in the summary of the experiment, "These data indicate that AE target multiple molecules responsible for cellular invasion, migration and angiogenesis" and Inhibitory effect on angiogenic and metastatic regulatory processes make AE a sensible candidate as a specific blocker of tumor-associated events".

Taken altogether, herbal Aloe vera processed a major bioactive compound Aloe emodin may be considered a functional remedy for the prevention and combined with conventional medicine for the treatment of colon cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells by Suboj P, Babykutty S, Srinivas P, Gopala S.(PubMed)
(2) Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB by Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S.(PubMed)
(3) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler. (PMC)
(4) Western diet increases colorectal cancer risk in Japanese women: Cohort study by 25-Jul-2017 By Gary Scattergood. (NUTRA)

Herbal Andrographis The Natural and Potential Anti Oral Cancer Functional Plant

By Kyle J. Norton

Scientists may have found a bioactive compound for the prevention and treatment of oral cancer with no side effects, according to studies.

Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Most cases of oral cancer start in the cells on the surface of the inner lining of the oral cavity.

At stage 0 and 1, patients may not experience any symptoms as the cancer is localized in the outermost layer of tissue in the oral cavity or oropharynx less than 2 cm across.

However, as the cancer proliferation, at the advanced stage, the cancerous cells may travel a distance away from the oral cavity to infect other healthy tissue or organs, leading to secondary metastasis.

The liver, lungs, lymph nodes, and bones are common areas of oral cancer metastasis.

According to the statistic provided by the American Cancer Society, in the US, every year, approximately 51,000 people will get oral cavity or oropharyngeal cancer causing the death of 10,000 patients.

Depending on the stage of cancer, the 5 years survival rate of early stages (1 and 0) is 84% and 64% if cancer has spread to surrounding tissues or organs and/or the regional lymph nodes.

Men, age, exposure to the Ultraviolet light, genetic preposition, tobacco use, alcohol and chew betel quid are the risk factors associated with the early onset of oral cancer.

Some researchers suggested that infected by the Human papillomaviruses is the most common cause of oropharyngeal cancers in the Western world found in 25 percent of patients.

The cases controlled study consisted of newly diagnosed patients with squamous cell carcinoma of the oral cavity and oropharynx.conducted by the McGill University in examining the association between human papillomavirus (HPV) infection and risk of developing oral cancer showed that

* HPV DNA was detected in 19% of cases (14 out of 72), and 5% of controls (six out of 129).

* Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21). 

* The OR for tonsil-related cancers for high-risk HPV types was 19.32.

The findings clearly provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers. 

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The medical plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

On finding a natural ingredient for the treatment of oral cancer with no side effects, researchers examined the effects of Andrographolide (Andro) isolated from an herbal plant, Andrographis paniculata.

Injection of Andro potently suppressed squamous cell carcinogenesis induced by 7,12-dimethyl-1,2-benzanthracene (DMBA) in the hamster model of cheek buccal pouch.

Andro reduced the genes associated with the activation of a protein (The nuclear factor NF-κB) that promotes cell proliferation and prevents cell apoptosis.

Furthermore, Andro suppressed transcription factors that attenuate neoplastic cell proliferation, promoted cancerous cell apoptosis, and mitigated tumor-induced angiogenesis.

Moreover, Andro retarded growth decreased proliferation, and promoted apoptosis of Tb cells, a human tongue squamous cell carcinoma cell line, in time- and dose-dependent manners.

Dr. Wang LJ, the lead scientist wrote, "Our results thus demonstrate that NF-κB activation plays important roles in the pathogenesis of chemically induced squamous cell carcinoma". and By inhibition of aberrant NF-κB activation, Andro treats chemically induced oral squamous cell carcinogenesis".

In-depth analysis, Andro reduced the production of cytokines, chemokines and the nuclear factor (NF)-κB signaling pathway that involves the initiation of cancer cells.

