Strawberry and It's Bioactive Flavonoids That Eradicate Risk Factors of Heart Disease

By Kyle J. Norton

Scientists may have found a fruit which has a potential effect in reduced risk and treatment of heart disease, some studies suggested.

According to statistic, heart disease, after lung cancer kills more than 2,000 Americans every day.

Approximately, 60 million Americans have heart disease.

There are many causes of heart diseases.

Most of the heart diseases are caused by high blood pressure which contributes to hardening of the arteries.

Some researchers suggested that diet high in saturated and trans fats also plays an important role in the initiated risk of coronary heart disease. As the long-term unhealthy diet can cause obesity, high blood pressure,... and diabetes.

Dr. McNamara DJ, in the study of dietary cholesterol, heart disease risk and cognitive dissonance, wrote, "....dietary cholesterol has a small effect on the plasma cholesterol levels with an increase in the cholesterol content of the LDL particle and an increase in HDL cholesterol, with little effect on the LDL: HDL ratio, a significant indicator of heart disease risk"(4).

Truly, everything that adds to the formation of atherosclerosis lesions, damages the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart, is considered prevalent risk factors of arterial blockage, the main cause of heart disease.

Strawberry is a genius of Fragaria × ananassa belongings to the family Roseaceae.

The edible plants have been grown all over the world with a suitable climate for commercial profits due to their's health benefits.

 Chemicals constituents of strawberry
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

According to the followed up study to examine the relationship between anthocyanins, the largest group of water-soluble pigments and the risk of MI, anthocyanin, strawberries intake was found to be potential in preventing myocardial infarction (MI) in young and middle-aged women.

Intake of strawberries was also associated with a decreased risk of MI, in a comparison of those consuming >3 servings a week and those with lower intake.

Dr. Cassidy A, the lead scientist, in the study conducted by the University of East Anglia, including a total of 93 600 women 25 to 42 years of age from the database of the Nurses' Health Study (NHS) II, after taking into account of multivariate adjustment said, "An inverse association between higher intake of anthocyanins and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval, 0.49-0.96; P=0.03, highest versus lowest quintiles)".

Further differentiation of the effects of anthocyanins in reduced risk of a heart problem, also found that anthocyanins efficacy may be associated to improve a variety of effects on blood vessels, platelets, and lipoproteins, the coronary heart diseases reducers.

Moreover, the study of participants includes 34 489 postmenopausal women in the Iowa Women's Health Study who were free of CVD and had complete food-frequency questionnaire information  that include Intakes of total flavonoids and 7 subclasses categorized into quintiles at baseline, using the proportional hazards rate ratios (RR) to compute for CVD, coronary heart disease (CHD), stroke, and total mortality after 16 y of follow-up, showed,

* There was a significant inverse association between anthocyanidins and CHD, CVD, and total mortality in compared to no intake of proportional hazards rate ratios (RR) of 0.88, 0.91, and 0.90, respectively.

* The proportional hazards rate ratios (RR) between flavanones and CHD [RR for highest quintile versus lowest 0.78 and between flavones and total mortality [RR for highest quintile versus lowest: 0.88.

* Intake of strawberry were associated with significantly reduced risk of cardiovascular diseases in compared to other foods in the questionnaire.

These results suggested that dietary intakes of flavanones, anthocyanidins, and foods rich in flavonoids were associated with reduced risk of death due to CHD, CVD, and all causes, according to Dr. Mink PJ, the lead scientist.

Taken altogether, strawberry with rich of flavanones, anthocyanidins, and flavonoids may be considered as a functional food in the prevention of early onset and treatment of heart disease.

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References
(1) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women by Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB..(PubMed)
(2) Anthocyanins and heart health by Mazza GJ. (PubMed)
(3) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. byMink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr.(PubMed)
(4) Dietary cholesterol, heart disease risk and cognitive dissonance by McNamara DJ(PubMed)

Butterbur, The Functional Herb Which Protects Neurons Integrity, Scientist Find

Kyle J. Norton

Scientists have found a herbal plant which processes a potential and therapeutic effect in the protection against damage and death of neurons.

Neuroprotective effects are the protection against anything which causes harm to the brain and spinal cord

In other words, herbal butterbur promotes neuronal integrity against the reduction in the rate of neuronal loss that causes neurodegenerative disease.

