Herbal Aloe Vera Gobbles Up Cancer Cells in Vivo and Vitro

By Kyle J. Norton

Aloe Vera may be the next target for the pharmaceutical companies to extract a single ingredient for the treatment of cancers, some scientists suggested.

Cancers are a class of medical diseases associated with cell growth irregularly and disorderly in some specific tissue and organs.

Most cancer starts at the cell on the surface of the inner lining of organ's tissue. At the later stage, cancer cells can be found in the deeper of layers of the infected organ.

In the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy tissue and organ through the circulation of fluids and blood.

The causes of cancer are the results of the alternation of healthy cell DNA. Researchers do not why the health cells DNA are alternated.

Normally, healthy cells undergo a certain number of cell cycle divisions than die. In a cancerous cell, cell division undergoes indefinitely.

According to the statistic, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

The genetic mutation of the cancer cell may be associated with certain risk factors. Epidemiological studies suggested that long-term exposure to carcinogens, the increased in age, gender, inherited genetic defects and skin type can increase the risk the cancer onset.

Most common and general symptoms of cancer are an unintended weight loss, lump, fatigue, loss of appetite and persistent localized symptoms and localized pain in the later stage.

If you experience some of the above symptoms, please check with your doctor right the way to rule out the possibility of cancer.

Out of numbers of the risk factor, genetic preposition has been under intensive studied by many scientists.

Dr. Eric T, the lead author in the study of genetic implication on the cancer risk said, "Genetic testing for inherited cancer risk is now widely used to target individuals for screening and prevention" and


"Overall, 17,340 PVs were identified in 17,000 (6.7%) of the tested individuals. The pathogenic variants (PV) positive rate was 9.8% among individuals with a personal cancer history, compared to 4.7% in unaffected individuals. PVs were most common in BRCA1/2 (42.2%), other breast cancer (BR) genes (32.9%), and the LS genes (13.2%)".

These results clearly stated that people who carry certain mutated genes are at the substantial risk of cancer onset, compared to those who do not.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

 It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera are amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

In the finding, a natural ingredient for the treatment of breast cancer without inducing side effects, researchers at the National Chung Hsing University conducted a study to compare the efficacy of Emodin and Aloe-Emodin, the major bioactive compound found in herbal Aloe Vera.

By analyzing the estrogenic activity as phytoestrogens on the estrogen receptor α (ER α ) activation and breast cancer cell growth, application of both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by reducing the ER α protein levels which has been found in high levels in patient with breast cancer thereby suppressing ER α transcriptional (mRNA) activation..

High expression of ERα mRNA is found associated with patients with breast cancer.

Breast cancer treatment with aloe-emodin also decreases the expression of the levels of ERα associated with the protein that stimulate the division of breast cancer cells by increasing the cancer cells degradation.

The efficacy of aloe-emodin inhibited breast cancer proliferation and induced apoptosis is attributed to the breaking down the cytoplasm of ER α protein in the breast cancer cells.

The results suggested that aloe-emodin suppressed breast cell proliferation emodin by targeting ER α protein expression through distinct mechanisms.

Further demonstration of the effect of aloe-emodin on the risk of cancer, researchers examined whether aloe emodin exerts a similar effect on the growth of human cervical cancer cells, HeLa.

Human cervical cancer cells, HeLa used in the experiment was treated by different doses of aloe emodin for 1-5 days,.

Measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, aloe-emodin displays significant effects in the inhibition of the growth of HeLa cells in a dose-dependent manner at concentrations ranging between 2.5 and 40 micromol/L. 

Aloe-emodin induces HeLa cells death by disrupting the cell cycle division at the G2/M phase, according to the flow cytometric analysis.

The effects of aloe emodin inhibited the human by increasing the expression of proteins associated with cell death programming and reducing the expression of proteins associated with cancer prefiltration and survival. 

