Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 2 November 2018

Black beans, The Legume in the Prevention and Treatment of Benign Prostatic Hyperplasia (Enlarged Prostate)

By Kyle J. Norton

Black bean, a glossy black shell legume may have a potential effect in protecting the prostate gland against the onset of prostatic hyperplasia, scientists found.

Prostatic hyperplasia is a medical condition associated with the enlarged prostate that impedes the urinary flow.

The prostate is a gland that surrounds part of your urethra, the tube with a function to carry urine and semen out of men penis.

The condition is found mostly in aging men, as a result of free testosterone converting to hormone dihydrotestosterone (DHT). Overabundant DHT in the men body is a major cause of an enlarged prostate.

Truly, DHT has been found to plays a beneficial role in the developing prostate but it can be detrimental in the adult prostate in facilitating pathologic prostate growth, including the enlarged prostate.

The role of DHT in other adult tissues is uncertain. DHT has not been shown to perform beneficial functions unique from testosterone in the adult male, and it is believed that its fundamental effect may amplify testosterone's weaker hormonal signal.

The 5alpha-reductase inhibitors play an important role in the protection of the prostate gland by blocking the process of prostate diseases, by reducing the prostate volume, and reduce the risk of acute urinary retention and enlarged prostate.

5alpha-reductase inhibitors have been found in the low levels in aging male with prostate diseases.

Some researchers suggested that by targeting the conversion of testosterone to DHT, the enlarged prostate can be preventable.

Men who follow an unhealthy diet and lifestyle of the Western diet with a lot of saturated and trans fat, red meat, process and less in fruits and vegetable and whole grain are associated with a substantial risk of the early onset of LUTS (lower urinary tract symptoms) in describing the symptoms related to problems of the lower urinary tract (bladder, prostate, and urethra), including enlarged prostate.

Dr. Pao-Hwa Lin, the lead author in the study "Lifestyle and LUTS: what is the correlation in men?" reconfirm these statements said, "1) Epidemiological data repeatedly show a favorable relationship between healthy eating habits and regular physical activity level and a lower risk for LUTS or progression of LUTS, 2) certain specific nutrients or dietary factors may contribute to the link between diet and LUTS due to their anti-inflammatory potential, and 3) very little research has been conducted to test the epidemiological findings in randomized controlled trials".

"A healthy lifestyle with good quality diet and regular physical activity is beneficial not only for potentially improving or reducing LUTS but also for cardiovascular and overall health".

In other words, an enlarged prostate can be preventable in aging male, if they follow a healthy diet and lifestyle with moderate exercise.

Black bean is a small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The legume can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Chemical constituents of black bean include
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

In the examination to reconfirm the effect of black soybeans on benign prostatic hyperplasia (BPH), researchers launched an investigation to evaluate the anti benign prostatic hyperplasia (BPH) anthocyanin extracted from the legume on rat induced enlarged prostate.

The study included a total of male rats whose were divided into five experimental groups: a control group, a BPH-induced group, and three BPH-induced groups that received oral doses of anthocyanin (40, 80, and 160 mg/kg).

Prostate hyperplasia was induced by the administration of testosterone propionate for 4 weeks.

Anthocyanin-treated groups received the compound for 4 weeks after the induction of enlarged prostate.

The mean prostate weights for the rats receiving 40, 80, and 160 mg/kg anthocyanin were 323.00, 324.00, and 617.50 mg, respectively.

This assessment indicated the preferred dose of anthocyanin in the prevention of enlarged prostate is 40 mg.

In groups comparison, the average prostate weight in the BPH-induced group was significantly higher than in the control group (p < 0.05), whereas the prostate weights in the anthocyanin-administered groups were significantly lower than in the BPH-induced group (p < 0.05).

Furthermore, anthocyanin administration helped to prevent the change of prostate weight caused by injecting testosterone to induce prostatic hyperplasia.

Moreover, apoptotic body counts were significantly higher in groups receiving anthocyanin than in the BPH-induced group.

These results suggested that anthocyanin may be effective in decreasing the volume and suppressing the proliferation of the prostate, through inhibiting the conversion of testosterone to hormone dihydrotestosterone (DHT).

