* Male + Smoking + High Caffeinated Coffee Consumption = ↑ Risk of Lung Cancer, Scientists Found

Kyle J. Norton, Master of Nutrition

Recent study suggested that regular high amounts of caffeinated coffee consumption may be associated to increase risk of lung cancer.

Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.

At the advance stage, the cancerous cells can travel a distance away from the lung to infect other healthy tissue and organs

Most common form of primary lung cancers are derived from epithelial cells. 

In US, lung cancer is the leading cause of cancer death. Approximately, 88,329 men and 70,354 women died from the disease, according to 2007 statistic.

Non-small cell lung cancer is the most common type of lung cancer, developed in the squamous-cells of the lung. 

Although the exact causes of lung cancer are debatable, some researchers suggested that smoking, second hand smoke, exposure to certain chemicals, lung disease, family history,..... and excessive alcohol drinking are associated to substantially increased risk of the disease.

Most common symptoms are coughing up blood.and shortness of breath, however, some patients may also experience symptoms of chest pain, lung fluid retention, wheezing and hoarseness,..... and bone pain.

If you suffer from some of the above symptoms, please see your doctor to rule out the disease possibility

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the clarified risk of coffee in induced lung cancer, the Shanghai Institute of Pharmaceutical Industry conducted a search in the data base of PubMed and Embase, from 1966 to January 2009. In 5 prospective studies and 8 case-control studies involving 5347 lung cancer cases and 104,911 non-cases selected, researchers found that
* Coffee high amount intake is associated to a significant positive lung cancer risk.

*. Risk of lung cancer is increased by 14% for additional 2 cups consumed daily.

Dr. Wang Y, the lead author said, "a linear dose-response relationship exists between (caffeinated) coffee consumption and risk of lung cancer".

Interestingly, prospective studies conducted in America and Japan showed a significantly associated with increased risk of lung cancer in highest coffee consumption, but borderline significantly associated with decreased risk of lung cancer in non-smokers in compared to studies conducted from other countries.

And people drinking decaffeinate coffee showed a decreased risk of lung cancer in all studies.

Other, in the review of seventeen studies (5 cohort and 12 case-control studies) involving 12 276 cases and 102 516 controls met the predetermined inclusion criterion, extracted from data base of literature, the total risk of caffeinated coffee intake and lung cancer incidence was 1.17 in compared to non drinkers.

 Also in compared to non drinkers, the relative risk of lung cancer was associated to numbers of cup per day consumed,
* 1.10 (95% CI: 0.92-1.31) for ⩽1 cup per day,

* 1.10 (95% CI: 0.93-1.30) for 2-3 cups per day,
 and
* 1.20 (95% CI: 1.02-1.39) for ⩾3 cups per day.


More importantly, Dr. Xie Y, the lead author said, " Significant associations for high coffee intake with increased risk of lung cancer were observed in men (OR=1.41 95% CI: 1.21-1.63), but not in women (OR=1.16, 95% CI: 0.86-1.56), ..... but not in nonsmokers (OR=0.85, 95% CI: 0.64-1.11)".


Taking altogether, there is no doubt that regular coffee intakes of large amounts is associated linearly in increased risk of lung cancer in men and smokers.

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Holistic System In Existence That Will Show You How To
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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and tea consumption and risk of lung cancer: a dose-response analysis of observational studies by Wang Y, Yu X, Wu Y, Zhang D.(PubMed)
(2) Coffee consumption and risk of lung cancer: a meta-analysis by Tang N1, Wu Y, Ma J, Wang B, Yu R.(PubMed)
(3) Lung cancer by Kyle J. Norton

* Aloe Vera, the Natural Whole Food That Inhibits Ulcerative Colitis

Kyle J. Norton, Master of Nutrition.


Aloe Vera may have a potential efficacy in reduced risk and treatment of ulcerative colitis, some scientists found.

Ulcerative colitis is condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract, affecting the function of lining of large intestine (colon) and rectum.

Onset of the disease may induce a persistent change in your bowel habits.

Most common symptoms of ulcerative colitis include, diarrhea with blood,  abdominal pain, rectal pain bleeding,..... unintended weight loss.