Most importantly, after taking into account co and confounders, researchers discovered, aloe-emodin also activates the enzyme associated with the break down the protein of  ER α and deactivates the enzyme associated with cell proliferation

Taken altogether,  Aloe vera with the abundant aloe-emodin may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for treatment of cancer without inducing adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(3) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(4) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(5) Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories by (Research Gate)

Herbal Cayenne May Process A Potency to Cure Allergic Rhinitis

By Kyle J. Norton

Herbal cayenne may be a pharmaceutical target to identify the single ingredient medicine for the treatment of allergic rhinitis with no side effects, some scientists suggested.

Nonallergic rhinitis is a condition with symptoms resemble an allergy causes of rhinitis but without a known cause.

Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis.

Allergic rhinitis is caused by the immune overreaction when a person breathes in an allergen such as pollen, mold, animal dander, or dust, leading to the irritation and inflammation of the mucous membrane inside the nose.

Most common symptoms of allergic rhinitis are the stuffy nose, runny nose, sneezing, and post-nasal drip.

Contrast to general belief, allergic rhinitis is not the syndrome which comes and goes depending on the seasons.

Untreated allergic rhinitis can lead to complications of chronic nasal inflammation and obstruction, a leading cause of upper respiratory tract infection.

There is some strong evidence suggested that allergic rhinitis can affect the quality of life, productivity, and other comorbid conditions, including asthma.

The World Health Organization in the differentiation fo the condition, suggesting that the treatment of allergic rhinitis should include a combination of patient education, allergen avoidance, pharmacotherapy, and immunotherapy

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The kitchen spice has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In the finding a natural formula for the treatment of allergic rhinitis with no side effects, researchers at the University of Cincinnati College of Medicine examine the efficacy and safety of ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum and Eucalyptol, versus placebo.

In the total of Forty-two consented subjects meeting inclusion/exclusion criteria randomized to ICX72 (n = 20) or control (n = 22) administered twice daily over 2 weeks, the primary endpoint was changed in total nasal symptom scores (TNSS) from baseline to end of the study.

During the study, application of ICX72 exhibited significant differences in changes from baseline to end of study for TNSS and each ISS (P < .01), compared to placebo.

ICX72 exerted a significantly faster relief at 52.6 seconds.

The formula also improved nasal congestion, sinus pain, sinus pressure, and headache at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain.

No subjects experienced rebound congestion or impaired olfaction at the end of the study.

There is no adverse effect in the treatment group.

These result firmly suggested that intranasal capsaicin used continuously over 2 weeks, rapidly and safely improves symptoms in rhinitis subjects with a significant NAR component.

Further analysis of the effect of intranasal capsaicin, researchers conducted a double-blind double-dummy parallel groups trial to determine whether a more practical capsaicin application schedule is equally effective.

Thirty patients were randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals, followed by a placebo dummy once every second or third day for a total of five treatments 2 weeks after the capsaicin application (group A).

The other group (B) received the placebo dummy five times on the first day followed by capsaicin once every second or third day for a total of five treatments 2 weeks after the placebo application.

According to the reading, visual analog scale scores for overall nasal symptoms, group A showed significant deeper decrease rhinorrhea and nasal blockage, compared to group B.

There is a significant reduction in the cold dry air responsiveness up to 9 months after therapy in both groups, reflecting a decrease in nasal hyperreactivity.

Taken altogether, Herbal cayenne containing bioactive compound capsaicin may be considered a functional spice for the treatment of allergic rhinitis with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. (PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ. (PubMed)

Ginger, May Be A Natural Alternative for Testosterone Hormone Therapy with No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have a pungent spice which processes a potential to increased levels of testosterone deficiency, particularly in the elderly with no side effects according to studies.

Testosterone is a steroid hormone found in humans made mostly from the testicles in men and a small amount in women's ovaries.

According to epidemiological studies, treatment for hypogonadism is on the rise, particularly in the population due to natural reduced production of levels of testosterone other than normal aging.