Dr. Vajda FJ, the scientist at the St. Vincent's Hospital, Melbourne in the expression of neuro diseases said, "neuroprotection is an effect that may result in salvage, recovery or regeneration of the nervous system, its cells, structure, and function. It is thought that there are many neurochemical modulators of nervous system damage" and " Acute and chronic nervous system damage in response to an insult may lead to acute or delayed neuronal death, apoptotic cell death, neuronal degeneration, injury and loss, and gliosis"(4).

The Mcgovern Istitute in the article related to brain disorder wrote, "Many brain disorders are chronic and incurable conditions whose disabling effects may continue for years or even decades. Thus, the overall disease burden from these disorders is much greater than would be suggested by mortality figures alone. The extent of this burden is underlined by data from the World Health Organization".

Most common brain disease neurodegenerative disease including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), affecting millions of people worldwide.

And, dementia is an umbrella term that describes a variety of diseases and conditions caused by nerve cells in the brain die or no longer function normally. Symptoms may affect memory, behavior and ability to think clearly.

According to statistic, approximately over 5.7 million Americans of all ages have Alzheimer's. as of 2018, 1 in 8 people age 65 and older (10 percent) has Alzheimer's disease in the US. Sadly, The numbers of Alzheimer's disease are growing and growing fast.

Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belongings to the family Asteraceae, native to Northern Hemisphere.

The herbal medicine has been used in herbal medicine as an pain reliever in the digestive system, including stomach, bile ducts,...... and duodenum.

The Ingredients
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

In the study to investigate neuroprotective effects in a rat transient focal cerebral ischemia-reperfusion model, and in an in vitro cerebral ischemia model, oxygen-glucose deprivation of cultured nerve cells, researchers found that application of total bakkenolides, a major bioactive constituent isolated immediately after reperfusion at doses of 5, 10 and 20 mg/kg markedly reduced brain infarct volume and neurological deficits.

Additional analysis also suggested, the administrated doses also significantly attenuated cell death and apoptosis in primarily cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation.

The efficacy of herbal butterbur in protected neurons was attributed by total bakkenolides in inhibited an enzyme activators with function in propagated the cellular response to inflammation through NF-κB, a protein complex regulated transcription of DNA, cytokine production and cell survival.

In other words, application of total bakkenolides reduced brain infarct volume and over expression of pro inflammation cytokines in response to focal cerebral ischemia-reperfusion that have a strong impact in decreased neuro cell damage and death at the site of reperfusion injure.

Dr. Jiang Q, the lead author after taking into account of other co and confounder said, "(The) results provide a strong pharmacological basis for further understanding the potential therapeutic role of total bakkenolides in cerebral ischemic disease.

Some researchers in the study of Bakkenolides in primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults, suggested, Bakkenolides exerted neuro protective effects may be results from properties of its antioxidant properties.

Moreover, petaslignolide A (PA), a furfuran lignan isolated from butanol fraction of Petasites japonicus (Sieb. et Zucc.) (Compositae) leaves in study of the oxidative damage in the brain of mice, facilitated a significant effect at dose of 40 mg/kg in alleviated the behavioral signs of kainic acid neurotoxicity and reduced the mortality (50%) by kainic acid to 12.5%.

Administration of PA also restore the levels of antioxidants in the mice that were reduced by injection of kainic acid in compared to control.

Further analsysis found that  PA (40 mg/kg) effectiveness is comparable to those of butanol fraction (200 mg/kg) of P. japonicus extract in reducing kainic acid neurotoxicity.

These results indicated that  butanol fraction (200 mg/kg) of P. japonicus extract exhibited strong neuro protective, probably is due to the presence of petaslignolide A (PA).

The findings suggested herbal butterbur may be considered as a functional herb for neuro protection, however, the volume of the herb used should only be prescribed herbal doctor.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food  during the course of the disease will be necessary to complete the picture of butterbur neuro protective possibilities.

.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI.(PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE.(PubMed)
(4) Neuroprotection and neurodegenerative disease by Vajda FJ(PubMed)

The Herb and Plant Inhibits Mucus Accumulation That Cause Acute and Chronic Cough, Scientists Show

Kyle J. Norton

Fennel may have a potential and positive effect in reduced cough through its expectorant activity, some scientists suggested.