Most patients with ulcerative colitis also experience urgency to defecate and inability to defecate despite urgency.

In children, the onset of the disease may also cause persistent fever and grow retardation.

If you experience persistent and severe bowel symptoms that do not response to over counter medicine, you may have ulcerative colitis, please see your doctor as soon as possible. Untreated ulcerative colitis can cause perforated colon and colon cancer.

The actual causes of ulcerative colitis are debatable, some researchers suggested that long term intake of unhealthy diet(5) and stress may have strong effects in induction of the disease.

According to the joint study lead by the Tabriz University of Medical Sciences, including 62 newly diagnosed cases of UC and 124 healthy age and sex-matched controls, returned questionnaire indicated that dietary patterns play an important role in increased risk of the condition(5).

Dr. Jedel S the lead author in "A randomized controlled trial of mindfulness-based stress reduction to prevent flare-up in patients with inactive ulcerative colitis". said, "mindfulness-based stress reduction (MBSR) did not affect the rate or severity of flare-ups in UC patients in remission. However, MBSR might be effective for those with high stress reactivity (high perceived stress and urinary cortisol) during remission. MBSR appears to improve QOL in UC patients by minimizing the negative impact of flare-ups on QOL"(6).

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The popular herb has become very popular for commercial cultivation due to its health benefits. Aloe Vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes,..... and elevated of cholesterol.

In a double-blind, randomized, placebo-controlled trial of 44 hospital out-patients with ulcerative colitis randomly given oral aloe vera gel or placebo, 100 mL twice daily for 4 weeks, researchers found that oral administrated group shows an improvement and response occurred in nine (30%), viewed in the Simple Clinical Colitis Activity Index and histological scores.

Dr. Langmead , the lead researcher said, "Oral aloe vera taken for 4 weeks produced a clinical response more often than placebo; it also reduced the histological disease activity and appeared to be safe".

Furthermore, in the study of male Sprague Dawley rats fed experimental diets for 2 weeks before and during the induction of colitis, dietary aloe vera gel significantly ameliorated intestinal inflammatory responses in a dextran sulfate sodium (DSS) induced ulcerative colitis.

In fact, the efficacy is also found to associate to the abundant bioactivity of the herbs.

Other researchers suggested that the anti ulcerative colitis activity of aloe vera gel may be due to the healing properties of antioxidants, scavengers, chelators as well as strongly inhibited inflammation, electrical/mechanical impairment in the gut, and a great majority of oxidative stress.

Taking altogether, herbal aloe vera may process anti ulcerative colitis properties, through expression of bioactivity in induced production of antioxidant and reduced intestinal inflammatory responses. but further studies are necessary to re confirm this possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis by Langmead L1, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS.(PubMed)
(2) Advances in treatment of ulcerative colitis with herbs: from bench to bedside by Wan P1, Chen H1, Guo Y1, Bai AP1.(PubMed)
(3) Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitismodel by Park MY1, Kwon HJ, Sung MK.(PubMed)
(4) The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis in rats by Korkina L1, Suprun M, Petrova A, Mikhal'chik E, Luci A, De Luca C.(PubMed)
(5) Dietary patterns and risk of ulcerative colitis: a case-control study by Rashvand S1, Behrooz M1, Samsamikor M2, Jacobson K3, Hekmatdoost A(PubMed)
(6) A randomized controlled trial of mindfulness-based stress reduction to prevent flare-up in patients with inactive ulcerative colitis by Jedel S1, Hoffman A, Merriman P, Swanson B, Voigt R, Rajan KB, Shaikh M, Li H, Keshavarzian A(PubMed)

Papaya, The Tropical Fruit Which Normalizes Red (RBC) and White Blood Cell (WBC) Counts and Hemoglobin (Hb) Concentration Against Anemia

By Kyle J. Norton, Master of Nutrition

Anemia is characterized by a deficiency in the hemoglobin of the red blood cells, diminished the ability of the blood to transport oxygen to body cells and remove carbon dioxide from the body

The condition is the most common blood syndrome in the U.S, affecting approximately .6% of the general population.