And, Andro  inhibited cancer growth progression through a series of mechanisms, including inhibition of proteins that involved in cell growth, survival, development, and differentiation (such as Janus tyrosine kinases-signal transducers and activators of transcription, phosphatidylinositol 3-kinase and NF-κB signalling pathways) and cell division through activation of genes (p53 and p21) that are associated with tumor suppression.

These results clearly suggested Andro processes a strong effect in the inhibition of cancer cell proliferation, survival, metastasis, and angiogenesis.

Taken altogether, herbal Andrographis processed a bioactive compound Andro may be considered a functional herb for the prevention and combined with primary therapy for the treatment of oral cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation by Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG. (PubMed)
(2) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. by Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS(PubMed)
(3) Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada by Pintos J1, Black MJ, Sadeghi N, Ghadirian P, Zeitouni AG, Viscidi RP, Herrero R, Coutlée F, Franco EL. (PubMed)

Phytochemical Allyl isothiocyanate, the Anti Prostate Cancer Bioactive Ingredient

By Kyle J. Norton

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

Bioactive compound Allyl isothiocyanate have a profound and potential effect in reducing risk and treatment of prostate cancer, some scientists suggested.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

Prostate cancer is a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth in the prostate tissue.

Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissue. At this stage, patients do not experience any symptoms.

However, as the tumor continued to grow, in the short distance in the future, it will suppress the nearby healthy tissue and nerve cells, leading to localized symptoms and severe pain.

At the advanced stage, most primary prostate cancer cells can travel a distance away to infect other healthy tissue and organ, leading to secondary cancer metastasis.

According to the statistic, In the US, approximately 164,690 new cases of prostate cancer were diagnosed and  29,430 will die from prostate cancer in 2018.

In fact, more than 2.9 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.

Early diagnosis is the key to survival in prostate cancer. The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years. 

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

The causes of prostate cancer are unknown. However, certain risk factors, epidemiologically are associated with an increased risk of the disease, including the increase in age, ethnicity, family history, genetic preposition, and poor diet. 

Dr. Amir Bagheri, the lead author in the study "Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men" firmly suggested that a healthy dietary pattern was associated with a decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81;trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037).

Therefore, by a chance of the diet pattern which contains high in fruits and vegetables and whole grain and few in saturated and trans fat, red meat and processed foods, a healthy man can substantially decrease the risk of prostate cancer

On finding a natural ingredient or whole food for the prevention and treatment of prostate cancer, researchers evaluated the effects of allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, against the growth of human prostate cancer xenografts in vivo.

Injection of 10 micromol AITC, three times per week (Monday, Wednesday and Friday) beginning the day of tumor cell implantation significantly inhibited the growth of PC-3 xenograft.

On the 26 days after tumor cell implantation, the average tumor volume in control mice (1025 +/- 205 mm3) was approximately 1.7-fold higher compared with AITC-treated mice. 

According to the histological analysis of tumors excised at the termination of the experiment,  revealed a statistically significant increase in a number of apoptotic bodies with a concomitant decrease in cells undergoing mitosis in the tumors of AITC-treated mice compared with that of control mice. 

The Western blot analysis indicated the injection of  AITC inhibited the 70% of the levels of anti-apoptotic protein in the tumor lysate of AITC-treated mice compared with that of control mice.

The injection of AITC also exerted a statistically significant reduction in the expression of several proteins associated with the regulation of G2/M progression.

The finding suggested that AITC administration inhibits the growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity.

Futhermore, in order to understand the effect of dietary isothiocyanates (ITCs) in the protection against chemically induced cancers in laboratory animals, researchers examined the allyl isothiocyanate (AITC) anti-cancer activity in the cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cell.

Application of AITC inhibited all the tested cancer cell lines in a dose-dependent manner with an IC(50) of approximately 15-17 micro M.without affecting the normal prostate cancer cells.

