Phytochemical Allicin, Protects the Cardiovascular System With NO Side Effects, Scientists Find

By Kyle J, Norton

Allicin, a bioactive compound found abundantly in garlic and onion may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of cardiovascular disease, some scientists suggested.

Cardiovascular diseases are a class of chronic and medical conditions of heart and blood vessel disease related to the plaque build up in the walls of the arteries that cause the blockage of blood flow and reduced the oxygen and nutrients rich blood to reach the heart, leading to heart attack and stroke,

There are many causes of heart diseases. Most heart diseases are caused by high blood pressure that contributes to hardening of the arteries.
High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat.

All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Dr. P. Scarborough, the lead author in the study "An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation" wrote, "Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of an unhealthy lifestyle".

These result suggested that people who follow the Western diet with high consumption of saturated and trans fat, red meats and processed food accompanied physical inactivity are associated with the substantially increased risk of cardiovascular disease.

On the other hand, people who are nonsmokers and follow a traditional diet with high intake fruits and vegetables and whole grain and daily moderate exercise have a lower risk of the disease onset.

If you experience symptoms of chest pain, tightness, and chest discomfort (angina), shortness of breath and weakness or coldness in your legs or arms, please check with your doctor immediately, you may be at the early onset of cardiovascular disease.


Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

In the concerns of hyperlipidemia.cause of cardiovascular disease, researhcer at the Taishan Medical University, conducted an investigation to test the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats.

In the study, healthy male Wistar rats fed high-fat diet were treated with fenofibrate (80 mg/kg per day) alone, allicin (60 mg/kg per day) alone and a lower dosage of combined therapy (allicin 20 mg/kg per day and fenofibrate 30 mg/kg per day) respectively for 8 weeks.

At the final phase, compared with high fat diet control, fenofibrate alone or the combined therapy increased remarkably the levels of high-density lipoprotein respectively (P<0.05).

Both single and combined therapy of fenofibrate and allicin significantly enhanced the levels of NO (P<0.01 or P<0.05), but the combined therapy had the greatest high endothelial-dependent vascular relaxation (EDVR) responses. These suggested that both ingredients processed a significant effect in enhancing vascular relaxation.

Futhermore, the combined therapy also inhibited the levels of ALT and AST caused by infection of a high-fat diet in the stimulation of oxidative stress.

Additionally, in the search of chemicals that arise from natural food source with the potential to provide beneficial effects to the cardiovascular system, researchers at the heart team at The Hong Kong Polytechnic University launched a study to test the effect of allicin om heart diseases.

Application of Allicin demonstrated cardioprotective effects by inducing vasorelaxation and alleviating various pathological conditions of CVD, including cardiac hypertrophy, angiogenesis, platelet aggregation, hyperlipidemia, and hyperglycemia.

Allicin was also discovered to further protect the cardiovascular system by enhancing the antioxidant status by lowering the level of reactive oxygen species and stimulating the production of glutathione.

Dr. Chan JY, the lead author, said, "From the pharmacokinetic studies, allicin is known to be hydrophobic and can be readily absorbed through the cell membrane without inducing any damage to the phospholipid bilayer and then rapidly metabolized to exert pharmacological effects that are important to the cardiovascular system".

Taken all together, Allicin, the bioactive compound may be considered a functional supplement for the prevention and treatment of cardiovascular diseases, depending on the further differentiation in the human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(3) The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats BY Li W, Wang D, Song G, Zuo C, Qiao X, Qin S.(PubMed)
(4) A review of the cardiovascular benefits and antioxidant properties of allicin by Chan JY, Yuen AC, Chan RY, Chan SW.(PubMed)
(5) An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation by P. Scarborough,⁎ S. Allender, M. Rayner, and M. Goldacre. (PMC)

Anacardic Acids, The Potential Anti Breast Cancer Phytochemical

By Kyle J. Norton

Anacardic acids, a phytochemical found abundantly in the may process a potential effect in reducing risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a chronic condition associated with the irregular cell growth caused by the alternation of  DNA of breast cell.