Additionally, in the testing to examine whether Seoritae extract (SE) form the black soybeans have beneficial effects on the reduction of prostate weight in a rat model of benign prostatic hyperplasia (BPH), researchers at the joint study led by the The Catholic University of Korea College of Medicine conducted an experiment with BPH induced by intramuscular injections of testosterone enanthate once a week for 5 weeks in Sprague-Dawley rats, then rats were treated with or without daily oral doses of SE during BPH induction.

After 5 weeks, the SE treatment group showed a significant decrease in prostate weight, oxidative stress, apoptosis, and 5alpha-reductase activity compared to the nontreated BPH group.

These results coincidently showed that SE is effective in decreasing the weight and proliferation of the prostate similar to those of the above study

Dr. Hoon Jang, the lead scientists suggest that SE may be an effective treatment for BPH.

Taken all together, black beans containing the abundant major bioactive compound anthocyanin may

be considered a functional food for the prevention and treatment of the early phase of enlarged prostate with no side effects, depending on the further the human studies.

References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia by Hoon Jang,1 Woong-Jin Bae,1 Seung-Mo Yuk,1 Dong-Seok Han,1 U-Syn Ha,1 Seong-Yeon Hwang,2 Shin-Hee Yoon,3 Sae-Woong Kim,1 and Chang-Hee Han. (Hinwadi)
(3) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model. by Jang H, Ha US, Kim SJ, Yoon BI, Han DS, Yuk SM, Kim SW. (PubMed)
(4) Lifestyle and LUTS: what is the correlation in men? by Pao-Hwa Lin, PhD1 and Stephen J. Freedland, MD. (PMC)

Thursday, 1 November 2018

Banana Enhances the Immune Function Against Infectious Diseases, Scientists Say

By Kyle J. Norton

Scientists may have found a whole food which processes a potential effect to improve the function of the immune system against infectious micro-pathogens, some studies suggested.

The immune system is the body's defense against infectious organisms and other invaders, by activating the systematic immune response.

In the acute phase of infection, macrophages, the first line of immune defenses stimulate the production of proinflammatory cytokines to the site of infection with an aim to protect the injured or damaged tissue against foreign invasion.

However, overproduction of the proinflammatory cytokines can cause damage to the healthy cells and improper healing with the formation of scars.

Immune system disorders are a chronic condition caused by the abnormal under-activity or over-activity of the immune system.

In an overactive immune system or autoimmune disorders, the immune white blood cells mistakenly attack and damage the bodily tissue.

The underactive immune disorders are also known as the immune deficiency diseases, weakening the immune ability to fight invaders, and increasing the risk of infections.

Dr. Wypych TP, the lead author in the study "The Impact of Diet on Immunity and Respiratory Diseases" wrote, "the "diet hypotheses," pointing to the importance of changes in our dietary habits" and "the interplay between the Western diet, microbiota, and inflammatory conditions".

In other words, the Western diet high in saturated and trans fat, a lot of red meats, processed foods and less in fruits and vegetable may play an important role in either weakening the immune system or causing overactive immune system in the facilitation of the onset of autoimmune diseases.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belonging to the family of the lily and the orchid.

In the examining the effect of the hot-extracts isolated from fruit's peel of banana on human health researchers at the joint study led by the National Pingtung University of Science and Technology launched an evaluation to observe the antibacterial activity from aquatic animals, and immunostimulating potential, disease resistance and anti-hypothermal stress in giant freshwater prawn, Macrobrachium rosenbergii.

The injection od banana hot extracts demonstrated a strong activity against 1 Gram-positive and 3 Gram-negative pathogens, including Lactococcus garvieae, Photobacteria damsella.

Prawn received BPE via injection at 1-6 μg (g prawn)(-1) significantly enhanced the immunity through the increased total hemocyte count (THC), hyaline cell (HC), granular cell (GC), phenoloxidase (PO) activity and phagocytic activity against L. garvieae from 3 to 6 days.

