Detoxification: Coffee, The Beverage Which Detoxes Our Body Against Chemo-Drugs, Radiation and Chemicals Toxins, Scientists Say

Kyle J. Norton (Master of Nutrition, All right reserved)
Coffee and coffee caffeine may have a profound and positive effect in detoxification of genotoxicity, caused by chemo-drugs, radiation and environment chemicals toxins, some scientists suggested.

Genotoxicity is activity of substances that can cause alternation of DNA of healthy cells to promote irregular cells growth. In other words, genotoxicity is an action that induces cancers.

Genotoxins are gene mutagens which have the property of genotoxicity,  including radiation and chemical toxins.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In rat liver and primary hepatocytes, regular intake of coffee daily illustrated a enormous effect in cellular antioxidant defenses through regulating exhibited enzymes involved mRNA and protein expression.

The study also suggested that coffee and coffee caffeine through expression of detoxifying enzymes GSTs and AKR(in cellular detoxification) also demonstrated a significant activity in reduced risk of genotoxicity and cytotoxicity caused by injection of aflatoxin B1 (AFB1).

Dr. Cavin C, ther lead author said, " the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses".
(Please note that Nrf2-ARE pathway is an indicator and modulator of oxidative stress)

Other, in the evaluated L5178Y mouse lymphoma cell line to assess modulatory effects of coffee against genotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG), researchers found that
* 3 doses of instant coffee caffeine injection displayed a decrease in genotoxicity following co-treatment of mouse lymphoma cells.

*. Coffee caffeine pre-treatment or co-treatment exhibited significant antigenotoxic effects against MNNG(an environmental carcinogen that causes DNA mutation) expression.

* Both caffeinated and decaffeinated instant coffee demonstrated a similar effect against genotoxicity in the experiment samples.

Dr. Abraham SK, the lead authors said, " Results from three or five independent experiments demonstrated significant protective effects of caffeinated instant coffee against MNNG-induced DNA damage in the comet assay, mutation at the Tk locus and chromosomal damage in the cytokinesis-block micronucleus test".

The Swiss Federal Institute of Technology (ETH), in the study of protective effects of coffee against somatic mutation and mitotic recombination induced by chemo drugs, cyclophosphamide (CPH)(, mitomycin C (MMC) and urethane (URE), using standard (ST) and high bioactivation (HB) crosses of the wing spot test in Drosophila melanogaster assays, suggested that in dose depending, coffee injection showed a strong effect in the genotoxicity of URE in the ST and the genetically susceptible HB cross as well as the genotoxicity caused by MMC application.

Dr. Abraham SK, the lead researcher said, "The magnitude of the protective effects of coffee against these three genotoxins was independent of the genotype of the larvae used for treatment, that is it was independent of the bioactivation capacity of these larvae".

The collective information showed a definitive support in used of coffee and coffee caffeine as functional food in reduced risk against genotoxic expression, including side effects of chemo medicine used in treatment of multi types of cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science,  ISSN 0975-6299.

Sources
(1) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)
(2) Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells by Abraham SK1, Stopper H.(PubMed)
(3) Protection by coffee against somatic genotoxicity in Drosophila: role of bioactivation capacity by Abraham SK1, Graf U.(PubMed)

Infectious Diseases: Herbal Fennel, The Natural Alternative to Antibiotics With No Side Effects

By Kyle J. Norton, Master of Nutrition

Fennel may be the next natural antibiotics used for treatment of diseases caused bacterial infection with no side effects, some researchers suggested.

Although most micro bacteria are harmless, some are pathogenic.

Most common bacterial pathogens that cause human diseases are Staphylococcus aureus and group A β-hemolytic streptococci.

According to statistic provided by the World Health organization, approximately, 50,000 men, women and children are dying from infectious diseases every day world wide.

Some researchers suggested that over span decades or centuries, the epidemiological transition provides the central narrative of global health, including a reduction in mortality and creation of larger and older populations in which the main causes of illness are chronic infectious diseases.

Although, in comparison to the third world, the prevalence of infectious diseases in the UK has reduced dramatically over the last century, the rate of infectious diseases caused by pathogen still have a strong and negative impact in major health, social and economic issues.

Each year in UK, infectious diseases was found to cause 576 of days lost due to disability, out of 1000 population, according to statistic reported by Somerset Intelligence.

