Tualang Honey Protects the Oral Cells Against Cancer With No Side Effects

Kyle J. Norton

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at the increased risk of the disease.

The Canadian Cancer Society in the explanation of how weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".

Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"

If you experience symptoms of a sore that does heal  within a few days, a growth, lump or thickening of the skin or lining of your mouth, tongue and jaw pain that do not heal in weeks, persistent sore throat, difficult or  chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effect compared to surgery followed by chemo and.or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.

The study procedures include several concentrations of Tualang honey (1% - 20%) were applied directly on OSCC cell lines for 3, 6, 12, 24, 48 and 72 hours.

The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit.to detect the cell apoptosis.

Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.

In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.

The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.

The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.

The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.

Dr. Ghashm AA the lead scientist at the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".

Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.

Due to the limitation of the above study, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)

Avocado, the Anti Inflammatory Diseases Functional Food

By Kyle J. Norton

Intake avocado daily may have a strong effect in reducing the risk of acute and chronic inflammation, some researchers suggested.

Inflammation is a natural and systematic immune response with an aim to protect our body against the invasion of foreign pathogens.

Acute inflammation is caused by overproduction of proinflammatory cytokines which is activated the immune macrophages, a first line of the immune defense.

Chronic inflammation that lasts for several months and even year usually is the result of the immune system failing to eliminate all pathogenic invasion in the acute inflammation.

In some cases, chronic inflammation can also be caused by the immune white blood cells mistakenly attacks the body healthy tissue.

Some researchers suggested that long-term exposure to lower levels of irritants, such as industrial chemicals or polluted air may also cause chronic inflammation.

According to the statistic,  in 2000, nearly 125 million Americans were living with chronic conditions and 61 million (21%) had more than one. And these numbers are expected to increase substantially, 

More scarcely,  3 of 5 people die due to chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes, worldwide.

If you experience symptoms of depression, anxiety and mood disorders, persistent gastrointestinal complications like constipation, diarrhea, and acid reflux,  weight gain, and frequent infections, you may be at the early stage of the development of chronic inflammation. Please check with your doctor to rule out the possibility.

Dr. Roma Pahwa and Dr. Ishwarlal Jialal in the article of chronic inflammation suggested that many dietary and lifestyle changes may be helpful in removing inflammation triggers and reducing chronic inflammation as listed below. The most effective is weight loss.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

In the finding a natural ingredient for the treatment of skin inflammation caused by exposure to ultraviolet (UV) radiation without inducing side effects, researchers at the Granot Initiative Center conducted a study to test the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin.

Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6, and PGE(2), the proinflammatory cytokines and enhancing DNA repair.

In human skin explants, treating with PFA reduced significantly UV-induced cellular damage.

Furthermore, in the evaluation of the anti-inflammatory effect of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG) on cyclooxygenase-2 (COX-2) expression which is responsible for increase the inflammatory response and prostaglandin E(2) (PGE(2)) production in cytokine-activated equine chondrocytes, the cells harvested from normal or OA joints .

Before application of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG), equine chondrocytes responded to cytokine activation by up-regulated gene expression of COX-2 and increased PGE(2) production.

Application of ASU and EGCG marginally inhibited COX-2 expression and PGE(2) production in activated chondrocytes. 

The combination of ASU and EGCG reduced COX-2 expression close to non-activated control levels and significantly inhibited PGE(2) production. 

The inhibition of COX-2 expression and PGE(2) production was associated with the inhibition of NF-kappaB translocation in the regulation of cytokines and immune responses.

These results suggested that the combination may offer an attractive supplement or alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis, a chronic inflammatory disease.

Additional study on the effects of avocado soybean unsaponifiables (ASU) on proinflammatory mediators in chondrocytes and monocyte/macrophage-like cells, researchers also found that
* ASU reduced proinflammatory cytokines, TNF-alpha, IL-1beta, COX-2, and iNOS expression in LPS-activated chondrocytes to levels similar to nonactivated control levels.

* The suppression of COX-2 and iNOS expression was paralleled by a significant reduction in PGE(2) and nitrite, respectively.