The extracts also significantly increased clearance efficiency against L. garvieae and a significantly decreased coagulation time of prawn from 1 to 6 days and levels of antioxidant enzymes in the body.

The survival rates of Macrobrachium rosenbergii injected with BPE at concentrations of 1, 3 and 6 μg (g prawn)(-1) were significantly higher than those injected with saline control after challenge with L. garvieae for 4-6 days, and the respective relative survival percentages of prawn were 28.6%, 38.1%, and 47.8%, respectively at 6 days, an indication of the improved immune system against the attack of pathogens.

These results suggested that BPE may be a pharmaceutical candidate to be used as the bacteriostat, and immunostimulant and physiological regulator through enhancing the immunity, physiological responses, and resistance against infectious stimuli.

Additionally, in the evaluate the antagonistic mechanisms of Lactobacillus plantarum CIF17AN2 (an infant isolate), saba starch (banana), and their synbiotic combination against Salmonella Typhimurium SA2093, researchers found that
* The L. plantarum CIF17AN2 exhibited anti-Salmonella mechanisms through secretion of antimicrobial compounds, adhesion ability and competitive adhesion to mucin on HT-29 cell line.

* The effects of Lactobacillus plantarum CIF17AN2 on the Salmonella inhibition was significantly reduced in the presence of human fecal microflora.

* The combination of saba starch with L. plantarum CIF17AN2 showed the greatest inhibition against Sal. Typhimurium SA2093 in the colon model.

* The enhancement of anti-Salmonella activity due to the addition of saba starch corresponded a significant decrease in pH and an increase of lactic acid and short chain fatty acids.

These results suggested that banana starch can be used alone or combined with other ingredients for the treatment of Salmonella T. infection.

Taken altogether, banana may be considered a function in enhancing the immune function against microorganisms, which cause infectious diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.

References
(1) Effects of hot-water extract of banana (Musa acuminata) fruit's peel on the antibacterial activity, and anti-hypothermal stress, immune responses and disease resistance of the giant freshwater prawn, Macrobrachium rosenbegii by Rattanavichai W1, Cheng W. (PubMed)
(2) Antagonistic mechanisms of synbiosis between Lactobacillus plantarum CIF17AN2 and green banana starch in the proximal colon model challenged with Salmonella Typhimurium by Uraipan S1, Brigidi P2, Hongpattarakere T3. (PubMed)
(3) The Impact of Diet on Immunity and Respiratory Diseases by Wypych TP1, Marsland BJ1, Ubags NDJ.(PubMed)

Strawberry, the Functional Food Which Processes anti Neurological Diseases Potential, Scientists Say

By Kyle J. Norton

Strawberries may process strong neuroprotective effects by protecting the brain cell integrity and viability against the onset of neurological diseases, some scientists suggested.

A neuroprotective effect is an event that protects the central nervous system (CNS) by relatively preserving of neuronal structure and/or function.

Neurological diseases are the medical conditions of brain disorder. Anything that involves the structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves, including brain damage are considered as neuro diseases.

Most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunction, dementia can be Parkinson's, Alzheimer's, and Huntington's disease.

Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant inherited cause of stroke and vascular dementia.

Poor lifestyle choices, such as smoking, overuse of alcohol, lack of physical activity and inadequate relief of chronic stress and poor diet with high in saturated and trans fat, red meat, processed foods and less in fruits and vegetable and whole grain are some of the key contributors in the development and progression of chronic diseases, including neurological diseases.

Dr. Null G, the lead author in the study "Nutrition and Lifestyle Intervention on Mood and Neurological Disorders" said, "a vegan diet, fruit and vegetable juices, nutritional supplements, regular exercise, and de-stressing techniques, would affect 27 subjects with anxiety, depression, poor memory, dementia, Alzheimer's disease, Parkinson's disease, history of stroke, or multiple sclerosis. Several subjects had overlapping conditions" and " an intervention of diet, juicing, supplements, exercise, and lifestyle may provide considerable benefits for all conditions addressed.".

These results suggested that if you are following a healthy diet and lifestyle, your risk of neurological diseases is substantially lower compared to people who follow the Werten diet with physical inactivity.

