Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 26 December 2018

Ginger In the Prevention and Treatment of Nonalcoholic Hepatic Steatosis (Fatty Liver)

By Kyle J, Norton

Ginger may have a profound effect in reducing the risk and treatment of hepatic steatosis, the early stage of liver disease, some scientists suggested.

Hepatic steatosis or fatty liver is a condition caused excess fat accumulated in the liver.

At the early stage of hepatic steatosis, the patient may not experience any symptoms. However, at the condition progress, the condition induces liver inflammation, which may progress to scarring and irreversible damage. Patients at this stage can have symptoms of abdominal swelling, enlarged blood vessels in the skin and spleen accompanied by jaundice.

The most common risk factors are the increase in age, (older than 45 years of age). overweight and obesity and ethnicity.

However, some researchers suggested the coincidence of widespread obesity and the onset of hepatic steatosis might indicate a closed correlation of the e 2 conditions.

Dr. Festi D, the lead author in the finding the relation between obesity and hepatic steatosis that causes a wide spectrum of liver damage as simple steatosis may progress to advanced fibrosis and to cryptogenic cirrhosis through steatohepatitis launched an investigation to examine the risk of hepatic steatosis in obese patients.
After taking account co and confounders wrote, "Obesity is the most significant single risk factor for the development of fatty liver, both in children and in adults; obesity is also predictive of the presence of fibrosis, potentially progressing to advanced liver disease".

The risk of fatty liver may be associated with insulin resistance in the obese patients that play a central role in the accumulation of triglycerides within the hepatocytes and in the initiation of the inflammatory cascade.

Although conventional treatment with insulin-sensitizing agents, anti-oxidants or cytoprotective drugs may be useful, however, they are no randomized clinical trials to support the efficacy.

As of today, there is no direct treatment of hepatic steatosis but relieve the symptoms.

Some researchers suggested, modifications in lifestyle (e.g. diet and exercise) to reduce obesity remain the mainstay of prevention and treatment of a disease,

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In the finding a natural whole food which may have a potent to prevent and treat nonalcoholic fatty liver, researchers at the Tajen University, Yanpu Township investigate the effects of [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models of the non-alcoholic fatty liver.

[6]-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells.

In the study of male golden hamsters were dosed orally with [6]-gingerol (25, 50 or 100 mg/kg/day) once daily for 8 weeks after being fed a high-fat diet (HFD) for 2 weeks, injection of [6]-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed plasma markers of metabolic syndrome in HFD-fed hamsters.

[6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.

These results indicated a significant effect of [6]-Gingerol in the attenuation of the HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.

Additionally, in the concern of widespread Nonalcoholic fatty liver disease (NAFLD) may reach epidemic proportions, Dr. Sahebkar A. launched a study to evaluate the ginger effect at the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-inflammatory cytokines among the key promoters of the disease.

Application of ginger prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing insulin effects, and down-regulates pro-inflammatory cytokines.

Ginger promoted considerable antioxidant effects and antidyslipidemic properties and reduced hepatic triglyceride content which can prevent steatosis.

All these mechanisms suggested that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD.

Sources
(1) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(2) Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease by Sahebkar A. (PubMed)
(3) Hepatic steatosis in obese patients: clinical aspects and prognostic significance by Festi D1, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G.(PubMed)

Tuesday, 25 December 2018

Herbal Chamomile Kills Cancer Cells Before They Can Spread

By Kyle J. Norton

Scientists may have found a herbal plant which processes a strong potential for the treatment of cancer without inducing any side effects, some studies suggested.

Cancers are a class of diseases associated with the irregular and disorder cell growth in the tissue or organs in the body due to the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of the tissue and organ tissue. However, as the cancer proliferation, they can penetrate into the deeper layers of the tissue or organ.

At the advanced stage, the primary cancer site can travel a distance away from the primary site to infect other healthy tissue and organ through fluids and blood circulation.

The exact causes of cancer are unknown. According to the epidemiological studies, the most common risk factors associated with the early onset of the diseases are smoking and tobacco, diet, physical inactivity, long-term exposure to the.sun and radiation and a certain type of virus and bacteria.