Most common symptoms of infectious diseases include fever, diarrhea, fatigue, tiredness, muscle aches,..... coughing. However, signs and symptoms may vary, depending on the pathogen, causing the infection.

Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), native to the shores of the Mediterranean. It is now widely cultivated all around the globe to use as food and herb.

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

Chemical constituents(1)(2)
1. 1,3-benzenediol
2. 1-methoxycyclohexene
3. O-cymene
4. Sorbic acid,
5. 2-hydroxy-3-methyl-2-cyclopenten-1-one
6. Estragole
7. Limonene-10-ol
8. 3-methyl-2-cyclopenten-1-one
9. Linoleic acid
10. Oleic acid
11. Undecanal
12. 2,4-undecadienal
13. trans-Anethole
14. Fenchone
15. Limonene


In the study to examine 3 different essential oils from grown cultivars of Egyptian fennel, researchers found that according to chromatography/mass spectrometry analysis, all chemical compounds isolated from 3 essential oil processing a strong antioxidant activity in inhibited pathogenic bacteria including two species of fungi, two species of Gram negative and two species of Gram positive bacteria.

Further analysis also suggested that the efficacy of compounds isolated from essential oil from 3 species of fennel was attributed to its free radical scavenging, anti lipid peroxidation and metal chelating properties.

Additionally, in the observation of essential oils antioxidant activity from Foeniculum vulgare commercial aerial parts and fruits isolated by hydrodistillation, researchers at the Universidade do Algarve conducted an experiment, using different distillation times (30 min, 1 h, 2 h and 3 h), and analyzed by GC and GC-MS in isolated chemical compounds from obtained fennel essential oil.

According to the analysis of the agar diffusion method. trans-Anethole (31-36%), alpha-pinene (14-20%) and limonene (11-13%), the main components of the essentials oil isolated from F. vulgare dried aerial parts, and exerted a significant anti bacterial activity compared to methyl chavicol (= estragole) (79-88%) dominant in the fruit oils.

In DPPH method, according to measurement of  oxidative stress, plant essential oils showed better antioxidant activity compared to the fruits oils.

Dr, Miguel MG, the lead author wrote at the end of the experimental report, "None of the oils showed a hydroxyl radical scavenging capacity > 50%, but they showed an ability to inhibit 5-lipoxygenase. The essential oils showed a very low antimicrobial activity. In general, the essential oils isolated during 2 h were as effective, from the biological activity point of view, as those isolated during 3 h".

These results suggested that the effect of chemical compounds in inhibited pathogenic bacteria is isolated time dependable. Only those isolated less than 2 hours are process strong anti bacterial capability.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

References
(1) Antimycobacterial activity of constituents from Foeniculum vulgare var. dulce grown in Mexico.by Esquivel-Ferriño PC1, Favela-Hernández JM, Garza-González E, Waksman N, Ríos MY, del Rayo Camacho-Corona M.(PubMed)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA.(PubMed)
(3) Foeniculum vulgare essential oils: chemical composition, antioxidant and antimicrobial activities by Miguel MG1, Cruz C, Faleiro L, Simões MT, Figueiredo AC, Barroso JG, Pedro LG.(PubMed)

Strawberries, The Healthy Fruit Which Protects Cell Membranes Integrity Against Lipid Peroxidation in Induction of Chronic Syndromes and Diseases, Researchers Reveal

Kyle J. Norton (Master of Nutrition, All right reserved)

Strawberries may be the next natural whole used as inhibitor for treatment of  syndromes and diseases caused by over expression of lipid peroxidation, the process which free radical steal molecules from the lipids of the cell membranes to induce cells damage.

Lipid peroxidation occurred naturally in small amount in the body. In healthy individual, the process generated by ROS is neutralized by antioxidants produced in the host tissue.

However, over expression of lipid peroxidant can cause imbalance of the ratio of free radicals and antioxidants, weakening the antioxidant enzyme in induction of oxidative stress, a leading cause of numbers of chronic diseases, including diabetes,.... and cardiovascular disease.

More precisely, over expression of free radicals is characterized by inflammation or cell injury hydroxyoctadecadienoic acids (HODEs), markers of disease involving oxidative stress of low density lipoproteinomes (LDL) at 10-100 higher concentration in compared to LDL from healthy individuals.

Epidemiological studies also found that the effect of selected dietary factors plays an essential role of lipids in induction of oxidative stress and antioxidant defenses. Increase intake of antioxidant vitamins C (ascorbic acid) and E (alpha tocopherol) and the type of fatty acids (mono- and poly-unsaturated) may have a strong implication in reduced over expression of lipid peroxidation.

