Cascara Sagrada Chemotherapeutic and Mutated Gene Blocker Bioactive Components That Cut Off Energy Supply To Prostate Cancer Cells

Cascara sagrada may have a potential effect in inhibited onset and progression of prostate cancer, some scientists suggested.

Prostate cancer is medical a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams. However, some protatecancers can grow and become invasive quickly.

According to the study of The University of Texas MD Anderson Cancer Center, metastasis to the bone caused by tumor/microenvironment interactions remains the major cause of death in advanced prostate cancer(3).

In other words, this invasion may be a result of certain cancer cells that can reseed the primary site and gain more metastatic potential in the process.

The exact causes of prostate cancer is unknown, however, certain conditions may associate to increase risk of prostate cancer, including age, ethnic group, family history,... and obesity.

Some researcher suggested that diet high in calcium is linked to an increased risk of developing prostate cancer and maternal high fat diet (HFD) is associated in increased risk children prostate cancer(4).

Most patients may not experience any symptoms until advance stage.
Most common symptoms includes frequent urination, lost of bladder control such as weak or interrupted urine flow or the need to strain to empty the bladder, the urge to urinate frequently at night. In severe cases, patients may also find blood in the urine and lost of erection.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belongings to the family Rhamnaceae, native to western North America,

The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..

The Ingredients
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

Aloe-emodin, a chemical constituent found in Cascara Sagrada is found to inhibit both proliferation and anchorage-independent growth of PC3 cells by targeting the protein complex that plays an impotant role in stimulated cancer cell metabolism (mTORC2) for survival and expansion.

Further analysis also found that application of aloe-emodin also suppressed the function of Protein kinase B, (Akt) of cancer cell in signalling protection of cell survival, increased cell cycle progression and cellular growth and protein kinase C alpha (PKCα) in promotion of cancer cell migration.

Dr. Liu K, the lead author at The World Class Institute and Chemical Biology Research Center at the end of the experiment wrote, " Aloe-emodin (also) exhibited tumor suppression effects in vivo in an athymic nude mouse model" and "Collectively, our data suggest that mTORC2 plays an important role in prostate cancer development and aloe-emodin suppresses prostate cancer progression by targeting mTORC"

Epidemiologically, emodin (ED), another bioactive compound found in cascara sagrada, also processed anti proliferation and induced apoptosis, suppressed angiogenesis, impeded metastasis, and enhanced chemotherapy.

In DU145 and A549 cells, application of emodin suppressed the expression of both mutation gene CXCR4 and HER2 which are associated to prorate cancer risk without affecting cell viability in tumor cells and protection healthy cell integrity against mutated gene CXCL12 in induction of cancer cells migration and invasion.

Additional differentiation suggested, the efficacy of emodin in inhibited mutated gene expression of prostate cancer was attributed to the bioactive activity in prevetion of cancer cell in promoted mRNA expression and suppressed of NF-κB in activation of cancer cells proliferation.

These results indicated that emodin may have a potential used as a novel blocker of CXCR4 expression as well as a powerful therapeutic agent for metastatic cancer. 

The findings showed that, herbal Cascara Sagrada (Rhamnus purshiana) with bioactive components that have strong effects in inhibited prostate cancer cells may be considered as functional foods for treatment of prostate cancer.

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How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

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Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Steps in prostate cancer progression that lead to bone metastasis by Jin JK1, Dayyani F, Gallick GE(PubMed)
(4) Maternal High-Fat Diet Promotes the Development and Progression of Prostate Cancer in Transgenic Adenocarcinoma Mouse Prostate Offspring by Yang T1,2, Wu X1,2, Hu J1,2, Hu M1,2, Xu H1,2, Jiang H1,2, Ding Q(PubMed)

Arnica, The Herbal Remedy Which Not Only Gobbles Up Breast Cancer Cells But Also Speeds Up Recovery After Post Breast Mastectomy, Medical Literature Showed

Kyle J. Norton (Scholar, Master of Nutrition)

Arnica may have a positive and therapeutic effects in reduced risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue.

According to general belief, 1 in 8 women will be diagnosed with breast cancer during her lifetime.

The causes of breast are unknown. Researchers do not know why some women are susceptible to DNA alternated in healthy breast tissue while others do not. Truly, many women who have risk factors never develop breast cancer. 