Out of all the risk factors that increase the cancer risk, physical activity is one of the factors which has not been under intensified study by the science community.

In the study to examine the accumulate on the benefits of physical activity in relation to cancer risk, progression, and mortality, researchers suggested

* Sedentary behavior may independently affect cancer risk

* The associations with physical activity, including cancer risk factors existed for precancerous lesions.

Although researchers know that physical activity is an important issue associated with the onset of cancer, they do not know the subgroup risk defined by body size, age or sex and tumors subgroups defined by the organ location, receptor status, or molecular subtype.

Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

In the reaffirming the traditional use of chamomile for the treatment of chronic ailments, researchers examine the anticancer properties of aqueous and methanolic extracts of chamomile against various human cancer cell lines.

Chamomile extracts a significant decrease in cell viability in various human cancer cell lines without inducing herm to the healthy cells.

Injection of the herbal extract causes the apoptosis of cancer cells, with causing herm to the normal cells.

The anti cancers effect of chamomile extract was attributed to the bioactive compound apigenin 7-O-glucoside, the major constituent of chamomile; some minor glycoside components.

These results reconfirm the use of chamomile extract in the treatment of cancers in traditional medicine.

Furthermore, the study to compare the anticancer activity of phenolic profile of six herbal infusions namely Cretan marjoram, pink savory, oregano, mountain tea, pennyroyal and chamomile by LCDAD-MS and by GC-MS, suggested
* All herbal infusions exhibit antiradical activity correlated positively with total phenolic content

* All infusions exhibit the potential to inhibit cell proliferation and to reduce IL-8 levels in HT29 colon and PC3 prostate cancer cells.

* The efficacy of all herbal medicines in inhibition of cancer cell line was attributed to the activation of the proteins associated to the cell death programming and production of the inflammatory cytokine.

Interestingly, in the comparison the cancer property of 20 essential oil from herbal plants, Dr. Mitoshi M, the lead scientists indicated, EOs from the herbal plants showed patterns of inhibition of DNA replicative property, similar to their cancer cell growth inhibitory activity, and their inhibitory activity and EOs from chamomile (Matricaria chamomilla L.) showed significant effects on both cancer cell growth and mast cell degranulation.

Taken altogether, chamomile extract, essential oil may be used with no side effects for the prevention and combined with the primary medicine for the treatment of cancers.

References
(1) Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells.
Srivastava JK1, Gupta S.(PubMed)
(2) Herbal infusions; their phenolic profile, antioxidant and anti-inflammatory effects in HT29 and PC3 cells by Kogiannou DA1, Kalogeropoulos N, Kefalas P, Polissiou MG, Kaliora AC. (PubMed)
(3) Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities by Mitoshi M1, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y, Jippo T, Kanazawa K, Yoshida H, Mizushina Y. (PubMed)
(4) Physical Activity and Cancer by Jessica Clague and Leslie Bernstein. (PMC)

Honey, The Functional Food Which Kills Bladder Cancer Cells in Vivo and Vitro, Scientists Find

By Kyle J. Norton

Scientists may have found a natural food source which processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.

Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.

Most cases of the primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.

At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distance metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.

At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.

Researchers do not the exact causes of bladder cancer. But certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition and exposure to chemicals are at a higher risk of the onset of the disease.

The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.

In fact, most people with some of the above risk factors have never developed bladder cancer even they are associated with the increased risk all their life.

Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to the epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.

Sadly, People with gene mutation are at the 70 % higher risk of bladder cancer compared to those do not.

Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".

And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".

Honey, is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.

The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).

In vitro studies application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.

Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.

FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.

Flowcytometry (FCM). in the measurement of can cancer cells physical and chemical characteristics showed lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.

Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.

These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.

And, honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.

Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".

Taken altogether, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)

Ginger, The Anti Gastrointestinal Disorder Functional Pungent Spice

By Kyle J. Norton

Scientists may have found a kitchen pungent spice for the treatment of the gastrointestinal disorder, some studies suggested.

Gastrointestinal diseases are the conditions of the digestive system associated with the disorders involving the gastrointestinal tract, including esophagus, stomach, small intestine, large intestine, and rectum.