Strawberries are a genius of Fragaria × ananassa belongs to the family Roseaceae.

The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

In the assessment of the neuroprotective effects of a unique class of nutraceutical antioxidants, anthocyanins, against the MOS-induced death of cultured cerebellar granule neurons (CGNs), researchers at the University of Denver conducted a study to evaluate the effect of callistephin and kuromanin, the anthocyanins derived from strawberries.

The tested anthocyanins derivatives demonstrated significant protection from MOS-induced apoptosis, equivalent to those of the green tea polyphenol, epigallocatechin 3-gallate.

Callistephin and kuromanin also exerted a neuroprotective activity by preventing inhibition of Bcl-2, a cellular proliferative protein that causes a significant reduction of mitochondrial GSH, cell antioxidant enzyme.

Furthermore, the anthocyanins derivative inhibited iron-induced lipid peroxidation in rat brain homogenates and prevented cardiolipin oxidation in the induction of neurological damage.

Moreover, the anthocyanin derivative significantly enhanced GSH, an antioxidant enzyme produced by the host body observed by the peroxidase activity in a cell-free assay.

Additionally, in the reassessment the mechanisms involved in the repair or elimination of damaged neurons, Dr. Winter AN, the team leader scientist at joint study led by the University of Denver, launched an evaluate to compare the ability of same derivatives of anthocyanins, callistephin (pelargonidin-3-O-glucoside) and kuromanin (cyanidin-3-O-glucoside) in the protection of cerebellar granule neurons from damage induced by either oxidative or nitrosative stress.

Both callistephin (pelargonidin-3-O-glucoside) and kuromanin protected neurons from oxidative stress induced by glutamate excitotoxicity, observed under conditions of nitrosative stress.

Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides, they cannot be given orally and do not enter the brain if given intravenously.

However, only kuromanin displayed the capacity to defend neurons from nitric oxide (NO)-induced apoptosis.

The team at the final report, said, "(There must be) a unique mechanism by which slight structural variances, specifically the absence or presence of a catechol moiety, lend kuromanin the unique ability to generate superoxide, which acts as a scavenger of NO".

These results suggested that anthocyanins may be used for treating neurodegenerative diseases, even kuromanin and compounds that share similar chemical characteristics may be more effective than the therapeutic agents forthan callistephin and related (non-catechol) compounds.

In the summary Dr. Shukitt-Hale B, the lead scientist at the USDA-ARS Human Nutrition Research Center on Aging at Tufts University there is no coincidence that the berry fruit supplementation, polyphenolic compounds found in berry fruits, such as blueberries and strawberries, exerted their beneficial effects either through their ability to lower oxidative stress and inflammation or directly by altering the signaling involved in neuronal communication, calcium buffering ability, neuroprotective stress shock proteins.

Taken all together, intake of strawberry daily and regularly may have a profound effect in the protection the brain neurons against the onset of neurological diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) The strawberry: composition, nutritional quality, and impact on human health. by Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M.(PubMed)
(2) Phenolic Composition of Strawberry Genotypes at Different Maturation Stages(ACS Publication)
(3) The Promise of Neuroprotective Agents in Parkinson’s Disease by Stacey E. Seidl and Judith A. Potashkin(Frontiers in Neurology)
(4) Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress. by Kelsey N, Hulick W, Winter A, Ross E, Linseman D.(PubMed)
(5) Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin, and kuromanin, against nitrosative stress by Winter AN1, Ross EK1, Khatter S1, Miller K2, Linseman DA. (PubMed)
(6) Berry fruit supplementation and the aging brain. by Shukitt-Hale B, Lau FC, Joseph JA.(PubMed)
(7) Nutrition and Lifestyle Intervention on Mood and Neurological Disorders by Null G1, Pennesi L2, Feldman M. (PubMed)

Green Tea and its Bioactive Polyphenol Epigallocatechin 3-gallate (EGCG) in the Alleviated Symptoms, Reduced Risk and Treatment of Arthritis

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reducing risk, progression, and treatment of arthritis, some scientists suggested.