Some researchers suggested that family history, early puberty and late onset of menopause, having high breast density, excessive alcohol drinking,.... and aging are associated to increase risk of breast cancer.

Furthermore, Women who are inherited gene mutation from parent, have previous cancer,..and
have taking certain medicine such as diethylstilbestrol (DES) are also associated to risk of the disease.

Today modern technology are developed to detect breast cancer in early stage, but self examination is still one of best method to catch the cancer before they can become invasive.

The survival rates of breast cancer have also increased, and the number of deaths associated is steadily decreasing, largely due to factors that women are more awareness of the early onset of the disease.

If you experience of some symptoms such as breast lump, nipple changes, breast change in the size, shape, inverted nipple,  breast skin peeling, scaling, flaking of the pigmented area of skin surrounding the nipple, please check with your doctor to rule out the possibility

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia. The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

According to the evaluation of cytotoxic chemotherapeutic agents with efficacy without inducing adverse effects from major compound extracted from Arnica helenalin and to exam whether the compound activity was maximized by encapsulation in β-cyclodextrin nanoparticle, application of β-cyclodextrin nanoparticle alone exerted an significantly inhibitory property against breast cancer cells.

β-Cyclodextrin (β-CD) is a cyclic oligosaccharide comprising seven D-glucopyranoside units, linked through 1,4-glycosidic bonds.

Interestingly, when helenalin was encapsulation in β-cyclodextrin nanoparticle, the combination demonstrated a significant effect in induction of breast cancer cell cytotoxicity in compared to administration of helenalin alone.

These results suggested that certain compounds in β-cyclodextrin may have potential in stimulated and enhanced the helenalin action through some unknown interacted mechanisms.

In T47D breast cancer cell line, injection of β-cyclodextrin- helenalin complexes inhibited the preoperative effect in prevented expanse of the colony in dose-dependent manner.

Some researchers suggested that the induction of breast cancer cell apoptosis and profileration may be attributed to helenalin anti oxidants activity in restrict the the growth of cells through its stimulation of  ROS in facilitated cell death.

More importantly, application of β-cyclodextrin- helenalin also improved the ratio of antioxidant and ROS in the infectious cell line. These results were observed in the expression of telomerase gene through the r q-PCR.

Truly, the length of terminal transferase was shortening in the treated cell lines in compared to untreated control.

Furthermore, application of Arnica also expressed a profound effect in reduced blood and serum volumes and  pain, and the presence of bruising or hematomas during period of drainage.

According to study of 53 women, undergoing unilateral total mastectomy, selected from 2012 to 2014 randomly assigned to A. montana or placebo and followed up for 5 days, conducted by the Niguarda Ca' Granda Hospital, Milan, Arnica treatment of group displayed a strong reduction of the of mean volume of blood and serum collected in drainages in compared to control group observed by the per-protocol analysis.

Analysis of the questionnaire returned from the patients, researchers found that patient weight showed a statistically significant difference in favor in use of Arnica, according the regression model including treatment, volume collected in the drainage on the day of surgery.

Moreover, the blood and serum volumes collected on the day of surgery and the following days were significantly lower with Arnica at days 2 in compared to untreated patients.

Dr.Sorrentino L , the lead author, after taking into account of other co and con founders said, " reduce post-operative blood and seroma collection in women undergoing unilateral total mastectomy".

The findings suggested that Arnica and its major bioactive helenalin may be used as a secondary herbal treatment or combination with standard medicine for treatment of breast cancer and speeding up recovery after post total mastectomy. 

Intake of herbal supplement should be taken with extreme care to prevent acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Is there a role for homeopathy in breast cancer surgery? A first randomized clinical trial on treatment with Arnica montana to reduce post-operative seroma and bleeding in patients undergoing total mastectomy by Sorrentino L1, Piraneo S1, Riggio E1, Basilicò S2, Sartani A1, Bossi D3, Corsi F4.(PubMed)
(2) Inhibitory effects of β-cyclodextrin-helenalin complexes on H-TERT gene expression in the T47D breast cancer cell line - results of real time quantitative PCR by Ghasemali S1, Nejati-Koshki K, Tafsiri E, Rahmati-Yamchi M, Akbarzadeh A, Alizadeh E, Abbasi M, Barkhordari A, Tozihi M, Kordi S, Zarghami N.(PubMed)

How to Protect Your Skin Against Histamine Release In Induction of Hives Effectively

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk of sudden appearance of hives, some scientists suggested.