The digestive system includes gastrointestinal tract (GI), liver, pancreas, and gallbladder with a healthy function of breaking down food into nutrients and fluids for the body need.

There are many different types of gastrointestinal diseases, including irritable bowel syndrome (IBS), Crohn's disease, celiac disease, and lactose intolerance.

There are many causes of gastrointestinal disorders, such as bacterial and viral infection, inflammation, poor circulation to the intestines, muscle dysfunction, gallstones, stress, particularly long-term use of anti-inflammatory drugs.

Conventional medicine used for the treatment of gastrointestinal disorders are depending on the disease that triggers the disorder.such as antibiotics for bacterial infection, painkillers for stomach pain.

Sherry Coleman Collins, MS, RDN, LD in the article, Natural Remedies for Digestive Disorders outlined the percentage of the use of natural remedies for the treatment of gastrointestinal disorders, and how much money that the American spend a year in purchasing these remedy.

Believe or not, it is equivalent to about one-third of out-of-pocket dollars spent on prescription drugs.

The dietitian wrote, " more clients and patients are looking for ways to treat their digestive disorders with natural medicines sold over the counter. According to a 2007 National Institutes of Health-funded survey on the use of complementary and alternative medicines in the United States, roughly 38% of adults use natural remedies, such as diet-based therapies (eg, gluten-free diets) and herbs, among others" and

"Also in 2007, it was estimated that nearly $34 billion was spent on complementary and alternative medicines, including about $15 billion on “nonvitamin, nonmineral, natural products:.

With an aim to reconfirm the traditional use of ginger against various gastric ailments, researchers at the Tehran University of Medical Sciences conducted an experiment to review the ginger effect in the prevention of antituberculosis-induced gastrointestinal adverse reactions.
A randomized pilot clinical trial included 60 patients who were placed into ginger and placebo groups (30 patients in each group) received either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks.

After examining the Patients' gastrointestinal complaints (nausea, vomiting, dyspepsia, and abdominal pain) and antituberculosis drug-induced hepatotoxicity were recorded during the study period, researchers showed that application ginger to the 48 (80%) patients experienced nausea caused by antituberculosis drug-induced gastrointestinal adverse reactions, reduced gastrointestinal disorders by 56% compared to 43% in the placebo.

Patients in the ginger group experienced less, but not statistically significant, antituberculosis drug-induced hepatotoxicity than the placebo group (16.7% vs 36.7%, respectively, p = 0.07).

Dr. Emrani Z, the lead author in the final report wrote, "ginger may be a potential option for prevention of antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity".

Additionally, in the concern of the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract, a joint study led by the North Carolina Agricultural and Technical State University was conducted to examine the ginger effect in reducing the risk of gastrointestinal disorder caused by injection of low dose aspirin.

Injection of ginger exerted a strong activity in the ameliorated ASA-induced gastric ulceration.

[6]-gingerol aspirinate (GAS), the combination of ginger bioactive compound [6[-gingerol and aspirin demonstrated anti-cancer properties in vitro and superior gastroprotective effects in mice.

The combination (GAS) was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release ASA and [6]-gingerol.

GAS inactivates both COX-1 and COX-2 equally to reduce symptoms of inflammation and pain caused by ASA-induced gastric ulceration.

The findings suggested that ginger processes gastroprotective effects and GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa.

Taken altogether, ginger with abundant gingerols may be considered a functional food for the prevention and adjunct therapy for the treatment of gastrointestinal disorder with no side effects.

Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)
(3) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)

Monday, 24 December 2018

Celery, in the Prevention and Treatment of Liver Disease

By Kyle J. Norton

Scientists may have found a whole food for the prevention and treatment of liver disease without inducing any side effects, according to some studies.

Liver disease is a medical and chronic condition characterized by impeding the function of the liver.

There is no single cause of liver disease. However, certain conditions such as hepatitis virus, liver scars, and long-term intake of certain medication such as Vicodin, Norco, and statins, are associated with the onset of the disease.

The liver, one of the main organ in the human plays a critical role in the metabolism of protein such as changing amino acids in foods so that they can be absorbed to produce energy, or make carbohydrates or fats, blood clotting to cholesterol, glucose, and iron metabolism.