Most cases of breast cancer start on the cells in the surface of the in the inner lining tissue of the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

However, after colonizing most of the breast tissue, the cancer cell at the later stage can travel a distance away to infect other healthy tissue and organs through the circulation of lymph and blood.

According to the statistic, every year, 75,000 and 234,000 patients are diagnosed with breast cancer (BC) in Germany and in the USA, respectively.

 In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Although genetic preposition such as mutated gene BRCA 1 and 2 are the best-known risk factor associated with the 60% increased the risk of breast cancer.

Unhealthy lifestyle including poor diet and physical inactivity are also the most mentioned risk factor by scientists.

Dr. Max Dieterich, the lead scientist in the study "Influence of Lifestyle Factors on Breast Cancer Risk" wrote, "epidemiological studies that lifestyle factors play an important role in the development of BC. For example, daughters of Asian women who have migrated to the USA revealed an increased risk of developing BC, which was attributed to the exposure to a different lifestyle and nutritional factors".

These results suggested regardless of ethical origin, if you follow the Western diet and lifestyle, you are at the higher levels of risk, compared to those who follow the traditional diet.

More precisely, if you are following the diet high saturated and trans fat, red meat and processed food, regardless of where you're from, you are at higher risk of breast cancer.

Therefore by modifying the lifestyle risk factors to develop a strategy for BC prevention is an urgency for the prevention of breast cancer.

Other risk factors associated with breast cancer are age, family history of BC, personal breast history (pre-malignant lesions), breast density, thorax radiation, and a number of menstrual cycles during the lifetime.

In order to understanding the effect of Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid), a dietary and medicinal phytochemical anticancer activity in cell and animal models, researchers at the cancer team program at the University of Louisville School of Medicine, conducted an experiment to test the mechanisms of the AnAc in the inhibition of breast cancer cell proliferation.

Application of the AnAc 24:1(omega5) purified from geranium (Pelargonium x hortorum) inhibited the proliferation of estrogen receptor alpha (ERalpha)-positive MCF-7 and endocrine-resistant LCC9 and LY2 breast cancer cells with greater efficacy than ERalpha-negative primary human breast epithelial cells, MCF-10A normal breast epithelial cells, and MDA-MB-231 basal-like breast cancer cells.

AnAc 24:1(omega5) inhibited cell cycle progression and induced apoptosis in a cell-specific manner.

AnAc 24:1(omega5) inhibited the breast cancer cell line was attributed to stimulation of proteins which are responsible for program cells death and anti-cell proliferation.

. 
Dr. Schultz DJ, the lead scientist at the end of the study said, "These data indicate that AnAc 24:1(omega5) inhibits cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner by reducing ER-DNA interaction and inhibiting ER-mediated transcriptional responses".

Furthermore, in examining the series of N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-alkyl (and alkenyl) benzamides related to the anacardic acid derivative CTPB prepared from 2,6-dihydroxybenzoic acid, researchers found that In U937 cells
* Derivatives labeled 7 c, 7 d, 7, and 7 j exerted a potential effect in inducing cell-cycle arrest in the G1 phase,

* The derivative also cause apoptosis in about 20 % of the cells and increased the acetylation of H3. Loss of acylation levels of H3 was associated with patients with breast cancer.

Taken together, Anacardic acids may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM. (PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)

Phytochemical Allicin, the Potential Natural Antibiotic Alternative

By Kyle J. Norton

Phytochemical Allicin may be the next generation of natural antibiotic alternative for the prevention and treatment of infectious diseases caused by the bacterium, some studies suggested.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

Under the normal condition, the immune system does a great job of keeping people healthy and preventing infections. 

Foods and nutritional supplements, herbs may also play an important role in enhancing the immune system defense against viruses and bacteria attacks.

Infection is a result of the battle of the invasion of the foreign organisms body tissues by disease-causing agents and the reaction of the immune system response.