Hives, also known as Urticaria, is the condition characterized by a sudden outbreak of swollen, pale red bumps or plaques on the skin.

The exact causes of hives are unknown, However, epidemiological studies all agreed that a set of conditions such as allergic reactions, chemicals in foods, insect stings, sunlight exposure, or medications can all cause histamine release initiated the onset of hives.

Certain diseases such as thyroid disease, hepatitis, infection,.... and cancer are also associated with the onset of chronic hives.

Acute condition of Hives are diseases that last less than six weeks. 

Most common symptoms of chronic hives include red, itchy or skin color welts on the skin that appear in varying shapes and sizes and anywhere in the body that last no longer than six to 12 hours.

In severe cases, chronic hives may induce symptoms of dizziness. wheezing. difficulty breathing,........ and swelling of the tongue, lips, or face.

According to statistic, approximately, 20 percent of people may develop hives at sometime in their live.

According to the returned of 437 response rate (95%) questionnaires from the fourth to sixth-grade students at an elementary school in Yongin conducted by the J Dankook University to examine the food allergy that affects between 10.9% to 12.6% general population(2).

* The prevalence of food allergy among respondents was 19.7%.

* The the most common food allergy-related symptoms were urticaria

These results suggested that food allergens are one of the leading cause of the onset of hives among children between age from 9 - 12.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the investigated the roles of dietary factors in aggravating, preventing, or treating skin diseases such as chronic urticaria, and psoriasis patients, researchers at the University, New Brunswick, researchers found that green tea not only reduces risk of skin cancers but also processes a strong effect in inhibited chronic urticaria symptoms(1).

The study also suggested that green tea inhibits hives onset through its antihistamine effect. 

Furthermore, Green tea also processes anti inflammatory properties that can soothe swelling and reduce skin discomfort.

According to the Universidad de Málaga and CIBER de Enfermedades Raras (CIBERER), green tea bioactive compound epigallocatechin-3-gallate (EGCG), exerted anti allergen caused by histamine-producing cells through alterations in their behavior such as their proliferative, adhesion, migration, and invasion potentials.

By exhibiting the anti antihistamine effect, green tea may have a potency in reduced risk of acute and chronic skin diseases caused by food allergens, including hives(2). 

Dr. Melgarejo E, the lead author said, "green tea EGCG has been shown to have potent anti-inflammatory, anti-tumoral, and anti-angiogenic effects and to be a potent inhibitor of the histamine-producing enzyme, histidine decarboxylase"(2).

Taken together, green tea and its bioactive phytochemical EGCG may be considered as functional food in inhibit hives caused by overexpression of histamine.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including world wide health, ezine articles, article base, healthblogs, self growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis by Murzaku EC1, Bronsnick T2, Rao BK1(PubMed)
(2) Targeting of histamine producing cells by EGCG: a green dart against inflammation? by Melgarejo E1, Medina MA, Sánchez-Jiménez F, Urdiales JL(PubMed)
(3) Food allergy knowledge, perception of food allergy labeling, and level of dietary practice: A comparison between children with and without food allergy experience by Choi Y1, Ju S2, Chang H2.(PubMed)

Andrographis aniculata, The Herbal Remedy Which Blocks Pathogens In Initiated Acute Upper Respiratory Tract Infection, Scientists Say

By Kyle J. Norton, Master of Nutrition

Andrographis paniculata may be one of the best herb in inhibited pathogens (viruses and bacteria) that cause acute upper respiratory tract infection, including the infection of the nose, sinuses, pharynx or larynx. some researchers suggested.

The acute infection is very contagious, anyone who comes to contact with patients may also be infected by inhaling respiratory droplets from coughing or sneezing. 

People who are infected by virus that can be resolved without prescription drugs. However, upper respiratory tract infection caused by bacteria, in most case is treated with antibiotics used such as Penicillin VK(Penicillin V) Amoxicillin and (Amoxil, Moxatag, Trimox) Penicillin.

Due to over use of the medicine, some bacteria have developed antibiotic-resistant in response to these medicines.

Intake of antibiotics may be effective, but they have known to interact with others medicine such as medicine that lower cholesterol, treat  migraine,.... and gout, induce serious side effects such as vomiting,  diarrhea, rash........ and abdominal cramps. 