Truly, lipid peroxidant is a double edge sword, on one hand, under normal condition, it exerts physiological and protective function as signaling molecule stimulating gene expression and cell survival.  And on the other hand, in the over expression environment, the process plays a cytotoxic role in inhibiting gene expression and promoting cell death.

Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood.

The special particle called lipoprotein moves this waxy, soft substance from place to place.

If you have too much low density lipoprotein LDL, overtime over expression of lipid peroxidation can cause cholesterol  building up in your arterial walls, leading to  arterial blockage induction of heart attack and stroke.

Strawberries is a genius of Fragaria × ananassa belongs to the family Roseaceae., grown all over the world with suitable climate for commercial profits and for health benefits.

Nutrients and Chemicals constituents
1. Carbohydrate
2. Dietary fiber
3. Omega 3 fatty acid
4. Calcium
5. Iron
6. Magnesium
7. Phosphorus
8. Potassium
9. Sodium
10. Zinc
11. Copper
12. Manganese
13. Selenium
14. Vitamin C
15. Thiamin
16. Niacin
17. Pantothenic acid
18. Vitamin B-6
19. Folate
20. Vitamin B-12
21. Vitamin A
22. Vitamin E
23. Vitamin K
24. Etc.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

According to the study by the Università Politecnica delle Marche, stawberry processes high content of essential nutrients and beneficial phytochemicals, such as major antioxidants anthocyanin and ellagitannins which has been found to inhibit ROS in initiation of cytotoxic attack of the cell membrane, a leading cause of lipid peroxidants.

Highest concentrations of anthocyanins were found from ripe strawberry in compared to unripe one.

Furthermore, the study of strawberry flavonoids in extertion of potent antioxidants and anti-inflammatory activity, researchers conducted a test of freeze-dried strawberry powder (FSP) properties of lowering fasting lipids and biomarkers of oxidative stress and inflammation at four weeks in compared to baseline.

In the total of 16 female enrolled in the study, 3 features of metabolic syndrome with waist circumference >35 inches, triglycerides > 150 mg/dL, fasting glucose > 100 mg/dL and < 126 mg/dL, HDL <50 mg/dL, or blood pressure >130/85 mm Hg).

Participants were given two cups of the strawberry drink daily for four weeks with each cup had 25 g FSP blended in water. Biomarkers of oxidative stress and inflammation were measured using ELISA techniques. Plasma ellagic acid was measured using HPLC-UV techniques.

At the end of the study, researchers found that

* Total cholesterol and LDL-cholesterol levels were significantly lower at 4 weeks versus baseline (-5% and -6%, respectively, p < 0.05),

* Lipid peroxidation in the form of malondialdehyde and hydroxynonenal (-14%, p < 0.01) was also lower significantly.

* Interestingly, Oxidized-LDL showed a decreasing trend at 4 weeks

These results suggested that short-term supplementation of freeze-dried strawberries exert hypocholesterolemic effects and decrease lipid peroxidation in women with metabolic syndrome.

Moreover, in the examine the effects of strawberry major phytochemicals on the radicals DPPH and OH with doese ofrom 50-100 μl extract in vitro, researchers showed that

* Injection of strawberry deceases activity of lipid peroxidation (LPO) through intercepted levels of level of Malondialdehyde (MDA)-2-thiobarbituric acid in compared to baseline.

* Administration of strawberry extract, depending on the decrease in LPO formation, also preserved amounts of other antioxidants such as oleic acid and linoleic acid.

Dr. Ozsahin AD, the lead author at the Bitlis Eren University, after taking into accounts of other co and con founders, said, "Consequently, it has been confirmed that the strawberry fruit that has a scavenging effect against the radicals prevents that lipid peroxidation in in vitro environment"..