The inhibition of the proliferation of PC-3 as well as LNCaP cells in the presence of AITC is correlated with accumulation of cells in G(2)/M phase and induction of apoptosis. 

At 24 h treatment of PC-3 and LNCaP cells with 20 micro M, AITC scored a similar effect as that of the previous study by causing a significant decrease in the levels of proteins that regulate G(2)/M progression, and the levels of anti-apoptotic protein.

Taken altogether, Allyl isothiocyanate may be considered a dietary source for the prevention and treatment of prostate cancer with no side effects.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits the growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV. (PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis by Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV. (PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

Phytochemical Anacardic Acid, the Natural Antibiotic Alternative with No Side Effects

By Kyle J. Norton

Scientists may have found a bioactive compound for the replacement of antibiotics with no side effects, some studies suggested.

Infection is a human disease characterized by the invasion of an organism that multiplied in the specific tissue or organ.

In the bodily injury due to physical impact, the white blood cells of the immune first line of defense stimulates the production of proteins associated with the coagulation to cover the wound against the entrance of the microorganisms and inflammatory cytokines to kill off the infectious pathogens before they can enter the body and cause damage.

Most microorganisms were killed in the acute phase of the infection.

The infection is progressing through 5 stages, including

1. The incubation stage is a stage that the microorganisms have successfully entered the host and started a period of multiplication. At this period patients do not experience any symptoms.

2. The prodromal stage, followed after the incubation period, after gaining the strength in numbers and continued multiplication, the presence of the invasive pathogens is noticed by the immune system, leading to an immune systematic response. At this period, patients may experience symptoms fever, pain, and swelling.

3. The stage of illness is a stage that a disease is formed with signs and symptoms of the disease are most obvious and severe.

4. The stage of decline, the stage that saw the immune system has won the battle. In this stage, the number of pathogens and the signs and symptoms of illness begin to decline.

5. The stage of convalescence is a stage of recovery.

Some scientists in the study of the immune evolution suggested that the immune system is designed to kill off invasive pathogen in 3-8 weeks, otherwise, it will adapt to the change, leading to diseases associated with chronic infection.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

With an aim to find a natural antibiotic for the replacement of conventional medicine for the prevention and treatment of microbial infection, researchers examined the anacardic acid mixture antibacterial quorum sensing (QS), which is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity.

An anacardic acid mixture (AAM) use in the experiment was produced by the A. adstringens hexane extract (HE) in bacterial strain Chromobacterium violaceum.

By comparing the 2 extracts, researchers found that

* HE induced a 91.6% of inhibition of the violecin production at 55 μg/mL concentration, whereas AAM showed 94% of inhibition at 166 μg/mL.

* Interestingly, both extracts were found to inhibit violacein production with affecting the viability of the bacterium.

* Furthermore, AAM inhibited the substance which stimulates redox cycling in bacteria (pyocyanin 86% at 200 μg/mL) and glycolipid biosurfactants of bacterial structure (rhamnolipid, 91% at 500 μg/mL) production in a dose/response form and decrease the elastase (75% at 500 μg/mL) activity in P. aeruginosa without affecting its development.

Where violecin is a naturally-occurring bis-indole pigment with antibiotic properties produced by the bacteria.

These results indicated that Anacardic acid disrupts the quorum sensing (QS) of bacteria through inhibiting the substances which play a critical role for microbial survival in cell-cell communication.

Dr.Castillo-Juárez I, the lead scientist said, " anacardic acids mixture isolated from A. adstringens demonstrated anti-QS, it could be further exploited for novel molecules to treat the emerging infections of antibiotic-resistant bacterial pathogens".

Additionally, in the evaluated new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method, researchers showed that compounds 1-4 exhibited antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL.

Where compounds 1-4 are 6-[16'Z-nonadecenyl]-salicylic acid (1), 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0), (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4).

Taken altogether, anacardic acid and its bioactive derivatives may be considered antibiotics alternative for the prevention and treatment of bacterial infection with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)