The results of the study were conducted by numbers of institutes, including the Kaunas University of Medicine and published on online literature
is a natural and infrequent reaction of body to clear the throat caused by excessive mucus or foreign irritants.The aim of these function are to make the airway free for air inhaling and expelling.

Acute coughing normally caused by hay fever and the common cold is healed itself within 3 weeks. Chronic coughing are a condition that last longer than 3 weeks.

As of today, researchers do not know the exact causes of chronic coughing. However, researchers suggested, the condition may be resutlted of postnasal drip, asthma, gastroesophageal reflux disease (GERD),... and chronic bronchitis. And cigarette smoking is considered as a main culprit.  

Long term use of an ACE inhibitor, a pharmaceutical drug used primarily for the treatment of hypertension and congestive heart failure are also associated to the risk of a chronic cough.

Dr. Terasaki G, the lead author at the University of Washington, said, " Cough hypersensitivity syndrome is a new area of research and has been hypothesized to be the underlying factor in many cases of a chronic cough, regardless of the inciting factor" and " More clinical research is needed to further elucidate the cough reflex pathway and the factors involved in modulating its sensitivity, which may eventually lead to new antitussive therapeutics"(5).

Expectorant is a medicine with a function to promote the secretion of sputum of the air passages for treatment of coughs.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the comparison of the effect of some herbal agents in velocity of mucus secretion isolated from ciliated epithelium of the frog oesophagus, researchers found that application fo fructus foeniculi (fennel) exerts a stronger effect than  fructus anisi (anise). Herba plantaginis (plantain), flores verbasci (torch weed), and radix liquiritiae (liquorice) but lessers than the application of Folia farfarae (coltsfoot).

These protective effect in the further analysis was found to attribute to mucous layers in the hypopharynx and spasmolytic, secretolytic and bactericide effects found in fennel.

Furthermore, in the experiment to confirm the efficacy of some herbal medicine for treatment of throat clearing used since ancient times, researchers conducted a study to evaluate the bronchial mucus secretion stimulating and antispasmodic, antimicrobial, antiphlogistic and stimulating effect on the ciliated epithelium of two new formulations of throat clearing herbal tea.

The first formulation consists of liquorice roots, sweet fennel and thyme, and the second one consists of pine gemmae, thyme and elder flowers.

At the end of the experiment, researchers showed that both formulas exerted a significant activity against in inhibited mucus secretion in tested subjects without inducing intolerant adverse effects.

However, loss of the efficacy was found in use of formulas after 2 years of expiration, and the purity of the mixtures may also be decreased due to loss on drying, total ash, microbial contamination, contamination with radionuclides, heavy metals, pesticides and foreign matter.

These result suggested that although herbal medicine may be effective in exhibited mucus secretion for treatment of a cough, appliers should also be beware of the contamination caused by several aspects.

Moreover, in the investigation to a water extract of a mixture of eight herbs (chamomile, saffron, anise, fennel, caraway, licorice, cardomom and black seed) tested for its inhibitory effect on histamine released in initiated cough from rat peritoneal mast cells stimulated either by compound 48/80 or be IgE/anti-IgE, researchers at the Helwan University indicated that in compared to flavonoid quercetin, the extract demonstrated inhibited histamine released from chemically- and immunologically-induced cells by 81% and 85%, respectively.

Intake of the water extract of tested subjects also displayed a significantly and clinically expectorant expectancy in improvements of sleep discomfort, cough frequency and cough intensity.

The application also increased percentages of FEV1/FVC in patients suffering from allergic asthma in compared to placebo tea participants.

Where The FEV1/FVC ratio, also called Tiffeneau-Pinelli index, is a calculated ratio used in the diagnosis of obstructive and restrictive lung disease, according to Wikipedia

FEV1: Volume that has been exhaled at the end of the first second of a forced expiration

VC: Vital capacity: the volume of air breathed out after the deepest inhalation
RV/TLC%: Residual volume expressed as percent of TLC

FEFmax: The maximum instantaneous flow achieved during a FVC maneuver

VL: Actual volume of the lung including the volume of the conducting airway

FRC: Functional residual capacity: the volume in the lungs at the end-expiratory position

TLC: Total lung capacity: the volume in the lungs at maximal inflation, the sum of VC and RV