Taken altogether, avocado processed a significant anti-inflammatory activity may be considered a functional food for the prevention of inflammatory disease and an adjunct therapy combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Polyhydroxylated fatty alcohols derived from avocado suppress the inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(2) Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate by Heinecke LF1, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG.(PubMed)
(3) Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages by Au RY1, Al-Talib TK, Au AY, Phan PV, Frondoza CG.(PubMed)
(4) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)

Phytochemical Allicin, Protects the Cardiovascular System With NO Side Effects, Scientists Find

By Kyle J, Norton

Allicin, a bioactive compound found abundantly in garlic and onion may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of cardiovascular disease, some scientists suggested.

Cardiovascular diseases are a class of chronic and medical conditions of heart and blood vessel disease related to the plaque build up in the walls of the arteries that cause the blockage of blood flow and reduced the oxygen and nutrients rich blood to reach the heart, leading to heart attack and stroke,

There are many causes of heart diseases. Most heart diseases are caused by high blood pressure that contributes to hardening of the arteries.
High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat.

All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Dr. P. Scarborough, the lead author in the study "An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation" wrote, "Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of an unhealthy lifestyle".

These result suggested that people who follow the Western diet with high consumption of saturated and trans fat, red meats and processed food accompanied physical inactivity are associated with the substantially increased risk of cardiovascular disease.

On the other hand, people who are nonsmokers and follow a traditional diet with high intake fruits and vegetables and whole grain and daily moderate exercise have a lower risk of the disease onset.

If you experience symptoms of chest pain, tightness, and chest discomfort (angina), shortness of breath and weakness or coldness in your legs or arms, please check with your doctor immediately, you may be at the early onset of cardiovascular disease.


Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

In the concerns of hyperlipidemia.cause of cardiovascular disease, researhcer at the Taishan Medical University, conducted an investigation to test the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats.

In the study, healthy male Wistar rats fed high-fat diet were treated with fenofibrate (80 mg/kg per day) alone, allicin (60 mg/kg per day) alone and a lower dosage of combined therapy (allicin 20 mg/kg per day and fenofibrate 30 mg/kg per day) respectively for 8 weeks.

At the final phase, compared with high fat diet control, fenofibrate alone or the combined therapy increased remarkably the levels of high-density lipoprotein respectively (P<0.05).

Both single and combined therapy of fenofibrate and allicin significantly enhanced the levels of NO (P<0.01 or P<0.05), but the combined therapy had the greatest high endothelial-dependent vascular relaxation (EDVR) responses. These suggested that both ingredients processed a significant effect in enhancing vascular relaxation.

Futhermore, the combined therapy also inhibited the levels of ALT and AST caused by infection of a high-fat diet in the stimulation of oxidative stress.

Additionally, in the search of chemicals that arise from natural food source with the potential to provide beneficial effects to the cardiovascular system, researchers at the heart team at The Hong Kong Polytechnic University launched a study to test the effect of allicin om heart diseases.

Application of Allicin demonstrated cardioprotective effects by inducing vasorelaxation and alleviating various pathological conditions of CVD, including cardiac hypertrophy, angiogenesis, platelet aggregation, hyperlipidemia, and hyperglycemia.

Allicin was also discovered to further protect the cardiovascular system by enhancing the antioxidant status by lowering the level of reactive oxygen species and stimulating the production of glutathione.

Dr. Chan JY, the lead author, said, "From the pharmacokinetic studies, allicin is known to be hydrophobic and can be readily absorbed through the cell membrane without inducing any damage to the phospholipid bilayer and then rapidly metabolized to exert pharmacological effects that are important to the cardiovascular system".