Arthritis is a chronic condition characterized by painful inflammation and stiffness of the joints.

According to statistic, arthritis is the common autoimmune disorder affected over 50 million worldwide.

The exact causes of arthritis are unknown, Some researchers suggested that longterm use in stimulating the wear and tear is a major cause of rheumatoid arthritis (RA), the most common forms of arthritis.

An infection or injury to the joints that were not treated properly can also exacerbate the natural breakdown of cartilage tissue, leading to arthritis in the later life.

Certain risk factors proved by clinical trials and human studies such as overweight and obesity, occupations that require the use of hand or leg in the repetitive movement, including knee bending and squatting are associated with the early onset of arthritis.

Smoking, family history, gender and gene mutation inherited from the parents, such as human leukocyte antigen (HLA) genes, are also considered some prevalent risk factors of the disease.

Depending on the type of arthritis that affects the patients. Patients with arthritis may be experiencing symptoms of pain stiffness swelling and reduced the range of motion. If you have some of the above symptoms, you may already be infected by arthritis.

Moreover, if you are taking medicine to alleviate symptoms of arthritis, please make sure that you discuss the side effects with your doctor.

According to the Arthritis Foundation, long-term untreated rheumatoid arthritis can complicate the risk of heart disease.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in the treatment of arthritic disease.

In vitro, application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reducing expression of proinflammatory cytokines IL-1β, TNFα, and IL-6 and modulated extracellular matrix (ECM) turnover-induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well as driving the progression of the disease in the presence of inflammation.

Normal extracellular matrix (ECM) is a composed collagen type II with a function to provide tensile support for the tissue.

Further analysis in the expression of proinflammatory factors researchers found that the overexpression of proinflammatory cytokines IL-1 and IL-6 associated correlatively in knee joints in arthritis were inhibited by green tea EGCG.

Some researchers also suggested that interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions that lead to chronic inflammation.

In the expression of tumor necrosis factor (TNF), tumor necrosis factor alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα , the proinflammatory cytokine with a function in inducing synovial fibroblast cytotoxicity.

Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in the stimulation of free radical chain reaction to initiate production of pro-inflammatory cytokines in precipitating chronic diseases.

Rats treated with green tea EGCG also showed a significant improvement in restoring the natural antioxidant glutathione (GSH) and protein thiol levels produced by the body.

Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered a risk factor for the development of arthritis.

Increased activity glucose 6-phosphate dehydrogenase was associated with reactive oxygen species (ROS) generated in oxidative metabolism that inflicts damage on all classes of macromolecules.

Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) in mice, compared to control received phosphate buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorating clinical symptoms and reducing histological scores in arthritic mice, through modulating the immune activity by stimulating the production of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.

EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes, and microglia in the activation of the immune system to attack the dendritic cell located on the surface on the joint tissue.

Application of the EGCG also increased frequencies of T regs with a dominant role in the suppression of autoimmune pathology.

Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect in both the prevented and reversed arthritis disease.

Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered a functional food and supplement in alleviating the symptoms, reducing risk, and treatment of arthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM. (PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)

Green Tea, The Beverage Which Protects the Brain Functioning Against the Onset of Mood Disorder

By Kyle J. Norton, Master of Nutrition

Green tea may have a potential and positive effect in treating mood disorder, some scientists suggested.

Mood disorder is a psychological condition characterized by an elevated mood, including mania or hypomania. In other words, the syndrome is a group of mental illnesses that can affect how a person feel and think of him/herself and people in the public life.

Mood disorder can be classified into depression, dysthymic disorder,... and bipolar disorder depending on the symptoms of expression.

The condition not only affects the personal life of the patient but also cause psychological and financial burdens to the immediate family members as the condition can only get worse over time.

According to the statistic in 2017, over 2.6 millions Canadian age 12 and over were diagnosed with mood disorders, affecting over 8% of general population. Sadly, about one in seven Canadian will experience a mood disorder at some point in their life.

The exact causes of mood disorders are unknown, however, there are some underlying factors that can elevate the risk of the condition, including family history, previous mood disorder, depression, certain medical conditions and long-term use of some medication.