Taken together, fennel used alone or combination with other herbal medicine may be used to get rid of mucus, improve quality of life and treat asthma.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) [Effect of various phytotherapeutic expectorants on mucociliary transport].[Article in German] by Müller-Limmroth W, Fröhlich HH.(PubMed)
(2) The effect of a herbal water-extract on histamine release from mast cells and on allergic asthma by Haggag EG1, Abou-Moustafa MA, Boucher W, Theoharides TC.(PubMed)
(3) [Use of herbal medicine in German children - prevalence, indications and motivation].[Article in German]by Hümer M1, Scheller G, Kapellen T, Gebauer C, Schmidt H, Kiess W.(PubMed)
(4) FEV1/FVC ratio(Wikipedia)
(5) Evaluation and treatment of chronic cough by Terasaki G 1 , Paauw DS(PubMed)

The Herbs That Protect Digestive Function Against Gastroesophageal Reflux Disease (GERD)

By Kyle J. Norton

Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is a chronic condition characterized by liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. 

According to the study of "Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease." by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. 

Most common symptoms are burning sensation in your chest (heartburn), chest pain, regurgitation of food or sour liquid and sensation of a lump in your throat.  

In the severe case, people with GERD may experience symptoms of difficulty swallowing, lump in the throat asthma,... and chronic cough.

According to the Assaf Harofeh Medical Center, GERD may also facilitate symptoms of chest pain, similar to those with noncardiac chest pain (NCCP)(5).

The causes of GERD are not fully understood. However, some researchers suggested that obesity, poor diet, lack of physical activity, consumption of tobacco and alcohol, and respiratory diseases are associated with the prevalent risk of the diseases(6).

Properly manage diet such as two meals a day with an intake of only fluids in between, whenever the patient feels hungry or thirsty, is a useful dietary regimen for the management of GERD(7) and avoid foods and beverages that trigger GERD symptoms(8).

Use of proton pump inhibitors (PPIs) may be effective but long-term application may cause severe side effects.

Types of food to prevent and treat Gastroesophageal reflux disease (GERD)
1. Peppermint
According to the study of the review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.)." by McKay DL, Blumberg JB. posted in PubMed, in vitro, peppermint has significant antimicrobial and antiviral activities, strong antioxidant and antitumor actions, and some antiallergenic potential.

 Animal model studies demonstrate a relaxation effect on gastrointestinal (GI) tissue, analgesic and anesthetic effects in the central and peripheral nervous system.

However, human studies of peppermint leaf are limited and clinical trials of peppermint tea are absent. 

Adverse reactions to peppermint tea have not been reported, although caution has been urged for peppermint oil therapy in patients with GI reflux, hiatal hernia or kidney stones(1).


2. Ginger
Gingerol, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger and in a variety of other plants. 

Ginger has been used for thousands of years to enhance the function of digestive system and treat stomach distress including nausea, vomiting, diarrhea and indigestion, acid reflux, motion sickness, dyspepsia, etc. due to its due to its anti-inflammatory, antimicrobial and analgesic properties. 

According to the study of " Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori", the methanol extract of ginger rhizome inhibited the growth of all 19 strains in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml. 

One fraction of the crude extract, containing the gingerols, was active and inhibited the growth of all HP strains with a MIC range of 0.78 to 12.5 micrograms/ml and with significant activity against the CagA+ strains(2). 

Other research of [6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol. and it effects in nausea and vomiting found that the efficiency of ginger in reducing nausea and vomiting may be based on a weak inhibitory effect of gingerols and shogaols at cholinergic M (3) receptors and serotonergic 5-HT (3) receptors. 

Serotonergic 5-HT (4) receptors, which play a role in gastroduodenal motility, appear not to be involved in the action of these compound. (3)

3. Aloe Vera Juice
According to the study described in article of "Effect Of Orally Consumed Aloe Vera Juice On Gastrointestinal Function in Normal Humans",  by Jeffrey Bland, Ph.D. (Linus Pauling Institute of Science & Medicine) involved ten healthy subjects - five men (median age: 42; standard deviation: 14 years), and five women (median age: 32; standard deviation: 5 years), Aloe vera juice injection promoted proper gastrointestinal function through  regulating gastrointestinal pH and improved gastrointestinal motility, increased stool specific gravity, and reduced populations of certain fecal micro-organisms, including yeast(4).