DPPH is an organic chemical compound 2,2-diphenyl-1-picrylhydrazyl composed of stable free-radical molecules, 

The findings strongly suggested that strawberries processed numbers of antioxidants may be used as functional food in inhibited free radicals over expression causes of lipid peroxidants, a leading cause of chronic syndromes and diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
Reference
(1) The strawberry: composition, nutritional quality, and impact on human health. by Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M.(PubMed)
(2) Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects. by Basu A, Wilkinson M, Penugonda K, Simmons B, Betts NM, Lyons TJ.(PubMed)
(3) The fruit extract of three strawberry cultivars prevents lipid peroxidationand protects the unsaturated fatty acids in the Fenton reagent environment. by Ozsahin AD, Gokce Z, Yilmaz O, Kirecci OA.(PubMed)

Banana, The Fruit Which Promotes Gut Microbiota and Bowel Movement Against Acute and Chronic Constipation, Medline Studies Show

Kyle J. Norton (Master of Nutrition, All right reserved)
Banana may be used as functional foods in prevention and treatment of acute and chronic constipation, some scientists suggested.

Constipation is natural condition characterized by infrequence or hard to pass of bowel movements

People with chronic constipation may experience symptoms of abdominal pain, bloating,.... and a feeling of not completely passed the bowel movement.

Untreated long term constipation may increase risk of hemorrhoids, anal fissure or fecal impaction, the most common complications of patient with chronic condition.

Acute constipation is a condition which starts suddenly and lasts for a 3 days or less due to prolonged inactivity, medication, dehydration, or missing a bowel movement. And chronic constipation is condition of a stool frequency of less than three per week that lasts several months.

Believe or not, constipation is the most common digestive complaint in the North America.

 The prevalence of chronic constipation ranges from 2-28%, affecting 63 million people in North America . Some studies suggested that prevalence of constipation increases with age and is more common in women than men.

The exact causes of constipation are still under evaluation. However, some researchers suggested that medical condition such as colon cancer, colon damage, diabetes, thyroid disorders, Parkinson’s disease, pregnancy and medications such as pain medications (narcotics), blood pressure medications (calcium channel blockers), anti-seizure medication, and antispasmodics are common risk factors  of constipation onset.

Furthermore, aging which has a strong implication in structural lesions of the colon may also associate to increased risk of the condition.

Dr. Lazebnik LB, in the final report of chronic constipation conducted by using data collected from 1189 randomly selected subjects older than 18 year old, said, "... low level of dietary fiber and fluid intake and low physical activity (in male younger 55 y.o. with increased body mass index)".

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

Nutrients
1. Vitamin B6
2. Vitamin C
3. Fiber
4. Potassium
5. Magnesium
6. Iron7. Etc.

Chemical constituents
1. Sterols
2. 3-Methyl butyl butanoate ester
3. steryl esters
4. Diacylglycerols,
5. SAteryl glucosides,
6. Long chain fatty alcohols
7. Aromatic compounds
8. Linoleic acid
9. Linolenic acid
10. Oleic acids
11. Lectin
12. Fructooligosaccharides

In the study of fructooligosaccharides (FOS) which are oligosaccharides occurred naturally in banana, researchers found that

* Dietary FOS are not hydrolyzed by small intestinal glycosidases and reach the cecum structurally unchanged.

* FOS are considered as soluble dietary fibre which processes a strong effect in prevention of risk acute constipation and treatment of chronic constipation.

* Furthermore, FOS are increasingly included in food products and infant formulas due to their prebiotic effect stimulate the growth of nonpathogenic intestinal microflora

* Moreover, consumption of banana fructooligosaccharides (FOS) not only increases fecal bolus and the frequency of depositions, but at a dose of 4-15 g/day given to healthy subjects, the oligosaccharides also will reduce constipation, one of the growing problems of modern society, and newborns during the first months of life.

These results suggested that banana containing major compound of fructooligosaccharides (FOS) may be used as functional foods in improved digestive system in absorbed nutrients and fluids and promoted bowel movement in prevention and treatment of acute and chronic constipation.

Unfortunately, in the investigated the significance and risk factors of bowel obstruction caused by the consumption of wild bananas (BOWB) in Laos, researchers at the SFE Medical Project suggested that while banana fruits are considered as digestive enhancer, intake of wild banana which often containing seeds can cause bowel obstruction, including constipation.

According to the study, out of participants of 227, 91.2% had eaten WB; 46.3% had also eaten the seeds and 45.4% knew of complications resulting from eating WB; 42.3% were aware of the complications of ingesting the seeds (constipation [37.9%], appendicitis/abdominal pain/vomiting [2.6% each] and bloated stomach/death [1.3% each]). 

The findings suggested that eating banana seeds is associated to increase risk of digestive dysfunction.

Taking altogether, the edible part of banana, containing major active compound fructooligosaccharides (FOS) may be used as alternative treatment for patients with acute and chronic chronic without inducing side effects.