Epidemiological studies suggested that the most common cause of liver disease in the Western world may result from excessive alcohol drinking.

According to the statistic provided by the Alcohol consumption, by Hannah Ritchie and Max Roser, the US adult drink averaging around 8 to 9 liters per year.

And, the article by Linda Carroll, "(Researchers found that between 1999 and 2016, annual deaths due to cirrhosis increased by 65 percent, from 20,661 to 34,174" and "Overall, deaths due to liver cancer more than doubled, increasing from 5,112 to 11,073 annually".

These results clearly support the increased alcohol drinking in the US adults is a culprit which contribute to the risk and onset of liver disease.

Sadly to find out that over nearly a decade, deaths from liver disease have been rising rapidly in the U.S., according to the article.

Celery is a species of Apium graveolens, belongings to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

In the concern of acetaminophen (APAP)-induced liver damage, one of the most common problems among the population, researchers at the Rajalakshmi Engineering College examined the hepatoprotective effect of celery leaves on APAP-induced toxicity in a freshwater fish.

The study included fish divided into four experimental groups of 6 fish each. Group 1 served as control. Group 2 fish were exposed to APAP (500 mg/kg) for 24 h. Groups 3 and 4 fish were exposed to APAP + celery leaf powder (CE) (500 mg/kg) and CE for 24 h, respectively.

Fish treated with APAP showed significant liver damage through the observation of the elevated levels of both circulating and tissue hepatotoxic markers (AST, ALT, and ALP), reduced hepatic glycogen and lipid contents (TG and cholesterol), reduced hepatic ions (Na(+), K(+) and Ca(2+)) and abnormal liver histology.

APAP treatment group also exerted an increased lipid peroxidation marker (TBARS, LHP, and PCO), an indication of oxidative stress and reduced levels of antioxidant enzymes (SOD, CAT, GPx, and GST) and non-enzymatic (GSH) antioxidants.

Furthermore, cellular thiol levels (T-SH, P-SH, and NP-SH)were also reduced in the APAP treatment group, an indication of reduction-oxidation (redox) state against ROS.

These abnormalities associated with APAP exposure were reversed by the treatment with CE.

Additional differentiation suggested that celery hepatoprotective effect was attributed to the presence of flavonoids such as rutein, quercetin, and luteolin.

Interestingly, the Panjab University in the study to reconfirm the traditional use of celery for the treatment of liver ailment, examine the celery antihepatotoxic effect of methanolic extracts of the seeds on rat liver damage induced by a single dose of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.).

Application of the methanolic extract of the seeds demonstrated liver protective effect by restoring liver damage caused by the injection of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.), according to the by monitoring several liver function tests.

In support of the above results, the Helwan University, in the study of the composition of Celery, chicory leaves, and barley grains, suggested that a positive effects in decreasing the elevation of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and blood lipids in rat cholesterol-enriched diet.

Taken altogether, celery may be considered a functional food for the prevention and treatment of liver disease with side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(1) Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi) by Shivashri C1, Rajarajeshwari T, Rajasekar P.(PubMed)
(2) Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats by Singh A1, Handa SS.(PubMed)
(3) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats by Abd El-Mageed NM. (PubMed)
(4) Alcohol-related liver failure deaths rising among U.S. young adults by Linda Carroll. (Reuter)

Banana, the Natural Antibiotic and Anti Oxidative Stress Functional Food

By Kyle J. Norton

Banana may have a potential and substantial effect on balancing the levels of free radicals and antioxidants in the body, according to the studies.

Oxidative stress is a condition of imbalance of the ration of free radicals and antioxidant enzymes produced by the body, leading to the damage of cell, protein, and alternation of cell DNA.

The causes of oxidative are either associated with overexpression of free radicals and depressed the host antioxidant enzymes.

Free radicals are highly reactive molecules with the unpaired electron on the outer ring of the atom. In order for them to become balanced, they must donate or steal an electron from the stable molecules, leading to the chain of reaction which can not be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.

This chain of domino's effect is known as oxidation.