4. Mastic Gum
According to the article of "Strategies to Protect Against Potential Bone-Destroying Effects"By Chris D. Meletis, ND, while much of the research on mastic gum revolves around its ability to support the health of patients with ulcers and the ability to inhibit the bacteria H. pylori,  has been equally useful in patients with GERD and acid reflux(4).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/16767798
(2) http://www.ncbi.nlm.nih.gov/pubmed/14666666
(3) http://www.ncbi.nlm.nih.gov/pubmed/21305447
(4) http://www.desertharvest.com/physicians/documents/DH127.pdf

(5) Comparison of central and intraesophageal factors between gastroesophageal reflux disease (GERD) patients and those with GERD-related noncardiac chest pain by Shapiro M1, Simantov R, Yair M, Leitman M, Blatt A, Scapa E, Broide E(PubMed)

(6) Epidemiology of gastroesophageal reflux disease, by Rubenstein JH1, Chen JW(PubMed)

(7) An old dietary regimen as a new lifestyle change for Gastro esophageal refluxdisease: A pilot study by Randhawa MA1, Mahfouz SA2, Selim NA2, Yar T3, Gillessen A(PubMed)

(8) Management of gastroesophageal reflux disease: lifestyle modification and alternative approaches by Eherer A1(PubMed)

The Edible Button Mushroom Which Protects the Liver Against Hepatic Steatosis (Fatty Liver Diseases)

Kyle J. Norton

Hepatic steatosis is a medical condition characterized by fat accumulation accompanied by a progressive inflammation of the liver.

The disease is also known as fatty liver disease.

Depending on the risk factors that cause fatty liver,

 * Obesity, high blood cholesterol including high triglycerides, diabetes, and certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodorone (Pacerone), and valproic acid (Depakote) are associated nonalcoholic fatty disease. And

* Alcohol fatty liver disease is associated with long-term excessive alcohol drinking.

Prolonged untreated hepatic steatosis is also a leading cause of cirrhosis and liver cancer. 

Hepatic steatosis symptoms may include poor appetite, weight loss, abdominal pain, physical weakness fatigue. However, patients in the severe case may experience symptoms of jaundice of the skin and eyes confusion,.... and abnormal bleeding if hepatic steatosis develops to its advanced stage.

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source.

The edible mushroom is a genus A. Muscaria and belongings to the family Amanitaceae and cultivated in many cultures all over the world for foods and health benefits.

Chemical constituents of button mushroom include astraodorol, psilocybin, lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil and D-mannitol(a).

Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat.

However, too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place.

In ovariectomized (OVX) mice (a model of postmenopausal women) induced hepatic steatosis by a high-fat diet supplemented with WBM powder, researchers found that(1)

* Dietary WBM intake in tested mice significantly lowers liver weight and hepatic injury markers.

* Treated mice also shows less fat accumulation in the livers, according to liver tissue analysis.

* More importantly, treatment mice exerts a significant improvement of glucose clearance ability. 

Glucose clearance ability is correlated with measures of insulin sensitivity and acute insulin response to glucose, in compared to a normal range of hepatic extraction of 25.8% [32.7%], and extrahepatic insulin clearance of 20.7 mL/kg/min [11.7 mL/kg/min])(2).

Further analysis of microarray analysis also revealed that genes related to the fatty acid biosynthesis pathway, including the genes for fatty acid synthetase (Fas) and fatty acid elongase 6 (Elovl6), the enzymes which are responsible for lipogenesis (the metabolic formation of fat)(1) found to decrease in the liver of mushroom-fed mice.

Moreover, in a vitro mechanistic studies using the HepG2 cell line, scientists explained, the efficacy in reduced expression of FAS and ELOVL6 in liver fat formation was attributed to button mushroom property in inhibition of liver X receptor (LXR)(1) signaling in activated and promoted above genes.

Dr. Kanaya N, the lead author, after taking into account of other co and confounders said, "WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women".

Taking all together, button mushroom may be considered as functional food in the protection of liver against the onset of hepatic steatosis, the early stage of fatty liver diseases.

However, further data collection on large example size and multi-center studies performed with human consumption of the whole food of button mushroom during the course of the disease will be necessary to complete the picture of anti-fatty liver possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Hepatic and Extrahepatic Insulin Clearance Are Differentially Regulated: Results From a Novel Model-Based Analysis of Intravenous Glucose Tolerance Data by David C. Polidori,1 Richard N. Bergman,2 Stephanie T. Chung,3 and Anne E. Sumner(PMC)

Coffee, The Beverage Which Normalizes Levels of Sex Hormone Testosterone and Estrogen, Scientists Say

By Kyle J. Norton, Master of Nutrition

A recent study suggested that coffee may have a direct effect in influence the production of the sex hormone estrogen and testosterone.