Testosterone production starts to produce significantly during puberty and dip after age 30. 

In males, the early onset of reduced production of levels of testosterone is associated with a highly prevalent burden of comorbid medical conditions and polypharmacy complicates compared to those of normal aging,

Also, low levels of testosterone in the males are associated with the early onset of metabolic syndrome in the induction of cardiovascular disease and type 2 diabetes.

Conventional medicine used for the treatment in this population is found to be a unique challenge to clinicians. 

Apart from normal aging, low levels of testosterone are found to induce symptoms of decreased sex drive,  low energy, weight gain, the risk of depression, and moodiness, loss of hair and thinner bones.

If you are experiencing some of the above symptoms, you may have low levels of testosterone. Please make sure you check with your doctor to rule out the possibility.

Dr. Giagulli VA, in examining the complications of testosterone in men wrote, "Testosterone deficiency syndrome (TDS) induces several negative effects that generally involve different organs such as testis, bone, skeletal muscle, and heart, leading to reduction in testis function, causing osteoporosis, strongly reducing muscle mass, decreasing exercise capacity and strength and facilitating heart failure".

And, " Approximately 25% of patients affected by chronic heart failure (CHF) is characterized by plasma Testosterone (T) levels below normal ranges also related to disease progression".

These results clearly suggested apart from normal aging, males with testosterone deficiency are associated with the complications of many ailments.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists on finding a natural compound which processes a function in enhancing and protecting primary sex hormone in males examined the effects of ginger activity in enhancing testosterone production in males.

By searching the PubMed, Scopus, and Web of Science databases for English language articles (full texts or abstracts) from November 1991 through August 2018 using the keywords "ginger" and "Zingiber officinale" versus "testosterone" linking the effects of ginger on testosterone researchers found that ginger supplementation, particularly in oxidative stress conditions, enhances testosterone production in males.

The mechanisms by which this occurs mainly by enhancing luteinizing hormone (LH) production in stimulating the Leydig cell production of testosterone, increasing the level of cholesterol in synthesizing male sex steroid, testosterone (T), by reducing oxidative stress and lipid peroxidation in the testes.

Furthermore, application of ginger also inhibited the expression of free radical by promoting the activity of the antioxidant enzymes.

Ginger also normalized the blood glucose by increasing blood flow to the testes.

Moreover, ginger improved production of testosterone by increasing testicular weight and recycling testosterone receptors.

The finding strongly supports the use of ginger in the enhanced testosterone production for treatment of diseases associated with the testosterone deficiency.

In order to reveal more information about ginger in the production of testosterone by examing the
ginger effects on multiple animal models, including 60adult male Sprague Dawley rats divided into * Group A served as normal control,

* Group B received 0.3% lead acetate in drinking water,

*Group C and group D received supplementary 0.5 and 1 gm/Kg body weight of ginger respectively along with lead acetate in drinking water.

During the experiments, co-administration with different doses of ginger showed a significant rise in the testosterone levels in of teste, compared to the lead-treated group.

Interestingly, ginger application at different doses showed no significant change of LH levels, compared to the rise in the previous ginger treatment,

These results strongly suggested there must other compounds from ginger that exhibits the increased levels of LH that is not mentioned in both studies.

Taken altogether, ginger may be considered a functional remedy for the prevention and combined with primary medicine for the treatment for diseases associated with testosterone deficiency.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger and Testosterone by Banihani SA. (PubMed)
(2) Protective role of ginger on lead induced derangement in plasma testosterone and luteinizing hormone levels of male Sprague Dawley rats by Riaz F1, Khan UA, Ayub M, Shaukat S.(PubMed)
(3) Testosterone deficiency in male: a risk factor for heart failure by Giagulli VA1, Guastamacchia E, De Pergola G, Iacoviello M, Triggiani V.(PubMed)

Piperine, the Anti Hyperglycemic Plant Base Compound

By Kyle J. Norton

Bioactive piperine may have a strong and positive effect in reducing the risk and treatment of hyperglycemia in the management of type 2 diabetes, according to the studies.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

Hyperglycemia is a condition of abnormally high blood sugar which is considered a hallmark sign of diabetes (both type 1 diabetes and type 2 diabetes) and prediabetes.