Taken all together, Allicin, the bioactive compound may be considered a functional supplement for the prevention and treatment of cardiovascular diseases, depending on the further differentiation in the human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(3) The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats BY Li W, Wang D, Song G, Zuo C, Qiao X, Qin S.(PubMed)
(4) A review of the cardiovascular benefits and antioxidant properties of allicin by Chan JY, Yuen AC, Chan RY, Chan SW.(PubMed)
(5) An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation by P. Scarborough,⁎ S. Allender, M. Rayner, and M. Goldacre. (PMC)

Anacardic Acids, The Potential Anti Breast Cancer Phytochemical

By Kyle J. Norton

Anacardic acids, a phytochemical found abundantly in the may process a potential effect in reducing risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a chronic condition associated with the irregular cell growth caused by the alternation of  DNA of breast cell.

Most cases of breast cancer start on the cells in the surface of the in the inner lining tissue of the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

However, after colonizing most of the breast tissue, the cancer cell at the later stage can travel a distance away to infect other healthy tissue and organs through the circulation of lymph and blood.

According to the statistic, every year, 75,000 and 234,000 patients are diagnosed with breast cancer (BC) in Germany and in the USA, respectively.

 In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Although genetic preposition such as mutated gene BRCA 1 and 2 are the best-known risk factor associated with the 60% increased the risk of breast cancer.

Unhealthy lifestyle including poor diet and physical inactivity are also the most mentioned risk factor by scientists.

Dr. Max Dieterich, the lead scientist in the study "Influence of Lifestyle Factors on Breast Cancer Risk" wrote, "epidemiological studies that lifestyle factors play an important role in the development of BC. For example, daughters of Asian women who have migrated to the USA revealed an increased risk of developing BC, which was attributed to the exposure to a different lifestyle and nutritional factors".

These results suggested regardless of ethical origin, if you follow the Western diet and lifestyle, you are at the higher levels of risk, compared to those who follow the traditional diet.

More precisely, if you are following the diet high saturated and trans fat, red meat and processed food, regardless of where you're from, you are at higher risk of breast cancer.

Therefore by modifying the lifestyle risk factors to develop a strategy for BC prevention is an urgency for the prevention of breast cancer.

Other risk factors associated with breast cancer are age, family history of BC, personal breast history (pre-malignant lesions), breast density, thorax radiation, and a number of menstrual cycles during the lifetime.

In order to understanding the effect of Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid), a dietary and medicinal phytochemical anticancer activity in cell and animal models, researchers at the cancer team program at the University of Louisville School of Medicine, conducted an experiment to test the mechanisms of the AnAc in the inhibition of breast cancer cell proliferation.

Application of the AnAc 24:1(omega5) purified from geranium (Pelargonium x hortorum) inhibited the proliferation of estrogen receptor alpha (ERalpha)-positive MCF-7 and endocrine-resistant LCC9 and LY2 breast cancer cells with greater efficacy than ERalpha-negative primary human breast epithelial cells, MCF-10A normal breast epithelial cells, and MDA-MB-231 basal-like breast cancer cells.

AnAc 24:1(omega5) inhibited cell cycle progression and induced apoptosis in a cell-specific manner.

AnAc 24:1(omega5) inhibited the breast cancer cell line was attributed to stimulation of proteins which are responsible for program cells death and anti-cell proliferation.

. 
Dr. Schultz DJ, the lead scientist at the end of the study said, "These data indicate that AnAc 24:1(omega5) inhibits cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner by reducing ER-DNA interaction and inhibiting ER-mediated transcriptional responses".

Furthermore, in examining the series of N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-alkyl (and alkenyl) benzamides related to the anacardic acid derivative CTPB prepared from 2,6-dihydroxybenzoic acid, researchers found that In U937 cells
* Derivatives labeled 7 c, 7 d, 7, and 7 j exerted a potential effect in inducing cell-cycle arrest in the G1 phase,

* The derivative also cause apoptosis in about 20 % of the cells and increased the acetylation of H3. Loss of acylation levels of H3 was associated with patients with breast cancer.

Taken together, Anacardic acids may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM. (PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)

Phytochemical Allicin, the Potential Natural Antibiotic Alternative

By Kyle J. Norton

Phytochemical Allicin may be the next generation of natural antibiotic alternative for the prevention and treatment of infectious diseases caused by the bacterium, some studies suggested.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

Under the normal condition, the immune system does a great job of keeping people healthy and preventing infections. 