Infectious disease is a condition caused by prolonged infection and the failure of the macrophages, the body's first line of defense of the immune system to completely destroy the invasive pathogens through production pro-inflammatory cytokines in the acute phase of infection.

Antibiotics are the most common treatment of infectious diseases. Treatment can be targeted more precisely with the diagnosis. Application of Antibiotics in most cases are quite effective in reversing bacterial infections.

However, by killing the infectious bacteria and healthy cells nearby, the medication may induce some side effects such as common gastrointestinal discomforts.

In serious cases, the use of antibiotics may also cause blood in the stool and persistent and intense stomach cramping or pain and uncontrol vomiting.

If you currently taking antibiotics, please make sure that you know all the side effect for preventive measure.

The research team of infectious disease at The Hebrew University-Hadassah School of Dental Medicine in the concerns of the side effects of antibiotics launched an investigation to test the antimicrobial activity of garlic allicin on oral pathogens associated with dental caries and periodontitis.

The experiment found that Allicin is effective against all the tested bacteria.

Injection of the broth dilution from Allicin inhibited the planktonic growth of the cariogenic, gram-positive species Streptococcus mutans, S. sobrinus, and Actinomyces oris at the concentration of 600 μg/mL or higher.

Gram-negative periopathogenic species Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum were inhibited by a minimum allicin concentration of 300 μg/mL.

Allicin at the concentration of (2,400 μg/mL). exerted the lowest effect against Porphyromonas gingivalis, an anaerobic, gram-negative pathogen and the bacterium most associated with chronic periodontitis.

Further analysis also discovered that Allicin inhibited levels of the arginine and lysine gingipains, the major virulence factors of this organism.

And, A gingipain-inactivated mutant demonstrated high sensitivity to allicin (<300 μg/mL), revealing that gingipains confer resistance to allicin.  

After taking into account of co and confounders, Dr. Bachrach G, the lead author wrote in the final report, " these results support the traditional medicinal use of garlic and suggest the use of allicin for alleviating dental diseases".

Additionally, in the reaffirming of the effects of Allicin against Streptolysin O (SLO), a potent cytolytic toxin and an important virulence factor produced by almost all strains of group A streptococci researchers revealed that application of Allicin neutralizes SLO in a dose- and time-dependent manner.

Moreover, A 15 min incubation of SLO with 35 microg allicin totally inhibited the hemolytic activity of SLO [IC(50) (concentration necessary to reach half maximum inhibition)=5.97 microg], the was equipotency similar to those of pure allicin (IC(50)=6.27 microg; P<0.05).

In contrast, fresh extract of garlic inhibited the SLO hemolytic activity at lower concentrations (IC(50)=1.59 microl; 1.9 microg allicin).

These result suggested that Allicin and allicin may be a potential alternative drug against streptococcal diseases.

Taken altogether, Allicin found in great amount in garlic may be considered a functional bioactive compound for the prevention and treatment of bacterial infection, depending to the result of larger sample size and multicenter in the human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Garlic allicin as a potential agent for controlling oral pathogens by Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D.(PubMed)
(2) Inhibition of streptolysin O by allicin - an active component of garlic by Arzanlou M, Bohlooli S.(PubMed)

Phytochemicals Phytic Acid Which Reduces Risk and Treatment of Colorectal Cancer

By Kyle J. Norton

Phytic acid, an organic compound found much in healthy food sources may have a potential effect in reducing risk and treatment of colorectal cancer, some studies suggested.

Foods that containing high levels of phytic acid including nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds,...
By Kyle J. Norton

Colorectal cancer also is known as bowel cancer, is a medical and chronic condition characterized by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix due to the alternation of DNA with unidentified origin.

Colorectal cancer (CRC) is relatively very common cancer in the Western world. The cancer is considered a slowly growing and progressing cancer in a predictable way.

Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food and the  2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Why colorectal cancer is more susceptible to the  West than other parts of the world. Some researchers suggested it may a result of the Western diet. People who the diet with high saturated and trans fats, red meat, processed foods, and fewer fruits and vegetables, whole grain are associated with a substantially higher risk to colorectal cancer, compared to traditional diet.

Dr. Alan Moss, the lead author in the cancer program at The University of Melbourne, a diet that contains high levels of red meat is associated with risk of CRC.

The risk of colorectal is increased proportionally to the increased intake of red meat. In other words, the redder consumed the higher the risk of CRC.

And, processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage are also in the list of elevated the risk of colorectal cancer. 

In the comparison of the “Western” and “prudent” dietary patterns on the incidence of CRC, researchers showed that people who follow the Western diet have a 31% increased risk of the disease onset, compared to a 14% reduced risk of CRC in people who follow the prudent diet with high fruits and vegetables, fewer red meat and processed foods.

These results suggested, regardless to present the colorectal cancer risk, change of diet pattern today, your risk the cancer is continuously lower, compared to before of the change.

Dr, Shafie NH, the lead scientists in the researchers at the cancer program team at the Universiti Putra Malaysia in the examine whether the phytic acid, a natural dietary ingredient and an essential component of nutritional diets effect in colorectal cancer risk showed that

* Phytic acid exerted a strongly inhibitory colorectal cancer activity by increasing the function of proteins (up-regulation of Bax)associated with program cells death and (down-regulation of Bcl-xl) anti-cancer cells proliferation.
* Furthermore, when exposed to IP6 (phytic acid), the phytochemical up-regulates of caspase-3 and -8 expressions and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells.  

The results suggested, combined with t rice bran IP6 (phytic acid) induced apoptosis, by regulating the pro- and anti-apoptotic markers.

Moreover, in the reaffirming the significant role of phytic acid in inhibition of colorectal cancer, Dr. Saad N, the team leader and colleagues launched an investigation of expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence after treatment with rice bran PA by immunocytochemistry.

The experiment includes a total of 72 male Sprague-Dawley rats divided into 6 equal groups with 12 rats in each group.

Cancer induction by two intraperitoneal injections of azoxymethane (AOM) was given at 15 mg/kg body weight over a 2-week period. During the post-initiation phase, two different concentrations of PA, 0.2% (w/v) and 0.5% (w/v) were administered in the diet.

Before treatment with PA, rats induced cancer showed that β-catenin, a marker of alternation of gene transcription, COX-2 expressions associated with cancer cells proliferation and cell proliferation of Ki-67 associated to a significant contribution in colonic cancer progression.

And, a significant positive expression and correlation were found between COX-2 expression and proliferation and the total β-catenin also demonstrated a significant positive linear relationship with total COX-2. 

After application phytic acid, researchers found that the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence were totally inhibited by rice bran PA.

Taken all together, there is no doubt that phytic acid can be considered a functional supplement in the prevention of colorectal cancer and combined with primary therapy for the treatment of the disease with inducing any side effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of phytic acid anti-colorectal cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK.(PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice branphytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations by Alan Moss and Kumanan Nalankilli (Gastroenterology)

Cruciferous Vegetables, The Functional Food May Process Anti Bladder Cancer Potency

By Kyle J. Norton

Cruciferous vegetables may process a significant effect in the reducing risk and treatment of bladder cancer, some scientists suggested.

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is a medical and chronic condition caused by cell growth irregularly and disorderly in the bladder tissue as a result of cell DNA alternation.

Most cases of primary bladder cancer start on the surface of the inner lining of the bladder. At the cancer progress, the cancerous cell can penetrate deeper in the bladder tissue and travel a distance away to infect other healthy tissue and organs.

According to the statistic, men are 4 times more likely than women to be diagnosed with the disease. and 90% of people with bladder cancer are older than 55, and the average age people are diagnosed with bladder cancer is 73.

 Cancer causes 17,000 deaths (12,500 men and 4,500 women) every year.