People who are at infrequent bowel movement may want to add a portion of banana into their diet for preventive measure

Some types of banana in the tropical world contain seeds. Please don't eat them, if you find one

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
References
(1) [Prevalence and risk factors of constipation in the adult population of Moscow (according to population-based study MUSA)].[Article in Russian] by Lazebnik LB, Prilepskaia SI, Baryshnikov EN, Parfenov AI, Kosacheva TN.(PubMed)
(2) Dietary fructooligosaccharides and potential benefits on health by Sabater-Molina M1, Larqué E, Torrella F, Zamora S.(PubMed)
(3) Intestinal obstruction due to phytobezoars of banana seeds: a case report by choeffl V1, Varatorn R, Blinnikov O, Vidamaly V.(PubMed)
(4) Bowel obstruction from wild bananas: a neglected health problem in Laos by Slesak G1, Mounlaphome K, Inthalad S, Phoutsavath O, Mayxay M, Newton PN.(PubMed)

Asparagus, The Miracle Anti Diabetes and Diabetes Complications Functional Food, Scientists Say

Kyle J. Norton, Master of Nutrition

Asparagus may have a potential and profound effect in reduced risk of diabetes in patients with no diabetes and diabetic complications in patients with diabetes, some studies suggested.


Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.

The actual causes of diabetes are debatable. As researchers do not know why some people without genetic mutations are susceptible to disease development, while other do not.

Researchers believed that onset of diabetes type 2 is associated to a set of risk factors. According to the retrospective cohort study, using the data of 8337 adolescent respondents from Add Health (1994-2008) including 5131 non-Hispanic Whites, 1651 non-Hispanic Blacks, 1223 Hispanics, and 332 American Indians/Alaska Natives lead by College of Medicine, Washington State University,

* Pre-diabetes and diabetes were more prevalent in non-Hispanic Blacks (55% and 12%, respectively) than in American Indians/Alaska Natives (43% and 11%),

* Higher body mass index and family history of diabetes were associated with higher risk of pre-diabetes and diabetes.

* Female sex was associated with lower risk of pre-diabetes in compared to male counterpart.

Furthermore
* Physical inactivity, sedentary behaviors, or fast food consumption are associated to independent and preventive risk factors that induce early onset of prediabetes and diabetes.

Most people with prediabetes do not experience any symptoms. However, untreated diabetes or  diabetes that do not manage properly, may lead to serious complications of cardiovascular diseases, kidney damage, nerve, foot and eye damage, skin wound that can heal,....... and dementia such as Alzheimer's disease.

Asparagus is a flowering plant belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia.

The vegetable have been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

In Streptozotocin (90 mg/kg) injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes, researchers found that rats treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg per d) expressed lowering fasting blood glucose, improved serum insulin, total antioxidant status and qualitative and quantitative in β-cell function(1) in compared to placebo group.

Additional observation also discovered that the methanolic extract also exerts a significant effect in reduced complications of kidney disease by inhibiting renal hypertrophy, polyuria, hyperfiltration, microalbuminuria and abnormal changes in the renal tissue(1).

Furthermore, asparagus extract enhanced production of antioxidants from the host in neutralize the unbalanced ratio of antioxidants and free radical in initiated oxidative stress(1) induced by injection of Streptozotocin (90 mg/kg) effectively.

Moreover, according to the study by Smt. Kashibai Navale College of Pharmacy, oral administration of ethanolic extract of Asparagus racemosus (EEAR) at a dose level of 100 and 250 mg/kg daily for 4 weeks, significantly reduced the expression of streptozotocin-induced early diabetic nephropathy in compared with control group(2).

Dr. Somania R, the lead researcher said, " A. racemosus treatment significantly decreased plasma glucose, creatinine, ..... total cholesterol and triglyceride levels. Renal hypertrophy,....and abnormal changes in the renal tissue".

These efficacy can be attributed to the extract's anti-diabetic effects by improving insulin secretion and β-cell function(2).

Interestingly, the 21 days continuous administration of aqueous extract of asparagus by-product (AEA) to examine the hypoglycaemic effect in a streptozotocin (STZ)-induced diabetic rat model indicated(3), found
* Rat treated with the extract showed to decrease fasting serum glucose and triglyceride levels but markedly increased body weight and hepatic glycogen level.