Foods and nutritional supplements, herbs may also play an important role in enhancing the immune system defense against viruses and bacteria attacks.

Infection is a result of the battle of the invasion of the foreign organisms body tissues by disease-causing agents and the reaction of the immune system response.

Infectious disease is a condition caused by prolonged infection and the failure of the macrophages, the body's first line of defense of the immune system to completely destroy the invasive pathogens through production pro-inflammatory cytokines in the acute phase of infection.

Antibiotics are the most common treatment of infectious diseases. Treatment can be targeted more precisely with the diagnosis. Application of Antibiotics in most cases are quite effective in reversing bacterial infections.

However, by killing the infectious bacteria and healthy cells nearby, the medication may induce some side effects such as common gastrointestinal discomforts.

In serious cases, the use of antibiotics may also cause blood in the stool and persistent and intense stomach cramping or pain and uncontrol vomiting.

If you currently taking antibiotics, please make sure that you know all the side effect for preventive measure.

The research team of infectious disease at The Hebrew University-Hadassah School of Dental Medicine in the concerns of the side effects of antibiotics launched an investigation to test the antimicrobial activity of garlic allicin on oral pathogens associated with dental caries and periodontitis.

The experiment found that Allicin is effective against all the tested bacteria.

Injection of the broth dilution from Allicin inhibited the planktonic growth of the cariogenic, gram-positive species Streptococcus mutans, S. sobrinus, and Actinomyces oris at the concentration of 600 μg/mL or higher.

Gram-negative periopathogenic species Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum were inhibited by a minimum allicin concentration of 300 μg/mL.

Allicin at the concentration of (2,400 μg/mL). exerted the lowest effect against Porphyromonas gingivalis, an anaerobic, gram-negative pathogen and the bacterium most associated with chronic periodontitis.

Further analysis also discovered that Allicin inhibited levels of the arginine and lysine gingipains, the major virulence factors of this organism.

And, A gingipain-inactivated mutant demonstrated high sensitivity to allicin (<300 μg/mL), revealing that gingipains confer resistance to allicin.  

After taking into account of co and confounders, Dr. Bachrach G, the lead author wrote in the final report, " these results support the traditional medicinal use of garlic and suggest the use of allicin for alleviating dental diseases".

Additionally, in the reaffirming of the effects of Allicin against Streptolysin O (SLO), a potent cytolytic toxin and an important virulence factor produced by almost all strains of group A streptococci researchers revealed that application of Allicin neutralizes SLO in a dose- and time-dependent manner.

Moreover, A 15 min incubation of SLO with 35 microg allicin totally inhibited the hemolytic activity of SLO [IC(50) (concentration necessary to reach half maximum inhibition)=5.97 microg], the was equipotency similar to those of pure allicin (IC(50)=6.27 microg; P<0.05).

In contrast, fresh extract of garlic inhibited the SLO hemolytic activity at lower concentrations (IC(50)=1.59 microl; 1.9 microg allicin).

These result suggested that Allicin and allicin may be a potential alternative drug against streptococcal diseases.

Taken altogether, Allicin found in great amount in garlic may be considered a functional bioactive compound for the prevention and treatment of bacterial infection, depending to the result of larger sample size and multicenter in the human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Garlic allicin as a potential agent for controlling oral pathogens by Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D.(PubMed)
(2) Inhibition of streptolysin O by allicin - an active component of garlic by Arzanlou M, Bohlooli S.(PubMed)

Phytochemicals Phytic Acid Which Reduces Risk and Treatment of Colorectal Cancer

By Kyle J. Norton

Phytic acid, an organic compound found much in healthy food sources may have a potential effect in reducing risk and treatment of colorectal cancer, some studies suggested.

Foods that containing high levels of phytic acid including nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds,...
By Kyle J. Norton

Colorectal cancer also is known as bowel cancer, is a medical and chronic condition characterized by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix due to the alternation of DNA with unidentified origin.