Some patients may also experience allergic reaction induction of shortness of breath, hives, swelling of lips, face, or tongue, fainting.

If you are treated with such medicine, please make sure you discuss the effects with your doctor.

Furthermore, according to the study of Georgia Regents University, "Acute respiratory tract illnesses are the most frequent illnesses of humans and are an important cause of disability and days lost from school or work. Respiratory infections are an important cause of mortality and hospitalization, particularly in the winter in temperate regions" and " In children less than 5 years of age, they are the leading cause of death. Most acute respiratory infections are caused by viruses and bacteria, including rhinoviruses, respiratory syncytial viruses, adenoviruses, influenza viruses, and parainfluenza viruses"(4).

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belongings to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

According to the joint study lead by the ilpakorn University in the review of the existence data of the literature and meta-analysis of randomized controlled trials, application of andrographis paniculata exerted a strong implication in the symptomatic treatment of uncomplicated upper respiratory tract infection by measuring the reduction in symptom severity scores.

In a total of 433 patients reported in three trials included in the statistical analysis, patient treated with combination of Andrographis aniculata, Acanthopanax senticosus and Andrographis aniculata alone exhibited a significant improvement of 2.13 points and 10.85 points on the symptom severity score respectively, in compared placebo.

Dr. Poolsup N, the lead author said, "A. paniculata extract alone or in combination with A. senticosus extract may be more effective than placebo and may be an appropriate alternative treatment of uncomplicated acute upper respiratory tract infection".

Furthermore, in the review to prevent the over-prescription of antibiotics and absence from work due to acute upper respiratory tract infection, reseahcers found the A. paniculata is found to be more superior to placebo in alleviating the subjective symptoms of uncomplicated upper respiratory tract infection.

The study also indicated that all review trials scored at least three, out of a maximum of five, for methodological quality on the Jadad scale.

More importantly, the efficacy of A. paniculata in relieving symptoms of uncomplicated upper respiratory tract infection only induced generally mild and infrequent adverse effects.


Moreover, in supporting the Andrographis aniculata's anti upper respiratory tract infection property, a total of 223 patients of both sexes randomized in two groups which received either KalmCold (200 mg/day) or placebo, scientists showed that A. paniculata ameliorates symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise/fatigue and sleep disturbance from day 1 to day 3 of treatment in compared to placebo group.

Additionally, the overall efficacy of extract of Andrographis paniculata was found to be 2.1 times (52.7%) higher than placebo.

Taking together, there is no doubt that Andrographis aniculata has a potency used as therapeutic agent for relieving symptoms and treatment of acute upper respiratory tract infection but intake of large doses and long term intake should be taken with care.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Andrographis paniculata in the symptomatic treatment of uncomplicated upperrespiratory tract infection: systematic review of randomized controlled trials by Poolsup N1, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U.(PubMed)
(2) Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy by Coon JT1, Ernst E.(PubMed)
(3) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upperrespiratory tract infection by Saxena RC1, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A.(PubMed)
(4) The Epidemiology of Upper Respiratory Infections at a Tertiary Care Center: Prevalence, Seasonality, and Clinical Symptoms by Christy S. Stover and Christine M. Litwin(Hindawi)

Chamomile, The Herb Which Processes Benzodiazepine-Like Hypnotic Activity For Pain, Anxiety,... and Sleep Disorder With No Adverse Effects, Scientists Say

By Kyle J. Norton, Master of Nutrition


"Let foods be your medicine and let medicines be your food", using foods as medication has been a dream of many scholars and scientists over past many centuries.

 In order to achieve these, consumption of whole food medicine must be accompanied by moderated exercise, change of diet and life style.

Chamomile, the most frequently used medical plant may be next generation of whole herb to act as sedative agent to treat pain, anxiety,...... and sleep disorder.

Sedation is a action that induces calm or sleep by using medicine, drugs, or substances to suppress the activity of central nervous system.

Over dose of sedative substances can be fatal.

Medicine such as placidyl, ethchlorvynol. a mild sedative-hypnotic drug used for treatment may be effective, but they can cause serious side effects such as skin condition, such as skin rash or hives dizziness,...... nervousness and restlessness.

In some cases, patients overdose with sedative drugs can also cause darkening of urine, pale stools, yellow eyes,....skin easily bled or bruised, confusion, change of vision or (continuing),..... and double vision.