Hyperglycemia doesn't cause symptoms until glucose values are significantly elevated to the levels above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L). Most common symptoms of hyperglycemia include headaches, fatigue, blurred vision, hunger, confusion, and trouble with concentrating.

Diabetes is a chronic and medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

The disease is either caused by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.

According to the statistic, in the US, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes In 2015.

The disease is on the rise at an alarming rate. Most cases of hypoglycemia are the results of a medical condition such as hypothyroidism, pancreatitis, long-term use of certain medication such as prednisone, estrogens, beta-blockers, glucagon, and stress.

Some researchers suggested that unhealthy lifestyle, in fact, is the major cause of the onset of hyperglycemia.

According to the study of a total of 485 subjects of Bai Ku Yao and 501 subjects of Han Chinese ethnicity aged 40 years and older surveyed by a stratified cluster random sampling technique, the prevalence of hyperlipidemia was significantly lower among ethnic Bai Ku Yao than among ethnic Han individuals, which might mainly be attributed to the more favorable dietary patterns, lifestyle choices, and physical activity levels in the former ethnic group.

These results strongly suggested that an unhealthy diet high in saturated and trans fat, red meat and processed food and low fruits and vegetables are associated with the onset and early onset of hyperglycemia.

With an aim to find a natural ingredient or whole food for the prevention of diabetes, a metabolic disorder and emerging pandemic of the 21st century, researchers investigated the anti-diabetes activity of piperine, the chief alkaloid present in Piper nigrum (black pepper). The study included albino mice induced diabetes by injection of alloxan.

The tested mice were randomly divided into 5 groups (n = 6). In acute study, drugs were administered orally as: control (2% gum acacia, 10 mL/kg), standard (metformin 150 mg/kg), P10 (piperine 10 mg/kg), P20 (piperine 20 mg/kg) and P40 (piperine 40 mg/kg) and drug intervention for subacute study consisted of once daily oral administration for 14 days of 2% gum acacia 10 mL/kg, metformin 250 mg/kg, and piperine 5, 10 and 20 mg/kg, respectively.

By examing the blood glucose levels before and at 1, 2, 3 and 4 h post dosing, respectively, in the acute study and on day 7 and 14 in the subacute study, researchers showed that acute study showed that at 2 h post-dosing piperine at high dose of 40 mg/kg showed a significant rise in blood glucose level (p < 0.05) in comparison to control group.

Contrastly, significant blood glucose lowering effect was seen with piperine at a dose of 20 mg/kg on day 14 (p < 0.05) in the subacute study.

These results clearly suggested that subacute administration of piperine has a statistically significant antihyperglycemic activity while acutely it raises blood glucose at high doses.

In other words, in order for the piperine to exert antihyperglycemic activity, the initial dose should be reduced and increased gradually during the course of treatment. 

The G. Pulla Reddy College of Pharmacy in the evaluation of the associated among Piperine and P. longum is a known inhibitor of various enzymes (CYP isozymes) responsible for the biotransformation of drugs, suggested that by inhibiting the metabolism of drugs, piperine improves the bioavailability of drugs.

Truly, pretreatment of Piperine (10 mg/kg) accompanied by the anti-hyperglycemic activity of nateglinide (CAS no: 105816-04-4) exerted significantly increased the concentration of the drug. In other words, nateglinide is more effective in inhibiting hyperglycemia compared to the drug when it is applied alone.

Dr. Sama V, the lead author, after taking into account co and confounders said, "The synergistic anti-hyperglycemic activity of nateglinide when administered with piperine can be attributed to increased plasma concentration of nateglinide" and " The results of this study demonstrate that piperine could be used as a potential bioenhancer along with nateglinide".

In diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats, piperine treatment intraperitoneally at the dose of 10 mg/kg/day for 14 days also reversed the diabetic effects caused by oxidative stress by improving the levels of antioxidant enzymes and inhibiting the levels of free radicals.

Taken altogether, piperine, a bioactive compound found in black pepper may be used for the prevention and treatment of abnormally high blood glucose in patients with diabetes, with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice by Atal S, Agrawal RP, Vyas S, Phadnis P, Rai N.(PubMed)
(2) Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide by Sama V, Nadipelli M, Yenumula P, Bommineni MR, Mullangi R.(PubMed)
(3) Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats by Rauscher FM, Sanders RA, Watkins JB 3rd.(PubMed)

Phytochemical Isothiocyanates, the Cardio-Protective Organic Agent

By Kyle J. Norton

Bioactive dithiolthiones found in cruciferous vegetables may be the next generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Cardiovascular disease is a class of condition associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of heart and blood vessels.

According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.

Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium overtime can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.

Other risk factors associated with the onset of cardiovascular disease include unhealthy diet, lack of exercise, being overweight and smoking.

Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).

How to prevent the onset of CVD
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/

For people with higher risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".

With an aim to find a natural ingredient or whole food with cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.

Sprague-Dawley rats selected to the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.

Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts. 

Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in effluent during reperfusion, similar to that of 5-hydroxydecanoic acid (5-HD).

Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.

Particularly, sulforaphane also protected the heart cell against damage and apoptosis by promoting heart cell cycle division.

The finding clearly indicated the cardioprotective effect of the sulforaphane against acute  I/R injury.

In order to understand the therapeutic effect of sulphoraphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.

The study included two groups of rat fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given vehicle only for the same period of time. 

At the end of the study, by examing the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischaemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.

These results were attributed the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidant and decreasing the levels of proteins associated with cells damage and apoptosis.

More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group. 

Dr. Mukherjee S, the lead scientist said, "the present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"

Taken altogether, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References

(1) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)

Sulforaphane (Isothiocyanates), the Neuroprotective Plant Base Bioactive Compound

By Kyle J. Norton

Dithiolthiones, the bioactive compound found abundantly in the cruciferous vegetables may have a potential effect on reducing the risk of neurodegenerative disease, some scientists found.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

A neurodegenerative disease is a group of conditions which primarily affect the neurons in the brain, including Parkinson's disease (PD) and Alzheimer's disease.

In other words, a neurodegenerative disease is caused by the progressive death of neurons in different regions of the nervous system. 

The progressive loss of neurons induced neurological and neuropsychological signs and symptoms have also been found in comparison to the stage of disease onset of patients.

The causes of neurodegenerative diseases are unknown,  However, researchers do know that the increase in age is one most consistent risk factor for developing a neurodegenerative disease, especially AD or PD, as the disease has been found over 60% in the population aged 65 and beyond compared to another group.

And this numbers is found to increase at the alarming rate. Dr. Serge Przedborski, the lead author in the investigate the risk of neurodegenerative disease in elderly said, "it can be anticipated that, over the next generations, the proportion of elderly citizens will double, and, with this, possibly the proportion of persons suffering from some kind of neurodegenerative disorder".

Epidemiologically, geographical, hereditary and viral and toxicological exposure correlates and deficiencies of elements such as calcium and selenium are some of the risk factors in the development of neurological diseases.

Also, people who follow the Western diet pattern are at the increased risk of the disease. According to the 2018 Alzheimer's Association International Conference, July 22-26, 2018 in Chicago, Illinois, the Western diet is known to include high consumption of red meats, processed meats, as well as fatty and fried foods. This dietary pattern has been linked to a greater risk of cognitive decline and dementia.

As the autopsied participants' brains followed the Western diet showed a significant change of neuropathologies such as β-amyloid plaques, tau tangle density, neocortical Lewy bodies, cerebral atherosclerosis, among others.