Although there are many risk factors associated with the onset of bladder cancer, long-term cigarette smoking use is considered a significant cause of the disease. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers.

However, most of the cigarette smoker has never developed bladder cancer.

Dr. Neal D Freedman, the lead author in the concerns of bladder cancer widespread in men launched an investigation to evaluate the cigarette smoking in the risk of bladder cancer.

The study included a total of 81,394 men and 86,134 of women who complete the NIH-AARP cohort lifestyle questionnaire and followed from 1995 through Dec 31, 2006.

During 4,518,938 years of follow-up, incident bladder cancer occurred in 3,896 men (144.0/100,000 person-years) and 627 women (34.5/100,000 person-years).

Former smokers and current smokers were found to have higher risks of bladder cancer than never smokers.

The summary risk estimate for current smoking followed from 1963–1987) was 2.94.

The risk of bladder cancer of ever smoking in our study was 0.50 in men and 0.52  in women.

The findings not only suggested that the risk of bladder cancer not only increases in the current smoker but also elevates in previous smokers.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Its chemical constituents of cruciferous vegetables include glucosinolates, dithiolthiones, indoles, glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc.

In the reaffirming the epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk, researchers at The Ohio State University conducted an evaluation to test the mechanisms whereby broccoli and broccoli sprout extracts and pure isothiocyanates inhibit normal, noninvasive (RT4), and invasive (J82, UMUC3) human urothelial cell viability. 

Sulforaphane (IC(50) = 5.66 ± 1.2 μM) and erucin (IC(50) = 8.79 ± 1.3 μM), the major compounds found in the broccoli and broccoli sprout are the most potent inhibitors without harming to the normal cells.

Further analysis suggested that the efficacy of the tested veggies are attributed to the inhibition of survivin, which plays an important role in the protection of cell death, epidermal growth factor receptor (EGFR), a growth factor receptor that induces cell differentiation and proliferation upon and human epidermal growth factor receptor 2 (HER2/neu) in the initiation of cancer development, G(2) /M cell cycle accumulation, and apoptosis.

In a murine UMUC3 xenograft model, injection of diets containing 4% broccoli sprouts, or 2% broccoli sprout isothiocyanate extract; or gavaged pure sulforaphane or erucin (each at 295 μmol/kg, similar to dietary exposure) showed a tumor weight reduction of 42%, 42%, 33% and 58%, respectively.

These results showed that broccoli and broccoli sprout has a strong effect in targeting bladder cancer prevention.

Moreover, in the reconfirmation of the effects of Sulforaphane (SF) inhibits bladder cancer in vivo, researchers at the Roswell Park Cancer Institute conducted an investigation SF effect in both human bladder cells in vitro and mouse bladder tissue in vivo.

Application of SF activates NF-E2 related factor-2 (Nrf2), which is a well-recognized chemopreventive target and activates the Nrf2-regulated cytoprotective signaling pathway in response to oxidative stress.

Comparison between wild-type mice and mice without Nrf2 shows that Nrf2 activation is required by SF for inhibition of Androgen-binding protein (ABP)-induced DNA damage.

Additionally, Nrf2 activation by SF in the bladder occurs primarily in the epithelium, which is the principal site of bladder cancer development. 

Accompanied with the result of SF-enriched broccoli sprout extracts strongly inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer development, suggest that SF is a highly promising agent for bladder cancer prevention and provides a mechanistic insight into the repeated epidemiological observation that consumption of broccoli is inversely associated with bladder cancer risk and mortality.

Taken altogether, cruciferous vegetables, including broccoli and broccoli sprout processed high amounts of bioactive compounds may be considered functional for the prevention and an adjunct therapy combined with primary medicine for the treatment of bladder cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion by Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi A.(PubMed)
(2) Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues by Ding Y, Paonessa JD, Randall KL, Argoti D, Chen L, Vouros P, Zhang Y.(PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)

Ginger, the Potential Remedy for the Prevention and Treatment of Atherosclerosis with No Side Effects

By Kyle J Norton

Ginger may have a potential and profound effect in blocking the accumulation of plaques on the arterial wall in initiating the risk of atherosclerosis,  some scientists suggested.