Sleep disorder is a problem of sleeping. classification of sleep disorder deepening to types of condition includes, insomnia, a problem of falling and staying asleep, excessive daytime sleepiness, sleep-disruptive behaviors,.... and sleep rhythm problem.

According to statistic, between 50-70 million US adults have a sleep disorder.

Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae, 

The herbal medicine has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

In a quasi-experimental clinical trial, included 77 cases of elderly hospitalized in nursing homes, using random continuous sampling by divided into intervention group received 400 mg oral capsules of chamomile twice daily, after lunch and after dinner for 4 weeks. and control groups received nothing to test the efficacy of chamomile in sleep disorder, researchers showed that oral administration of chamomile extract has sedative properties in sleep quality in compared to control.

These results were observed by analyzing the Pittsburgh Sleep Quality Index questionnaire in compared to no different of the mean score of sleep quality both experimental and control groups before experiment, the mean score of sleep quality was a significant difference between experimental and control groups after 4 weeks.

Moreover, in a triple blind clinical trial performed on 114 eligible women at Ommolbanin Hospital in Mashhad, Iran in 2014, randomly assigned to two groups using random blocks. After delivery, 

* mothers in the intervention group are received 0.5 g of prescribed chamomile

* Mothers in the control group are given placebo cream on the stitch twice a day lasting ten days.

At the end of the study, researchers found that mothers received chamomile cream is found to reduce episiotomy pain sedately in primiparous women in compared to control.

Additional differentiation and after taking into account of other co con founders, researchers also discovered, although there are no difference before and 12 hours and the first day after delivery. on the seventh, tenth and fourteenth day after delivery according to McGill mean (SD) pain score,  experimental group was 11.36, 4.44 and 7.16 in compared to control group of 14.88, 7.41 and 9.96 respectively.

Dr. McKay DL said, " Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects" and "(Unfortunately) However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent."

In fact, in the investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats, researcher at the Okayama University insisted, chamomile extract at a dose of 300 mg/kg exerted significantly decrease sleep latency.

The study also suggested, chamomile extract is a herb having benzodiazepine-like hypnotic activity.

Taking altogether, Chamomile may be helpful to aid pain, calm and sleep through its sedative effects, but intake of correct amount should only be given by qualified herbalist



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial by Abdullahzadeh M1, Matourypour P2, Naji SA1.(PubMed)
(2) The Effect of Chamomile Cream on Episiotomy Pain in Primiparous Women: A Randomized Clinical Trial by Aradmehr M1, Azhari S2, Ahmadi S3, Azmoude E4.(PubMed)
(3) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)

Green Tea and Its Bioactive Polyphenol EGCG Kill Bacteria That Cause Carbuncle

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of carbuncle, a skin disease, some scientists suggested.

Carbuncle is a collection of boils developed under the skin caused by bacterial infection of hair follicles in the induction of swelling.

Although the infections are most likely developing on the follicles of the hair, they can also appear on other areas of the body such as the buttocks, thighs, groin, and armpits.

Researchers suggested that people who are older age, obesity, poor hygiene, and poor health are most likely associated with increased risk of carbuncles. 

However,  chronic skin conditions, chronic kidney disease,.... and liver disease are also increased the prevalent risk the infection.

According to University of Miami School of Medicine, "Skin infections account for a significant portion of dermatologic disease, often resulting in or as a consequence of a disruption in the skin's integrity" and " The infections presented herein include impetigo, ecthyma, folliculitis, carbuncles/furuncles, cellulitis, toxic shock syndrome, and ecthyma gangrenosum"(4).

The differentiation hinted that people with carbuncle are also susceptible to the onset of skin disease.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the searching of the natural ingredient to replace the use of antibiotics in treatment of bacterial infection of carbuncle, researchers at the J the Rockefeller University  found that epigallocatechin-3-gallate isolated from green tea extracts exerts a significant effect iinhibitinged the activity of Staphylococcus aureus (S. aureus), a leading candidate in exhibited risk of carbuncle.


Further analysis also suggested that application EGCG inhibited the typhimurium type III protein effectors in restriction of bacterial invasion into tested cells.

The type III secretion system of Salmonella typhimurium is found to have a direct effect in  translocation of proteins into host cells in initiated infection.

Dr. Tsou LK, the lead authors said, "These results reveal additional dietary plant metabolites that can attenuate bacterialvirulence and infection of host cells".