Symptoms of mood disorders are totally depending to types of the syndrome. If you are experiencing symptoms of feelings of hopelessness, long-term trouble sleeping or daytime sleepiness, poor concentration and trouble concentrating or making decisions accompanied by physical symptoms of fatigue or low energy, you may have mood disorders. Please check with your doctor to rule out the possibility.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In the concerns of the widespread of mental disorders, researchers at the Elsevier GmbH.lauched an investigation to examine the effects of green tea or green tea extracts, l-theanine and epigallocatechin gallate both components of green tea-on general neuropsychology, on the sub-category cognition and on brain functions in humans.

By searching the database of medical literature in PubMed for qualified studies that are satisfied the guidelines and criteria set by the PRISMA statement.

Out of 21 selected studies, 4 were randomized controlled trials, 12 were cross-over studies (both assessed with an adapted version of the DELPHI-list), 4 were cross-sectional studies and one was a cohort study (both assessed with an adapted version of the Newcastle-Ottawa assessment scale).

After assessing the results of all studies, researchers found that injection of green tea exerts a significant effect in psychopathological symptoms (e.g. reduction of anxiety), cognition (e.g. benefits in memory and attention) and brain function (e.g. activation of working memory seen in functional MRI).

Further analysis also suggested that the effects of green tea may be attributed to the combined influence of both caffeine and l-theanine, as separate administration of either substance is found to have a lesser impact.

Moreover, in the systematic review and meta-analysis conducted on 11 randomized placebo-controlled human studies of acute effects of tea constituents L-theanine and epigallocatechin gallate, administered alone or in combination with caffeine, on cognitive function and mood, researchers discovered that

* Combined caffeine and L-theanine demonstrated some moderate effects in the first 2 hours postdose, on ladder alertness, attentional switching accuracy, and, to a lesser extent, some unisensory and multisensory attentional outcomes.

* Caffeine and L-theanine doses revealed trends toward greater change in effect size for caffeine dose than for L-theanine dose, particularly during the first hour postdose.

Additionally, in the study to evaluate whether tea has any effect on mood and performance benefits, such as relaxation and concentration, researchers at the From Unilever Research and Development also conducted an extensive search of studies with consistent evidence for improved attention.

At the final report, researchers concluded after taking into account co and confounders
* Tea consumption also consistently improved self-reported alertness and arousal, whereas effects on pleasure or relaxation were less consistent.

* Intake of tea regularly has a strong impact on psychological function such as work performance and creativity.

The findings suggested that moderate green tea consumption regularly and daily has significant acute benefits in both mood and performance in real-life situations.

Taken all together, there is no doubt that green tea containing numbers of highly bioactive compounds such as caffeine, l-theanine, and epigallocatechin gallate may be considered a functional food to protect the brain functioning against the onset of mood disorders.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea effects on cognition, mood and human brain function: A systematic review by Mancini E1, Beglinger C2, Drewe J2, Zanchi D1, Lang UE1, Borgwardt S3(PubMed)
(2) Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis by Camfield DA1, Stough C, Farrimond J, Scholey AB(PubMed)
(3) Acute effects of tea consumption on attention and mood by Einöther SJ1, Martens VE. (PubMed)

Fennel Essential Oil and Extract, The Potent Anti Hypoglycemic Remedies, Scientists Reveal

Kyle J. Norton, Master of Nutrition

Fennel may process a strong effect in preventing the abnormal rise of blood glucose in patients with diabetes, some scientists found.

In compared to hyperglycemia with an excessive amount of glucose that circulates in the blood plasma, hypoglycemia is a condition of blood sugar, that falls below the levels of the normal range.

Patient with acute hypoglycemia may experience symptoms of clumsiness, trouble talking, confusion, loss of consciousness, seizures or death.

Most cases of hyperglycemia in patients with diabetes are due poor management. However, eating more carbohydrates than usual, less physical activity compared to normal day being sick or high levels of stress in patients with diabetes also can cause blood glucose uptake.