Atherosclerosis is a medical condition associated with plaque building up in the arteries, leading to the narrowing the arterial function in the transportation of oxygenated blood to the heart and other blood of the body.

Plaques are substance made up from the accumulated fat, cholesterol, calcium, and other substances found in the blood, including cadmium.

Long-term accumulation of plaque can also cause hardening and stiffing arterial wall can lead to the blockage of the arteries and risk of heart disease depending on the location of the blockage.

Most people in the early stage of atherosclerosis do not experience any symptoms. However, as the condition progresses and the location affected, patients may develop chest pain, shortness of breath, sweating, and anxiety.

Most common causes of atherosclerosis are the imbalance of the ratio of bad cholesterol and good cholesterol in the blood, long-term smoking, obesity, increase in age, obesity and some medical conditions, such as diabetes and high blood pressure.

Therefore adding a portion of olive oil into your daily diet can reduce the risk of high blood cholesterol

Dr. Siasos G, the lead scientists in the heart disease team in the concerns of the smoking detrimental effect to many organ systems and is responsible for illnesses such as lung cancer, pneumonia, chronic obstructive pulmonary disease said, " smoking is an important modifiable risk factor for the development of cardiovascular disease,....via initiation and progression of atherosclerosis".

And, " variety of studies has proved that cigarette smoking induces oxidative stress, vascular inflammation, platelet coagulation, vascular dysfunction and impairs serum lipid profile in both current and chronic smokers, active and passive smokers and results in detrimental effects on the cardiovascular system".

The statement clearly indicated that cigarette smoking has a strong implication of the onset and progression of atherosclerosis.

Some researchers suggested that cigarette smoke contain a high amount of toxic chemicals that cause inflammation and formation of blood clot in the arteries and oxidation of low-density lipoprotein cholesterol.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient or whole food for the prevention and treatment, researchers at the joint study led by the University of Sistan and Baluchestan examined the potential protective effects of ginger in atherosclerosis and atherosclerotic cardiovascular disease.

The randomized, experimental, and controlled study included thirty healthy overweight women aged 20-30 years randomly divided into three equal groups, namely, ginger, ginger + high-intensity interval training (HIIT), and placebo + HIIT.

The training groups performed high-intensity interval exercises (i.e. 40-m maximal shuttle run) for ten consecutive weeks. The supplement groups daily took 3 g of ginger pills and the third group took the placebo.

The paired t-test revealed a significant decrease in the density of type 1 monocytes chemotactic protein (MCP-1) in HIIT + ginger (P = 0.026) and HIIT + placebo (P = 0.001) groups, an indication of reduced inflammation.

These results suggested that the relative and efficient role of HIIT combined with the ginger supplement in overweight women in inducing antioxidant/anti-inflammatory activity against atherosclerosis.

Furthermore, the investigation of the effects of air-dried ginger powder (0.1g/kg body weight, po, for 75 days) was carried out by the RNT Medical College, on experimentally induced atherosclerosis in rabbits by cholesterol feeding (0.3g/kg body weight, po).

Before administration of ginger powder, cholesterol feeding for 75 days led to the distinct development of atheroma in the aorta and coronary arteries of the rabbits.

The accumulation of plaque in the arteries was significantly inhibited by about 50% following ginger administration.

Moreover, ginger treatment also decreases lipid peroxidation and enhanced fibrinolytic activity associated to dissolve blood clots.

The findings indicated that ginger distinct protection from the development of atherosclerosis is attributed probably because of its free radical scavengings, prostaglandin inhibitory and fibri 

properties.