Colorectal cancer (CRC) is relatively very common cancer in the Western world. The cancer is considered a slowly growing and progressing cancer in a predictable way.

Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food and the  2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Why colorectal cancer is more susceptible to the  West than other parts of the world. Some researchers suggested it may a result of the Western diet. People who the diet with high saturated and trans fats, red meat, processed foods, and fewer fruits and vegetables, whole grain are associated with a substantially higher risk to colorectal cancer, compared to traditional diet.

Dr. Alan Moss, the lead author in the cancer program at The University of Melbourne, a diet that contains high levels of red meat is associated with risk of CRC.

The risk of colorectal is increased proportionally to the increased intake of red meat. In other words, the redder consumed the higher the risk of CRC.

And, processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage are also in the list of elevated the risk of colorectal cancer. 

In the comparison of the “Western” and “prudent” dietary patterns on the incidence of CRC, researchers showed that people who follow the Western diet have a 31% increased risk of the disease onset, compared to a 14% reduced risk of CRC in people who follow the prudent diet with high fruits and vegetables, fewer red meat and processed foods.

These results suggested, regardless to present the colorectal cancer risk, change of diet pattern today, your risk the cancer is continuously lower, compared to before of the change.

Dr, Shafie NH, the lead scientists in the researchers at the cancer program team at the Universiti Putra Malaysia in the examine whether the phytic acid, a natural dietary ingredient and an essential component of nutritional diets effect in colorectal cancer risk showed that

* Phytic acid exerted a strongly inhibitory colorectal cancer activity by increasing the function of proteins (up-regulation of Bax)associated with program cells death and (down-regulation of Bcl-xl) anti-cancer cells proliferation.
* Furthermore, when exposed to IP6 (phytic acid), the phytochemical up-regulates of caspase-3 and -8 expressions and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells.  

The results suggested, combined with t rice bran IP6 (phytic acid) induced apoptosis, by regulating the pro- and anti-apoptotic markers.

Moreover, in the reaffirming the significant role of phytic acid in inhibition of colorectal cancer, Dr. Saad N, the team leader and colleagues launched an investigation of expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence after treatment with rice bran PA by immunocytochemistry.

The experiment includes a total of 72 male Sprague-Dawley rats divided into 6 equal groups with 12 rats in each group.

Cancer induction by two intraperitoneal injections of azoxymethane (AOM) was given at 15 mg/kg body weight over a 2-week period. During the post-initiation phase, two different concentrations of PA, 0.2% (w/v) and 0.5% (w/v) were administered in the diet.

Before treatment with PA, rats induced cancer showed that β-catenin, a marker of alternation of gene transcription, COX-2 expressions associated with cancer cells proliferation and cell proliferation of Ki-67 associated to a significant contribution in colonic cancer progression.

And, a significant positive expression and correlation were found between COX-2 expression and proliferation and the total β-catenin also demonstrated a significant positive linear relationship with total COX-2. 

After application phytic acid, researchers found that the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence were totally inhibited by rice bran PA.

Taken all together, there is no doubt that phytic acid can be considered a functional supplement in the prevention of colorectal cancer and combined with primary therapy for the treatment of the disease with inducing any side effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of phytic acid anti-colorectal cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK.(PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice branphytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations by Alan Moss and Kumanan Nalankilli (Gastroenterology)

Cruciferous Vegetables, The Functional Food May Process Anti Bladder Cancer Potency

By Kyle J. Norton

Cruciferous vegetables may process a significant effect in the reducing risk and treatment of bladder cancer, some scientists suggested.

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is a medical and chronic condition caused by cell growth irregularly and disorderly in the bladder tissue as a result of cell DNA alternation.

Most cases of primary bladder cancer start on the surface of the inner lining of the bladder. At the cancer progress, the cancerous cell can penetrate deeper in the bladder tissue and travel a distance away to infect other healthy tissue and organs.

According to the statistic, men are 4 times more likely than women to be diagnosed with the disease. and 90% of people with bladder cancer are older than 55, and the average age people are diagnosed with bladder cancer is 73.