This analysis may indicate that by changing to a healthy diet with a high in fruits and vegetables and whole grain and less in saturated and trans fat, red meat and processed foods, the risk of neurodegenerative disease can be reduced substantially.

Researchers on the finding a natural ingredient or whole food investigated the epidemiologically suggested that sulforaphane, an organosulfur compound present in cruciferous vegetables processed neuroprotective effects in experimental in vitro and in vivo models of neurodegeneration. Using the Morris water maze researchers tested the sulforaphane effects on scopolamine-induced memory impairment in mice.

Sulforaphane (10 or 50mg/kg) was administered to C57BL/6 mice by oral gavage for 14 days (days 1-14), Memory impairment was induced by intraperitoneal injection of scopolamine (1mg/kg) for 7 days (days 8-14). 

Mice receive an injection of scopolamine showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex. The results were observed by a decreased acetylcholine (ACh) level and increased acetylcholinesterase (AChE) activity.

Where acetylcholine (ACh) is a neurotransmitter, associated with the function in sending signals to other cells [neurons, muscle cells, and gland cells] and acetylcholinesterase (AChE) is an enzyme that catalyzes the breakdown of acetylcholine.

Treatment of sulforaphane significantly attenuated the scopolamine-induced memory impairment and improved cholinergic system reactivity.

In other words, sulforaphane exerted a neuroprotective effect against the scopolamine in the induction of oxidative stress to the neurons. Sulforaphane at the doses of 10 or 20μM increased the ACh level, decreased the AChE activity, and increased ChAT expression in scopolamine-treated primary cortical neurons.

Dr. Lee S, the lead scientists suggest "Sulforaphane might exert a significant neuroprotective effect on the cholinergic deficit and cognitive impairment".

Additionally, in the concern of no drugs treatment of schematic/traumatic brain injury, Alzheimer's disease, and Parkinson's disease which share common characteristics such as oxidative stress, misfolded proteins, excitotoxicity, inflammation, and neuronal loss, researchers investigated the effect of sulforaphane against the mentioned diseases.

In several in vitro and in vivo studies isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects.

The efficacy was attributed to the activity of sulforaphane in activating the Nrf2/ARE pathway in modulating the expression of oxidative stress.

Dr. Tarozzi A, the lead author in the final report of the experiment wrote, " sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurodegeneration".

 More importantly, in dopaminergic neurotoxicity in mice induced by 6-hydroxydopamine (6-OHDA), the phytochemical showed the neuroprotective effect through its ability to enhance the antioxidant enzymes of the host and improve neuronal survival.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane alleviates scopolamine-induced memory impairment in mice by Lee S1, Kim J1, Seo SG2, Choi BR3, Han JS3, Lee KW4, Kim J5. (PubMed)
(2) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases byTarozzi A1, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P.(PubMed)
(3) Neuroprotective effect of sulforaphane in a 6-hydroxydopamine-lesioned mouse model of Parkinson's disease byMorroni F1, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P.(PubMed)
(4) Series Introduction: Neurodegeneration: What is it and where are we?by Serge Przedborski,1,2,3 Miquel Vila,1 and Vernice Jackson-Lewis. (PMC)

Ginger, The Best Functional Food For Symptoms of Nausea and Vomiting

By Kyle J Norton

Scientists may have discovered a pungent and kitchen spice which processes a significant effect in reducing nausea and vomiting with no side effects, according to some studies.

Nausea and vomiting are the natural protection of the digestive system reacted to many causes, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer, or bulimia.

Morning sickness or nausea and vomiting are common experiences in pregnancy, affecting 70–80% of all pregnant women.

Nausea and vomiting that often develop by five to six weeks of pregnancy are the results of the rise of the hormone estrogen in the early stage of pregnancy. The syndrome may get even worse in women have a sensitive stomach which tries to adapt to the changes of pregnancy.