Some researchers at the Mashhad University of Medical Sciences, after lenghty searching for effective agent without inducing intolerant adverse effect for treatment of bacterial infection, found that green tea catechins, the major green tea polyphenols, shows antimicrobial activity against resistant pathogens, including Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).

In compared of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates, inhibited bacterial activities by a minimum inhibitory concentration (MICs) of gentamicin in the range of 0.312 - 320 μg/mL and The MIC values of both types of catechins were 62.5 - 250 μg/ mL. in compared to no effect in methylxanthines  application.

Interestingly, the dose of gentamicin was reduced substantial if addina g dose of green tea extract and cactechin according to the MICs.

These result indicated that green extract and major bioactive polyphenol catechin may be used alone or combined with gentamicin for treatment of bacterial infection, including carbuncle without inducinthe g adverse effect.

Dr. Fazly Bazzaz BS, the lead scientist after taking into account of other co and confounders said, "green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains" and "combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance".

Additionally, the evaluatthe e antibacterial activity of the Indonesian water soluble green tea extract, Camellia sinensis, against clinical isolates of methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR-P. aeruginosa conducted by theUniversity of Indonesia suggested
* The inhibition zone diameters of green tea extracts for S. aureus ATCC 25923 and MRSA were 18.970 ± 0.287 mm, and (19.130 ± 0.250) mm respectively.

* The inhibition zone diameter for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were (17.550 ± 0.393) mm and (17.670 ± 0.398) mm respectively.

*The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 µg/mL and 400 µg/mL, respectively.

And
* The MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were 800 µg/mL, and 800 µg/mL, respectively.

Taking altogether, green tea extract and its bioactive polyphenol catechin may be considered as a functional food in reduced risk and treatment of carbuncle caused by Staphylococcus aureus (S. aureus).

Howvwer, intake of green tea extract should be taken with extreme care as acute liver toxicity has been reported by numbers of medical literature.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells by Tsou LK1, Yount JS2, Hang HC3.(PubMed)
(2) Effect of Catechins, Green tea Extract and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria by Fazly Bazzaz BS1, Sarabandi S2, Khameneh B3, Hosseinzadeh H4.(PubMed)
(3) Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa by Radji M1, Agustama RA, Elya B, Tjampakasari CR.(PubMed)
(4) Common bacterial skin infections by Trent JT1, Federman D, Kirsner RS(PubMed)

Papaya Fruit Extract, The Potent and Future Chemotherapeutic Medicine With No Side Effects, Scientists Say

By Kyle J. Norton

Papaya extract may be the next potential pharmacological target to identify the ingredients for treatment of cancers, some scientists suggested(2).

Cancer is a class of chronic diseases, characterized by cell growth uncontrollably and disorderly.
Some cancers are slow growing and some are very invasive. However, at the advanced state, most cancers can travel a distance away from the original site to infect other healthy organs and tissue.

According to the World center fund International, in 2012, there were 14.1 million cancer cases, affecting 7.4 million in men and 6.7 million in women. This number is expected to increase to 24 million by 2035(3).

Most common types of cancer include non-melanoma skin cancer, lung cancer, breast cancer, prostate cancer, colorectal cancer, bladder cancer and melanoma.

The Canadian Cancer Society statistic, an estimated 206,200 new cases of cancer and 80,800 deaths from cancer occurred in Canada in 2017. (The number of estimated new cases does not include non-melanoma skin cancer cases.).

Papaya, a species of Carica Papaya, belongings to the family Caricaceae, native to the tropics of the Americas.

The fruit has been used in traditional medicine as remedies for many various ailments, including gastric problems, inflammation, and cancer.

Nutrients of papaya include Vitamin A, Thiamine (Vitamin B1), Riboflavin (Vitamin B2), Niacin (Vitamin B3), Vitamin B6, Vitamin C, Iron, Magnesium, Phosphorus, Potassium, etc. and major chemical constituent and ethanol extract including benzylisothiocyanate are said to exhibit immunomodulatory, anti-inflammatory, hyperlipidemic, anti cellular oxidative stress, anti neural tube defect, etc. effects(1).

 The University of Tokyo, in the study to examine the effect of aqueous-extracted CP leaf fraction on the growth of various tumor cell lines and on the anti-tumor effect of human lymphocytes, application of the extract inhibit significant growth activity, through immunomodulatory effects through stimutulated natural production of interleukin 12 (also known as natural killer cell stimulatory factor 2) which plays an essential role in blocking pathogens and to transplantable and chemical substances that cause tumors(4).