According to common belief, people with chronic diseases are the most at risk to develop anemia.

Some researchers suggested that genetic mutation can also cause anemia. Children born with gene mutation are associated highest risk of the condition.

Sickle cell disease (SCD) is a genetic disease associated with unusually large numbers of immature blood cells. 

Women are susceptible to iron-deficiency anemia because of the blood loss from menstruation.

Older adults who follow a poor diet pattern and some medical conditions also increase the risk of development of anemia.

Sadly, long-term intake of certain conventional medication such as Cephalosporins, Dapsone,... and  Levodopa has a strong effect in the induction of the disease too.

 The joint study lead by the Maulana Azad Medical College went further to suggest, "The prevalence of anemia was 79.9% according to the WHO criteria of hemoglobin <12 g/dl in females. Age, education, marital status, financial dependence, diagnosed chronic disease, diet, calorie intake, history of worm infestation, and body mass index (BMI) were significantly associated with anemia on univariate analysis".

Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a).

According to Covenant University, Methanolic extracts from S. monostachyus, C. papaya seed oil, exhibited particular antisickling properties coupled with the potential to reduce stress in sickle cell patients(1).

 In beta-hemoglobinopathies, fermented papaya preparation (FPP), increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased  reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), through ameliorating oxidative status, without a significant change in the hematological parameters, probably due to its additional function as an iron chelator(2)

According to the Hebrew University Medical Center study, oral administration of FPP to beta-thalassemic mice (50 mg/mouse/day for 3 months) and to patients (3 g x 3 times/day for 3 months), reduced all the aspects of oxidative stress (p < 0.001 in mice and patients).

Furthermore, The preparation also alleviated symptoms associated with oxidative stress in severe forms of thalassemia(3) as well as a significantly reduced number of sickle cells(4).

People who have anemia or are at higher risk of anemia incidence may want to add a portion of papaya into their diet.

Taken together, whole food papaya and its fermented products may be used in combination with standard therapy in attenuated symptoms and treatment of all forms of anemia.

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How To Get Rid Of Eye Floaters
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Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed) (a) Chemical composition and bioactivity of dried fruits and honey of Ficus caricacultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT.(PubMed)
(2) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation by Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. (PubMed)
(3) Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E(PubMed)
(4) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)
(5) Magnitude and Correlates of Anemia in Elderly Women of a Resettlement Colony of Delhi by Singh T1, Nagesh S2, Ray TK(PubMed)

*Calendula (Calendula officinalis), The Herb That Cuts Off the Energy Supply to Cancers

Kyle J. Norton

 Herbal calendula may process a profound and sustainable effect in inhibited the key step in tumor angiogenesis, some scientists suggested.

Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation. 

Cancers are the class of diseases caused by alternation of DNA that initiates healthy cells to  grow disorderly and uncontrollably.

At the later stage, the cancerous cells may travel a distant away from the original site to infect healthy cells of other tissue and organs.

Cancers are the second leading cause of death worldwide besides heart diseases. 

According to statistic from the Canada Government, approximately 1 in 2 Canadians will be diagnosed with cancer during their life time, and 1 in 4 will die from the disease.

Most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.

Believe or not, 1/4 of cancers death are due to lung cancer.

Depending to types of cancer, people with cancers may experience general and specific symptoms.

The American Cancer Society wrote, "A cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer. For example, some cancers of the pancreas can release substances that cause blood clots in veins of the legs".

DNA alternation is the major cause of the diseases.

Some researchers suggested, smoking, radiation, viruses, carcinogens, obesity, hormones, chronic inflammation,.... and physical inactivity are associated to increased risk of cancers.

Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belongings to the family Asteraceae, native to Southern Europe.

The herb has been used in traditional medicine as spasmolytic, spasmogenic, inflammatory agent and to treat abdominal cramps, wound healing, skin diseases, colitis,.... and constipation.

Chemicals Compounds
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin,.... and n-paraffins.

The study of Calendula against the Angiogenesis of most solid tumors, suggested that calendula consists a strong and positive effect in suppressed tumors growth through its anti infectiously endothelial cells proliferation(1).