Antioxidants are the stable molecules which inhibit oxidation.

There are 2 types of antioxidant in the human body. The antioxidants are produced by the host and antioxidant come from dietary sources.

Every day, our body is bombarded by the invasion of free radical. Believe or not, substances include fried foods, alcohol, tobacco smoke, pesticides, air pollutants, can produce harmful free radicals to our body.

Epidemiological studies agreed that oxidative stress is involved in several age-related conditions, including cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer.

Dr. Seungyoun Jung,, the lead scientists in the evaluation of a healthy diet pattern and the risk of oxidative stress suggested, "Foods rich in healthy diets—characterized by a high intake of fruit, vegetables, and whole grains as well as a low intake of saturated fat—are aggregate sources of bioactive compounds. These compounds work as components in antioxidant systems, such as superoxide dismutases or glutathione peroxidase, and may break free radical chain reactions."

These results strongly indicated a healthy diet can form a significant part in reducing the risk of diseases associated with oxidative stress.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

On the finding a natural antioxidant ingredient or whole food for the prevention and treatment of the diseases associated with overexpression of free radical, researchers compared the antioxidant properties of banana (Musa paradisiaca) and Sapodilla/Chikoo (Manilkara zapota) peel extracts in chicken patties.

The chicken patties were assigned to 4 treatments viz., I. Control (meat + 2% salt), II.BHT (meat + 2% salt + 0.1% BHT), III. BPE (meat + 2% salt + 2% banana peel extract) and IV. SPE (meat + 2% salt + 2% sapodilla/chikoo peel extract).

By comparing the changes in color and lipid oxidation during 8 days refrigerated storage (4 ± °C) in 4 groups, researchers showed that

* The average phenolic content was 550.2 and 550.8 mg gallic acid equivalent per 10 g peel in BPE and SPE respectively.

* Free radical scavenging activity was 66.9 and 67.8% in BPE and SPE respectively.

* Banana peel extract had significantly (P < 0.05) higher reducing activity (1.6) as compared to sapodilla peel extract (0.91).

* Observation on lipid oxidation showed a significantly (P < 0.05) higher TBARS values used for the determination of oxidative stress in control than other three treatments.

* The increase in TBARS from the initial day of storage to last day of storage was highest in control (514.3%)compared to BHT (387.7%), BPE (370.6%) and SPE (383.7%). Both synthetic antioxidants and natural extracts significantly decreased the TBARS.

These results clearly suggested that the water extracts obtained from banana and sapodilla peel process natural antioxidants in poultry meat and meat products.

Furthermore, in examining the antioxidant activity of different Musa sp. leave extracts of hexane, ethyl acetate, and methanol, researchers found that

* All the Musa sp. extracts showed moderate antibacterial activities expect Musa paradisiaca with the inhibition zone ranging from 8.0 to 18.6 mm.

* Among four species ethyl acetate extracts of Musa paradisiaca showed the highest activity against tested pathogens particularly E. coli, P. aeruginosa, and Citrobacter sp.

* The minimum inhibitory concentrations were within the value of 15.63- 250 µg/mL and minimum bactericidal concentrations were ranging from 31.25- 250 µg/mL.

* Antioxidant activity of Musa acuminate exhibited maximum activity among other three Musa species.

Taken altogether, banana may be considered a functional for the prevention and treatment of bacterial infections and diseases associated with oxidative stress.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Comparative antioxidant effect of BHT and water extracts of banana and sapodilla peels in raw poultry meat by Devatkal SK, Kumboj R, Paul D.(PubMed)
(2) Antibacterial and antioxidant activities of Musa sp. leaf extracts against multidrug resistant clinical pathogens causing nosocomial infection by Karuppiah P1, Mustaffa M.(PubMed)
(3) Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study by Seungyoun Jung,1,2,3,* Stephanie A. Smith-Warner,1,2 Walter C. Willett,1,2,4 Molin Wang,2Tianying Wu,5 Majken Jensen,2,4 Susan E. Hankinson,4,6 and A. Heather Eliassen. (PMC)

Black beans May Process Anti Gastric Cancer Potency, Scientists Find

By Kyle J. Norton

Scientists may have found a legume which processes a potential in reducing the risk and treatment of gastric/ stomach cancer.