* In an oral glucose tolerance test, both the blood glucose level measured at 30, 60 and 120 min after glucose loading and the area under the glucose curve showed a significant decrease after AEA treatment.

* The extract also exhibited the hypoglycaemic and hypotriglyceridaemic effects in preventing diabetic complications associated with hyperglycaemia and hyperlipidaemia(3).

Taking altogether, there is no doubt that many aspects have contributed to the effectiveness of asparagus in reduced risk of diabetic complications and treatment of diabetes, but large amount of asparagus extract intake should only be prescribed by related field specialist.

However, further data collection on large example size and multi centers clinical studies and trials performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti diabetes possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Asparagus racemosus Willd (Liliaceae) ameliorates early diabetic nephropathy in STZ induced diabetic rats by Somania R1, Singhai AK, Shivgunde P, Jain D.(PubMed)
(2) Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats by Hafizur RM1, Kabir N, Chishti S.(PubMed)
(3) The aqueous extract of Asparagus officinalis L. by-product exerts hypoglycaemic activity in streptozotocin-induced diabetic rats by Zhao J1, Zhang W, Zhu X, Zhao D, Wang K, Wang R, Qu W.(PubMed)
(4) Risk factors for pre-diabetes and diabetes in adolescence and their variability by race and ethnicity by Zamora-Kapoor A1, Fyfe-Johnson A2, Omidpanah A2, Buchwald D2, Sinclair K(PubMed)

Herbal Burdock, The Functional Herb Which Protects Skin Against Aging Caused by Reactive Oxidative Species (ROS)

Kyle J. Norton (Master of Nutrition, All right reserved)

Herbal Burdock may process a profound and positive effect in inhibited free radicals activity in induction of early onset of natural aging, some scientists suggested.

Burdock is plant in the group of biennial thistles, genus Arctium,belongings to the family Asteraceae, native to the Euro.

The herb has been used over thousand of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein,.... unsaturated fatty acid.

Prolonged over expression of free radical were found to cause widespread damage through domino's  chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

Truly, epidemiological studies strongly suggested that reactive oxygen and nitrogen species (ROS/RNS) existed as radicals or nonradicals, as well as reactive sulfur species and reactive carbon species, play a major role in aging processes.

Dr. Wölfle U, the lead scientist in the examine the effect of ROS in induction of skin aging said, " When RMS concentrations exceed a certain threshold, cell compartments and cells are injured and destroyed" and " Endogenous physiological mechanisms are able to neutralize RMS to some extent, thereby limiting damage. In the skin, however, pollutants and particularly UV irradiation are able to produce additional oxidants which overload the endogenous protection system and cause early aging, debilitation of immune functions, and skin cancer".

Some researchers suggested that unhealthy diet with low nutrition high in advanced glycation end products (AGEs) may also contribute to oxidation induced early aging process.

The Chemical Ingredients of Herbal Burdock include
Carbonated water, sugar, manloid colourings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

In the study of the activity of superoxide dismutase (SOD) and the content of Malondialdehyde (MDA) and lipofuscin in the tissues of the liver, brain and blood serum of the lab rats at the 30 days after feeding with the Niubanggen decoction, researchers found that

* Levels of SOD in the liver tissue and blood serum were improved substantiallyin decoction treat rats

* Levels of the content of MDA in the brain tissue and blood serum were lower in compared to baseline.

* Levels of lipofuscin were also dropped significantly.

These results suggested that herbal burdock exerts strong anti-aging effects through activating antioxidant of the host in inhibited ROS in induction oxidative stress through expression of biomarkers of SOD and MDA and lipofuscin.

Herbal burdock antioxidant activity in the differentiation of 23 distinct herbal medicine was found to process anti-elastase activities up to 51% in prevention of destruction of elastic fiber.

Furthermore, in the review of the therapeutic effects of the active compounds presented in the different botanical parts of burdock, researchers at the The Hong Kong Polytechnic University, found that the root of burdock containing active ingredients "detoxify" blood in terms of TCM and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema.

However, burdock may induce contact dermatitis and other allergic/inflammatory responses, the University continued.