Application of calendula extract also displayed antiangiogenic activity through a direct inhibitory activity against the key step in tumor angiogenesis(1).

Furthermore, according to Universidad de Granada, the extract exhibited cytotoxic tumor cell activity, induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival days of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).

Caspase 3 is one of member of caspases that acts as crucial mediator in programmed cell death (apoptosis).

On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, calendula officinalis flower extract  reduced the lung tumor nodules by 74% with 43.3% increase in life span, probably through the inhibition of key enzymes involved in processes of metastasis(3).

These results suggested that herbal calendula officinalis and its extracts processed cytotoxic activity in induction of tumor cells apoptosis by blocking cancer in facilitated growth, invasion, and metastasis.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of herbal calendula anti cancer possibilities.
 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)

The Veggie and Plant Suppressed Oxidative Stress That Causes Atherosclerosis, Cancers, Diabetes, Rheumatoid Arthritis, Post-ischemic Perfusion Injury, Myocardial Infarction, Cardiovascular Diseases,... and Stroke

Kyle J. Norton

Carrots may have a profound and positive effect in reduced oxidative stress in the induction of related chronic diseases, including atherosclerosis, cancers, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases,... and stroke, some scientists suggested.

Oxidative stress is the indication of overexpression free radicals in the body due to depletion of antioxidants produced by the host tissue.

According to the Department of Biotechnology, M. J. College, "Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases".

The studies of carrots in reduced overproduction of reactive oxygen species in facilitated oxidative stress were carried out by several respectable institutes and the results were published online medical literature.

Carrot, a root vegetable with an orange color is a sub species of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.


In the investigation of the relation of dietary supplementation with lycopene (LYC), a major active biochemical compound found in carrot, on age-induced cognitive impairment, and the potential underlying mechanisms, using the behavioral tests, researchers at Northwest A&F University, researchers found that chronic injection of LYC exerts a potential effect in alleviated age-associated memory loss and cognitive defects through several mechanisms

Application of lycopene improved antioxidant produced by the host body in countering to the over expression of free radicals, including glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme.

Treatment of the phytochemical displayed a strong activity in reversed age-associated neuronal damage and synaptic dysfunctions in the brain, through inhibited the levels of malondialdehyde (MDA) levels in associated to oxidative stress.

Malondialdehyde (MDA) levels is considered as oxidative maker usedthe in treatment of cancers and other oxidative related diseases.

Interestingly, researchers also indicated that chronic injection of bioactive lycopene lower the levels of the accumulation of Aβ1-42 in the brains in aged CD-1 mice model.

Evidences findings suggested that Aβ-induced oxidative stress may place the majority of the causative effect of increased cellular oxidative stress upon oligomeric Aβ(1–42).

Further more, LYC supplementation also significantly reduced age-associated neuroinflammation caused by over expression of free radicals in activation of proinflammatory cytokines by inhibiting microgliosis (Iba-1) in response to damage to the central nervous system (CNS) and related inflammatory chemicals mediators.

These results overwhelmingly suggested that lycopene injection processes a strong effect in reduced risk  and treatment of diseases associated to over production of ROS, through re-balancing the ratio of antioxidant and free redials in the host body.

Moreover, in d-galactose induced CD-1 male mice cognitive impairments, chronic LYC supplementation (50 mg/kg bodyweight per day) demonstrated a significant activity in inhibition of oxidative stress-induced cognitive defects.

Injection of lycopene also ameliorated histopathological damage and restored brain derived neurotrophic factor (BDNF) levels in the hippocampus of mice. This findings reaffirms the conclusion of the Northwest A&F University study.

LYC treatment an in animal model,  also increased antioxidant of the host by activating the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited the oxidative stress the in induction of inflammatory cytokines IL-1β and TNF-α in host hippocampus.

More precisely, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling in increased levels of anti inflammatory mytokines and inactivation of NF-κB translocation in signalling pro inflammatory expression.

Dr. Zhao B, the lead scientist, after taking into account of co and confounders said, " LYC could ameliorate oxidative stress induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".