Taken altogether, ginger may be considered a functional food for the prevention and an adjunct therapy for the treatment of atherosclerosis without inducing any adverse effects.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Spices and Atherosclerosis by Tsui PF1,2, Lin CS3, Ho LJ4, Lai JH. (PubMed)
(2) The effect of a 10-week high-intensity interval training and ginger consumption on inflammatory indices contributing to atherosclerosis in overweight women by Nayebifar S1, Afzalpour ME2, Kazemi T3, Eivary SH4, Mogharnasi M2. (PubMed)
(3) Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits by Verma SK1, Singh M, Jain P, Bordia A.(PubMed)
(4) Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches by Siasos G, Tsigkou V, Kokkou E, Oikonomou E, Vavuranakis M, Vlachopoulos C, Verveniotis A, Limperi M, Genimata V, Papavassiliou AG, Stefanadis C, Tousoulis D. (PubMed)

Tualang Honey May Process a Potential for the Prevention and Treatment of Osteosarcoma

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of osteosarcoma without inducing any side effects, according to some studies suggested.

Osteosarcoma is a medical condition caused by the production of immature bone, affecting mostly younger population under the age of 25.

Male are more susceptible to the incidence, compared to female.

At the advanced stage, cancer cells can travel a distance away to infect other healthy tissue and organs, particularly, the lung.

There are 2 types of osteosarcoma.

A localized osteosarcoma is seen only in the bone. This type of osteosarcoma.
 normally started on the surface of the tissues next to the bone, such as muscle, tendon, or fat.

A metastatic osteosarcoma is a tumor which has spread to other parts of the body.

Genetic mutation of gene p53, the tumor suppressed gene is the most common cause of osteosarcoma.

However, the disease can also be acquired, due to the alternation of cells DNA caused by long-term exposure to toxic chemicals and radiation therapy.

Some researchers suggested that the increase in age, gender, height, ethnicity and other forms of bone diseases are also the prevalent risk factors associated with the onset of osteosarcoma.

Dr. Julie D. K. McNairn, the lead author in the cancer team at the SUNY Upstate Medical University examined the connection of the inheritance of osteosarcoma and Paget’s disease of bone, said, "Pagetoid osteosarcoma is a complication of Paget’s disease of bone. Sarcomatous transformation is most often seen in severe, long-standing Paget’s disease".

And, "some researchers have shown loss of heterozygosity in a region of chromosome 18q in a relatively high percentage of studied patients affected with either Paget’s disease alone, in Pagetoid osteosarcoma, and in uncomplicated osteosarcoma".

These results clearly suggested that the alternation of certain genetic material found in the chromosome 18q, more specifically 18q21-22  is associated with the onset of Pagetoid osteosarcoma.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient or whole food for the treatment of osteosarcoma without indiu=cuiing any side effects compared to the conventional treatment of surgery followed by the radio and chemotherapy, researchers investigated the antiproliferative activity of local honey (Tualang) on human osteosarcoma (HOS) cell lines.

Different concentrations of Tualang honey (1% - 20%) were applied on HOS cell lines for 3, 6, 12, 24, 48 and 72 hours.

Cellular apoptosis was done using the Annexin V-FITC Apoptosis Detection Kit.

By examining the morphological appearance after application of Tualang honey, HOS cell showed apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus.

In others words, Tualang honey incubated with the cancer cell line demonstrated a strong effect in inducing cell apoptosis through degradation.

The 50% inhibitory concentration (IC50) for HOS cell lines was found to be 3.5%.

The maximum inhibition of cell growth of ≥80% was at the concentration of 15%.

These results suggested that Tualang honey induces HOS cells apoptosis through suppressing the cancer cell viability and integrity.

Taken altogether, Tualang honey may be used as a functional food for the prevention and combined with the primary medicine for the treatment of osteosarcoma

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-osteosarcoma possibilities.

.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
(2) Inheritance of Osteosarcoma and Paget’s Disease of Bone. A Familial Loss of Heterozygosity Study by Julie D. K. McNairn,* Timothy A. Damron,† Steve K. Landas,* J. Lee Ambrose,‡ and Antony E. Shrimpton. (PMC)