 Cancer causes 17,000 deaths (12,500 men and 4,500 women) every year.

Although there are many risk factors associated with the onset of bladder cancer, long-term cigarette smoking use is considered a significant cause of the disease. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers.

However, most of the cigarette smoker has never developed bladder cancer.

Dr. Neal D Freedman, the lead author in the concerns of bladder cancer widespread in men launched an investigation to evaluate the cigarette smoking in the risk of bladder cancer.

The study included a total of 81,394 men and 86,134 of women who complete the NIH-AARP cohort lifestyle questionnaire and followed from 1995 through Dec 31, 2006.

During 4,518,938 years of follow-up, incident bladder cancer occurred in 3,896 men (144.0/100,000 person-years) and 627 women (34.5/100,000 person-years).

Former smokers and current smokers were found to have higher risks of bladder cancer than never smokers.

The summary risk estimate for current smoking followed from 1963–1987) was 2.94.

The risk of bladder cancer of ever smoking in our study was 0.50 in men and 0.52  in women.

The findings not only suggested that the risk of bladder cancer not only increases in the current smoker but also elevates in previous smokers.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Its chemical constituents of cruciferous vegetables include glucosinolates, dithiolthiones, indoles, glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc.

In the reaffirming the epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk, researchers at The Ohio State University conducted an evaluation to test the mechanisms whereby broccoli and broccoli sprout extracts and pure isothiocyanates inhibit normal, noninvasive (RT4), and invasive (J82, UMUC3) human urothelial cell viability. 

Sulforaphane (IC(50) = 5.66 ± 1.2 μM) and erucin (IC(50) = 8.79 ± 1.3 μM), the major compounds found in the broccoli and broccoli sprout are the most potent inhibitors without harming to the normal cells.

Further analysis suggested that the efficacy of the tested veggies are attributed to the inhibition of survivin, which plays an important role in the protection of cell death, epidermal growth factor receptor (EGFR), a growth factor receptor that induces cell differentiation and proliferation upon and human epidermal growth factor receptor 2 (HER2/neu) in the initiation of cancer development, G(2) /M cell cycle accumulation, and apoptosis.

In a murine UMUC3 xenograft model, injection of diets containing 4% broccoli sprouts, or 2% broccoli sprout isothiocyanate extract; or gavaged pure sulforaphane or erucin (each at 295 μmol/kg, similar to dietary exposure) showed a tumor weight reduction of 42%, 42%, 33% and 58%, respectively.

These results showed that broccoli and broccoli sprout has a strong effect in targeting bladder cancer prevention.

Moreover, in the reconfirmation of the effects of Sulforaphane (SF) inhibits bladder cancer in vivo, researchers at the Roswell Park Cancer Institute conducted an investigation SF effect in both human bladder cells in vitro and mouse bladder tissue in vivo.

Application of SF activates NF-E2 related factor-2 (Nrf2), which is a well-recognized chemopreventive target and activates the Nrf2-regulated cytoprotective signaling pathway in response to oxidative stress.

Comparison between wild-type mice and mice without Nrf2 shows that Nrf2 activation is required by SF for inhibition of Androgen-binding protein (ABP)-induced DNA damage.

Additionally, Nrf2 activation by SF in the bladder occurs primarily in the epithelium, which is the principal site of bladder cancer development. 

Accompanied with the result of SF-enriched broccoli sprout extracts strongly inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer development, suggest that SF is a highly promising agent for bladder cancer prevention and provides a mechanistic insight into the repeated epidemiological observation that consumption of broccoli is inversely associated with bladder cancer risk and mortality.

Taken altogether, cruciferous vegetables, including broccoli and broccoli sprout processed high amounts of bioactive compounds may be considered functional for the prevention and an adjunct therapy combined with primary medicine for the treatment of bladder cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion by Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi A.(PubMed)
(2) Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues by Ding Y, Paonessa JD, Randall KL, Argoti D, Chen L, Vouros P, Zhang Y.(PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)