Some researchers suggested that not getting the right dosage of insulin and glucose-lowering medication also cause increased blood glucose levels.

Long-term untreated hyperglycemia can elevate the onset of some serious complications including nerve damage, kidney damage and failure, heart disease and eye disease, particularly in food and skin problems. or retinopathy foot problems caused by damaged nerves and poor blood flow skin problems, such as bacterial and fungal infections

Fennel (Foeniculum vulgare) is a plant species belongings to the family Apiaceae (Umbelliferae), native to the Mediterranean

The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the examine the antihyperglycemic activity of fennel essential oil in an animal model, researchers launched an investigation to evaluate of rats induced by bacterial streptozotocin.

At the concentrations of 30 mg/kg body weight, essential oil of fennel demonstrated a correction of hyperglycemia in the doses from 162.5 mg/dL to 81.97 ± 1.97 mg/dL by increased the serum of antioxidants activity of serum glutathione peroxidase from 59.72 U/g Hb to 99.60 U/g Hb produced by the host.

The application also improved the pathological changes noticed in their kidney and pancreas, compared to the control group.

After making the final adjustment, researchers suggested that the study not only reaffirms the use of essential oil of fennel for the treatment of hyperglycemia in folk medicine but also raises the possibility of essential oil inclusion in the antidiabetic drug industry.

Further analysis of the ethanolic and aqueous extracts of selected Sudanese plants, including fennel that is traditionally used to treat diabetes, researchers at the Khartoum College of Medical Sciences, suggested that fennel extract reveals a significant antioxidant activity in DPPH free radical scavenging assay.

However, injection of fennel extract exhibited the highest toxicity.

These findings indicated that although fennel extract processes a substantial and positive effect in reducing the spike of blood glucose intake and the use of the fennel extract can only be prescribed by herbalists and professionals in the related field.

Additionally, in the testing, the hypoglycemic effect of single dose of Gluconorm-5 (150, 300 and 600 mg/kg body weight) made up of five plants namely Camellia sinensis, Punica granatum, Macrotyloma uniflorum, Foeniculum vulgare and Trigonella foenum-graecum in normal, glucose loaded normal and diabetes-induced rats, researchers found that

* Fifteen days of oral feeding of the Gluconorm-5 (300 and 600 mg/kg) to diabetic rats resulted in a significant (P < 0.01) reduction of blood glucose, lipid profile, liver weight, and marker enzymes as compared to those rats in whom STZ induced toxicity was untreated.

* The diabetic rats treated with the formula showed the expanded islets compared to the untreated diabetic rats, which showed the shrunken islets.

* Treated rats received 300 mg/kg of Gluconorm-5 showed pronounced antidiabetic, antihyperlipidemic and hepatoprotective effect.

This comprehensive differentiation showed that Gluconorm-5 processes a potent antidiabetic antihyperlipidemic and hepatoprotective effect properties.

Taken altogether, fennel extract, fennel essential oil used alone or combined with other herbal antidiabetic herbal medicine can be considered an adjuvant in the treatment of hyperglycemia and diabetes mellitus.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential by Hilmi Y1, Abushama MF, Abdalgadir H, Khalid A, Khalid H(PubMed)
(3) The Dietary Furocoumarin Imperatorin Increases Plasma GLP-1 Levels in Type 1-Like Diabetic Rats by Wang LY1,2,3, Cheng KC4, Li Y5,6, Niu CS7, Cheng JT8,9, Niu HS(PubMed)
(4) Antidiabetic antihyperlipidemic and hepato-protective effect of Gluconorm-5: A polyherbal formulation in steptozotocin induced hyperglycemic rats by Gengiah K1, Hari R2, Anbu J(PubMed)

Green Tea, A Potential Healthy and Longevity Functional Food, Scientists Find

By Kyle J. Norton

Regular and daily moderate green tea intake may have a potential effect in increasing the lifespan in human, some scientists suggested.

Some researchers suggested that human longevity without health issue can be achieved through a healthy diet and lifestyle.