Morning sickness in the pregnancy may seem obvious in general population, however in a group of women with severe nausea and vomiting during pregnancy due to hyperemesis gravidarum (HG), an entity distinct from nausea and vomiting of pregnancy (NVP),  may lead to significant maternal and fetal morbidity if untreated.

Dr.Noel M. Lee, the lead author at the University of Wisconsin School of Medicine and Public Health in the study " Nausea and Vomiting of Pregnancy" said, "Various metabolic and neuromuscular factors have been implicated in the pathogenesis of NVP and HG; however, their exact cause is unknown. Consequently, treatment of NVP and HG can be difficult as neither the optimal targets for treatment nor the full effects of potential treatments on the developing fetus are known".

Where hyperemesis gravidarum (HG) is a pregnancy complication characterized by severe nausea, vomiting, weight loss, and possibly dehydration.

Other causes of nausea and vomiting are due to the prolonged period exposure to stress and long-term fatigue.

Patients who are having chemotherapy are associated with an increased risk of nausea and vomiting because of the injection of chemo drugs can affect parts of the stomach and brain that detect toxic (poisonous) substances.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The pungent spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to clarify the effect of ginger extract in treating chemotherapy-induced nausea and vomiting (CINV), a joint study led by Taipei Medical University-Shuang Ho Hospital was conducted to determine whether ginger could be used to treat CINV, which was interpreted using the PICOS (patient, problem/population, intervention, comparison, outcome, study) framework, with P being patients who underwent chemotherapy.

After searching the studies in English from 2000 to 2017 databases. 2 on a total of 10 studies with complete data. was included in the meta-analysis using Comprehensive Meta-analysis.

Ginger exerted a significant effect in reducing the symptoms of nausea and vomiting with the odds ratio (OR) of 0.71 

Further analysis also discovered that ginger could only reduce acute CINV in patients, particularly acute vomiting.

After taking additional ]assessment of the co and confounders, Dr. Chang WP the lead scientist said, "Ginger displayed significant efficacy with regard to controlling CINV in the experimental groups".

In the reaffirming the effect of ginger in the early pregnancy symptoms of nausea and vomiting of pregnancy (NVP), a joint study led by the Iran University of Medical Sciences launched an evaluation to compare the effects of ginger, pyridoxine (vitamin B6), and placebo.

The triple blind clinical trial on pregnant women suffering mild to moderate NVP between 6 and 16 weeks of pregnancy. 

In these women ginger, 500 mg twice daily, vitamin B6 40 mg twice daily and placebo twice daily were administered for 4 d.

The severity of NVP was evaluated 24 h before entering the study and up to 4 d after using medications and results were compared among the three groups.

The women of the three groups did not have significant differences according to age, gestational age, parity, and severity of each symptom before treatment and educational status.

After assessing the returned questionnaires, researchers indicated
* Ginger and vitamin B6 could reduce the severity of all items of Rhodes questionnaire significantly.

* Ginger and vitamin B6 were more effective than placebo

* total score of Rhodes did not show a significant difference between ginger and vitamin B6 (p = .128). Ginger was more effective for nausea (intensity and distress).

These results once against illustrate the efficacy of ginger in the treatment of nausea and vomiting in early pregnancy.

Taken altogether, there is no doubt that ginger may be used as a functional food for the treatment of nausea and vomiting in both early pregnancy and side effects of chemo treatment.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) A Meta-analysis of 10 Randomized Controlled Trials by Chang WP1, Peng YX.(PubMed)
(2) A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP) by Sharifzadeh F1, Kashanian M1, Koohpayehzadeh J2, Rezaian F1, Sheikhansari N3, Eshraghi N. (PubMed)
(3) Nausea and Vomiting of Pregnancy by Noel M. Lee, M.D., Gastroenterology Fellow and Sumona Saha, M.D., Assistant Professor of Medicine. (PMC)