Interestingly, researchers found that CP extract inhibited pro-inflammatory cytokines IL-2 and IL-4 without affecting IL-12p40, IL-12p70, IFN-gamma and TNF-alpha function.

These results suggested Carica papaya leaf extract can mediate a Th1 type shift in human immune system activated interleukin-12 (IL-12), making IL-12 the potential to act as anti-inflammatory cytokine during secondary responses in the site that alternated healthy cell DNA.

Dr. Otsuki N, the lead author said, " CP leaf extract may potentially provide the means for the treatment and prevention of selected human diseases such as cancer, various allergic disorders, and may also serve as immunoadjuvant for vaccine therapy".

 IL-12p70(a heterodimer), IFN-gamma(regulation of immunologically relevant genes) and TNF-alpha an are an innate immune response to fight off viral infection)(4).

Furthermore, fermented papaya, a traditional dish of many Southeast Asian cultures, is said to process antioxidant and immune-modulating potentials, through the influence of signaling cascades associated with cell growth and survival, from epidemiological and in-vitro studies of a patient with diabetes(5).

Truly, application of papaya peel extract (PapPE), also demonstrated that the efficacy not only  controls blood glucose, excessive inflammation, but also modulates free radical-induced oxidative damage which are triggers of liver, bladder, breast and prostate cancers in type 2 diabetics(6).

In cultured human lung cancer H69 cell, researchers showed that benzyl glucosinolate (BG) found in the pulp and the seed of papaya, inhibited cancer cell proliferation in an administration of doses of 6.5 μmol(7), probably through its effect in superoxide generation and apoptosis induction(8).

Benzylisothiocyanate (BITC), another chemical constituent also mediated apoptosis of prostate and pancreases cancer cells through activation both procaspase-8 pathways(initiation of apoptosis) and cell cycle arrest(9), inhibited advanced ovarian cancer cell lines through activation of caspase-3(activation in the apoptotic cell) and -9(activation of apoptotic process), and cleavage of PARP-1(repair of DNA damage)(10) and breast cancer through generation of reactive oxygen species and cleavage of caspase-9, caspase-8, and caspase-3(11).

Dr/ Nguyen and the research team at The University of Queensland told PubMed "(The) extract-based or specific compound-based investigations and emphasize the aspects (of papaya) that warrant future research to explore the bioactives in C. papaya for their anticancer activities"(2).

Taken altogether, fermented papaya and it major chemical constituents such as Benzyl glucosinolate (BG) and Benzylisothiocyanate (BITC) may be effective in reduced risk and treatment for certain types of cancer, through cell cycle arrest and unregulated apoptotic pathways but further studies with large sample size and multi-centers are necessary to identify the main ingredients in comparison of currently pharmacological medicine use to improve its validation.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) #Healthy #Foods - Fruits - Papaya (Carica Papaya)(Better living and living health)
(2) Anticancer activity of Carica papaya: a review by Nguyen TT1, Shaw PN, Parat MO, Hewavitharana AK.(PubMed)
(3) Cancer statistics Worldwide(World center fund International)
(4) Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects by Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C.(PubMed)
(5) Diabetes as a risk factor to cancer: Functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer by Aruoma OI, Somanah J, Bourdon E, Rondeau P, Bahorun T(PubMed)
(6) Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts by Waly MI, Al-Rawahi AS, Al Riyami M, Al-Kindi MA, Al-Issaei HK, Farooq SA, Al-Alawi A, Rahman MS.(PubMed)
(7) Content determination of benzyl glucosinolate and anti-cancer activity of its hydrolysis product in Carica papaya L, by Li ZY1, Wang Y, Shen WT, Zhou P.(PubMed)
(8) Papaya seed represents a rich source of biologically active isothiocyanate by Nakamura Y, Yoshimoto M, Murata Y, Shimoishi Y, Asai Y, Park EY, Sato K, Nakamura Y.(PubMed)
(9) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(10) Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancercells in vitro by Kalkunte S, Swamy N, Dizon DS, Brard L(PubMed)
(11) Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak by Xiao D1, Vogel V, Singh SV.(PubMed)
(12) Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities by Mawa S, Husain K, Jantan I.(PubMed)