The findings indicated that carrot with major active compound lycopene may be considered as function foods in prevention and treatment of oxidative related diseases by restoring the ratio of reactive oxygen species and levels of antioxidant in the body.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice by Zhao B1, Liu H1, Wang J1, Liu P1, Tan X1, Ren B1, Liu Z1, Liu X(PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X2(PubMed)

*How To Protect Against Retinal Degeneration, US National Library of Medicine Studies Show

Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.


Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.

The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.

In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicy of free radicals in induction of retinal cellular apoptosis.

Administration of green tea phynolic compound exerted 10 times more effective in treatment of retinal degeneration, in compared to potent medicine trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.


Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease of photoreceptor-specific markers (RET-P1, rhodopsin kinase), an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness.

Also, the application reduced an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)

Caspase 3 is an important marker of apoptosis and one of side effect of sodium nitroprusside (SNP) is cyanide toxicity, that can induce over expression ROS in facilitated free radical chain reaction.


According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina.

Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".


More interestingly, BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, showed a strong protective effect on the retina against light damage (LD) in compared to the control group.


In the examine the retinal structure and function after LD, according to the optical coherence tomography (OCT) and electroretinography (ERG), application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors in compared to control.

Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.

Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".


Importantly, in study to evaluate green tea EGCG effect in reduced glutamate and induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly assigned into
*. A normal control group (n = 9);
*. Saline control group with intravitreal saline injections (n = 54);
*. NMDA control group with an intravitreal NMDA injection;
*. Intraperitoneal saline injections (n = 54); and
*. NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections.

Observation of the groups at 2 weeks after additional injection of NMDA, showed that group treated with intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through
* Inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors.

These results were observed by differentiation of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.

Thy-1 is mostly is expressed by the ganglion cells within the retina and used to index ganglion cell death after ischemia and excitotoxicity.

And NMDA excitotoxicity is associated to the death of retinal ganglion cells (RGCs).


Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be used combination with standard therapy for protection and treatment of retinal degenerative disease


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299Sources

(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--

Garlic, The Best Whole Food That Gobbles Up Cancer Cells, Scientists Say

Kyle J. Norton, Master of Nutrition

Garlic (Allium sativum) may have a potential effect in prevention and treatment of cancers by gobbling up cancer cells before they can proliferate to the invasive tumor, some studies suggested.

Cancers is a class of chronic diseases characterized by uncontrollable cells grown in tissue in the body.

At the later stage,  the cancerous cells can infect other healthy cells and tissue far away from the original site by traveling through blood and lymph.

The diseases are the second cause of death in the US.

According to statistic, between 2011-2015, by the national Cancer Institute, 440 per 100,000 adults are diagnosed with cancers, inducing 163.5 per 100,000 death

Depending on types of cancer, patients may experience certain general and specific symptoms.

DNA alternation caused by an inherited gene mutation in induction abnormal cells proliferation is the major cause of cancers.

The National Cancer Institute suggested that age, excessive alcohol consumption, unhealthy diet and lifestyle, smoking, radiation, viruses, carcinogens, obesity,... and chronic inflammation,  are also considered as some major risk factors that can cause cancers. (As these factors are accumulated through many studies in which all point to a similar association between a potential risk factor and an increased risk of cancer).

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. 

The pungent herb has been used popularly in traditional and Chinese medicine for treating common cold and flu, blood pressure cholesterol levels,..... and as a natural antibiotic.

Garlic appears to be generally safe although some people may suffer mild allergic reactions.

A recent study lead by author Dr. Oommen S indicated that allicin, the main ingredient found in garlic induces the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells, causing cell death.

Researchers in the study of ingredient allicin also showed that the phytochemical is capable in inducing an increase of the rate of apoptosis by obstructing the expression the cell cycle division and  pro-inflammation.

On cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway through promoted GSH depletion and changes in the intracellular redox status.

In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.

Other compounds found in garlic such as organosulfur, its extract and phyto-compounds also suppressed cancer cells proliferation and induced cell cycle arrest.

Therefore, people who are at higher risk of the diseases may consider adding a portion of garlic whole food into their diet for preventive measure.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC.(PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3.(PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)