Sex hormones are a class of hormones, affecting sexual development or reproduction.

Steroid-binding globulin(SSBG), is a sex hormone, having a direct effect on androgen and estrogen, in compared to corticosteroid-binding globulin (CBG) binding glucocorticoids and progesterone.

According to the University of Western Ontario, in differentiation of steroid-binding globulin(SSBG) wrote, "The access of testosterone and estradiol to target tissues is regulated by sex hormone–binding globulin (SHBG) in human blood" and "Serum SHBG levels are low in patients with hyperandrogenism, especially in association with polycystic ovarian syndrome (PCOS) and in individuals at risk for diabetes and heart disease".

Furthermore, Patients wit, idiopathic hirsutism, or ovarian failure are also associated with low levels of Steroid-binding globulin(SSBG), Dr. Hogeveen KN, the lead author said.
Moreover, reduced circulating testosterone and sex hormone-binding globulin (SHBG) in an aging population are also implicated as risk factors for metabolic syndrome, probably due to its relationship with insulin sensitivity.

Therefore, raising SHBG may be used as protective therapy against the development of metabolic syndrome in older men.

These results suggested regulated serum SHBG levels to normal levels not only have a strong effect in prevented disease associated to aging male but also reduce diseases associated to high levels of testosterone such as polycystic ovarian syndrome (PCOS), in women.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In an 8-week parallel-arm randomized controlled trial with Healthy adults (n = 42) recruited from the Boston community, including regular coffee consumers, nonsmokers, and overweight, randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water per day, at 4 weeks, researchers surprisingly found that
* Decaffeinated coffee drinking was associated with a borderline significantly increased levels of SHBG in women, but not in men.

* At week 4, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased only total testosterone in women.

* Contrasted to women participants, men consumption of caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol hormones.

* The study also indicated that caffeinated coffee consumption does not exert any effect on SHBG in either men or women.

But conflicted to the healthy young adult, coffee and coffee caffeine showed an elevated effect as a mediator of sex hormone-binding globulin in both androgen and estrogen in type 2 diabetic patients, particularly in women.

Additionally, according to the cross-sectional study of 2377 nondiabetic pre- and postmenopausal women from the E3N cohort study in a multivariate-adjusted model, intake of more than 3 cups of coffee daily coffee and caffeine ≥265 mg/day were associated with an increased SHBG level distribution (<46.3 nmol/L), in compared to no risk association of decaffeinated coffee subgroup.

Moreover, the prevention of low level of SHBG of both caffeinated coffee and caffeine may demonstrate a potential and positive effect in reduced risk of T2DM.

More importantly, in the examine a study during a median follow-up of 10 years of 359 postmenopausal women with newly diagnosed type 2 diabetes matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw, coffee and caffeine were associated to increased levels of fee and total testosterone among postmenopausal women.

The findings suggested that coffee and caffeine has an extreme effect in the exhibition of the sex hormone estrogen and testosterone throughthe lower level of SHBG in menopause women and prevented onset of type 2 diabetes.

Decaffeinated coffee decreased total and free testosterone through significantly increased levels of SHBG in women. And caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol in men.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.Sources
(1) The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial by Wedick NM1, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM.(PubMed)
(2) Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women by Pihan-Le Bars F1,2, Gusto G3,4,5, Boutron-Ruault MC3,4,5, Fagherazzi G3,4,5, Bonnet F1,2,3.(PubMed)
(3) Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women by Goto A1, Song Y, Chen BH, Manson JE, Buring JE, Liu S.(PubMed)

(4) Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Studyin European Journal of Endocrinology

(5) Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction by Kevin N. Hogeveen,1 Patrice Cousin,2 Michel Pugeat,2 Didier Dewailly,3 Benoît Soudan,3 andGeoffrey L. Hammon(PubMed)

The Vegetable Juice Which Stops Leukemia Cells From Spreading, Researchers Found

Kyle J. Norton

Carrots may have a profound and positive impact in inhibited lymphoid leukemia cells from cell cycle division, some scientists suggested.

Leukemia is a medical condition characterized by the abnormal growth of the cells in the blood.