Dr. Small GW, the lead author in the study "A short-term healthy lifestyle program combining mental and physical exercise, stress reduction, and healthy diet was associated with significant effects on cognitive function and brain metabolism. Reduced resting activity in the left dorsolateral prefrontal cortex may reflect the greater cognitive efficiency of a brain region involved in working memory".

Would these results be enough for a person to live longer and healthier?

Eating the right foods can lead to a longer, healthier life. Some researchers recommended the following diet for the elderly to liver longevity without some major health issues.

* A basic heart-healthy diet including fruits and vegetables, whole grains, low-fat dairy products like yogurt and cheese, skinless poultry, lots of fish nuts and beans and non-tropical vegetable oils can help to control your weight, because more than a third of people 65 and older are obese, the major cause of diabetes, some cancers, and heart disease.

* A basic brain-healthy diet including lean meats, deep-sea fish, skim milk products and some whole grain cereals that reduces risk neurodegenerative disease can improve the memory.

* A basic protein diet to build the muscle diet including low-fat or fat-free yogurt, cheese, milk, lean meats, fish, other seafood, and beans.

* A basic diet including calcium and vitamin D in fortified foods, fish like salmon, and dairy products. to build the bone.

In the study to reaffirm the effect of green tea in increasing lifespan in various experimental animal models, researchers at the University of California Irvine launched an investigation to examine whether green tea acts to increase the lifespan of the fruit fly by modulating iron regulators, specifically, mitoferrin, a mitochondrial iron transporter, and transferrin, found in the hemolymph of flies

Application of green tea increased the lifespan of transferrin mutant lifespan but not the mitoferrin mutants and fertility, compared to the increased male fly lifespan and reduced male fertility in the non-mutant group.

These results suggested that green tea may act to increase the lifespan of Drosophila in part by the regulation of mitoferrin and reduction of mitochondrial iron.

Continued to the above investigation, researchers found that the lifespan extension properties of green tea were only observed in the presence of females which alludes to a reproductive (or mating) dependent mechanism.

Furthermore, the application of green tea exerted a strong and negatively impact on male fertility as shown by a reduced number of offspring produced and increased mating latency

These correlations suggested that green tea extends the lifespan of male flies by inhibiting reproductive potential, possibly by limiting iron uptake.

Researchers at the final report indicated green tea may have a profound effect in increasing lifespan but a negative effect on reproductive fitness in humans.

Moreover, in the study of a standardized epigallocatechin-3-gallate (EGCG) rich green tea extract (comprising > 90% EGCG) effects on fitness and lifespan as well as parameters of glucose metabolism and energy homeostasis in the fruit fly, Drosophila melanogaster, researchers found that
* The application of the green tea extract demonstrates a significant increase in the mean lifespan (+ 3.3 days) and the 50% survival (+ 4.3 days) as well as improved fitness

* These effects went along an increased expression of Spargel, the homolog of mammalian PGC1α whose dysfunction is associated with accelerated aging, decreased mobility and decreased lifespan.

* Treatment with the green tea extract decreased glucose concentrations.

Dr. Wagner AE, the lead scientist said, "a decrease in glucose metabolism in connection with an upregulated expression of Spargel contribute to the better fitness and the extended lifespan in EGCG-treated flies".

Taken all together, green tea may have a profound effect in increasing lifespan in human, depending on the confirmation of further data collection from the large example size and multi-center studies.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster by Lopez TE1, Pham HM1, Nguyen BV1, Tahmasian Y1, Ramsden S1, Coskun V1, Schriner SE1, Jafari M. (PubMed)
(2) Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness by Lopez T1, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M.(PubMed)
(3) Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster by Wagner AE1, Piegholdt S1, Rabe D1, Baenas N1,2, Schloesser A1, Eggersdorfer M3, Stocker A4, Rimbach G. (PubMed)
(4) Effects of a 14-day healthy longevity lifestyle program on cognition and brain function by Small GW1, Silverman DH, Siddarth P, Ercoli LM, Miller KJ, Lavretsky H, Wright BC, Bookheimer SY, Barrio JR, Phelps ME. (PubMed)
(5) Foods for a Strong Heart, Brain, and Bones By John Donovan