Taking altogether, function herb burdock processes bioactive ingredients which protect the skin against aging and disease through its antioxidants activity in inhibited over expression of free radicals.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
1. An experimental research into the anti-aging effects of Radix Arctii Lappae, by Liu S, Li Y, Li S, Luo M, Liu X.(PubMed)
2. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.
Thring TS, Hili P, Naughton DP.(PubMed)
4. A review of the pharmacological effects of Arctium lappa (burdock)" by Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW., (PubMed)
(5) Sugar Sag: Glycation and the Role of Diet in Aging Skin by Nguyen HP1, Katta R(PubMed)

White Button Mushroom, The Potential Ovarian Cancer Preventive Functional Food

White button mushroom may be next generation target of pharmaceutical extraction of single ingredient medicine for treatment of ovarian cancer , some scientists suggested.

Ovarian cancer is a chronic and medical condition characterized cell growth regularly and disorderly in the ovary. Normally, the alternated DNA healthy cancer cells start on the surface of the ovary. In the advance stage, the cancerous cell can travel a distance way from the originated site to infect other healthy tissue and organs.

Depending to where the healthy cells were infected, ovarian cancer can be classified as
* Epithelial ovarian tumor also known as surface epithelial-stromal tumor, as the name, it is a result of the cells on the surface of the ovary have become cancerous. Epithelial ovarian tumor is the most common form of ovarian cancer accounted for over 90% of ovarian cancer of all cases, including serous tumor, endometrioid tumor and mucinous cystadenocarcinoma.

* Germ cell ovarian tumor is a censer of the egg producing cells within the ovary and can be cancerous or non-cancerous tumors. It tends to occur in children and teens as a result of birth defects resulting from errors during development of the embryo.

* Sex cord stromal ovarian tumor is a cancer of the tissue of the ovary accounted for 8% of ovarian cancers. The excess estrogen produced by sex cord stromal ovarian tumor can lead to certain symptoms, such as adult granulosa cell tumours and thecomas, postmenopausal bleeding, menorrhagia, amenorrhea,.... and,endometrial hyperplasia.  The cancer tends to develop in older age group.

According to the statistic produced by the American Cancer Society, ovarian cancer is the fifth leading cancer which cause deaths among women. The cancer is found to account for more deaths than any other female reproductive cancer.

The average risk of a woman of getting ovarian cancer during her lifetime is about 1 in 78.

Ovarian cancer in early stage does not cause any symptoms, however, if you experience frequent and persistent symptoms of stomach and digestive issues, please check with your doctor to rule out the possibility. Ovarian cancer detected early is associated to significantly increased survival rate.

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, belongings to the family Amanitaceae

It has been cultivated in many cultures all over the world for foods and health benefits.

Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

In a hospital-based case-control study undertaken in Guangzhou, Guangdong Province, from 2006 to 2008. including 500 patients diagnosed with epithelial ovarian cancer and 500 controls, with a mean (SD) age of 59 (6) years, after examining the returned questionnaire reported by participants researchers found that

* Patients with ovarian cancer consumed less mushrooms (mean [SD], 28.48 [37.45] g/d) in compared to controls (mean [SD], 30.75 [41.85] g/d).

* high levels intake of the common white button mushroom are associated to reduced risk of ovairan cancer by 68%.

* Risk of ovarian cancer is educed substantially for women who consume more than 2 g per day in compared to those who consume less.

* High levels of mushroom intake also decrease risk of others serous and mucinous subtypes of epithelial ovarian tumors.

These results provide strong evidences to suggest that intake of mushrooms, particularly white button mushroom in amount higher to 2 g per day, is inversely associated with the incidence of epithelial ovarian cancer in southern Chinese women.

Dr. Xu T in the differentiation of prevention and treatment of various type of mushroom cancer said, ".... the potential cancer preventive effects of edible mushrooms have been less well-studied. With similar content of putative effective anticancer compounds such as polysaccharides, proteoglycans, steroids, etc., one might predict that edible mushrooms would also demonstrate anticancer and cancer preventive activity".

However, some researchers in concerns of mushroom collected from wild, that their co-occurrence with some hazardous elements including Cd, Pb, Hg, Ag, As, and radionuclides may cause more harm than good.

The findings indicated that white button mushroom may be used as functional food for prevention and treatment of ovarian cancer. Please make sure that you know what you are doing, if you try to pick and consume wild mushroom.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(2) The cancer preventive effects of edible mushrooms by Xu T1, Beelman RB, Lambert JD.(PubMed)
(3) Mushroom intake and risk of epithelial ovarian cancer in southern Chinese women by Lee AH1, Pasalich M, Su D, Tang L, Tran VD, Binns CW.(PubMed)
(4) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)