Lymphoid leukemia cells are the abnormal cell developed of cancerous cells from early (immature) forms of lymphocytes, a type of white blood cell.

The Leukemia and Lymphoma Society in 2018 statistic report wrote, "Approximately every 3 minutes one person in the United States (US) is diagnosed with a blood cancer. ... New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of the estimated 1,735,350 new cancer cases diagnosed in the US in 2018".

The disease affects mostly people aged 55 and over, however, it is also the most common cancer in children under 15 years of age.

There is no single cause of abnormal blood cells that do not die but accumulate and proliferate.

Some researchers suggested that use artificial ionizing radiation, infected by human T-lymphotropic virus (HTLV-1) and HIV, long-term contacted with benzene and some petrochemicals, medication used for the treatment of cancer, gene alternation and certain diseases such as Down syndrome are associated to increased risk of immature white blood cells development.

Frequent use of hair dyes and long-term and heavy smoking are also considered as preventable risk factors that cause leukemia.

Most common symptoms are pains in the bones or joints, swollen lymph nodes, fevers or night sweats,  bleeding and bruising easily, frequent infections, discomfort or swelling in the abdomen and general cancer symptoms of weight loss, loss of appetite, feeling weak or tired.

If you experience some of the above symptoms, please check with your doctor immediately, you may be at the early stage of leukemia.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In a study conducted by the Sheffield Hallam University to exam the potential effects of  injection of carrot juice in treatment of the 3 three lymphoid leukaemia cell lines and to test the suggestion of traditional medicine regarded to the used of carrot for potential treatment for leukaemia by using carrot the bioactive compounds such as three polyacetylenes (falcarinol, falcarindiol, and falcarindiol-3-acetate) and two carotenoids (beta-carotene and lutein) isolated from carrot juice extract (CJE) researchers found that

* Application of carrot juice exerts a significant effect in the induction of cancer cell apoptosis observed by the Annexin V/PI and Caspase 3 activity assays.

* Injection of carrot contained polyacetylenes and carotenoids in leukemia cell lines with the fraction from carrot extracts was significantly more cytotoxic in compared to other fractions.

* Treatment with purified polyacetylenes isolated from carrot juice also induced apoptosis, but in a dose and time responsive manner. 

*  Falcarinol and falcarindiol-3-acetate isolated from Daucus carota L induced a most significant cytotoxic activity in compared to falcarindiol.

Surprisingly, in contrast, the carotenoids, the major bioactive compound found abundantly in carrot demonstrated the insignificant effect on either apoptosis or cell proliferation in all tested cell line.

These result illustrated a strong message that the efficacy of carrot in the treatment of was attributed to chemical compound polyacetylenes rather than beta-carotene or lutein as hypothesized by some literature.

Further analysis also suggested that the cytotoxic effects of polyacetylenes were most efficacy in facilitated apoptosis and inhibited proliferation through the arrest of the cell cycle. 

Additional investigation of carrot juice extract against expression of on myeloid and lymphoid leukemia cell lines in compared to normal hematopoietic stem cells also conducted by the same institute, suggested that treatment of carrot juice extracts for up to 72 hours in vitro display a strong effect in induction of cancer cells death observed by the annexin V/propidium iodide staining followed by flow cytometric analysis.

Furthermore, in compared to normal cell lines, injection also inhibited the progression of the cancer division through the cell cycle arrested observed by the cell cycle analysis and cell counts.

Interestingly, application of the extract exerted a higher inhibitory effect in lymphoid cell lines in compared to myeloid cell lines, without affecting the normal and healthy hematopoietic stem cells.

Finally, after taking into account of other co and confounders, Dr. said, "extracts from carrots can induce apoptosis and cause cell cycle arrest in leukemia cell lines. The findings suggest that carrots may be an excellent source of bioactive chemicals for the treatment of leukemia ".

The found evidence suggested that carrot juice and its bioactive compound polyacetylenes may be considered as functional foods for ameliorated risk, progression, and treatment of lymphoid leukemia.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot juice anti-leukemia possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells by Zaini RG1, Brandt K, Clench MR, Le Maitre CL.(PubMed)
(2) Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia by Zaini R1, Clench MR, Le Maitre CL. (PubMed)
(3) Effects of carrot and tomato juice consumption on faecal markers relevant to coloncarcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G.(PubMed)