Gastric cancer is a medical condition caused by irregular cells growth in the stomach.

Most cases of gastric cancer start by the DNA alternation in the cells on the surface of the inner lining of the stomach. The stage of gastric cancer is depended to how far the cancer cells have penetrated in the deeper tissue of the stomach.

At the advanced stage, invasive cancer can leave the stomach and travel a distance away to infect other healthy tissue and organs.

Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.

Gastric cancer affects 2.1% of male cancer patients and 1.3% of female cancer patients in Canada.

In the later stages, stomach cancer has a 5-year survival rate of only 23%, meaning that 77% of stomach cancer patients die within 5 years of diagnosis.

The most common causable risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis,.

Some researchers suggested that long-term untreated pernicious anemia and growth of polyps are also associated with the increased risk of gastric cancer.

In the concerns of a poor diet in the risk of gastric cancer, Dr. Stojanovic J, the lead author at the joint study lead by the Università Cattolica del Sacro Cuore launched an investigation to examine the effects of Mediterranean diet in gastric cancer.

By comparing the different type of diet, Mediterranean diet consists of high consumption of fruit, vegetables, cereals, legumes, nuts, seeds, fish, other seafood, and olive oil lowers the risk of gastric cancer.

The risk gastric cancer increased substantially in participants who follow the Western diet rich in saturated and trans fat, red meat and processed foods.

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongs to the family Fabaceae and can be bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was first domesticated growth in South America.

The chemicals constituents of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

Scientists at the Gyeongsang National University School of Medicine in the findings a natural ingredient for the prevention and treatment of gastric cancer conducted an experiment to evaluate the effect black bean in risk of infection associated to the onset of gastritis, peptic ulcers, and gastric cancer.

Exposed gastric mucosa to H. pylori, showed a significant increase of gastric mucosal inflammatory cytokine interleukin-8 (Il-8) and reactive oxygen species.

In the infected gastric mucosa, application cation of Anthocyanins exerted a strong anti-oxidative, antibacterial and anti-inflammatory properties by decreasing H. pylori-induced ROS enhancement.

Furthermore, Anthocyanins protected the gastric cells by inhibiting phosphorylation of mitogen-activated protein kinases, which plays an important role involved in directing cellular responses to a diverse array of stimuli, translocation of nuclear factor-kappa B which promotes cell division and survival and Iκβα which blocks the apoptosis in response to death signals activated by proinflammatory cytokines degradation.

Moreover, Anthocyanins also inhibited H. pylori-induced inducible nitric oxide synthases in the promotion of the expression of proinflammation and cyclooxygenase-2 mRNA expression in the alternation of DNA of gastric cells.

The inflammatory IL-8 expression was also found to decrease by 48% after Anthocyanins injection.

In the examine the chemopreventive effects of black soybean extract against human AGS gastric cancer cells, researchers showed that
* The black soybean extract inhibited AGS cell growth in a dose-dependent manner with an IC(50) of 3.69 mg/mL as measured by the MTT assay.

* black soybean extract dose-dependently induced apoptosis of AGS cells.

Additional differentiation found that the effects of black soybean extract in inducing apoptosis were attributed to the activation of proteins associated with programming cell deaths.

The findings suggested black beans could be used as an apoptosis inducer in AGS cells and a natural chemopreventive agent in the treatment of human gastric cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-gastric cancer possibilities.

References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments by Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Anthocyanins from black soybean inhibit Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Kim JM, Kim KM, Park EH, Seo JH, Song JY, Shin SC, Kang HL, Lee WK, Cho MJ, Rhee KH, Youn HS, Baik SC. (PubMed)
(3) Effect of black soybean extract on the suppression of the proliferation of human AGS gastric cancer cells via the induction of apoptosis. by Zou Y, Chang SK. (PubMed)
(4) Adherence to Mediterranean diet and risk of gastric cancer: results of a case-control study in Italy. by Stojanovic J1, Giraldi L, Arzani D, Pastorino R, Biondi A, Persiani R, Boccia S, Leoncini E. (PubMed)